Traditional and new composite endpoints in heart failure clinical trials: Facilitating comprehensive efficacy assessments and improving trial efficiency

Journal article

Anker, Stefan D., Schroeder, Stefan, Atar, Dan, Bax, Jeroen J., Ceconi, Claudio, Cowie, Martin R., Crisp, Adam, Dominjon, Fabienne, Ford, Ian, Ghofrani, Hossein-Ardeschir, Gropper, Savion, Hindricks, Gerhard, Hlatky, Mark A., Holcomb, Richard, Honarpour, Narimon, Wouter Jukema, J., Kim, Albert M., Kunz, Michael, Lefkowitz, Martin P., ... Ruschitzka, Frank. (2016). Traditional and new composite endpoints in heart failure clinical trials: Facilitating comprehensive efficacy assessments and improving trial efficiency. European Journal of Heart Failure. 18(5), pp. 482 - 489. https://doi.org/10.1002/ejhf.516

Authors	Anker, Stefan D., Schroeder, Stefan, Atar, Dan, Bax, Jeroen J., Ceconi, Claudio, Cowie, Martin R., Crisp, Adam, Dominjon, Fabienne, Ford, Ian, Ghofrani, Hossein-Ardeschir, Gropper, Savion, Hindricks, Gerhard, Hlatky, Mark A., Holcomb, Richard, Honarpour, Narimon, Wouter Jukema, J., Kim, Albert M., Kunz, Michael, Lefkowitz, Martin P., Le Floch, Chantal, Landmesser, Ulf, McDonagh, Theresa A., McMurray, John J. V., Merkely, Bela, Packer, Milton, Prasad, Krishna, Revkin, James, Rosano, Giuseppe M. C., Somaratne, Ransi, Stough, Wendy Gattis, Voors, Adriaan A. and Ruschitzka, Frank
Abstract	Composite endpoints are commonly used as the primary measure of efficacy in heart failure clinical trials to assess the overall treatment effect and to increase the efficiency of trials. Clinical trials still must enrol large numbers of patients to accrue a sufficient number of outcome events and have adequate power to draw conclusions about the efficacy and safety of new treatments for heart failure. Additionally, the societal and health system perspectives on heart failure have raised interest in ascertaining the effects of therapy on outcomes such as repeat hospitalization and the patient's burden of disease. Thus, novel methods for using composite endpoints in clinical trials ( e.g. clinical status composite endpoints, recurrent event analyses ) are being applied in current and planned trials. Endpoints that measure functional status or reflect the patient experience are important but used cautiously because heart failure treatments may improve function yet have adverse effects on mortality. This paper discusses the use of traditional and new composite endpoints, identifies qualities of robust composites, and outlines opportunities for future research.
Keywords	heart failure; clinical trial; endpoint determination; surrogate endpoints
Year	2016
Journal	European Journal of Heart Failure
Journal citation	18 (5), pp. 482 - 489
Publisher	John Wiley & Sons Ltd
ISSN	1388-9842
Digital Object Identifier (DOI)	https://doi.org/10.1002/ejhf.516
Scopus EID	2-s2.0-84963679505
Page range	482 - 489
Research Group	Mary MacKillop Institute for Health Research
Publisher's version	File Access Level Controlled
Place of publication	United Kingdom

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Dewan, Pooja, Docherty, Kieran F. and McMurray, John J. V.. (2019). Sacubitril/valsartan in Asian patients with heart failure with reduced ejection fraction. Korean Circulation Journal. 49(6), pp. 469 - 484. https://doi.org/10.4070/kcj.2019.0136

Association of diabetes and kidney function according to age and systolic function with the incidence of sudden cardiac death and non-sudden cardiac death in myocardial infarction survivors with heart failure

Coiro, Stefano, Girerd, Nicolas, Sharma, Abhinav, Rossignol, Patrick, Tritto, Isabella, Pitt, Bertram, Pfeffer, Marc A., McMurray, John J. V., Ambrosio, Giuseppe, Dickstein, Kenneth, Moss, Arthur J. and Zannad, Faiez. (2019). Association of diabetes and kidney function according to age and systolic function with the incidence of sudden cardiac death and non-sudden cardiac death in myocardial infarction survivors with heart failure. European Journal of Heart Failure. 21(10), pp. 1248 - 1258. https://doi.org/10.1002/ejhf.1541

Angiotensin receptor-neprilysin inhibitors: A new paradigm in heart failure with reduced ejection fraction

Docherty, Kieran F. and McMurray, John J. V.. (2019). Angiotensin receptor-neprilysin inhibitors: A new paradigm in heart failure with reduced ejection fraction. International Journal of Cardiology. 281, pp. 179 - 185. https://doi.org/10.1016/j.ijcard.2018.05.124

Intravenous iron in patients undergoing maintenance hemodialysis

Macdougall, Iain C., White, Claire, Anker, Stefan D., Bhandari, Sunil, Farrington, Kenneth, Kalra, Philip A., McMurray, John J. V., Murray, Heather M., Tomson, Charles R.V., Wheeler, David C., Winearls, Christopher G. and Ford, Ian. (2019). Intravenous iron in patients undergoing maintenance hemodialysis. New England Journal of Medicine. 380(5), pp. 447 - 458. https://doi.org/10.1056/NEJMoa1810742

Renal function stratified dose comparisons of eplerenone versus placebo in the EMPHASIS-HF trial

Ferreira, João Pedro, Abreu, Paula, McMurray, John J. V., van Veldhuisen, Dirk J., Swedberg, Karl, Pocock, Stuart J., Vincent, John, Lins, Katharina, Rossignol, Patrick, Pitt, Bertram and Zannad, Faiez. (2019). Renal function stratified dose comparisons of eplerenone versus placebo in the EMPHASIS-HF trial. European Journal of Heart Failure. 21(3), pp. 345 - 351. https://doi.org/10.1002/ejhf.1400

Insulin treatment and clinical outcomes in patients with diabetes and heart failure with preserved ejection fraction

Shen, Li, Rørth, Rasmus, Cosmi, Deborah, Kristensen, Søren Lund, Petrie, Mark C., Cosmi, Franco, Latini, Roberto, Køber, Lars, Anand, Inder S., Carson, Peter E., Granger, Christopher B., Komajda, Michel, McKelvie, Robert S., Solomon, Scott D., Staszewsky, Lidia, Swedberg, Karl, Huynh, Thao, Zile, Michael R., Jhund, Pardeep S. and McMurray, John J. V.. (2019). Insulin treatment and clinical outcomes in patients with diabetes and heart failure with preserved ejection fraction. European Journal of Heart Failure. 21(8), pp. 974 - 984. https://doi.org/10.1002/ejhf.1535

Dilated cardiomyopathy

Schultheiss, Heinz-Peter, Fairweather, DeLisa, Caforio, Alida L. P., Escher, Felicitas, Hershberger, Ray E., Lipshultz, Steven E., Liu, Peter P., Matsumori, Akira, Mazzanti, Andrea, McMurray, John and Priori, Silvia G.. (2019). Dilated cardiomyopathy. Nature Reviews Disease Primers. 5(1), pp. 1 - 20. https://doi.org/10.1038/s41572-019-0084-1

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): A double-blind, randomised, placebo-controlled trial

Heerspink, Hiddo J. L., Parving, Hans-Henrik, Andress, Dennis L., Bakris, George, Correa-Rotter, Ricardo, Hou, Fan-Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John J. V., Melnick, Joel Z., Miller, Michael G., Pergola, Pablo E., Perkovic, Vlado, Tobe, Sheldon, Yi, Tingting, Wigderson, Melissa and de Zeeuw, Dick. (2019). Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): A double-blind, randomised, placebo-controlled trial. The Lancet. 393(10184), pp. 1937 - 1947. https://doi.org/10.1016/S0140-6736(19)30772-X

The prognostic value of troponin T and N-terminal pro B-type natriuretic peptide, alone and in combination, in heart failure patients with and without diabetes

Rørth, Rasmus, Jhund, Pardeep S., Kristensen, Søren L., Desai, Akshay S., Kober, Lars, Rouleau, Jean L., Solomon, Scott D., Swedberg, Karl, Zile, Michael R., Packer, Milton and McMurray, John J. V.. (2019). The prognostic value of troponin T and N-terminal pro B-type natriuretic peptide, alone and in combination, in heart failure patients with and without diabetes. European Journal of Heart Failure. 21(1), pp. 40 - 49. https://doi.org/10.1002/ejhf.1359

Dapagliflozin in patients with heart failure and reduced ejection fraction

McMurray, John J. V., Solomon, Scott D., Inzucchi, Silvio E., Kober, Lars, Kosiborod, Mikhail N., Martinez, Felipe A., Ponikowski, Piotr, Sabatine, Marc S., Anand, Inder S., Belohlavek, J., Bohm, Michael, Chiang, C.-E., Chopra, Vijay K., de Boer, Rudolf A., Desai, Akshay S., Diez, M., Drozdz, J., Dukat, Andrej, Ge, Junbo, ... Schou, Morten. (2019). Dapagliflozin in patients with heart failure and reduced ejection fraction. New England Journal of Medicine. 381(21), pp. 1995 - 2008. https://doi.org/10.1056/NEJMoa1911303

A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF)

McMurray, John J. V., DeMets, David L., Inzucchini, Silvio E., Køber, Lars, Kosiborod, Mikhail N., Langkilde, Anna M., Martinez, Felipe A., Bengtsson, Olof, Ponikowski, Piotr P., Sabatine, Marc S., Sjöstrand, Mikaela and Solomon, Scott D.. (2019). A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF). European Journal of Heart Failure. 21(5), pp. 665 - 675. https://doi.org/10.1002/ejhf.1432

N-Terminal Pro-B-Type natriuretic peptide levels for risk prediction in patients with heart failure and preserved ejection fraction according to atrial fibrillation status

Kristensen, Søren L., Mogensen, Ulrik M., Jhund, Pardeep S., Rørth, Rasmus, Anand, Inder S., Carson, Peter E., Desai, Akshay S., Pitt, Bertram, Pfeffer, Marc A., Solomon, Scott D., Zile, Michael R., Køber, Lars and McMurray, John J. V.. (2019). N-Terminal Pro-B-Type natriuretic peptide levels for risk prediction in patients with heart failure and preserved ejection fraction according to atrial fibrillation status. Circulation: Heart Failure. 12(3), pp. 1 - 10. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005766

Winter peaks in heart failure: An inevitable or preventable consequence of seasonal vulnerability?

Stewart, Simon, Moholdt, Trine T., Burrell, Louise M., Sliwa, Karen, Mocumbi, Ana O., McMurray, John J. V., Keates, Ashley K. and Hawley, John A.. (2019). Winter peaks in heart failure: An inevitable or preventable consequence of seasonal vulnerability? Cardiac Failure Review. 5(2), pp. 83 - 85. https://doi.org/10.15420/cfr.2018.40.2

Treatment of anemia with darbepoetin prior to dialysis initiation and clinical outcomes: Analyses from the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT)

McCausland, Finnian R., Claggett, Brian, Burdmann, Emmanuel A., Chertow, Glenn M., Cooper, Mark E., Eckardt, Kai-Uwe, Ivanovich, Peter, Levey, Andrew S., Lewis, Eldrin F., McGill, Janet B., McMurray, John J. V., Parfrey, Patrick, Parving, Hans-Henrik, Remuzzi, Giuseppe, Singh, Ajay K., Solomon, Scott D., Toto, Robert D. and Pfeffer, Marc A.. (2019). Treatment of anemia with darbepoetin prior to dialysis initiation and clinical outcomes: Analyses from the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT). American Journal of Kidney Diseases. 73(3), pp. 309 - 315. https://doi.org/10.1053/j.ajkd.2018.10.006

Efficacy of an implantable cardioverter-defibrillator in patients with diabetes and heart failure and reduced ejection fraction

Rørth, Rasmus, Dewan, Pooja, Kristensen, Søren L., Jhund, Pardeep S., Petrie, Mark C., Køber, Lars and McMurray, John J. V.. (2019). Efficacy of an implantable cardioverter-defibrillator in patients with diabetes and heart failure and reduced ejection fraction. Clinical Research in Cardiology. 108(8), pp. 868 - 877. https://doi.org/10.1007/s00392-019-01415-z

Effect of neladenoson bialanate on exercise capacity among patients with heart failure with preserved ejection fraction: A randomized clinical trial

Shah, Sanjiv J., Voors, Adriaan A., McMurray, John J. V., Kitzman, Dalane W., Viethen, Thomas, Wirtz, Antonieta Bomfim, Huang, Erya, Pap, Akos Ferenc and Solomon, Scott D.. (2019). Effect of neladenoson bialanate on exercise capacity among patients with heart failure with preserved ejection fraction: A randomized clinical trial. JAMA: Journal of the American Medical Association. 321(21), pp. 2101 - 2112. https://doi.org/10.1001/jama.2019.6717

Microvascular disease in patients with diabetes with heart failure and reduced ejection versus preserved ejection fraction

Tromp, Jasper, Lim, Shir Lynn, Tay, Wan Ting, Teng, Tiew-Hwa Katherine, Chandramouli, Chanchal, Ouwerkerk, Wouter, Wander, Gupreet S., Sawhney, Jitendra P. S., Yap, Jonathan, MacDonald, Michael R., Ling, Lieng Hsi, Sattar, Naveed, McMurray, John J. V., Richards, A. Mark, Anand, Inder S. and Lam, Carolyn S. P.. (2019). Microvascular disease in patients with diabetes with heart failure and reduced ejection versus preserved ejection fraction. Diabetes Care. 42(9), pp. 1792 - 1799. https://doi.org/10.2337/dc18-2515

Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up

Loader, Jordan, Chan, Yih-Kai, Hawley, John A., Moholdt, Trine, McDonald, Christine F., Jhund, Pardeep, Petrie, Mark C., McMurray, John J., Scuffham, Paul A., Ramchand, Jay, Burrell, Louise M. and Stewart, Simon. (2019). Prevalence and profile of "seasonal frequent flyers" with chronic heart disease: Analysis of 1598 patients and 4588 patient-years follow-up. International Journal of Cardiology. 279, pp. 126 - 132. https://doi.org/10.1016/j.ijcard.2018.12.060

MRAs in elderly HF patients: Individual patient-data meta-analysis of RALES, EMPHASIS-HF, and TOPCAT

Ferreira, João Pedro, Rossello, Xavier, Eschalier, Romain, McMurray, John J. V., Pocock, Stuart J., Girerd, Nicolas, Rossignol, Patrick, Pitt, Bertram and Zannad, Faiez. (2019). MRAs in elderly HF patients: Individual patient-data meta-analysis of RALES, EMPHASIS-HF, and TOPCAT. JACC: Heart Failure. 7(12), pp. 1012 - 1021. https://doi.org/10.1016/j.jchf.2019.08.017

Outcomes and effect of treatment according to etiology in HFrEF: An analysis of PARADIGM-HF

Balmforth, Craig, Simpson, Joanne, Shen, Li, Jhund, Pardeep S., Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R., Packer, Milton and McMurray, John J. V.. (2019). Outcomes and effect of treatment according to etiology in HFrEF: An analysis of PARADIGM-HF. JACC: Heart Failure. 7(6), pp. 457 - 465. https://doi.org/10.1016/j.jchf.2019.02.015

Impact of renal impairment on beta-blocker efficacy in patients with heart failure

Kotecha, Dipak, Gill, Simrat K., Flather, Marcus D., Holmes, Jane, Packer, Milton, Rosano, Giuseppe, Böhm, Michael, McMurray, John J. V., Wikstrand, John, Anker, Stefan D., van Veldhuisen, Dirk J., Manzano, Luis, von Lueder, Thomas G., Rigby, Alan S., Andersson, Bert, Kjekshus, John, Wedel, Hans, Ruschitzka, Frank, Cleland, John G. F., ... Coats, Andrew J. S.. (2019). Impact of renal impairment on beta-blocker efficacy in patients with heart failure. Journal of the American College of Cardiology. 74(23), pp. 2893 - 2904. https://doi.org/10.1016/j.jacc.2019.09.059

Lung ultrasound in acute heart failure: Prevalence of pulmonary congestion and short- and long-term outcomes

Platz, Elke, Campbell, Robert T., Claggett, Brian L., Lewis, Eldrin F., Groarke, John D., Docherty, Kieran F., Lee, Matthew M. Y., Merz, Allison A., Silverman, Montane, Swamy, Varsha, Lindner, Moritz, Rivero, Jose, Solomon, Scott D. and McMurray, John J. V.. (2019). Lung ultrasound in acute heart failure: Prevalence of pulmonary congestion and short- and long-term outcomes. JACC: Heart Failure. 7(10), pp. 849 - 858. https://doi.org/10.1016/j.jchf.2019.07.008

Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure

Felker, G. Michael, Borentain, Maria, Cleland, John G., DeSouza, Mary M., Kessler, Paul D., O'Connor, Christopher M., Seiffert, Dietmar, Teerlink, John R., Voors, Adriaan A. and McMurray, John J. V.. (2019). Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure. European Journal of Heart Failure. 21(8), pp. 1022 - 1031. https://doi.org/10.1002/ejhf.1504

Health-related quality of life in heart failure with preserved ejection fraction: The PARAGON-HF Trial

Chandra, Alvin, Vaduganathan, Muthiah, Lewis, Eldrin F., Claggett, Brian L., Rizkala, Adel R., Wang, Wenyan, Lefkowitz, Martin P., Shi, Victor C., Anand, Inder S., Ge, Junbo, Lam, Carolyn S. P., Maggioni, Aldo Pietro, Martinez, Felipe, Packer, Milton, Pfeffer, Marc A., Pieske, Burkert, Redfield, Margaret M., Rouleau, Jean L., van Veldhuisen, Dirk J., ... Solomon, Scott D.. (2019). Health-related quality of life in heart failure with preserved ejection fraction: The PARAGON-HF Trial. JACC: Heart Failure. 7(10), pp. 862 - 874. https://doi.org/10.1016/j.jchf.2019.05.015

Baseline characteristics of the VANISH cohort

Raja, Anna Axelsson, Shi, Ling, Day, Sharlene M., Russell, Mark, Zahka, Kenneth, Lever, Harry, Colan, Steven D., Margossian, Renee, Hall, E Kevin, Becker, Jason, Jefferies, John Lynn, Patel, Amit R., Choudhury, Lubna, Murphy, Anne M., Canter, Charles, Bach, Richard, Taylor, Matthew, Mestroni, Luisa, Wheeler, Matthew T., ... Ho, Carolyn Y.. (2019). Baseline characteristics of the VANISH cohort. Circulation: Heart Failure. 12(12), pp. 1 - 11. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006231

Temporal trends and patterns in mortality after incident heart failure: A longitudinal analysis of 86 000 individuals

Condrad, Nathalie, Judge, Andrew, Canoy, Dexter, Tran, Jenny, Pinho-Gomes, Ana-Catarina, Millett, Elizabeth R.C., Salimi-Khorshidi, Gholamreza, Cleland, John G., McMurray, John J. V. and Rahimi, Kazem. (2019). Temporal trends and patterns in mortality after incident heart failure: A longitudinal analysis of 86 000 individuals. JAMA Cardiology. 4(11), pp. 1102 - 1111. https://doi.org/10.1001/jamacardio.2019.3593

Association of diabetes mellitus on cardiac remodeling, quality of life, and clinical outcomes in heart failure with reduced and preserved ejection fraction

Yap, Jonathan, Tay, Wan Ting, Teng, Tiew-Hwa Katherine, Anand, Inder S., Richards, Authur Mark, Ling, Lieng Hsi, Macdonald, Michael R., Chandramouli, Chanchal, Tromp, Jasper, Siswanto, Bambang Budi, Zile, Michael R., McMurray, John and Lam, Carolyn S. P.. (2019). Association of diabetes mellitus on cardiac remodeling, quality of life, and clinical outcomes in heart failure with reduced and preserved ejection fraction. Journal of the American Heart Association. 8(17), pp. 1 - 19. https://doi.org/10.1161/JAHA.119.013114

The serendipitous story of SGLT2 inhibitors in heart failure: New insights from DECLARE-TIMI 58 [Editorial]

Verma, Subodh and McMurray, John J. V.. (2019). The serendipitous story of SGLT2 inhibitors in heart failure: New insights from DECLARE-TIMI 58 [Editorial]. Circulation. 139(22), pp. 2537-2541. https://doi.org/10.1161/CIRCULATIONAHA.119.040514

Diagnostic tests, drug prescriptions, and follow-up patterns after incident heart failure: A cohort study of 93,000 UK patients

Conrad, Nathalie, Judge, Andrew, Canoy, Dexter, Tran, Jenny, O'Donnell, Johanna, Nazarzadeh, Milad, Salimi-Khorshidi, Gholamreza, Hobbs, Richard, Cleland, John G., McMurray, John J. V. and Rahimi, Kazem. (2019). Diagnostic tests, drug prescriptions, and follow-up patterns after incident heart failure: A cohort study of 93,000 UK patients. PLoS Medicine. 16(5), pp. 1 - 18. https://doi.org/10.1371/journal.pmed.1002805

“Real World” eligibility for sacubitril/valsartan in unselected heart failure patients: Data from the Swedish Heart Failure Registry

Simpson, Joanne, Benson, Lina, Jhund, Pardeep S., Dahlstrom, Ulf, McMurray, John J. and Lund, Lars H.. (2019). “Real World” eligibility for sacubitril/valsartan in unselected heart failure patients: Data from the Swedish Heart Failure Registry. Cardiovascular Drugs and Therapy. 33(3), pp. 315 - 322. https://doi.org/10.1007/s10557-019-06873-1

B-Type natriuretic peptide during treatment with sacubitril/valsartan: The PARADIGM-HF Trial

Myhre, Peder Langeland, Vaduganathan, Muthiah, Claggett, Brian L., Packer, Milton, Desai, Akshay S., Rouleau, Jean L., Zile, Michael R., Swedberg, Karl, Lefkowitz, Martin P., Shi, Victor C., McMurray, John J. V. and Solomon, Scott D.. (2019). B-Type natriuretic peptide during treatment with sacubitril/valsartan: The PARADIGM-HF Trial. Journal of the American College of Cardiology. 73(11), pp. 1264 - 1272. https://doi.org/10.1016/j.jacc.2019.01.018

From ACE inhibitors/ARBs to ARNIs in coronary artery disease and heart failure (part 2/5)

Leong, Darryl P., McMurray, John J. V., Joseph, Philip G. and Yusuf, Salim. (2019). From ACE inhibitors/ARBs to ARNIs in coronary artery disease and heart failure (part 2/5). Journal of the American College of Cardiology. 74(5), pp. 683 - 698. https://doi.org/10.1016/j.jacc.2019.04.068

Personalized medicine and hospitalization for heart failure: If we understand it, we may be successful in treating it

Ahmad, Faheem A., Petrie, Mark C., McMurray, John J. V. and Lang, Ninian N.. (2019). Personalized medicine and hospitalization for heart failure: If we understand it, we may be successful in treating it. European Journal of Heart Failure. 21(6), pp. 699 - 702. https://doi.org/10.1002/ejhf.1463

Mean BMI, visit-to-visit BMI variability and BMI changes during follow-up in patients with acute myocardial infarction with systolic dysfunction and/or heart failure: Insights from the High-Risk Myocardial Infarction Initiative

Stienen, Susan, Ferreira, João Pedro, Girerd, Nicolas, Duarte, Kevin, Lamiral, Zohra, McMurray, John J. V., Pitt, Bertram, Dickstein, Kenneth, Zannad, Faiez and Rossignol, Patrick. (2019). Mean BMI, visit-to-visit BMI variability and BMI changes during follow-up in patients with acute myocardial infarction with systolic dysfunction and/or heart failure: Insights from the High-Risk Myocardial Infarction Initiative. Clinical Research in Cardiology. 108, pp. 1215 - 1225. https://doi.org/10.1007/s00392-019-01453-7

Reduced loop diuretic use in patients taking sacubitril/valsartan compared with enelapril: The PARADIGM-HF trial

Vardeny, Orly, Claggett, Brian L., Kachadourian, Jessica, Desai, Akshay S., Packer, Milton, Rouleau, Jean L., Zile, Michael R., Swedberg, Karl, Lefkowitz, Martin P., Shi, Victor C., McMurray, John J. V. and Solomon, Scott D.. (2019). Reduced loop diuretic use in patients taking sacubitril/valsartan compared with enelapril: The PARADIGM-HF trial. European Journal of Heart Failure. 21(3), pp. 337 - 341. https://doi.org/10.1002/ejhf.1402

Editor's choice- Impact of insulin-treated diabetes on cardiovascular outcomes following high-risk myocardial infarction

Rossello, Xavier, Ferreira, Joao Pedro, McMurray, John J. V., Aguilar, David, Pfeffer, Marc A., Pitt, Bertram, Dickstein, Kenneth, Girerd, Nicolas, Rossignol, Patrick and Zannad, Faiez. (2019). Editor's choice- Impact of insulin-treated diabetes on cardiovascular outcomes following high-risk myocardial infarction. European Heart Journal: Acute Cardiovascular Care. 8(3), pp. 231 - 241. https://doi.org/10.1177/2048872618803701

Higher body mass index in adolescence predicts cardiomyopathy risk in midlife: Long-term follow-up among Swedish men

Robertson, Josefina, Schaufelberger, Maria, Lindgren, Martin, Adiels, Martin, Schiöler, Linus, Torén, Kjell, McMurray, John J. V., Sattar, Naveed, Åberg, Maria and Rosengren, Annika. (2019). Higher body mass index in adolescence predicts cardiomyopathy risk in midlife: Long-term follow-up among Swedish men. Circulation. 140(2), pp. 117 - 125. https://doi.org/10.1161/CIRCULATIONAHA.118.039132

The Dapagliflozin and Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) Trial: Baseline characteristics

McMurray, John J. V., DeMets, David L., Inzucchi, Silvio E., Køber, Lars, Kosiborod, Mikhail N., Langkilde, Anna Maria, Martinez, Felipe A., Bengtsson, Olof, Ponikowski, Piotr, Sabatine, Marc S., Sjöstrand, Mikaela and Solomon, Scott D.. (2019). The Dapagliflozin and Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) Trial: Baseline characteristics. European Journal of Heart Failure. 21(11), pp. 1402 - 1411. https://doi.org/10.1002/ejhf.1548

Income level and inequality as complement to geographical differences in cardiovascular trials

Ferreira, Joao Pedro, Rossignol, Patrick, Dewan, Pooja, Lamiral, Zohra, White, William B., Pitt, Bertram, McMurray, John J. V. and Zannad, Faiez. (2019). Income level and inequality as complement to geographical differences in cardiovascular trials. American Heart Journal. 218, pp. 66 - 74. https://doi.org/10.1016/j.ahj.2019.08.019

Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): A phase 3, placebo-controlled, randomised trial

Bhatt, Deepak L., Steg, Philippe Gabriel, Mehta, Shamir R., Leiter, Lawrence A., Simon, Tabassome, Fox, Kim M., Held, Claes, Andersson, Marielle, Himmelmann, Anders, Ridderstrale, Wilhelm, Chen, Jersey, Song, Yang, Diaz, Rafael, Goto, Shinya, James, Stefan K., Ray, Kausik K., Parkhomenko, Alexander N., Kosiborod, Mikhail N., McGuire, Darren K., ... McMurray, John J. V.. (2019). Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): A phase 3, placebo-controlled, randomised trial. The Lancet. 394(10204), pp. 1169 - 1180. https://doi.org/10.1016/S0140-6736(19)31887-2

Effects of sacubitril/valsartan on biomarkers of extracellular matrix regulation in patients with HFrEF

Zile, Michael R., O'Meara, Eileen, Claggett, Brian L., Prescott, Margaret F., Solomon, Scott D., Swedberg, Karl, Packer, Milton, McMurray, John J. V., Shi, Victor C., Lefkowitz, Martin P. and Rouleau, Jean L.. (2019). Effects of sacubitril/valsartan on biomarkers of extracellular matrix regulation in patients with HFrEF. Journal of the American College of Cardiology. 73(7), pp. 795 - 806. https://doi.org/10.1016/j.jacc.2018.11.042

Impact of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with heart failure and left-ventricular systolic dysfunction: An individual patient-level meta-analysis of three randomized-controlled trials

Rossello, Xavier, Ariti, Cono A., Pocock, Stuart J., Ferreira, João Pedro, Girerd, Nicolas, McMurray, John J. V., van Veldhuisen, Dirk J., Pitt, Bertram and Zannad, Faiez. (2019). Impact of mineralocorticoid receptor antagonists on the risk of sudden cardiac death in patients with heart failure and left-ventricular systolic dysfunction: An individual patient-level meta-analysis of three randomized-controlled trials. Clinical Research in Cardiology. 108(5), pp. 477 - 486. https://doi.org/10.1007/s00392-018-1378-0

Metformin use and cardiovascular events in patients with type 2 diabetes and chronic kidney disease

Charytan, David M., Solomon, Scott D., Ivanovich, Peter, Remuzzi, Giuseppe, Cooper, Mark E., McGill, Janet B., Parving, Hans-Henrik, Parfrey, Patrick, Singh, Ajay K., Burdmann, Emmanuel A., Levey, Andrew S., Eckardt, Kai-Uwe, McMurray, John J. V., Weinrauch, Larry A., Liu, Jiankang, Claggett, Brian L., Lewis, Eldrin F. and Pfeffer, Marc A.. (2019). Metformin use and cardiovascular events in patients with type 2 diabetes and chronic kidney disease. Diabetes, Obesity and Metabolism. 21(5), pp. 1199 - 1208. https://doi.org/10.1111/dom.13642

Prognostic implications of congestion on physical examination among contemporary patients with heart failure and reduced ejection fraction: PARADIGM-HF

Selvaraj, Senthil, Claggett, Brian L., Pozzi, Andrea, McMurray, John J. V., Jhund, Pardeep S., Packer, Milton, Desai, Akshay S., Lewis, Eldrin F., Vaduganathan, Muthiah, Lefkowitz, Martin P., Rouleau, Jean L., Shi, Victor C., Zile, Michael R., Swedberg, Karl and Solomon, Scott D.. (2019). Prognostic implications of congestion on physical examination among contemporary patients with heart failure and reduced ejection fraction: PARADIGM-HF. Circulation. 140(17), pp. 1369 - 1379. https://doi.org/10.1161/CIRCULATIONAHA.119.039920

Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction

Solomon, Scott D., McMurray, John J. V., Anand, Inder S., Ge, Junbo, Lam, Carolyn S. P., Maggioni, Aldo Pietro, Martinez, Felipe, Packer, Milton, Pfeffer, Marc A., Pieske, Burkert, Redfield, Margaret M., Rouleau, Jean L., van Veldhuisen, Dirk J., Zannad, Faiez, Zile, Michael R., Desai, Akshay S., Claggett, Brian L., Jhund, Pardeep S., Boytsov, Sergey A., ... Lefkowitz, Martin P.. (2019). Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction. New England Journal of Medicine. 381(17), pp. 1609 - 1620. https://doi.org/10.1056/NEJMoa1908655

Anticoagulation therapy in heart failure and sinus rhythm: A systematic review and meta-analysis

Beggs, Simon A. S., Rørth, Rasmus, Gardner, Roy S. and McMurray, John J. V.. (2019). Anticoagulation therapy in heart failure and sinus rhythm: A systematic review and meta-analysis. Heart. 105(17), pp. 1325 - 1334. https://doi.org/10.1136/heartjnl-2018-314381

Prior pacemaker implantation and clinical outcomes in patients with heart failure and preserved ejection fraction

Shen, Li, Jhund, Pardeep S., Docherty, Kieran F., Petrie, Mark C., Anand, Inder S., Carson, Peter E., Desai, Akshay S., Granger, Christopher B., Komajda, Michel, McKelvie, Robert S., Pfeffer, Marc A., Solomon, Scott D., Swedberg, Karl, Zile, Michael R. and McMurray, John J. V.. (2019). Prior pacemaker implantation and clinical outcomes in patients with heart failure and preserved ejection fraction. JACC: Heart Failure. 7(5), pp. 418 - 427. https://doi.org/10.1016/j.jchf.2018.12.006

Impact of eplerenone on major cardiovascular outcomes in patients with systolic heart failure according to baseline heart rate

Chin, Ken Lee, Collier, Timothy J., Pocock, Stuart J., Pitt, Bertram, McMurray, John J. V., van Veldhuisen, Dirk J., Swedberg, Karl, Vincent, John, Zannad, Faiez and Liew, Danny. (2019). Impact of eplerenone on major cardiovascular outcomes in patients with systolic heart failure according to baseline heart rate. Clinical Research in Cardiology. 108(7), pp. 806 - 814. https://doi.org/10.1007/s00392-018-1410-4

T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: Results from RED-HF

Abraityte, Aurelija, Aukrust, Pål, Kou, Lei, Anand, Inder S., Young, James B., McMurray, John J. V., van Veldhuisen, Dirk J., Gullestad, Lars and Ueland, Thor. (2019). T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: Results from RED-HF. Clinical Research in Cardiology. 108(2), pp. 133 - 141. https://doi.org/10.1007/s00392-018-1331-2

Sex-related differences in heart failure with preserved ejection fraction

Dewan, Pooja, Rorth, Rasmus, Raparelli, Valeria, Campbell, Ross T., Shen, Li, Jhund, Pardeep S., Petrie, Mark C., Anand, Inder S., Carson, Peter E., Desai, Akshay S., Granger, Christopher B., Kober, Lars, Komajda, Michel, McKelvie, Robert S., O'Meara, Eileen, Pfeffer, Marc A., Pitt, Bertram, Solomon, Scott D., Swedberg, Karl, ... McMurray, John J. V.. (2019). Sex-related differences in heart failure with preserved ejection fraction. Circulation: Heart Failure. 12(12), pp. 1 - 10. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006539

High-sensitivity Troponin T and incident heart failure in older men: British Regional Heart Study

Welsh, Paul, Papacosta, Olia, Ramsay, Sheena, Whincup, Peter H., McMurray, John, Wannamethee, Goya and Sattar, Naveed. (2019). High-sensitivity Troponin T and incident heart failure in older men: British Regional Heart Study. Journal of Cardiac Failure. 25(4), pp. 230 - 237. https://doi.org/10.1016/j.cardfail.2018.08.002

Income inequality and outcomes in heart failure

Dewan, Pooja, Rørth, Rasmus, Jhund, Pardeep S., Ferreira, Joao Pedro, Zannad, Faiez, Shen, Li, Køber, Lars, Abraham, William T., Desai, Akshay S., Dickstein, Kenneth, Packer, Milton, Rouleau, Jean L., Solomon, Scott D., Swedberg, Karl, Zile, Michael R. and McMurray, John J. V.. (2019). Income inequality and outcomes in heart failure. JACC: Heart Failure. 7(4), pp. 336 - 346. https://doi.org/10.1016/j.jchf.2018.11.005

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: A systematic review and meta-analysis of cardiovascular outcome trials

Kristensen, Søren L., Rørth, Rasmus, Jhund, Pardeep S., Docherty, Kieran F., Sattar, Naveed, Preiss, David, Køber, Lars, Petrie, Mark C. and McMurray, John J. V.. (2019). Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: A systematic review and meta-analysis of cardiovascular outcome trials. The Lancet Diabetes & Endocrinology. 7(10), pp. 776 - 785. https://doi.org/10.1016/S2213-8587(19)30249-9

Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1‐receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction

Adriaan A. Voors, Sanjiv J. Shah, Jeroen J. Bax, Javed Butler, Mihai Gheorghiade, Adrian F. Hernandez, Dalane W. Kitzman, John McMurray, Antonieta Bomfim Wirtz, Vivian Lanius, Michael van der Laan and Scott Solomon. (2018). Rationale and design of the phase 2b clinical trials to study the effects of the partial adenosine A1‐receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced (PANTHEON) and preserved (PANACHE) ejection fraction. European Journal of Heart Failure. 20(11), pp. 1601-1610. https://doi.org/10.1002/ejhf.1295

Data-driven approach to identify subgroups of heart failure with reduced ejection fraction patients with different prognoses and aldosterone antagonist response patterns

Ferreira, Joao Pedro, Duarte, Kevin, McMurray, John, Pitt, Bertram, van Veldhuisen, Dirk J., Vincent, John, Ahmad, Tariq, Tromp, Jasper, Rossignol, Patrick and Zannad, Faiez. (2018). Data-driven approach to identify subgroups of heart failure with reduced ejection fraction patients with different prognoses and aldosterone antagonist response patterns. Circulation: Heart Failure. 11(7), pp. 1 - 12. https://doi.org/10.1161/CIRCHEARTFAILURE.118.004926

Natriuretic peptides as biomarkers of treatment response in clinical trials of heart failure

Vaduganathan, Muthiah, Claggett, Brian L., Packer, Milton, McMurray, John, Rouleau, Jean L., Zile, Michael R., Swedberg, Karl and Solomon, Scott. (2018). Natriuretic peptides as biomarkers of treatment response in clinical trials of heart failure. JACC: Heart Failure. 6(7), pp. 564 - 569. https://doi.org/10.1016/j.jchf.2018.02.007

Baseline characteristics and temporal differences in acarbose cardiovascular evaluation (ACE) trial participants

Theodorakis, Michael J., Coleman, Ruth L., Feng, Huimei, Chan, Juliana, Chiasson, Jean Louis, Ge, Junbo, Gerstein, Hertzel C., Huo, Yong, Lang, Zhihui, McMurray, John, Rydén, Lars E., Schröder, Stefan, Tendera, Michal, Tuomilehto, J., Yang, Wenying, Hu, Dayi, Pan, Changyu and Holman, Rury R.. (2018). Baseline characteristics and temporal differences in acarbose cardiovascular evaluation (ACE) trial participants. American Heart Journal. 199, pp. 170 - 175. https://doi.org/10.1016/j.ahj.2017.09.001

SGLT2 inhibitors and mechanisms of cardiovascular benefit: A state-of-the-art review

Verma, Subodh and McMurray, John. (2018). SGLT2 inhibitors and mechanisms of cardiovascular benefit: A state-of-the-art review. Diabetologia. 61(10), pp. 2108 - 2117. https://doi.org/10.1007/s00125-018-4670-7

N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk

Idzerda, Nienke M. A., Persson, Frederik, Pena, Michelle J., Brenner, Barry M., Brunel, Patrick, Chaturvedi, Nish, McMurray, John, Parving, Hans-Henrik, de Zeeuw, D. and Heerspink, Hiddo J. L.. (2018). N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk. Diabetes, Obesity and Metabolism. 20(12), pp. 2899 - 2904. https://doi.org/10.1111/dom.13465

Impact of systolic blood pressure on the safety and tolerability of initiating and up-titrating sacubitril/valsartan in patients with heart failure and reduced ejection fraction: Insights from the TITRATION study

Senni, Michele, McMurray, John, Wachter, Rolf, McIntyre, Hugh F., Anand, Inder S., Duino, Vincenzo, Sarkar, Arnab, Shi, Victor C. and Charney, Alan. (2018). Impact of systolic blood pressure on the safety and tolerability of initiating and up-titrating sacubitril/valsartan in patients with heart failure and reduced ejection fraction: Insights from the TITRATION study. European Journal of Heart Failure. 20(3), pp. 491 - 500. https://doi.org/10.1002/ejhf.1054

Effects of sacubitril/valsartan on physical and social activity limitations in patients with heart failure: a secondary analysis of the PARADIGM-HF trial

Chandra, Alvin, Lewis, E. F., Claggett, Brian L., Desai, Akshay S., Packer, Milton, Zile, Michael R., Sweberg, Karl, Rouleau, Jean L., Shi, Victor C., Lefkowitz, Martin P., Katova, T., McMurray, John and Solomon, Scott. (2018). Effects of sacubitril/valsartan on physical and social activity limitations in patients with heart failure: a secondary analysis of the PARADIGM-HF trial. JAMA Cardiology. 3(6), pp. 498 - 505. https://doi.org/10.1001/jamacardio.2018.0398

Estimated 5-Year number needed to treat to prevent cardiovascular death or heart failure hospitalization with angiotensin receptor-neprilysin inhibition vs standard therapy for patients with heart failure with reduced ejection fraction: An analysis of data from the PARADIGM-HF Trial

Srivastava, Pratyaksh K., Claggett, Brian L., Solomon, Scott, McMurray, John J. V., Packer, Milton, Zile, Michael R., Desai, Akshay S., Rouleau, Jean L., Swedberg, Karl and Fonarow, Gregg C.. (2018). Estimated 5-Year number needed to treat to prevent cardiovascular death or heart failure hospitalization with angiotensin receptor-neprilysin inhibition vs standard therapy for patients with heart failure with reduced ejection fraction: An analysis of data from the PARADIGM-HF Trial. JAMA Cardiology. 3(12), pp. 1226 - 1231. https://doi.org/10.1001/jamacardio.2018.3957

Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis

Hallow, Karen M., Helmlinger, Gabriel, Greasley, Peter J., McMurray, John and Boulton, David W.. (2018). Why do SGLT2 inhibitors reduce heart failure hospitalization? A differential volume regulation hypothesis. Diabetes, Obesity and Metabolism. 20(3), pp. 479 - 487. https://doi.org/10.1111/dom.13126

Growth differentiation factor-15 is not modified by sacubitril/valsartan and is an independent marker of risk in patients with heart failure and reduced ejection fraction: The PARADIGM-HF trial

Bouabdallaoui, Nadia, Claggett, Brian, Zile, Michael R., McMurray, John J. V., O'Meara, Eileen, Packer, Milton, Prescott, Margarett F., Swedberg, Karl, Solomon, Scott D. and Rouleau, Jean L.. (2018). Growth differentiation factor-15 is not modified by sacubitril/valsartan and is an independent marker of risk in patients with heart failure and reduced ejection fraction: The PARADIGM-HF trial. European Journal of Heart Failure. 20(12), pp. 1701 - 1709. https://doi.org/10.1002/ejhf.1301

Heart failure with mid-range ejection fraction in CHARM: characteristics, outcomes and effect of candesartan across the entire ejection fraction spectrum

Lund, Lars H., Claggett, Brian L., Liu, Jiankang, Lam, Carolyn S., Jhund, Pardeep, Rosano, Giuseppe, Sweberg, Karl, Yusuf, Salim, Granger, Christopher B., Pfeffer, Marc A., McMurray, John and Solomon, Scott. (2018). Heart failure with mid-range ejection fraction in CHARM: characteristics, outcomes and effect of candesartan across the entire ejection fraction spectrum. European Journal of Heart Failure. 20(8), pp. 1230 - 1239. https://doi.org/10.1002/ejhf.1149

Which patients with heart failure should receive specialist palliative care?

Campbell, Ross T., Petrie, Mark C., Jackson, Colette E., Jhund, Pardeep, Wright, Ann, Gardner, Roy S., Sonecki, Piotr, Pozzi, Andrea, McSkimming, Paula, McConnachie, Alex, Finlay, Fiona, Davidson, Patricia, Denvir, Martin, Johnson, Miriam J., Hogg, K. and McMurray, John. (2018). Which patients with heart failure should receive specialist palliative care? European Journal of Heart Failure. 20(9), pp. 1338 - 1347. https://doi.org/10.1002/ejhf.1240

Hyporesponsiveness to darbepoetin alfa in patients with heart failure and anemia in the RED-HF Study (Reduction of events by darbepoetin alfa in heart failure): Clinical and prognostic associations

van der Meer, Peter, Beverborg, Niels Grote, Pfeffer, Marc A., Olson, Kurt, Anand, Inder S., Westenbrink, B. Daan, McMurray, John, Sweberg, Karl, Young, James B., Solomon, Scott and van Veldhuisen, Dirk J.. (2018). Hyporesponsiveness to darbepoetin alfa in patients with heart failure and anemia in the RED-HF Study (Reduction of events by darbepoetin alfa in heart failure): Clinical and prognostic associations. Circulation: Heart Failure. 11(2), pp. 1 - 5. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004431

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (harmony outcomes): a double-blind, randomised placebo-controlled trial

Hernandez, Adrian F., Green, Jennifer, Janmohamed, Salim, D'Agostino, Ralph B., Granger, Christopher B., Jones, Nigel P., Leiter, Lawrence A., Rosenberg, Anne E., Sigmon, Kristina, Somerville, Matthew C., Thorpe, Karl M., McMurray, John and Prato, Stefano D.. (2018). Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (harmony outcomes): a double-blind, randomised placebo-controlled trial. The Lancet. 392(10157), pp. 1519 - 1529. https://doi.org/10.1016/S0140-6736(18)32261-X

Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: A secondary anaylisis of the PARADIGM-HF trial

Packer, Milton, Claggett, Brian, Lefkowitz, Martin P., McMurray, John J. V., Rouleau, Jean L., Solomon, Scott D. and Zile, Michael R.. (2018). Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: A secondary anaylisis of the PARADIGM-HF trial. The Lancet Diabetes & Endocrinology. 6(7), pp. 547 - 554. https://doi.org/10.1016/S2213-8587(18)30100-1

Class effect for sodium glucose-cotransporter-2 inhibitors in cardiovascular outcomes

Bethel, M. A. and McMurray, John. (2018). Class effect for sodium glucose-cotransporter-2 inhibitors in cardiovascular outcomes. Circulation. 137(12), pp. 1218 - 1220. https://doi.org/10.1161/CIRCULATIONAHA.117.030117

Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry

Tromp, Jasper, Tay, Wan Ting, Ouwekerk, Wouter, Teng, Tiew-Hwa Katherine, Yap, Jonathan, Macdonald, Michael R., Leineweber, Kirsten, McMurray, John, Zile, Michael R., Anand, Inder S. and Lam, Carolyn S. P.. (2018). Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry. PLoS Medicine. 15(3), pp. 1 - 22. https://doi.org/10.1371/journal.pmed.1002541

Prevalence and prognostic importance of precipitating factors leading to heart failure hospitalization: recurrent hospitalizations and mortality

Platz, Elke, Jhund, Pardeep, Claggett, Brian L., Pfeffer, Marc A., Sweberg, Karl, Granger, Christopher B., Yusuf, Salim, Solomon, Scott and McMurray, John. (2018). Prevalence and prognostic importance of precipitating factors leading to heart failure hospitalization: recurrent hospitalizations and mortality. European Journal of Heart Failure. 20(2), pp. 295 - 303. https://doi.org/10.1002/ejhf.901

Effect of digoxin in patients with heart failure and mid-range (borderline) left ventricular ejection fraction

Abdul-Rahim, Azmil H., Shen, Li, Rush, Christopher J., Jhund, Pardeep S., Lees, Kennedy R. and McMurray, John J. V.. (2018). Effect of digoxin in patients with heart failure and mid-range (borderline) left ventricular ejection fraction. European Journal of Heart Failure. 20(7), pp. 1139 - 1145. https://doi.org/10.1002/ejhf.1160

Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial

Kraus, William E., Yates, Thomas, Tuomilehto, Jaakko, Sun, Jie-Lena, Thomas, Laine, McMurray, John, Bethel, M. A. and Holman, Rury R.. (2018). Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial. BMJ Open Diabetes Research and Care. 6(1), pp. 1 - 7. https://doi.org/10.1136/bmjdrc-2018-000523

Circulating Cardiac Troponin I levels measured by a novel highly sensitive assay in acute decompensated heart failure: Insights from the ASCEND-HF Trial

Grodin, Justin L., Butler, Javed, Metra, Marco, Felker, G. Michael, Voors, Adriaan A., McMurray, John J., Armstrong, Paul W., Hernandez, Adrian F., O'Connor, Christopher, Starling, Randall C. and Tang, W. H. Wilson. (2018). Circulating Cardiac Troponin I levels measured by a novel highly sensitive assay in acute decompensated heart failure: Insights from the ASCEND-HF Trial. Journal of Cardiac Failure. 24(8), pp. 512 - 519. https://doi.org/10.1016/j.cardfail.2018.06.008

Treatment with insulin is associated with worse outcome in patients with chronic heart failure and diabetes

Cosmi, Franco, Shen, Li, Magnoli, Michela, Abraham, William T., Anand, Inder S., Cleland, John G.F., Cohn, Jay N., Cosmi, Deborah, De Berardis, Giorgia, Dickstein, Kenneth, Franzosi, Maria Grazia, Gullestad, Lars, Jhund, Pardeep, Kjekshus, John, Kober, Lars, Lepore, Vito, Lucisano, Giuseppe, Maggioni, Aldo Pietro, Masson, Serge, ... Latini, Roberto. (2018). Treatment with insulin is associated with worse outcome in patients with chronic heart failure and diabetes. European Journal of Heart Failure. 20(5), pp. 888 - 895. https://doi.org/10.1002/ejhf.1146

Post hoc analyses of SHIFT and PARADIGM-HF highlight the importance of chronic Chagas' cardiomyopathy Comment on: “Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: A post hoc analysis of the SHIFT trial” by Bocchi et al.

Ramires, Felix, Martinez, Felipe, Gomez, Efrain, Demacq, Caroline, Gimpelewicz, Claudio, Rouleau, Jean, Solomon, Scott, Sweberg, Karl, Zile, Michael R., Packer, Milton and McMurray, John. (2018). Post hoc analyses of SHIFT and PARADIGM-HF highlight the importance of chronic Chagas' cardiomyopathy Comment on: “Safety profile and efficacy of ivabradine in heart failure due to Chagas heart disease: A post hoc analysis of the SHIFT trial” by Bocchi et al. ESC Heart Failure. 5(6), pp. 1069 - 1071. https://doi.org/10.1002/ehf2.12355

Indications and practical approach to non-invasive ventilation in acute heart failure

Masip, J., Peacock, W. F., Price, Susanna, Cullen, Louise, Martín-Sánchez, Francisco J., Seferovic, Petar, Maisel, Alan, Miró, Òscar, Filippatos, Gerasimos, Vrints, Christiaan, Christ, M., Cowie, Martin R., Platz, Elke, McMurray, John, DiSomma, S., Zeymer, Uwe, Bueno, Hector, Gale, Chris, Lettino, Maddalena, ... Mueller, Christian. (2018). Indications and practical approach to non-invasive ventilation in acute heart failure. European Heart Journal. 39(1), pp. 17 - 25. https://doi.org/10.1093/eurheartj/ehx580

Aliskiren alone or in combination with enalapril vs. Enalapril among patients with chronic heart failure with and without diabetes: a subgroup analysis from the ATMOSPHERE trial

Kristensen, Søren L., Mogensen, Ulrik M., Tarnesby, Georgia, Gimpelewicz, Claudio, Ali, Mohammed A., Shao, Qing, Chiang, Yanntong, Jhund, Pardeep, Abraham, William T., Dickstein, Kenneth, McMurray, John and Kober, Lars. (2018). Aliskiren alone or in combination with enalapril vs. Enalapril among patients with chronic heart failure with and without diabetes: a subgroup analysis from the ATMOSPHERE trial. European Journal of Heart Failure. 20(1), pp. 136 - 147. https://doi.org/10.1002/ejhf.896

Rationale and protocol of the Study of Diabetic Nepropathy with AtRasentan (SONAR) trial: A clinical trial design novel to diabetic nepropathy

Heerspink, Hiddo J. L., Andress, Dennis L., Bakris, G., Brennan, John J., Correa-Rotter, Ricardo, Dey, Jyotirmoy, Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John, Perkovic, Vlado, Tobe, Sheldon, Wigderson, Melissa, Parving, Hans Henrik and de Zeeuw, Dick. (2018). Rationale and protocol of the Study of Diabetic Nepropathy with AtRasentan (SONAR) trial: A clinical trial design novel to diabetic nepropathy. Diabetes, Obesity and Metabolism. 20(6), pp. 1369 - 1376. https://doi.org/10.1111/dom.13245

Comparison of time-to-first event and recurrent event methods in randomized clinical trials

Claggett, Brian, Pocock, Stuart, Wei, L. J., Pfeffer, Marc A., McMurray, John J. V. and Solomon, Scott D.. (2018). Comparison of time-to-first event and recurrent event methods in randomized clinical trials. Circulation. 138(6), pp. 570 - 577. https://doi.org/10.1161/CIRCULATIONAHA.117.033065

Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL): study design and baseline data

MacDougall, Iain C., White, Claire, Anker, Stefan D., Bhandari, Sunil, Farrington, Kenneth, Kalra, Philip A., McMurray, John, Murray, Hear, Steenkamp, Retha, Tomson, Charles R. V., Wheeler, D. C., Winearls, Christopher G. and Ford, Ian. (2018). Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL): study design and baseline data. American Journal of Nephrology. 48(4), pp. 260 - 268. https://doi.org/10.1159/000493551

Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals

Conrad, Nathalie, Judge, Andrew, Tran, Jenny, Mohseni, Hamid, Hedgecott, Deborah, Crespillo, Abel Perez, Allison, Moira, Hemingway, Harry, Cleland, John G., McMurray, John J. V. and Rahimi, Kazem. (2018). Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. The Lancet. 391(10120), pp. 572 - 580. https://doi.org/10.1016/S0140-6736(17)32520-5

Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study

Welsh, Paul, Kou, Lei, Yu, Changhong, Anand, Inder S., van Veldhuisen, Dirk J., Maggioni, Aldo Pietro, Desai, Akshay S., Solomon, Scott, Pfeffer, Marc A., Cheng, Sunfa, Gullestad, Lars, Aukrust, Pål, Ueland, Thor, Swedberg, Karl, Young, James B., Kattan, Michael W., Sattar, Naveed and McMurray, John. (2018). Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study. European Journal of Heart Failure. 20(2), pp. 268 - 277. https://doi.org/10.1002/ejhf.988

Cost-effectiveness of sacubitril/valsartan in the treatment of heart failure with reduced ejection fraction

McMurray, John, Trueman, David, Hancock, Elizabeth, Cowie, Martin R., Briggs, Andrew, Taylor, Mathew, Mumby-Croft, Juliet, Woodcock, Fionn, Lacey, Michael, Haroun, Rola and Deschaseaux, Celine. (2018). Cost-effectiveness of sacubitril/valsartan in the treatment of heart failure with reduced ejection fraction. Heart. 104(12), pp. 1006 - 1013. https://doi.org/10.1136/heartjnl-2016-310661

Evidence-based therapy and its association with workforce detachment after first hospitalization for heart failure

Rørth, Rasmus, Fosbøl, Emil L., Mogensen, Ulrik M., Kragholm, Kristian, Jhund, Pardeep S., Petrie, Mark C., Schou, Morten, Gislason, Gunnar H., McMurray, John J. V., Torp-Pedersen, Christian, Køber, Lars and Kristensen, Søren L.. (2018). Evidence-based therapy and its association with workforce detachment after first hospitalization for heart failure. JACC: Heart Failure. 6(1), pp. 41 - 48. https://doi.org/10.1016/j.jchf.2017.09.019

Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials

Cleland, John G. F., Bunting, Karina V., Flather, Marcus D., Altman, Douglas G., Holmes, Jane, Coats, Andrew J. S., Manzano, Luis, McMurray, John J. V., Ruschitzka, Frank, van Veldhuisen, Dirk J., von Lueder, Thomas G., Böhm, Michael, Andersson, Bert, Kjekshus, John, Packer, Milton, Rigby, Alan S., Rosano, Giuseppe, Wedel, Hans, Hjalmarson, Åke, ... Kotecha, Dipak. (2018). Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials. European Heart Journal. 39(1), pp. 26 - 35. https://doi.org/10.1093/eurheartj/ehx564

Association is not causation: Treatment effects cannot be estimated from observational data in heart failure

Rush, Christopher J., Campbell, Ross T., Jhund, Pardeep, Petrie, Mark C. and McMurray, John. (2018). Association is not causation: Treatment effects cannot be estimated from observational data in heart failure. European Heart Journal. 39(37), pp. 3417 - 3438. https://doi.org/10.1093/eurheartj/ehy407

Initiation of domiciliary care and nursing home admission following first hospitalization of heart failure patients: a nationwide cohort study

Rørth, Rasmus, Fosbøl, Emil L., Kragholm, Kristian, Mogensen, Ulrik M., Jhund, Pardeep S., Petrie, Mark C., Torp-Pedersen, Christian, Gislason, Gunnar H., McMurray, John J. V., Køber, Lars and Kristensen, Søren L.. (2018). Initiation of domiciliary care and nursing home admission following first hospitalization of heart failure patients: a nationwide cohort study. Clinical Epidemiology. 10, pp. 917 - 930. https://doi.org/10.2147/CLEP.S164795

Non-ischaemic cardiomyopathy, sudden death and implantable defibrillators: a review and meta-analysis

Beggs, Simon A. S., Jhund, Pardeep, Jackson, Colette E., McMurray, John and Gardner, Roy S.. (2018). Non-ischaemic cardiomyopathy, sudden death and implantable defibrillators: a review and meta-analysis. Heart. 104(2), pp. 144 - 150. https://doi.org/10.1136/heartjnl-2016-310850

Talking to patients with heart failure about end of life

Campbell, Ross T., Petrie, Mark C. and McMurray, John. (2018). Talking to patients with heart failure about end of life. European Journal of Heart Failure. 20(12), pp. 1763 - 1765. https://doi.org/10.1002/ejhf.1321

Effect of sacubitril/valsartan on recurrent events in the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF)

Mogensen, Ulrik M., Gong, Jianjian, Jhund, Pardeep, Shen, Li, Kober, Lars, Desai, Akshay S., Lefkowitz, Martin P., Packer, Milton, Rouleau, Jean L., Solomon, Scott, Claggett, Brian L., Sweberg, Karl, Zile, Michael R., Mueller-Velten, Guenr and McMurray, John. (2018). Effect of sacubitril/valsartan on recurrent events in the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF). European Journal of Heart Failure. 20(4), pp. 760 - 768. https://doi.org/10.1002/ejhf.1139

Effects of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: a randomised double-blind trial

Hayes, Richard, Judge, Parminder K., Staplin, Natalie, Herrington, William G., Storey, Benjamin C., Bethel, Angelyn M., Bowman, Louise, Brunskill, Nigel, Cockwell, Paul, Hill, Michael, Kalra, Philip A., McMurray, John J. V., Taal, Maarten, Wheeler, David C., Landray, Martin J. and Baigent, Colin. (2018). Effects of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: a randomised double-blind trial. Circulation. 138(15), pp. 1505 - 1514.

Stroke risk in patients with reduced ejection fraction after myocardial infarction without atrial fibrillation

Ferreira, João Pedro, Girerd, Nicolas, Gregson, John, Latar, Ichraq, Sharma, A., Pfeffer, Marc A., McMurray, John, Abdul-Rahim, Azmil H., Pitt, Bertram, Dickstein, Kenneth, Rossignol, Patrick and Zannad, Faiez. (2018). Stroke risk in patients with reduced ejection fraction after myocardial infarction without atrial fibrillation. Journal of the American College of Cardiology. 71(7), pp. 727 - 735. https://doi.org/10.1016/j.jacc.2017.12.011

Incidence of hospitalisation for heart failure and case-fatality among 3.25 million people with and without diabetes

McAllister, David A., Read, Stephanie H., Kerssens, Jan, Livingstone, Shona, McGurnaghan, Stuart, Jhund, Pardeep, Petrie, John, Sattar, Naveed, Fischbacher, Colin, Kristensen, Soren Lund, McMurray, John, Colhoun, Helen M. and Wild, Sarah H.. (2018). Incidence of hospitalisation for heart failure and case-fatality among 3.25 million people with and without diabetes. Circulation. 138(24), pp. 2774 - 2786. https://doi.org/10.1161/CIRCULATIONAHA.118.034986

Employment status at time of first hospitalization for heart failure is associated with a higher risk of death and rehospitalization for heart failure

Rørth, Rasmus, Fosbøl, Emil L., Mogensen, Ulrik M., Kragholm, Kristian, Numé, Anna-Karin, Gislason, Gunnar H., Jhund, Pardeep S., Petrie, Mark C., McMurray, John J. V., Torp-Pedersen, Christian, Køber, Lars and Kristensen, Søren L.. (2018). Employment status at time of first hospitalization for heart failure is associated with a higher risk of death and rehospitalization for heart failure. European Journal of Heart Failure. 20(2), pp. 240 - 247. https://doi.org/10.1002/ejhf.1046

Systolic blood pressure reduction during the first 24h in acute heart failure admission: friend or foe?

Cotter, Gad, Metra, Marco, Davison, Beth A., Jondeau, Guillaume, Cleland, John G.F., Bourge, Robert C., Milo, Olga, O'Connor, Christopher M., Parker, John D., Torre-Amione, Guillermo, van Veldhuisen, Dirk J., Kobrin, Isaac, Rainisio, Maurizio, Senger, Stefanie, Edwards, Christopher, McMurray, John and Teerlink, John R.. (2018). Systolic blood pressure reduction during the first 24h in acute heart failure admission: friend or foe? European Journal of Heart Failure. 20(2), pp. 317 - 322. https://doi.org/10.1002/ejhf.889

Association between mean systolic and diastolic blood pressure throughout the follow-up and cardiovascular events in acute myocardial infarction patients with systolic dysfunction and/or heart failure: An analysis from the High-Risk Myocardial Infarction Database Initiative

Ferreira, João Pedro, Duarte, Kevin, Pfeffer, Marc A., McMurray, John J. V., Pitt, Bertram, Dickstein, Kenneth, Zannad, Faiez and Rossignol, Patrick. (2018). Association between mean systolic and diastolic blood pressure throughout the follow-up and cardiovascular events in acute myocardial infarction patients with systolic dysfunction and/or heart failure: An analysis from the High-Risk Myocardial Infarction Database Initiative. European Journal of Heart Failure. 20(2), pp. 323 - 331. https://doi.org/10.1002/ejhf.1131

Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: Results from the RED-HF study

Ueland, Thor, Gullestad, Lars, Kou, Lei, Aukrust, Pål, Anand, Inderjit S., Nordlund Broughton, Marianne, McMurray, John J., van Veldhuisen, Dirk J., Warren, David J. and Bolstad, Nils. (2018). Pro-gastrin-releasing peptide and outcome in patients with heart failure and anaemia: Results from the RED-HF study. ESC Heart Failure. 5(6), pp. 1052 - 1059. https://doi.org/10.1002/ehf2.12312

2017 cardiovascular and stroke endpoint definitions for clinical trials

Hicks, Karen A., Mahaffey, Kenneth W., Mehran, Roxana, Nissen, Steven E., Wiviott, Stephen D., Dunn, Billy, Solomon, Scott D., Marler, John R., Teerlink, John R., Farb, Andrew, Morrow, David A., Targum, Shari L., Sila, Cathy A., Thanh Hai, Mary T., Jaff, Michael R., Joffe, Hylton V., Cutlip, Donald E., Desai, Akshay S., Lewis, Eldrin F., ... Temple, Robert J.. (2018). 2017 cardiovascular and stroke endpoint definitions for clinical trials. Journal of the American College of Cardiology. 71(9), pp. 1021 - 1034. https://doi.org/10.1016/j.jacc.2017.12.048

Harmony outcomes: a randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus—rationale, design, and baseline characteristics

Green, Jennifer B., Hernandez, Adrian F., D'Agostino, Ralph B., Granger, Christopher B., Janmohamed, Salim, Jones, Nigel P., Leiter, Lawrence A., Noronha, Drusilla, Russell, Rachael, Sigmon, Kristina, Del Prato, Stefano and McMurray, John. (2018). Harmony outcomes: a randomized, double-blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus—rationale, design, and baseline characteristics. American Heart Journal. 203, pp. 30 - 38. https://doi.org/10.1016/j.ahj.2018.03.030

Contribution of cardiac and extra-cardiac disease burden to risk of cardiovascular outcomes varies by ejection fraction in heart failure

Wolsk, Emil, Claggett, Brian L., Kober, Lars, Pocock, Stuart J., Yusuf, Salim, Sweberg, Karl, McMurray, John, Granger, Christopher B., Pfeffer, Marc A. and Solomon, Scott. (2018). Contribution of cardiac and extra-cardiac disease burden to risk of cardiovascular outcomes varies by ejection fraction in heart failure. European Journal of Heart Failure. 20(3), pp. 504 - 510. https://doi.org/10.1002/ejhf.1073

Baseline characteristics of patients with heart failure and preserved ejection fraction in the PARAGON-HF Trial

Solomon, Scott, Rizkala, Adel R., Lefkowitz, Martin P., Shi, Victor C., Gong, Jianjian, Anavekar, Nagesh, Anker, Stefan D., Arango, Juan Luis, Arenas, Jose L., Atar, Dan, Ben-Gal, Turia, Boytsov, Sergey, Chen, -Huan Chen, Chopra, Vijay, Cleland, John G. F., Comin-Colet, Josep, Duengen, Hans-Dirk, Exheverria Correa, Luis E., Filippatos, Gerasimos S., ... Jr, Jiří Widimský. (2018). Baseline characteristics of patients with heart failure and preserved ejection fraction in the PARAGON-HF Trial. Circulation: Heart Failure. 11(7), pp. 1 - 10. https://doi.org/10.1161/CIRCHEARTFAILURE.118.004962

Heart failure. Epidemiology, pathophysiology, and management of heart failure in diabetes mellitus

Jorsal, Anders, Wiggers, Henrik and McMurray, John. (2018). Heart failure. Epidemiology, pathophysiology, and management of heart failure in diabetes mellitus. Endocrinology and Metabolism Clinics of North America. 47(1), pp. 117 - 135. https://doi.org/10.1016/j.ecl.2017.10.007

Baseline characteristics and enrichment results from the SONAR trial

Heerspink, Hiddo J. L., Andress, Dennis L., Bakris, George, Brennan, John J., Correa-Rotter, Ricardo, Hou, Fan Fan, Kitzman, Dalane W., Kohan, Donald, Makino, Hirofumi, McMurray, John, Perkovic, Vlado, Tobe, Sheldon, Wigderson, Melissa, Yi, Tingting, Parving, Hans-Henrik and de Zeeuw, Dick. (2018). Baseline characteristics and enrichment results from the SONAR trial. Diabetes, Obesity and Metabolism. 20(8), pp. 1829 - 1835. https://doi.org/10.1111/dom.13315

Who benefits from a defibrillator - balancing the risk of sudden versus non-sudden death

Beggs, Simon A. S., Gardner, Roy S. and McMurray, John J. V.. (2018). Who benefits from a defibrillator - balancing the risk of sudden versus non-sudden death. Current Heart Failure Reports. 15(6), pp. 376 - 389. https://doi.org/10.1007/s11897-018-0416-6

Risk of incident heart failure in patients with diabetes and asymptomatic left ventricular systolic dysfunction

Rorth, Rasmus, Jhund, Pardeep, Mogensen, Ulrik M., Kristensen, Søren L., Petrie, Mark C., Kober, Lars and McMurray, John. (2018). Risk of incident heart failure in patients with diabetes and asymptomatic left ventricular systolic dysfunction. Diabetes Care. 41(6), pp. 1285 - 1291. https://doi.org/10.2337/dc17-2583

2017 cardiovascular and stroke endpoint definitions for clinical trials

Hicks, Karen A., Mahaffey, Kenneth W., Mehran, Roxana, Nissen, Steven E., Wiviott, Stephen D., Dunn, Billy, Solomon, Scott, Marler, John R., Teerlink, John R., Farb, Andrew, Morrow, David A., Targum, Shari L., Sila, Cathy A., Hai, Mary T.T., Jaff, Michael R., Joffe, Hylton V., Cutlip, Donal E., Desai, Akshay S., Lewis, Eldrin F., ... Temple, Robert J.. (2018). 2017 cardiovascular and stroke endpoint definitions for clinical trials. Circulation. 137(9), pp. 961 - 972. https://doi.org/10.1161/CIRCULATIONAHA.117.033502

IGFBP7 (insulin-like growth factor-binding protein-7) and neprilysin inhibition in patients with heart failure

Januzzi, James L., Packer, Milton, Claggett, Brian L., Liu, Jiankang, Shah, Amil M., Zile, Michael R., Pieske, Burkert, Voors, Adriaan, Gandhi, Parul U., Prescott, Margaret F., Shi, Victor, Lefkowitz, Martin P., McMurray, John J. V. and Solomon, Scott D.. (2018). IGFBP7 (insulin-like growth factor-binding protein-7) and neprilysin inhibition in patients with heart failure. Circulation: Heart Failure. 11(10), pp. 1 - 9. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005133

Association of lipoprotein(a) with risk of recurrent ischemic events following acute coronary syndrome. Analysis of the dal-Ooutcomes randomized clinical trial

Schwartz, Gregory G., Ballantyne, Christie M., Barter, Phillip J., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John, Nicholls, Stephen J., Olsson, Anders G., Shah, Prediman K., Tardif, Jean C. and Kittelson, John. (2018). Association of lipoprotein(a) with risk of recurrent ischemic events following acute coronary syndrome. Analysis of the dal-Ooutcomes randomized clinical trial. JAMA Cardiology. 3(2), pp. 164 - 168. https://doi.org/10.1001/jamacardio.2017.3833

Renal effects and associated outcomes during angiotensin-neprilysin inhibition in heart failure

Damman, Kevin, Gori, Mauro, Claggett, Brian L., Jhund, Pardeep, Senni, Michele, Lefkowitz, Martin P., Prescott, Margaret F., Shi, Victor C., Rouleau, Jean L., Swedberg, Karl, Zile, Michael R., Packer, Milton, Desai, Akshay S., Solomon, Scott and McMurray, John. (2018). Renal effects and associated outcomes during angiotensin-neprilysin inhibition in heart failure. JACC: Heart Failure. 6(6), pp. 489 - 498. https://doi.org/10.1016/j.jchf.2018.02.004

Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association Of The European Society Of Cardiology

Seferovic, Petar, Petrie, Mark C., Filippatos, Gerasimos S., Anker, Stefan D., Rosano, Giuseppe, Bauersachs, J., Paulus, Walter J., Komajda, Michel, Cosentino, Francesco, de Boer, Rudolf A., Farmakis, Dimitrios, Doehner, Wolfram, Lambrinou, Ekaterini, Lopatin, Yuri, Piepoli, Massimo F., Theodorakis, Michael J., Wiggers, Henrik, Lekakis, John, Mebazaa, Alexandre, ... McMurray, John. (2018). Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association Of The European Society Of Cardiology. European Journal of Heart Failure. 20(5), pp. 853 - 872. https://doi.org/10.1002/ejhf.1170

Incidence, predictors, and outcomes associated with hypotensive episodes among heart failure patients receiving sacubitril/valsartan or enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor with Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure)

Vardeny, Orly, Claggett, Brian, Kachadourian, Jessica, Pearson, Scott M., Desai, Akshay S., Packer, Milton, Rouleau, Jean, Zile, Michael R., Swedberg, Karl, Lefkowitz, Martin, Shi, Victor, McMurray, John J. V. and Solomon, Scott D.. (2018). Incidence, predictors, and outcomes associated with hypotensive episodes among heart failure patients receiving sacubitril/valsartan or enalapril: The PARADIGM-HF Trial (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor with Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure). Circulation: Heart Failure. 11(4), pp. 1 - 8. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004745

Visit-to-visit blood pressure variation is associated with outcomes in a U-shaped fashion in patients with myocardial infarction complicated with systolic dysfunction and/or heart failure: findings from the EPHESUS and OPTIMAAL trials

Ferreira, João Pedro, Duarte, Kevin, Pitt, Bertram, Dickstein, Kenneth, McMurray, John, Zannad, Faiez and Rossignol, Patrick. (2018). Visit-to-visit blood pressure variation is associated with outcomes in a U-shaped fashion in patients with myocardial infarction complicated with systolic dysfunction and/or heart failure: findings from the EPHESUS and OPTIMAAL trials. Journal of Hypertension. 36(8), pp. 1736 - 1742. https://doi.org/10.1097/HJH.0000000000001742

Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: Analysis of ALTITUDE trial

Seferovic, Jelena P., Pfeffer, Marc A., Claggett, Brian L., Desai, Akshay S., de Zeeuw, D., Haffner, S. M., McMurray, John, Parving, Hans-Henrik, Solomon, Scott and Chaturvedi, Nish. (2018). Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: Analysis of ALTITUDE trial. Diabetologia. 61(3), pp. 581 - 588. https://doi.org/10.1007/s00125-017-4485-y

Relation of volume overload to clinical outcomes in acute heart failure (from ASCEND-HF)

Fudim, Marat, Parikh, Kishan S., Dunning, Allison, DeVore, Adam D., Mentz, Robert J., Schulte, Phillip J., Armstrong, P W., Ezekowitz, Justin A., Tang, W. H. Wilson, McMurray, John, Voors, Adriaan A., Drazner, Mark H., O'Connor, Christopher M., Hernandez, Adrian F. and Patel, Chetan B.. (2018). Relation of volume overload to clinical outcomes in acute heart failure (from ASCEND-HF). American Journal of Cardiology. 122(9), pp. 1506 - 1512. https://doi.org/10.1016/j.amjcard.2018.07.023

Microvascular complications in diabetes patients with heart failure and reduced ejection fraction-insights from the Beta-blocker Evaluation of Survival Trial

Kristensen, Søren L., Rørth, Rasmus, Jhund, Pardeep, Shen, Li, Lee, Matthew M. Y., Petrie, Mark C., Kober, Lars and McMurray, John. (2018). Microvascular complications in diabetes patients with heart failure and reduced ejection fraction-insights from the Beta-blocker Evaluation of Survival Trial. European Journal of Heart Failure. 20(11), pp. 1549 - 1556. https://doi.org/10.1002/ejhf.1201

Relation of High serum bilirubin to short-term mortality following a myocardial infarction complicated by left ventricular systolic dysfunction (from the High-risk myocardial infarction database initiative)

Frikha, Zied, Ferreira, João Pedro, Bozec, Erwan, McMurray, John, Pitt, Bertram, Dickstein, Kenneth, Rossignol, Patrick, Zannad, Faiez and Girerd, Nicolas. (2018). Relation of High serum bilirubin to short-term mortality following a myocardial infarction complicated by left ventricular systolic dysfunction (from the High-risk myocardial infarction database initiative). American Journal of Cardiology. 121(9), pp. 1015 - 1020. https://doi.org/10.1016/j.amjcard.2018.01.012

Independent Prognostic Value of Serum Soluble ST2 Measurements in Patients With Heart Failure and a Reduced Ejection Fraction in the PARADIGM-HF Trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure)

O'Meara, Eileen, Prescott, Margaret F., Claggett, Brian, Rouleau, Jean L., Chiang, Lu-May, Solomon, Scott D., Packer, Milton, McMurray, John J. V. and Zile, Michael R.. (2018). Independent Prognostic Value of Serum Soluble ST2 Measurements in Patients With Heart Failure and a Reduced Ejection Fraction in the PARADIGM-HF Trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure). Circulation: Heart Failure. 11(5), pp. 1 - 11. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004446

Heart failure with preserved ejection fraction in the young

Tromp, Jasper, Macdonald, Michael R., Tay, Wan Ting, Teng, Tiew-Hwa K., Hung, Chung-Lieh, Narasimhan, Calambur, Shimizu, Wataru, Ling, Lieng Hsi, Ng, Tze Pin, Yap, Jonathan, McMurray, John J. V., Zile, Michael R., Richards, A. Mark, Anand, Inder S. and Lam, Carolyn S. P.. (2018). Heart failure with preserved ejection fraction in the young. Circulation. 138(24), pp. 2763 - 2773. https://doi.org/10.1161/CIRCULATIONAHA.118.034720

Redefining heart failure phenotypes based on ejection fraction

Campbell, Ross T., Petrie, Mark C. and McMurray, John. (2018). Redefining heart failure phenotypes based on ejection fraction. European Journal of Heart Failure. 20(12), pp. 1634 - 1635. https://doi.org/10.1002/ejhf.1325

Retinopathy, neuropathy, and subsequent cardiovascular events in patients with type 2 diabetes and acute coronary syndrome in the ELIXA: The importance of disease duration

Seferovic, Jelena P., Bentley-Lewis, Rhonda, Claggett, Brian L., Diaz, Rafael, Gerstein, Hertzel C., Køber, Lars V., Lawson, Francesca C., Lewis, Eldrin F., Maggioni, Aldo Pietro, McMurray, John J. V., Probstfield, Jeffrey L., Riddle, Matthew C., Solomon, Scott D., Tardif, Jean-Claud and Pfeffer, Marc A.. (2018). Retinopathy, neuropathy, and subsequent cardiovascular events in patients with type 2 diabetes and acute coronary syndrome in the ELIXA: The importance of disease duration. Journal of Diabetes Research. 2018, pp. 1 - 9. https://doi.org/10.1155/2018/1631263

Type of atrial fibrillation and outcomes in patients with heart failure and reduced ejection fraction

Mogensen, Ulrik M., Jhund, Pardeep, Abraham, William T., Desai, Akshay S., Dickstein, Kenneth, Packer, Milton, Rouleau, Jean L., Solomon, Scott, Sweberg, Karl, Zile, Michael R., Kober, Lars and McMurray, John. (2017). Type of atrial fibrillation and outcomes in patients with heart failure and reduced ejection fraction. Journal of the American College of Cardiology. 70(20), pp. 2490 - 2500. https://doi.org/10.1016/j.jacc.2017.09.027

Reduced risk of hyperkalemia during treatment of heart failure with mineralocorticoid receptor antagonists by use of sacubitril/valsartan compared with enalapril: A secondary analysis of the PARADIGM-HF trial

Desai, Akshay S., Vardeny, Orly, Claggett, Brian L., McMurray, John, Packer, Milton, Sweberg, Karl, Rouleau, Jean L., Zile, Michael R., Lefkowitz, Martin P., Shi, Victor C. and Solomon, Scott. (2017). Reduced risk of hyperkalemia during treatment of heart failure with mineralocorticoid receptor antagonists by use of sacubitril/valsartan compared with enalapril: A secondary analysis of the PARADIGM-HF trial. JAMA Cardiology. 2(1), pp. 79 - 85. https://doi.org/10.1001/jamacardio.2016.4733

How robust are clinical trials in heart failure?

Docherty, Kieran F., Campbell, Ross T., Jhund, Pardeep S., Petrie, Mark C. and McMurray, John J. V.. (2017). How robust are clinical trials in heart failure? European Heart Journal. 38(5), pp. 338 - 345. https://doi.org/10.1093/eurheartj/ehw427

Updated risk factors should be used to predict development of diabetes

Bethel, Mary Angelyn, Hyland, Kristen A., Chacra, Antonio R., Deedwania, Prakash, Fulcher, Gregory R., Holman, Rury R., Jenssen, Trond, Levitt, Naomi S., McMurray, John J. V., Boutati, Eleni, Thomas, Laine, Sun, Jie-Lena and Haffner, Steven M.. (2017). Updated risk factors should be used to predict development of diabetes. Journal of Diabetes and Its Complications. 31(5), pp. 859 - 863. https://doi.org/10.1016/j.jdiacomp.2017.02.012

Importance of endogenous compensatory vasoactive peptides in broadening the effects of inhibitors of the renin-angiotensin system for the treatment of heart failure

Packer, Milton and McMurray, John. (2017). Importance of endogenous compensatory vasoactive peptides in broadening the effects of inhibitors of the renin-angiotensin system for the treatment of heart failure. The Lancet. 389(10081), pp. 1831 - 1840. https://doi.org/10.1016/S0140-6736(16)30969-2

ESRD after heart failure, myocardial infarction, or stroke in type 2 diabetic patients with CKD

Charytan, David M., Solomon, Scott, Ivanovich, Peter, Remuzzi, Guiseppe, Cooper, Mark E., McGill, Janet B., Parving, Hans H., Parfrey, Patrick, Singh, Ajay K., Burdmann, Emmanuel A., Levey, Andrew S., de Zeeuw, D., Eckardt, Kai U., McMurray, John, Claggett, Brian L., Lewis, E. F. and Pfeffer, Marc A.. (2017). ESRD after heart failure, myocardial infarction, or stroke in type 2 diabetic patients with CKD. American Journal of Kidney Diseases. 70(4), pp. 522 - 531. https://doi.org/10.1053/j.ajkd.2017.04.018

Seasonal variations in cardiovascular disease

Stewart, Simon, Keates, Ashley K., Redfern, Adele and McMurray, John J. V.. (2017). Seasonal variations in cardiovascular disease. Nature Reviews Cardiology. 14(11), pp. 654-664. https://doi.org/10.1038/nrcardio.2017.76

Renin-angiotensin system inhibition, worsening renal function, and outcome in heart failure patients with reduced and preserved ejection fraction: a meta-analysis of published study data

Beldhuis, Iris E., Streng, Koen W., Maaten, Jozine M.T., Voors, Adriaan A., van der Meer, Peter, Rossignol, Patrick, McMurray, John and Damman, Kevin. (2017). Renin-angiotensin system inhibition, worsening renal function, and outcome in heart failure patients with reduced and preserved ejection fraction: a meta-analysis of published study data. Circulation: Heart Failure. 10(2), pp. 1 - 12. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003588

Cost-effectiveness analysis of natriuretic peptide testing and specialist management in patients with suspected acute heart failure

Griffin, Edward A., Wonderling, David, Ludman, Andrew J., Al-Mohammad, Abdallah, Cowie, Martin R., Hardman, Suzanna, McMurray, John, Kendall, Jason, Mitchell, Polly, Shote, Aminat, Dworzynski, Katharina and Mant, Jonathan. (2017). Cost-effectiveness analysis of natriuretic peptide testing and specialist management in patients with suspected acute heart failure. Value in Health. 20(8), pp. 1025 - 1033. https://doi.org/10.1016/j.jval.2017.05.007

Dynamic changes and prognostic value of pulmonary congestion by lung ultrasound in acute and chronic heart failure: a systematic review

Platz, Elke, Merz, Allison A., Jhund, Pardeep, Vazir, Ali, Campbell, Ross T. and McMurray, John. (2017). Dynamic changes and prognostic value of pulmonary congestion by lung ultrasound in acute and chronic heart failure: a systematic review. European Journal of Heart Failure. 19(9), pp. 1154 - 1163. https://doi.org/10.1002/ejhf.839

Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/ valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF

Bohm, Michael, Young, Robin, Jhund, Pardeep, Solomon, Scott, Gong, Jianjian, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Sweberg, Karl, Zile, Michael R., Packer, Milton and McMurray, John. (2017). Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/ valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF. European Heart Journal. 38(15), pp. 1132 - 1143. https://doi.org/10.1093/eurheartj/ehw570

European Society of Cardiology - Acute cardiovascular care association position paper on safe discharge of acute heart failure patients from the emergency department

Miró, Òscar, Peacock, F., McMurray, John J., Bueno, Héctor, Christ, Michael, Maisel, Alan S., Cullen, Louise, Cowie, Martin R., Di Somma, Salvatore, Martín-Sánchez, Francisco J., Platz, Elke, Masip, Josep, Zeymer, Uwe, Vrints, Christiaan, Price, Susanna, Mebazaa, Alexander and Mueller, Christian. (2017). European Society of Cardiology - Acute cardiovascular care association position paper on safe discharge of acute heart failure patients from the emergency department. European Heart Journal: Acute Cardiovascular Care. 6(4), pp. 311-320. https://doi.org/10.1177/2048872616633853

Change in hemoglobin trajectory and darbepoetin dose approaching end-stage renal disease: data from the trial to reduce cardiovascular events with aranesp therapy trial

Mc Causland, Finnian R., Claggett, Brian L., Pfeffer, Marc A., Burdmann, Emmanuel A., Eckardt, Kai Uwe, Levey, Andrew S., McMurray, John, Remuzzi, Giuseppe, Singh, Ajay K., Solomon, Scott, Toto, Robert D. and Parfrey, Patrick. (2017). Change in hemoglobin trajectory and darbepoetin dose approaching end-stage renal disease: data from the trial to reduce cardiovascular events with aranesp therapy trial. American Journal of Nephrology. 46(6), pp. 488 - 497. https://doi.org/10.1159/000485326

Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: Analysis of the CHARMPreserved and I-Preserve trials

Abdul-Rahim, Azmil H., Perez, Ana-Cristina, Macisaac, Rachael L., Jhund, Pardeep S., Claggett, Brian L., Carson, Peter E., Komajda, Michel, McKelvie, Robert S., Zile, Michael R., Swedberg, Karl, Yusuf, Salim, Pfeffer, Marc A., Solomon, Scott D., Lip, Gregory Y. H., Lees, Kennedy R. and McMurray, John J. V.. (2017). Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: Analysis of the CHARMPreserved and I-Preserve trials. European Heart Journal. 38(10), pp. 742 - 750. https://doi.org/10.1093/eurheartj/ehw509

Valsartan for attenuating disease evolution in early sarcomeric hypertrophic cardiomyopathy: the design of the valsartan for attenuating disease evolution in early sarcomeric hypertrophic cardiomyopathy (vanish) trial

Ho, Carolyn Y., McMurray, John, Cirino, Allison L., Colan, Steven D., Day, Sharlene M., Desai, Akshay S., Lipshultz, Steven E., MacRae, Calum A., Shi, Ling, Solomon, Scott, Orav, E. and Braunwald, Eugene. (2017). Valsartan for attenuating disease evolution in early sarcomeric hypertrophic cardiomyopathy: the design of the valsartan for attenuating disease evolution in early sarcomeric hypertrophic cardiomyopathy (vanish) trial. American Heart Journal. 187, pp. 145 - 155. https://doi.org/10.1016/j.ahj.2017.02.008

International variation in outcomes among people with cardiovascular disease or cardiovascular risk factors and impaired glucose tolerance: Insights from the NAVIGATOR trial

Dos Santos, Marilia Harumi Higuchi, Sharma, Abhinav, Sun, Jie Lena, Pieper, Karen, McMurray, John J.V., Holman, Rury R. and Lopes, Renato D.. (2017). International variation in outcomes among people with cardiovascular disease or cardiovascular risk factors and impaired glucose tolerance: Insights from the NAVIGATOR trial. Journal of the American Heart Association. 6(1), pp. 1 - 11. https://doi.org/10.1161/JAHA.116.003892

European Society of Cardiology-Acute Cardiovascular Care Association Position paper on acute heart failure: A call for interdisciplinary care

Mueller, Christian, Christ, Michael, Cowie, Martin R., Cullen, Louise, Maisel, Alan S., Masip, Josep, Miró, Oscar, McMurray, John, Peacock, Frank W., Price, Susanna, DiSomma, Salvatore, Bueno, Hector, Zeymer, Uwe, Mebazaa, Alexandre, ESC Acute Cardiovascular Care Association, and ESC Acute Cardiovascular Care Association. (2017). European Society of Cardiology-Acute Cardiovascular Care Association Position paper on acute heart failure: A call for interdisciplinary care. European Heart Journal: Acute Cardiovascular Care. 6(1), pp. 81 - 86. https://doi.org/10.1177/2048872615593279

Long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure: primary results of the ENABLE trials

Packer, Milton, McMurray, John J.V., Krum, Henry, Kiowski, Wolfgang, Massie, Barry M., Caspi, Avi, Pratt, Craig M., Petrie, Mark C., DeMets, David, Kobrin, Isaac, Roux, Sebastien and Swedberg, Karl. (2017). Long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure: primary results of the ENABLE trials. JACC: Heart Failure. 5(5), pp. 317 - 326. https://doi.org/10.1016/j.jchf.2017.02.021

Aldosterone does not predict cardiovascular events following acute coronary syndrome in patients initially without heart failure

Pitts, Reynaria, Gunzburger, Elise, Ballantyne, Christie M., Barter, Philip J., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, Nicholls, Stephen J., Shah, Prediman K., Tardif, Jean-Claude, Olsson, Anders G., McMurray, John J.V., Kittelson, John and Schwartz, Gregory G.. (2017). Aldosterone does not predict cardiovascular events following acute coronary syndrome in patients initially without heart failure. Journal of the American Heart Association. 6(1), pp. 1 - 7. https://doi.org/10.1161/JAHA.116.004119

Health-related quality of life outcomes in PARADIGM-HF

Lewis, E. F., Claggett, Brian L., McMurray, John, Packer, Milton, Lefkowitz, Martin P., Rouleau, Jean L., Liu, Jiankang, Shi, Victor C., Zile, Michael R., Desai, Akshay S., Solomon, Scott and Sweberg, Karl. (2017). Health-related quality of life outcomes in PARADIGM-HF. Circulation: Heart Failure. 10(8), pp. 1 - 10. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003430

Effect of eplerenone in patients with heart failure and reduced ejection fraction: potential effect modification by abdominal obesity: insight from the EMPHASIS-HF trial

Olivier, Arnaud, Pitt, Bertram, Girerd, Nicolas, Lamiral, Zohra, Machu, Jean L., McMurray, John, Sweberg, Karl, van Veldhuisen, Dirk J., Collier, Timothy J., Pocock, Stuart J., Rossignol, Patrick, Zannad, Faiez and Pizard, Anne. (2017). Effect of eplerenone in patients with heart failure and reduced ejection fraction: potential effect modification by abdominal obesity: insight from the EMPHASIS-HF trial. European Journal of Heart Failure. 19(9), pp. 1186 - 1197. https://doi.org/10.1002/ejhf.792

Role of b-type natriuretic peptide and n-terminal prohormone BNP as predictors of cardiovascular morbidity and mortality in patients with a recent coronary event and type 2 diabetes mellitus

Wolsk, Emil, Claggett, Brian L., Pfeffer, Marc A., Diaz, Rafael, Dickstein, Kenneth, Gerstein, Hertzel C., Lawson, Francesca C., Lewis, E. F., Maggioni, Aldo P., McMurray, John, Probstfield, Jeffrey L., Riddle, Matthew C., Solomon, Scott, Tardif, Jean C. and Kober, Lars. (2017). Role of b-type natriuretic peptide and n-terminal prohormone BNP as predictors of cardiovascular morbidity and mortality in patients with a recent coronary event and type 2 diabetes mellitus. Journal of the American Heart Association. 6(6), pp. 1 - 28. https://doi.org/10.1161/JAHA.116.004743

Insufficient reduction in heart rate during hospitalization despite beta-blocker treatment in acute decompensated heart failure: Insights from the ASCEND-HF trial

Kitai, Takeshi, Grodin, Justin L., Mentz, Robert J., Hernandez, Adrian F., Butler, Javed, Metra, Marco, McMurray, John J. V., Armstrong, Paul W., Starling, Randall C., O'Connor, Christopher M., Swedberg, Karl and Tang, W. H. Wilson. (2017). Insufficient reduction in heart rate during hospitalization despite beta-blocker treatment in acute decompensated heart failure: Insights from the ASCEND-HF trial. European Journal of Heart Failure. 19(2), pp. 241 - 249. https://doi.org/10.1002/ejhf.629

B-type natriuretic peptides in chronic obstructive pulmonary disease: a systematic review

Hawkins, Nathaniel M., Khosla, Amit, Virani, Sean A., McMurray, John J.V. and FitzGerald, J. Mark. (2017). B-type natriuretic peptides in chronic obstructive pulmonary disease: a systematic review. BMC Pulmonary Medicine. 17(1), pp. 1 - 17. https://doi.org/10.1186/s12890-016-0345-7

Re-examination of the BEST trial using composite outcomes, including emergency department visits

Shen, Li, Jhund, Pardeep, Mogensen, Ulrik M., Kober, Lars, Claggett, Brian L., Rogers, Jennifer K. and McMurray, John. (2017). Re-examination of the BEST trial using composite outcomes, including emergency department visits. JACC: Heart Failure. 5(8), pp. 591 - 599. https://doi.org/10.1016/j.jchf.2017.04.005

Guía ESC 2016 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración con la EACTS

Kirchhof, Paulus, Benussi, Stefano, Kotecha, Dipak, Ahlsson, Anders, Atar, Dan, Casadei, Barbara, Castellá, Manuel, Diener, Hans C., Heidbuchel, Hein, Hendriks, Jeroen, Hindricks, Gerhard, Manolis, Antonis S., Oldgren, Jonas, Popescu, Bogdan A., Schotten, Ulrich, Van Putte, Bart Van, Vardas, Panagiotis, Agewall, Stefan, Camm, John, ... Suwalski, Piotr. (2017). Guía ESC 2016 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración con la EACTS. Spanish Review of Cardiology. 70(1), pp. 1 - 84. https://doi.org/10.1016/j.recesp.2016.11.014

Serum chloride and sodium interplay in patients with acute myocardial infarction and heart failure with reduced ejection fraction: an analysis from the high-risk myocardial infarction database initiative

Ferreira, João P., Girerd, Nicolas, Duarte, Kevin, Coiro, Stefano, McMurray, John, Dargie, H. J., Pitt, Bertram, Dickstein, Kenneth, Testani, Jeffrey M., Zannad, Faiez and Rossignol, Patrick. (2017). Serum chloride and sodium interplay in patients with acute myocardial infarction and heart failure with reduced ejection fraction: an analysis from the high-risk myocardial infarction database initiative. Circulation: Heart Failure. 10(2), pp. 1 - 11. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003500

Thirty years of evidence on the efficacy of drug treatments for chronic heart failure with reduced ejection fraction: A network meta-analysis

Burnett, Heather, Earley, Amy, Voors, Adriaan A., Senni, Michele, McMurray, John, Deschaseaux, Celine and Cope, Shannon. (2017). Thirty years of evidence on the efficacy of drug treatments for chronic heart failure with reduced ejection fraction: A network meta-analysis. Circulation: Heart Failure. 10(1), pp. 1 - 13. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003529

Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction

Cannon, Jane A., Shen, Li, Jhund, Pardeep S., Kristensen, Søren L., Kober, Lars, Chen, Fabian, Gong, Jianjian, Lefkowitz, Martin P., Rouleau, Jean L., Shi, Victor C., Swedberg, Karl, Zile, Michael R., Solomon, Scott D., Packer, Milton and McMurray, John J. V.. (2017). Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction. European Journal of Heart Failure. 19(1), pp. 129 - 137. https://doi.org/10.1002/ejhf.687

Prevalence of prediabetes and undiagnosed diabetes in patients with hfpef and hfref and associated clinical outcomes

Kristensen, Søren L., Jhund, Pardeep, Lee, Matthew M.Y., Kober, Lars, Solomon, Scott, Granger, Christopher B., Yusuf, Salim, Pfeffer, Marc A., Sweberg, Karl and McMurray, John. (2017). Prevalence of prediabetes and undiagnosed diabetes in patients with hfpef and hfref and associated clinical outcomes. Cardiovascular Drugs and Therapy. 31(4-6), pp. 545 - 549. https://doi.org/10.1007/s10557-017-6754-x

Heart failure in young adults is associated with high mortality: a contemporary population-level analysis

Wong, Chih M., Hawkins, Nathaniel M., Ezekowitz, Justin A., Jhund, Pardeep, Savu, Anamaria, Macdonald, Michael R., Kristensen, Søren L., Petrie, Mark C., McMurray, John, McAlister, Finlay A. and Kaul, Padma. (2017). Heart failure in young adults is associated with high mortality: a contemporary population-level analysis. Canadian Journal of Cardiology. 33(11), pp. 1472 - 1477. https://doi.org/10.1016/j.cjca.2017.05.009

Prognostic value of N-terminal pro-B-type natriuretic peptide levels in heart failure patients with and without atrial fibrillation

Kristensen, Søren L., Jhund, Pardeep, Mogensen, Ulrik M., Rørth, Rasmus, Abraham, William T., Desai, Akshay S., Dickstein, Kenneth, Rouleau, Jean L., Zile, Michael R., Sweberg, Karl, Packer, Milton, Solomon, Scott, Kober, Lars and McMurray, John. (2017). Prognostic value of N-terminal pro-B-type natriuretic peptide levels in heart failure patients with and without atrial fibrillation. Circulation: Heart Failure. 10(10), pp. 1 - 10. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004409

Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure: does it add useful prognostic information? An analysis of the value of endothelin receptor inhibition with tezosentan in acute heart failure study

Cleland, John G.F., Teerlink, John R., Davison, Beth A., Shoaib, Ahmad, Metra, Marco, Senger, Stefanie, Milo, Olga, Cotter, Gad, Bourge, Robert C., Parker, John D., Jondeau, Guillaume, Krum, Henry, O'Connor, Christopher M., Torre-Amione, Guillermo, van Veldhuisen, Dirk J. and McMurray, John. (2017). Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure: does it add useful prognostic information? An analysis of the value of endothelin receptor inhibition with tezosentan in acute heart failure study. European Journal of Heart Failure. 19(6), pp. 739 - 747. https://doi.org/10.1002/ejhf.786

Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure

Price, Susanna, Platz, Elke, Cullen, Louise, Tavazzi, Guido, Christ, Michael, Cowie, Martin R., Maisel, Alan S., Masip, Josep, Miro, Oscar, McMurray, John J., Peacock, W. Frank, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Bueno, Hector, Zeymer, Uwe and Mueller, Christian. (2017). Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure. Nature Reviews Cardiology. 14(7), pp. 427 - 440. https://doi.org/10.1038/nrcardio.2017.56

Contemporary characteristics and outcomes in chagasic heart failure compared with other nonischemic and ischemic cardiomyopathy

Shen, Li, Ramires, Felix, Martinez, Felipe, Bodanese, Luiz C., Echeverría, Luis E., Gomez, Efrain, Abraham, William T., Dickstein, Kenneth, Kober, Lars, Packer, Milton, Rouleau, Jean L., Solomon, Scott, Sweberg, Karl, Zile, Michael R., Jhund, Pardeep, Gimpelewicz, Claudio and McMurray, John. (2017). Contemporary characteristics and outcomes in chagasic heart failure compared with other nonischemic and ischemic cardiomyopathy. Circulation: Heart Failure. 10(11), pp. 1 - 9. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004361

Angiotensin receptor neprilysin inhibition in heart failure with preserved ejection fraction: rationale and design of the PARAGON-HF trial

Solomon, Scott, Rizkala, Adel R., Gong, Jianjian, Wang, Wenyan, Anand, Inder S., Ge, Junbo, Lam, Carolyn S.P., Maggioni, Aldo P., Martinez, Felipe, Packer, Milton, Pfeffer, Marc A., Pieske, Burkert, Redfield, Margaret M., Rouleau, Jean L., van Veldhuisen, Dirk J., Zannad, Faiez, Zile, Michael R., Desai, Akshay S., Shi, Victor C., ... McMurray, John. (2017). Angiotensin receptor neprilysin inhibition in heart failure with preserved ejection fraction: rationale and design of the PARAGON-HF trial. JACC: Heart Failure. 5(7), pp. 471 - 482. https://doi.org/10.1016/j.jchf.2017.04.013

Low YKL-40 in chronic heart failure may predict beneficial effects of statins: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA)

Arain, Fizza, Gullestad, Lars, Nymo, Ståle, Kjekshus, John, Cleland, John G., Michelsen, Annika, McMurray, John J., Wikstrand, John, Aukrust, Pål and Ueland, Thor. (2017). Low YKL-40 in chronic heart failure may predict beneficial effects of statins: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA). Biomarkers. 22(3 to 4), pp. 261 - 267. https://doi.org/10.1080/1354750X.2016.1204003

Declining risk of sudden death in heart failure

Shen, Li, Jhund, Pardeep, Petrie, Mark C., Claggett, Brian L., Barlera, Simona, Cleland, John GF, Dargie, H. J., Granger, Christopher B., Kjekshus, John, Kober, Lars, Latini, Roberto, Maggioni, Aldo P., Packer, Milton, Pitt, Bertram, Solomon, Scott, Sweberg, Karl, Tavazzi, Luigi, Wikstrand, John, Zannad, Faiez, ... McMurray, John. (2017). Declining risk of sudden death in heart failure. New England Journal of Medicine. 377(1), pp. 41 - 51. https://doi.org/10.1056/NEJMoa1609758

Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom heart and renal protection (HARP)- III - rationale, trial design and baseline data

Judge, P. K., Haynes, R., Herrington, W. G., Storey, B. C., Staplin, N., Bethel, A., Bowman, L., Brunskill, N., Cockwell, P., Dayanandan, R., Hill, M., Kalra, P. A., McMurray, John, Taal, M., Wheeler, D. C., Landray, M. J. and Baigent, Colin. (2017). Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom heart and renal protection (HARP)- III - rationale, trial design and baseline data. Nephrology Dialysis Transplantation. 32(12), pp. 2043 - 2051. https://doi.org/10.1093/ndt/gfw321

Effect of ularitide on cardiovascular mortality in acute heart failure

Packer, Milton, O'Connor, Christopher M., McMurray, John, Wittes, Janet T., Abraham, William T., Anker, Stefan D., Dickstein, Kenneth, Filippatos, Gerasimos S., Holcomb, Richard, Krum, Henry, Maggioni, Aldo P., Mebazaa, Alexandre, Peacock, W. F., Petrie, Mark C., Ponikowski, Piotr P., Ruschitzka, Frank, van Veldhuisen, Dirk J., Kowarski, L. S., Schactman, M. and Holzmeister, Johannes. (2017). Effect of ularitide on cardiovascular mortality in acute heart failure. New England Journal of Medicine. 376(20), pp. 1956 - 1964. https://doi.org/10.1056/NEJMoa1601895

Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: A post-hoc analysis from the PARADIGM-HF trial

Seferovic, Jelena P., Claggett, Brian L., Seidelmann, Sara B., Seely, Ellen W., Packer, Milton, Zile, Michael R., Rouleau, Jean L., Swedberg, Karl, Lefkowitz, Martin P., Shi, Victor C., Desai, Akshay S., McMurray, John J. V. and Solomon, Scott D.. (2017). Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: A post-hoc analysis from the PARADIGM-HF trial. The Lancet Diabetes & Endocrinology. 5(5), pp. 333 - 340. https://doi.org/10.1016/S2213-8587(17)30087-6

Cognitive impairment and heart failure: systematic review and meta-analysis

Cannon, Jane A., Moffitt, Peter, Perez-Moreno, Ana C., Walters, Matthew R., Broomfield, Niall M., McMurray, John and Quinn, Terry J.. (2017). Cognitive impairment and heart failure: systematic review and meta-analysis. Journal of Cardiac Failure. 23(6), pp. 464 - 475. https://doi.org/10.1016/j.cardfail.2017.04.007

Effects of Vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure. A randomized placebo-controlled trial

McMurray, John, Ponikowski, Piotr P., Bolli, Geremia B., Lukashevich, Valentina, Kozlovski, Plamen, Kothny, Wolfgang, Lewsey, James D. and Krum, Henry. (2017). Effects of Vildagliptin on ventricular function in patients with type 2 diabetes mellitus and heart failure. A randomized placebo-controlled trial. JACC: Heart Failure. 6(1), pp. 1 - 10. https://doi.org/10.1016/j.jchf.2017.08.004

Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF

Mogensen, Ulrik M., Kober, Lars, Jhund, Pardeep, Desai, Akshay S., Senni, Michele, Kristensen, Søren L., Dukat, Andrej, Chen, H. Chen, Ramires, Felix, Lefkowitz, Martin P., Prescott, Margaret F., Shi, Victor C., Rouleau, Jean L., Solomon, Scott, Sweberg, Karl, Packer, Milton and McMurray, John. (2017). Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF. European Journal of Heart Failure. 20(3), pp. 514 - 522. https://doi.org/10.1002/ejhf.1056

Effect of apixaban on all-cause death in patients with atrial fibrillation: a meta-analysis based on imputed placebo effect

Guimarães, Patrícia O., Lopes, Renato D., Wojdyla, Daniel M., Abdul-Rahim, Azmil H., Connolly, Stuart J., Flaker, Greg, Wang, Junyuan, Hanna, Michael, Granger, Christopher B., Wallentin, Lars, Lees, Kennedy R., Alexander, John H. and McMurray, John. (2017). Effect of apixaban on all-cause death in patients with atrial fibrillation: a meta-analysis based on imputed placebo effect. Cardiovascular Drugs and Therapy. 31(3), pp. 295 - 301. https://doi.org/10.1007/s10557-017-6728-z

Clinical and echocardiographic characteristics and cardiovascular outcomes according to diabetes status in patients with heart failure and preserved ejection fraction: A report from the I-Preserve Trial (Irbesartan in heart failure with preserved ejection fraction)

Kristensen, Søren L., Mogensen, Ulrik M., Jhund, Pardeep, Petrie, Mark C., Preiss, David, Win, Sithu, Kober, Lars, McKelvie, Robert, Zile, Michael R., Anand, Inder S., Komajda, Michel, Gottdiener, John S., Carson, Peter E. and McMurray, John. (2017). Clinical and echocardiographic characteristics and cardiovascular outcomes according to diabetes status in patients with heart failure and preserved ejection fraction: A report from the I-Preserve Trial (Irbesartan in heart failure with preserved ejection fraction). Circulation. 135(8), pp. 724 - 735. https://doi.org/10.1161/CIRCULATIONAHA.116.024593

Limited added value of circulating inflammatory biomarkers in chronic heart failure

Nymo, Ståle H., Aukrust, Pål, Kjekshus, John, McMurray, John J.V., Cleland, John G. F., Wikstrand, John, Muntendam, Pieter, Wienhues-Thelen, Ursula Henrike, Latini, Roberto, Askevold, Erik Tandberg, Gravning, Jørgen, Dahl, Christen P., Broch, Kaspar, Yndestad, Arne, Gullestad, Lars and Ueland, Thor. (2017). Limited added value of circulating inflammatory biomarkers in chronic heart failure. JACC: Heart Failure. 5(4), pp. 256 - 267. https://doi.org/10.1016/j.jchf.2017.01.008

Effect of valsartan on kidney outcomes in people with impaired glucose tolerance

Currie, Gemma, Bethel, M. A., Holzhauer, Björn, Haffner, S. M., Holman, Rury R. and McMurray, John. (2017). Effect of valsartan on kidney outcomes in people with impaired glucose tolerance. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. 19(6), pp. 791 - 799. https://doi.org/10.1111/dom.12877

Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the standard care vs. Celecoxib outcome trial (SCOT)

MacDonald, Thomas M., Hawkey, Christopher J., Ford, Ian, McMurray, John, Scheiman, James M., Hallas, Jesper, Findlay, Evelyn, Grobbee, Diederick E., Hobbs, F.D. Richard, Ralston, Stuart H., Reid, David M., Walters, Matthew, Webster, John, Ruschitzka, Frank, Ritchie, Lewis D., Perez-Gutthann, Susana, Connolly, Eugene C., Greenlaw, Nicola, Wilson, Adam, ... Mackenzie, Isla S.. (2017). Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the standard care vs. Celecoxib outcome trial (SCOT). European Heart Journal. 38(23), pp. 1843 - 1850. https://doi.org/10.1093/eurheartj/ehw387

Referral for Specialist Follow-up and Its Association With Post-discharge Mortality Among Patients With Systolic Heart Failure (from the National Heart Failure Audit for England and Wales)

Emdin, Connor A., Hsiao, Allan J., Kiran, Amit, Conrad, Nathalie, Salimi-Khorshidi, Gholamreza, Woodward, Mark, Anderson, Simon G., Mohseni, Hamid, McMurray, John J.V., Cleland, John G. F., Dargie, H. J., Hardman, Suzanna, McDonagh, Theresa and Rahimi, Kazem. (2017). Referral for Specialist Follow-up and Its Association With Post-discharge Mortality Among Patients With Systolic Heart Failure (from the National Heart Failure Audit for England and Wales). American Journal of Cardiology. 119(3), pp. 440 - 444. https://doi.org/10.1016/j.amjcard.2016.10.021

Mind the gap: current challenges and future state of heart failure care

McDonald, Michael A., Ashley, Euan A., Fedak, Paul W. M., Hawkins, Nathaniel, Januzzi, J., McMurray, John, Parikh, Victoria N., Rao, Vivek, Svystonyuk, Daniyil, Teerlink, John R. and Virani, Sean A.. (2017). Mind the gap: current challenges and future state of heart failure care. Canadian Journal of Cardiology. 33(11), pp. 1434 - 1449. https://doi.org/10.1016/j.cjca.2017.08.023

Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): A randomised, double-blind, placebo-controlled trial

Holman, Rury R., Coleman, Ruth L., Chan, Juliana C. N., Chiasson, Jean-Louis, Feng, Huimei, Ge, Junbo, Gerstein, Hertzel C., Gray, Richard, Huo, Yong, Lang, Zhihui, McMurray, John J., Rydén, Lars, Schröder, Stefan, Sun, Yihong, Theodorakis, Michael J., Tendera, Michal, Tucker, Lynne, Tuomilehto, Jaakko, Wei, Yidong, ... Pan, Changyu. (2017). Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): A randomised, double-blind, placebo-controlled trial. The Lancet Diabetes & Endocrinology. 5(11), pp. 877-886. https://doi.org/10.1016/S2213-8587(17)30309-1

The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF

Mogensen, Ulrik M., Kober, Lars, Kristensen, Søren L., Jhund, Pardeep, Gong, Jianjian, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Sweberg, Karl, Zile, Michael R., Solomon, Scott D., Packer, Milton and McMurray, John J.V.. (2017). The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF. American Heart Journal. 188, pp. 35 - 41. https://doi.org/10.1016/j.ahj.2017.02.034

Prognostic value of insulin-like growth factor-binding protein 7 in patients with heart failure and preserved ejection fraction

Gandhi, Parul U., Chow, Sheryl L., Rector, Thomas S., Krum, Henry, Gaggin, Hanna K., McMurray, John J. V., Zile, Michael R., Komajda, Michel, McKelvie, Robert S., Carson, Peter E., Januzzi, James L. and Anand, Inder S.. (2017). Prognostic value of insulin-like growth factor-binding protein 7 in patients with heart failure and preserved ejection fraction. Journal of Cardiac Failure. 23(1), pp. 20 - 28. https://doi.org/10.1016/j.cardfail.2016.06.006

Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization

Desai, Akshay S., Claggett, Brian L., Packer, Milton, Zile, Michael R., Rouleau, Jean L., Sweberg, Karl, Shi, Victor, Lefkowitz, Martin, Starling, Randall, Teerlink, John, McMurray, John J.V. and Solomon, Scott D.. (2016). Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization. Journal of the American College of Cardiology. 68(3), pp. 241 - 248. https://doi.org/10.1016/j.jacc.2016.04.047

SGLT2 inhibition and cardiovascular events: why did EMPA-REG outcomes surprise and what were the likely mechanisms?

Sattar, Naveed, McLaren, James, Kristensen, Søren L., Preiss, David and McMurray, John. (2016). SGLT2 inhibition and cardiovascular events: why did EMPA-REG outcomes surprise and what were the likely mechanisms? Diabetologia. 59(7), pp. 1333 - 1339. https://doi.org/10.1007/s00125-016-3956-x

Dichotomous relationship between age and 30-day death or rehospitalization in Heart Failure Patients Admitted with Acute Decompensated Heart Failure: Results From the ASCEND-HF Trial

Whellan, David J., Stebbins, Amanda, Hernandez, Adrian F., Ezekowitz, Justin A., McMurray, John J. V., Mather, Paul J., Hasselblad, Vic and O'Connor, Christopher M.. (2016). Dichotomous relationship between age and 30-day death or rehospitalization in Heart Failure Patients Admitted with Acute Decompensated Heart Failure: Results From the ASCEND-HF Trial. Journal of Cardiac Failure. 22(6), pp. 409 - 416. https://doi.org/10.1016/j.cardfail.2016.02.011

The neprilysin pathway in heart failure: a review and guide on the use of sacubitril/valsartan

Jhund, Pardeep and McMurray, John. (2016). The neprilysin pathway in heart failure: a review and guide on the use of sacubitril/valsartan. Heart. 102(17), pp. 1342 - 1347. https://doi.org/10.1136/heartjnl-2014-306775

Guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica

Ponikowski, Piotr, Voors, Adriaan A., Anker, Stefan D., Bueno, Héctor, Cleland, John G. F., Coats, Andrew J. S., Falk, Volkmar, González-Juanatey, José Ramón, Harjola, Veli-Pekka, Jankowska, Ewa A., Jessup, Mariell, Linde, Cecilia, Nihoyannopoulos, Petros, Parissis, John T., Pieske, Burkert, Riley, Jillian P., Rosano, Giuseppe, Ruilope, Luis Miguel, Ruschitzka, Frank, ... Zamorano, José Luis. (2016). Guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica. Revista Espanola de Cardiologia. 69(12), pp. 1167.e1 - 1167.e85. https://doi.org/10.1016/j.recesp.2016.10.014

Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure

Zile, Michael R., Claggett, Brian L., Prescott, Margaret F., McMurray, John J.V., Packer, Milton, Rouleau, Jean L., Sweberg, Karl, Desai, Akshay S., Gong, Jianjian, Shi, Victor C. and Solomon, Scott D.. (2016). Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure. Journal of the American College of Cardiology. 68(22), pp. 2425 - 2436. https://doi.org/10.1016/j.jacc.2016.09.931

Plasma biomarkers reflecting profibrotic processes in heart failure with a preserved ejection fraction: Data from the prospective comparison of ARNI with ARB on management of heart failure with preserved ejection fraction study

Zile, Michael R., Jhund, Pardeep, Baicu, Catalin F., Claggett, Brian L., Pieske, Burkert, Voors, Adriaan A., Prescott, Margaret F., Shi, Victor C., Lefkowitz, Martin, McMurray, John and Solomon, Scott. (2016). Plasma biomarkers reflecting profibrotic processes in heart failure with a preserved ejection fraction: Data from the prospective comparison of ARNI with ARB on management of heart failure with preserved ejection fraction study. Circulation: Heart Failure. 9(1), pp. 1 - 9. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002551

Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: An analysis of the EMPHASIS-HF study

Chin, Ken Lee, Collier, Timothy J., Pitt, Bertram, McMurray, John J. V., Swedberg, Karl, van Veldhuisen, Dirk J., Pocock, Stuart J., Vincent, John, Turgonyi, Eva, Zannad, Faiez and Krum, Henry. (2016). Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: An analysis of the EMPHASIS-HF study. European Journal of Heart Failure. 18(9), pp. 1175 - 1181. https://doi.org/10.1002/ejhf.485

Geographic variations in the PARADIGM-HF heart failure trial

Kristensen, Søren L., Martinez, Felipe, Jhund, Pardeep S., Arango, Juan Luis, Bĕlohlávek, Jan, Boytsov, Sergey, Cabrera, Walter, Gomez, Efrain, Hagege, Albert Alain, Huang, Jun, Kiatchoosakun, Songsak, Kim, Kee-Sik, Mendoza, Iván, Senni, Michele, Squire, Iain B., Vinereanu, Dragos, Wong, Raymond Chiew-Chiew, Gong, Jianjian, Lefkowitz, Martin P., ... McMurray, John J. V.. (2016). Geographic variations in the PARADIGM-HF heart failure trial. European Heart Journal. 37(41), pp. 3167 - 3174. https://doi.org/10.1093/eurheartj/ehw226

Prognostic value of baseline and changes in circulating soluble ST2 levels and the effects of nesiritide in acute decompensated heart failure

Tang, W. H. Wilson, Wu, Yuping, Grodin, Justin L., Hsu, Amy P., Hernandez, Adrian F., Butler, Javed, Metra, Marco, Voors, Adriaan A., Felker, G. Michael, Troughton, Richard W., Mills, Roger M., McMurray, John J., Armstrong, Paul W., O'Connor, Christopher M. and Starling, Randall C.. (2016). Prognostic value of baseline and changes in circulating soluble ST2 levels and the effects of nesiritide in acute decompensated heart failure. JACC: Heart Failure. 4(1), pp. 68 - 77. https://doi.org/10.1016/j.jchf.2015.07.015

Renal outcomes with aliskiren in patients with type 2 diabetes: A prespecified secondary analysis of the ALTITUDE randomised controlled trial

Heerspink, Hiddo J. L., Persson, Frederik, Brenner, Barry M.D., Chaturvedi, Nish, Brunel, Patrick, McMurray, John, Desai, Akshay S., Solomon, Scott D., Pfeffer, Marc A., Parving, Hans-Henrik Henrik and de Zeeuw, Dick. (2016). Renal outcomes with aliskiren in patients with type 2 diabetes: A prespecified secondary analysis of the ALTITUDE randomised controlled trial. The Lancet Diabetes & Endocrinology. 4(4), pp. 309 - 317. https://doi.org/10.1016/S2213-8587(15)00469-6

Clinical outcomes according to QRS duration and morphology in the Irbesartan in Patients with Heart Failure and Preserved Systolic Function (I-PRESERVE) trial

Cannon, Jane A., Shen, Li, Jhund, Pardeep S., Anand, Inder S., Komajda, Michel, McKelvie, Robert S., Zile, Michael R., Carson, Peter E. and McMurray, John J. V.. (2016). Clinical outcomes according to QRS duration and morphology in the Irbesartan in Patients with Heart Failure and Preserved Systolic Function (I-PRESERVE) trial. European Journal of Heart Failure. 18(8), pp. 1021 - 1031. https://doi.org/10.1002/ejhf.547

Influence of ejection fraction on outcomes and efficacy of Sacubitril/Valsartan (LCZ696) in heart failure with reduced ejection fraction: The prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure (PARADIGM-HF) trial

Solomon, Scott, Claggett, Brian L., Desai, Akshay S., Packer, Milton, Zile, Michael R., Swedberg, Karl, Rouleau, Jean L., Shi, Victor C., Starling, Randall C., Kozan, Ömer, Dukat, Andrej, Lefkowitz, Martin P. and McMurray, John. (2016). Influence of ejection fraction on outcomes and efficacy of Sacubitril/Valsartan (LCZ696) in heart failure with reduced ejection fraction: The prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure (PARADIGM-HF) trial. Circulation: Heart Failure. 9(3), pp. 1 - 5. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002744

Efficacy of sacubitril/valsartan relative to a prior decompensation: The PARADIGM-HF trial

Solomon, Scott D., Claggett, Brian L., Packer, Milton, Desai, Akshay S., Zile, Michael R., Swedberg, Karl, Rouleau, Jean L., Shi, Victor C., Lefkowitz, Martin P. and McMurray, John J.V.. (2016). Efficacy of sacubitril/valsartan relative to a prior decompensation: The PARADIGM-HF trial. JACC: Heart Failure. 4(10), pp. 816 - 822. https://doi.org/10.1016/j.jchf.2016.05.002

Predicting outcomes over time in patients with heart failure, left ventricular systolic dysfunction, or both following acute myocardial infarction

Lopes, Renato D., Pieper, Karen S., Stevens, Susanna R., Solomon, Scott D., McMurray, John J.V., Pfeffer, Marc A., Leimberger, Jeffrey D. and Velazquez, Eric J.. (2016). Predicting outcomes over time in patients with heart failure, left ventricular systolic dysfunction, or both following acute myocardial infarction. Journal of the American Heart Association. 5(6), pp. 1 - 23. https://doi.org/10.1161/JAHA.115.003045

Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives

Ferreira, João P.E., Girerd, Nicolas, Pellicori, Pierpaolo, Duarte, Kevin, Girerd, Sophie, Pfeffer, Marc A., McMurray, John J. V., Pitt, Bertram, Dickstein, Kenneth, Jacobs, Lotte, Staessen, Jan A., Butler, Javed, Latini, Roberto, Masson, Serge, Mebazaa, Alexandre, Brunner-La Rocca, Hans Peter, Delles, Christian, Heymans, Stephane, Sattar, Naveed, ... Rossignol, Patrick. (2016). Renal function estimation and Cockroft-Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart 'OMics' in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Medicine. 14(181), pp. 1 - 14. https://doi.org/10.1186/s12916-016-0731-2

Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction

Damman, Kevin, Kjekshus, John, Wikstrand, John, Cleland, John G. F., Komajda, Michel, Wedel, Hans, Waagstein, Finn and McMurray, John J. V.. (2016). Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction. European Journal of Heart Failure. 18(3), pp. 328 - 336. https://doi.org/10.1002/ejhf.462

Predictors and associations with outcomes of length of hospital stay in patients with acute heart failure: Results from VERITAS

Cotter, Gad, Davison, Beth A., Milo, Olga, Bourge, Robert C., Cleland, John G. F., Jondeau, Guillaume, Krum, Henry, O'Connor, Christopher M., Metra, Marco, Parker, John D., Torre-Amione, Guillermo, van Veldhuisen, Dirk J., Kobrin, Isaac, Rainisio, Maurizio, Senger, Stefanie, Edwards, Christopher, McMurray, John J. V. and Teerlink, John R.. (2016). Predictors and associations with outcomes of length of hospital stay in patients with acute heart failure: Results from VERITAS. Journal of Cardiac Failure. 22(10), pp. 815 - 822. https://doi.org/10.1016/j.cardfail.2015.12.017

Efficacy and safety of novel oral anticoagulants in patients with atrial fibrillation and heart failure: A meta-analysis

Savarese, Gianluigi, Giugliano, Robert P., Rosano, Giuseppe M.C., McMurray, John, Magnani, Giulia, Filippatos, Gerasimos S., Dellegrottaglie, Santo, Lund, Lars H., Trimarco, Bruno and Perrone-Filardi, Pasquale. (2016). Efficacy and safety of novel oral anticoagulants in patients with atrial fibrillation and heart failure: A meta-analysis. JACC: Heart Failure. 4(11), pp. 870 - 880. https://doi.org/10.1016/j.jchf.2016.07.012

The clinical course of health status and association with outcomes in patients hospitalized for heart failure: Insights from ASCEND-HF

Ambrosy, Andrew P., Hernandez, Adrian F., Armstrong, Paul W., Butler, Javed, Dunning, Allison, Ezekowitz, Justin A., Felker, G. Michael, Greene, Stephen J., Kaul, Padma, McMurray, John J. V., Metra, Marco, O'Connor, Christopher M., Reed, Shelby D., Schulte, Phillip J., Starling, Randall C., Tang, W. H. Wilson, Voors, Adriaan A. and Mentz, Robert J.. (2016). The clinical course of health status and association with outcomes in patients hospitalized for heart failure: Insights from ASCEND-HF. European Journal of Heart Failure. 18(3), pp. 306 - 313. https://doi.org/10.1002/ejhf.420

Pulse pressure is not an independent predictor of outcome in type 2 diabetes patients with chronic kidney disease and anemia - The Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT)

Theilade, S., Claggett, Brian L., Hansen, T. W., Skali, Hicham, Lewis, E. F., Solomon, Scott D., Parving, Hans-Henrik, Pfeffer, M. A., McMurray, John J. V. and Rossing, P.. (2016). Pulse pressure is not an independent predictor of outcome in type 2 diabetes patients with chronic kidney disease and anemia - The Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT). Journal of Human Hypertension. 30(1), pp. 46 - 52. https://doi.org/10.1038/jhh.2015.22

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Gailure of the European Society of Cardiology (ESC)

Ponikowski, Piotr, Voors, Adriaan A., Anker, Stefan D., Bueno, Héctor, Cleland, John G. F., Coats, Andrew J. S., Falk, Volkmar, González-Juanatey, José Ramón, Harjola, Veli-Pekka, Jankowska, Ewa A., Jessup, Mariell, Linde, Cecilia, Nihoyannopoulos, Petros, Parissis, John T., Pieske, Burkert, Riley, Jillian P., Rosano, Giuseppe M. C., Ruilope, Luis Miguel, Ruschitzka, Frank, ... Zamorano, Jose Luis. (2016). 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Gailure of the European Society of Cardiology (ESC). European Journal of Heart Failure. 18(8), pp. 891 - 975. https://doi.org/10.1002/ejhf.592

Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): A phase 2, pharmacokinetic, randomised, placebo-controlled trial

Teerlink, John R., Felker, G. Michael, McMurray, John J. V., Solomon, Scott D., Adams, Kirkwood F., Cleland, John G. F., Ezekowitz, Justin A., Goudev, Assen, Macdonald, Peter, Metra, Marco, Mitrovic, Veselin, Ponikowski, Piotr P., Serpytis, Pranas, Spinar, Jindrich, Tomcsányi, János, Vandekerckhove, Hans J., Voors, Adriaan A., Monsalvo, Maria Laura, Johnston, James, ... Honarpour, Narimon. (2016). Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): A phase 2, pharmacokinetic, randomised, placebo-controlled trial. The Lancet. 388(10062), pp. 2895 - 2903. https://doi.org/10.1016/S0140-6736(16)32049-9

Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study

Teerlink, John R., Felker, G. Michael, McMurray, John J.V., Ponikowski, Piotr Piotr, Metra, Marco, Filippatos, Gerasimos S., Ezekowitz, Justin A., Dickstein, Kenneth, Cleland, John G. F., Kim, Jae B., Lei, Lei, Knusel, Beat, Wolff, Andrew A., Malik, Fady I. and Wasserman, Scott M.. (2016). Acute Treatment with Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study. Journal of the American College of Cardiology. 67(12), pp. 1444 - 1455. https://doi.org/10.1016/j.jacc.2016.01.031

Coronary artery disease is a predictor of progression to dialysis in patients with chronic kidney disease, type 2 diabetes mellitus, and anemia: An analysis of the trial to reduce cardiovascular events with aranesp therapy (TREAT)

Sabe, Marwa A., Claggett, Brian, Burdmann, Emmanuel A., Desai, Akshay S., Ivanovich, Peter, Kewalramani, Reshma, Lewis, Eldrin F., McMurray, John J.V., Olson, Kurt A., Parfrey, Patrick, Solomon, Scott D. and Pfeffer, Marc A.. (2016). Coronary artery disease is a predictor of progression to dialysis in patients with chronic kidney disease, type 2 diabetes mellitus, and anemia: An analysis of the trial to reduce cardiovascular events with aranesp therapy (TREAT). Journal of the American Heart Association. 5(4), pp. 1 - 11. https://doi.org/10.1161/JAHA.115.002850

Initiating sacubitril/valsartan (LCZ696) in heart failure: Results of TITRATION, a double-blind, randomized comparison of two uptitration regimens

Senni, Michele, McMurray, John J. V., Wachter, Rolf, McIntyre, Hugh F., Reyes, Antonio, Majercak, Ivan, Andreka, Peter, Shehova-Yankova, Nina, Anand, Inder S., Yilmaz, Mehmet B., Gogia, Harinder, Martinez-Selles, Manuel, Fischer, Steffen, Zilahi, Zsolt, Cosmi, Franco, Gelev, Valeri, Galve, Enrique, Gómez-Doblas, Juanjo J., Nociar, Jan, ... Charney, Alan. (2016). Initiating sacubitril/valsartan (LCZ696) in heart failure: Results of TITRATION, a double-blind, randomized comparison of two uptitration regimens. European Journal of Heart Failure. 18(9), pp. 1193 - 1202. https://doi.org/10.1002/ejhf.548

Return to the workforce after first hospitalization for heart failure: A Danish nationwide cohort study

Rørth, Rasmus, Wong, Chih, Kragholm, Kristian, Fosbøl, Emil L., Mogensen, Ulrik M., Lamberts, Morten, Petrie, Mark C., Jhund, Pardeep, Gerds, Thomas A., Torp-Pedersen, Christian, Gislason, Gunnar H., McMurray, John, Kober, Lars and Kristensen, Søren L.. (2016). Return to the workforce after first hospitalization for heart failure: A Danish nationwide cohort study. Circulation. 134(14), pp. 999 - 1009. https://doi.org/10.1161/CIRCULATIONAHA.116.021859

Combined neprilysin and renin-angiotensin system inhibition in heart failure with reduced ejection fraction: A meta-analysis

Solomon, Scott D., Claggett, Brian L., McMurray, John J. V., Hernandez, Adrian F. and Fonarow, Gregg C.. (2016). Combined neprilysin and renin-angiotensin system inhibition in heart failure with reduced ejection fraction: A meta-analysis. European Journal of Heart Failure. 18(10), pp. 1238 - 1243. https://doi.org/10.1002/ejhf.603

Regional cardiac dysfunction and outcome in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction

Wang, Na, Hung, Chung-Lieh, Shin, Sung-Hee, Claggett, Brian L., Skali, Hicham, Thune, Jens Jakob, Kober, Lars, Shah, Amil, McMurray, John J. V., Pfeffer, Marc A. and Solomon, Scott D.. (2016). Regional cardiac dysfunction and outcome in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction. European Heart Journal. 37(5), pp. 466 - 472. https://doi.org/10.1093/eurheartj/ehv558

Efficacy and safety of digoxin in patients with heart failure and reduced ejection fraction according to diabetes status: An analysis of the Digitalis Investigation Group (DIG) trial

Abdul-Rahim, Azmil H., MacIsaac, Rachael L., Jhund, Pardeep S., Petrie, Mark C., Lees, Kennedy R. and McMurray, John J.V.. (2016). Efficacy and safety of digoxin in patients with heart failure and reduced ejection fraction according to diabetes status: An analysis of the Digitalis Investigation Group (DIG) trial. International Journal of Cardiology. 209, pp. 310 - 316. https://doi.org/10.1016/j.ijcard.2016.02.074

Practical approach on frail older patients attended for acute heart failure

Martín-Sánchez, Francisco J., Christ, Michael, Miró, Òscar, Peacock, W. Frank, McMurray, John J., Bueno, Héctor, Maisel, Alan S., Cullen, Louise, Cowie, Martin R., Di Somma, Salvatore, Platz, Elke, Masip, Joseph, Zeymer, Uwe, Vrints, Christiaan, Price, Susanna and Mueller, Christian. (2016). Practical approach on frail older patients attended for acute heart failure. International Journal of Cardiology. 222, pp. 62 - 71. https://doi.org/10.1016/j.ijcard.2016.07.151

Factors associated with noncompletion during the run-in period before randomization and influence on the estimated benefit of LCZ696 in the PARADIGM-HF trial

Desai, Akshay S., Solomon, Scott, Claggett, Brian L., McMurray, John, Rouleau, Jean L., Swedberg, Karl, Zile, Michael, Lefkowitz, Martin P., Shi, Victor C. and Packer, Milton. (2016). Factors associated with noncompletion during the run-in period before randomization and influence on the estimated benefit of LCZ696 in the PARADIGM-HF trial. Circulation: Heart Failure. 9(6), pp. 1 - 6. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002735

Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: The PARADIGM-HF trial

Vardeny, Orly, Claggett, Brian L., Packer, Milton, Zile, Michael R., Rouleau, Jean L., Swedberg, Karl, Teerlink, John R., Desai, Akshay S., Lefkowitz, Martin P., Shi, Victor C., McMurray, John J. V. and Solomon, Scott D.. (2016). Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: The PARADIGM-HF trial. European Journal of Heart Failure. 18(10), pp. 1228 - 1234. https://doi.org/10.1002/ejhf.580

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

Kirchhof, Paulus, Benussi, Stefano, Kotecha, Dipak, Ahlsson, Anders, Atar, Dan, Casadei, Barbara, Castella, Manuel, Diener, Hans-Christoph, Heidbuchel, Hein, Hendriks, Jeroen, Hindricks, Gerhard, Manolis, Antonis S., Oldgren, Jonas, Popescu, Bogdan Alexandru, Schotten, Ulrich, Van Putte, Bart, Vardas, Panagiotis, Agewall, Stefan, Camm, John, ... Zeppenfeld, Katja. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Journal of Cardio-Thoracic Surgery. 50(5), pp. e1 - e88. https://doi.org/10.1093/ejcts/ezw313

Risk related to pre-diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: Insights from prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial

Kristensen, Søren L., Preiss, David, Jhund, Pardeep, Squire, Iain, Cardoso, Jose Silva, Merkely, Bela, Martinez, Felipe, Starling, Randall C., Desai, Akshay S., Lefkowitz, Martin, Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, S. D., Swedberg, Karl, Zile, Michael R., McMurray, John and Packer, Milton. (2016). Risk related to pre-diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: Insights from prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial. Circulation: Heart Failure. 9(1), pp. 1 - 12. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002560

Influenza vaccination in patients with chronic heart failure: The PARADIGM-HF trial

Vardeny, Orly, Claggett, Brian L., Udell, Jacob A., Packer, Milton, Zile, Michael R., Rouleau, Jean L., Swedberg, Karl, Desai, Akshay S., Lefkowitz, Martin, Shi, Victor C., McMurray, John J.V. and Solomon, Scott D.. (2016). Influenza vaccination in patients with chronic heart failure: The PARADIGM-HF trial. JACC: Heart Failure. 4(2), pp. 152 - 158. https://doi.org/10.1016/j.jchf.2015.10.012

Predicting heart failure decompensation using cardiac implantable electronic devices: a review of practices and challenges

Hawkins, Nathaniel M., Virani, Sean A., Sperrin, Matthew, Buchan, Iain E., McMurray, John and Krahn, Andrew D.. (2016). Predicting heart failure decompensation using cardiac implantable electronic devices: a review of practices and challenges. European Journal of Heart Failure. 18(8), pp. 977 - 986. https://doi.org/10.1002/ejhf.458

Liver function tests in patients with acute heart failure and associated outcomes: Insights from ASCEND-HF

Samsky, Marc D., Dunning, Allison, DeVore, Adam D., Schulte, Phillip J., Starling, Randall C., Tang, W. H. Wilson, Armstrong, Paul W., Ezekowitz, Justin A., Butler, Javed, McMurray, John J. V., Teerlink, John R., Voors, Adriaan A., Metra, Marco, Mentz, Robert J., O'Connor, Christopher M., Patel, Chetan B. and Hernandez, Adrian F.. (2016). Liver function tests in patients with acute heart failure and associated outcomes: Insights from ASCEND-HF. European Journal of Heart Failure. 18(4), pp. 424 - 432. https://doi.org/10.1002/ejhf.440

Worsening renal function and outcome in heart failure patients with reduced and preserved ejection fraction and the impact of angiotensin receptor blocker treatment: data from the CHARM-study programme

Damman, Kevin, Solomon, Scott D., Pfeffer, Marc A., Swedberg, Karl, Yusuf, Salim, Young, James B., Rouleau, Jean L., Granger, Christopher B. and McMurray, John J. V.. (2016). Worsening renal function and outcome in heart failure patients with reduced and preserved ejection fraction and the impact of angiotensin receptor blocker treatment: data from the CHARM-study programme. European Journal of Heart Failure. 18(12), pp. 1508 - 1517. https://doi.org/10.1002/ejhf.609

Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial

Heerspink, Hiddo J. L., Ninomiya, T., Persson, Frederik, Brenner, Barry M., Brunel, Patrick, Chaturvedi, Nish, Desai, A. S., Haffner, S. M., McMurray, John J. V., Solomon, S. D., Pfeffer, M. A., Parving, Hans-Henrik and de Zeeuw, D.. (2016). Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial. Diabetes, Obesity and Metabolism. 18(2), pp. 169 - 177. https://doi.org/10.1111/dom.12600

Variation in hospital performance for heart failure management in the National Heart Failure Audit for England and Wales

Emdin, Connor A., Conrad, Nathalie, Kiran, Amit, Salimi-Khorshidi, Gholamreza, Woodward, Mark, Anderson, Simon G., Mohseni, Hamid, Dargie, Henry J., Hardman, Suzanna M. C., McDonagh, Theresa, McMurray, John J. V., Cleland, John G. F. and Rahimi, Kazem. (2016). Variation in hospital performance for heart failure management in the National Heart Failure Audit for England and Wales. Heart. 103, pp. 55 - 62. https://doi.org/10.1136/heartjnl-2016-309706

Aliskiren, enalapril, or aliskiren and enalapril in heart failure

McMurray, John J. V., Krum, Henry, Abraham, William T., Dickstein, Kenneth, Kober, Lars V., Desai, Akshay S., Solomon, Scott D., Greenlaw, Nicola, Ali, M. Atif, Chiang, Yanntong, Shao, Qing, Tarnesby, Georgia and Massie, Barry M.. (2016). Aliskiren, enalapril, or aliskiren and enalapril in heart failure. New England Journal of Medicine. 374(16), pp. 1521 - 1532. https://doi.org/10.1056/NEJMoa1514859

Rationale for and design of the TRUE-AHF trial: The effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure

Packer, Milton, Holcomb, Richard, Abraham, William T., Anker, Stefan D., Dickstein, Kenneth, Filippatos, Gerasimos S., Krum, Henry, Maggioni, Aldo Pietro, McMurray, John J. V., Mebazaa, Alexandre, O'Connor, Christopher M., Peacock, Frank, Ponikowski, Piotr P., Ruschitzka, Frank, van Veldhuisen, Dirk J. and Holzmeister, Johannes. (2016). Rationale for and design of the TRUE-AHF trial: The effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure. European Journal of Heart Failure. 19(5), pp. 673 - 681. https://doi.org/10.1002/ejhf.698

C-Reactive Protein and Risk of ESRD: Results From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT)

McCausland, Finnian R., Claggett, Brian L., Burdmann, Emmanuel A., Eckardt, Kai Uwe, Kewalramani, Reshma, Levey, Andrew S., McMurray, John, Parfrey, Patrick, Remuzzi, Guiseppe, Singh, Ajay K., Solomon, Scott, Toto, Robert D. and Pfeffer, Marc A.. (2016). C-Reactive Protein and Risk of ESRD: Results From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT). American Journal of Kidney Diseases. 68(6), pp. 873 - 881. https://doi.org/10.1053/j.ajkd.2016.07.022

Effect of single and dual renin-angiotensin blockade on stroke in patients with and without diabetes in VALIANT

Abdul-Rahim, Azmil H., Docherty, Kieran F., Skali, Hicham, Køber, Lars, Dickstein, Kenneth, Maggioni, Aldo P., Mareev, Viacheslav, Zannad, Faiez, Velazquez, Eric J., Califf, Robert M., Pfeffer, Marc A., Solomon, Scott D., Lees, Kenneth R. and McMurray, John J. V.. (2016). Effect of single and dual renin-angiotensin blockade on stroke in patients with and without diabetes in VALIANT. European Stroke Journal. 1(2), pp. 93 - 100. https://doi.org/10.1177/2396987316646025

Cost-effectiveness analysis of sacubitril/valsartan vs enalapril in patients with heart failure and reduced ejection fraction

Gaziano, Thomas A., Fonarow, Gregg C., Claggett, Brian L., Chan, Wing W., Deschaseaux-Voinet, Celine, Turner, Stuart J., Rouleau, Jean L., Zile, Michael R., McMurray, John and Solomon, Scott. (2016). Cost-effectiveness analysis of sacubitril/valsartan vs enalapril in patients with heart failure and reduced ejection fraction. JAMA Cardiology. 1(6), pp. 666 - 672. https://doi.org/10.1001/jamacardio.2016.1747

Importance of clinical worsening of heart failure treated in the outpatient setting: Evidence from the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF)

Okumura, Naoki, Jhund, Pardeep, Gong, Jianjian, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Swedberg, Karl, Zile, Michael R., Solomon, Scott, Packer, Milton and McMurray, John. (2016). Importance of clinical worsening of heart failure treated in the outpatient setting: Evidence from the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial (PARADIGM-HF). Circulation. 133(23), pp. 2254 - 2262. https://doi.org/10.1161/CIRCULATIONAHA.115.020729

Geographic Differences in Patients in a Global Acute Heart Failure Clinical Trial (from the ASCEND-HF Trial)

Metra, Marco, Mentz, Robert J., Hernandez, Adrian F., Heizer, Gretchen M., Armstrong, P. W., Clausell, Nadine, Corbalan, Ramon, Costanzo, Maria Rosa, Dickstein, Kenneth, Dunlap, Mark E., Ezekowitz, Justin A., Howlett, Jonathan G., Komajda, Michel, Krum, Henry, Lombardi, Carlo, Fonarow, Gregg C., McMurray, John J. V., Nieminen, Markku S., Swedberg, Karl, ... O'Connor, Christopher M.. (2016). Geographic Differences in Patients in a Global Acute Heart Failure Clinical Trial (from the ASCEND-HF Trial). American Journal of Cardiology. 117(11), pp. 1771 - 1778. https://doi.org/10.1016/j.amjcard.2016.03.002

Effects of sacubitril/valsartan in the PARADIGM-HF trial (prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure) according to background therapy

Okumura, Naoki, Jhund, Pardeep, Gong, Jianjian, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Swedberg, Karl, Zile, Michael R., Solomon, Scott, Packer, Milton and McMurray, John. (2016). Effects of sacubitril/valsartan in the PARADIGM-HF trial (prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure) according to background therapy. Circulation: Heart Failure. 9(9), pp. 1 - 8. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003212

Severity of renal impairment in patients with heart failure and atrial fibrillation: implications for non-vitamin K antagonist oral anticoagulant dose adjustment

Hawkins, Nathaniel M., Jhund, Pardeep S., Pozzi, Andrea, O'Meara, Eileen, Solomon, Scott D., Granger, Christopher B., Yusuf, Salim, Pfeffer, Marc A., Swedberg, Karl, Petrie, Mark C., Virani, Sean A. and McMurray, John J. V.. (2016). Severity of renal impairment in patients with heart failure and atrial fibrillation: implications for non-vitamin K antagonist oral anticoagulant dose adjustment. European Journal of Heart Failure. 18(9), pp. 1162 - 1171. https://doi.org/10.1002/ejhf.614

The incremental prognostic and clinical value of multiple novel biomarkers in heart failure

Jackson, Colette E., Haig, Caroline, Welsh, Paul, Dalzell, Jonathan R., Tsorlalis, Ioannis K., McConnachie, Alex, Preiss, David, Anker, Stefan D., Sattar, Naveed, Petrie, Mark C., Gardner, Roy S. and McMurray, John J. V.. (2016). The incremental prognostic and clinical value of multiple novel biomarkers in heart failure. European Journal of Heart Failure. 18(12), pp. 1491 - 1498. https://doi.org/10.1002/ejhf.543

Increased mortality with elevated plasma endothelin-1 in acute heart failure: An ASCEND-HF biomarker substudy

Perez, Antonio L., Grodin, Justin L., Wu, Yuping, Hernandez, Adrian F., Butler, Javed, Metra, Marco, Felker, G. Michael, Voors, Adriaan A., McMurray, John J. V., Armstrong, Paul W., Starling, Randall C., O'Connor, Christopher M. and Tang, W. H. Wilson. (2016). Increased mortality with elevated plasma endothelin-1 in acute heart failure: An ASCEND-HF biomarker substudy. European Journal of Heart Failure. 18(3), pp. 290 - 297. https://doi.org/10.1002/ejhf.456

Lessons in uncertainty and humility - Clinical trials involving hypertension

Pfeffer, Marc A. and McMurray, John J. V.. (2016). Lessons in uncertainty and humility - Clinical trials involving hypertension. New England Journal of Medicine. 375(18), pp. 1756 - 1766. https://doi.org/10.1056/NEJMra1510067

Venous thromboembolism and cardiovascular risk: Results from the NAVIGATOR trial

Katz, Marcelo, Califf, Robert M., Sun, Jie-Lena, McMurray, John J.V., Thomas, Laine and Lopes, Renato D.. (2015). Venous thromboembolism and cardiovascular risk: Results from the NAVIGATOR trial. American Journal of Medicine. 128(3), pp. 297 - 302. https://doi.org/10.1016/j.amjmed.2014.08.022

A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure

McMurray, John J. V., Packer, Milton, Desai, Akshay S., Gong, Jianjian, Greenlaw, Nicola, Lefkowitz, Martin, Rizkala, Adel R., Shi, Victor C., Rouleau, Jean L., Solomon, Scott D., Sweberg, Karl, Zile, Michael R., Andersen, Karl, Arango, Juan Luis, Arnold, Malcolm, Belohlávek, Jan, Bohm, Michael, Boytsov, Sergey, Burgess, Lesley, ... Wong, Raymond. (2015). A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure. European Heart Journal. 36(7), pp. 434 - 439. https://doi.org/10.1093/eurheartj/ehu455

Acute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial

Abualnaja, Seraj, Podder, Mohua, Hernandez, Adrian F., McMurray, John J.V., Starling, Randall C., O'Connor, Christopher M., Califf, Robert M., Armstrong, Paul W. and Ezekowitz, Justin A.. (2015). Acute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial. Journal of the American Heart Association. 4(8), pp. 1 - 8. https://doi.org/10.1161/JAHA.115.002092

Telomere length and outcomes in ischaemic heart failure: Data from the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA)

Haver, Vincent G., Leach, Irene Mateo, Kjekshus, John, Fox, Jayne C., Wedel, Hans, Wikstrand, John, de Boer, Rudolf A., van Gilst, Wiek H., McMurray, John J. V., van Veldhuisen, Dirk J. and van der Harst, Pim. (2015). Telomere length and outcomes in ischaemic heart failure: Data from the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA). European Journal of Heart Failure. 17(3), pp. 313 - 319. https://doi.org/10.1002/ejhf.237

Clinical characteristics and outcomes of patients with coronary artery disease and angina: Analysis of the Irbesartan in patients with heart failure and preserved systolic function trial

Badar, Athar A., Perez-Moreno, Ana C., Hawkins, Nathaniel M., Jhund, Pardeep, Brunton, Alan P. T., Anand, Inder S., McKelvie, Robert, Komajda, Michel, Zile, Michael R., Carson, Peter E., Gardner, Roy S., Petrie, Mark C. and McMurray, John. (2015). Clinical characteristics and outcomes of patients with coronary artery disease and angina: Analysis of the Irbesartan in patients with heart failure and preserved systolic function trial. Circulation: Heart Failure. 8(4), pp. 717 - 724. https://doi.org/10.1161/CIRCHEARTFAILURE.114.002024

Comparing LCZ696 with Enalapril According to Baseline Risk Using the MAGGIC and EMPHASIS-HF Risk Scores An Analysis of Mortality and Morbidity in PARADIGM-HF

Simpson, Joanne, Jhund, Pardeep S., Cardoso, Jose Silva, Martinez, Felipe, Mosterd, Arend, Ramires, Felix, Rizkala, Adel R., Senni, Michele, Squire, Iain, Gong, Jianjian, Lefkowitz, Martin P., Shi, Victor C., Desai, Akshay S., Rouleau, Jean L., Swedberg, Karl, Zile, Michael R., McMurray, John J.V., Packer, Milton and Solomon, Scott D.. (2015). Comparing LCZ696 with Enalapril According to Baseline Risk Using the MAGGIC and EMPHASIS-HF Risk Scores An Analysis of Mortality and Morbidity in PARADIGM-HF. Journal of the American College of Cardiology. 66(19), pp. 2059 - 2071. https://doi.org/10.1016/j.jacc.2015.08.878

Recommendations on pre-hospital and early hospital management of acute heart failure: a consensus paper from the Heart Failure Association Of The European Society Of Cardiology, The European Society Of Emergency Medicine and The Society Of Academic Emergency Medicine - short version

Mebazaa, Alexandre, Yilmaz, M. B., Levy, Phillip, Ponikowski, Piotr P.D.A.S, Peacock, W. F., Laribi, Said, Ristic, Arsen D., Lambrinou, Ekaterini, Masip, J., Riley, Jillian P., McDonagh, Theresa, Mueller, Christian, Defilippi, Christopher, Harjola, Veli-Pekka, Thiele, Holger, Piepoli, Massimo F., Metra, Marco, Maggioni, Aldo P., McMurray, John, ... Filippatos, Gerasimos S.. (2015). Recommendations on pre-hospital and early hospital management of acute heart failure: a consensus paper from the Heart Failure Association Of The European Society Of Cardiology, The European Society Of Emergency Medicine and The Society Of Academic Emergency Medicine - short version. European Heart Journal. 36(30), pp. 1958 - 1966. https://doi.org/10.1093/eurheartj/ehv066

Comparison of cardiac troponins i and T measured with high-sensitivity methods for evaluation of prognosis in atrial fibrillation: An ARISTOTLE substudy

Hijazi, Ziyad M., Siegbahn, Agneta, Andersson, Ulrika, Lindahl, Bertil, Granger, Christopher B., Alexander, John H., Atar, Dan, Gersh, Bernard J., Hanna, Michael, Harjola, Veli-Pekka, Horowitz, John, Husted, Steen, Hylek, Elaine, Lopes, Renato D., McMurray, John and Wallentin, Lars. (2015). Comparison of cardiac troponins i and T measured with high-sensitivity methods for evaluation of prognosis in atrial fibrillation: An ARISTOTLE substudy. Clinical Chemistry. 61(2), pp. 368 - 378. https://doi.org/10.1373/clinchem.2014.226936

Rationale, design, and baseline characteristics in evaluation of LIXisenatide in Acute Coronary Syndrome: A long-term cardiovascular end point trial of lixisenatide versus placebo

Bentley-Lewis, Rhonda, Aguilar, David, Riddle, Matthew C., Claggett, Brian, Diaz, Rafael, Dickstein, Kenneth, Gerstein, Hertzel C., Johnston, Peter, Køber, Lars V., Lawson, Francesca, Lewis, Eldrin F., Maggioni, Aldo P., McMurray, John J. V., Ping, Lin, Probstfield, Jeffrey L., Solomon, Scott D., Tardif, Jean-Claude, Wu, Yujun and Pfeffer, Marc A.. (2015). Rationale, design, and baseline characteristics in evaluation of LIXisenatide in Acute Coronary Syndrome: A long-term cardiovascular end point trial of lixisenatide versus placebo. American Heart Journal. 169(5), pp. 631 - 638e.7. https://doi.org/10.1016/j.ahj.2015.02.002

Physical activity as a determinant of fasting and 2-h post-challenge glucose: A prospective cohort analysis of the NAVIGATOR trial

Yates, Thomas, Davies, Melanie J., Haffner, S. M., Schulte, Phillip J., Thomas, L., Huffman, K. M., Bales, C. W., Preiss, David, Califf, Robert M., Holman, Rury R., McMurray, John J. V., Bethel, M. A., Tuomilehto, Jaakko and Kraus, W. E.. (2015). Physical activity as a determinant of fasting and 2-h post-challenge glucose: A prospective cohort analysis of the NAVIGATOR trial. Diabetic Medicine. 32(8), pp. 1090 - 1096. https://doi.org/10.1111/dme.12762

Site selection for heart failure clinical trials in the USA

Harinstein, Matthew E., Butler, Javed, Greene, Stephen J., Fonarow, Gregg C., Stockbridge, Norman L., O'Connor, Christopher M., Pfeffer, Marc A., Mehra, Mandeep R., Solomon, Scott D., Yancy, Clyde W., Fiuzat, Mona, Mentz, Robert J., Collins, Sean P., McMurray, John J. V., Vaduganathan, Muthiah, Dunnmon, Preston M., Rosano, Giuseppe M. C., Dinh, Wilfried, Misselwitz, Frank, ... Gheorghiade, Mihai. (2015). Site selection for heart failure clinical trials in the USA. Heart Failure Reviews. 20(4), pp. 375 - 383. https://doi.org/10.1007/s10741-015-9473-z

Secreted frizzled related protein 3 in chronic heart failure: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA)

Askevold, Erik T., Gullestad, Lars, Nymo, Ståle, Kjekshus, John, Yndestad, Arne, Latini, Roberto, Cleland, John G. F., McMurray, John, Aukrust, Pål and Ueland, Thor. (2015). Secreted frizzled related protein 3 in chronic heart failure: Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA). PLoS ONE. 10(8), pp. 1 - 13. https://doi.org/10.1371/journal.pone.0133970

Cardiovascular safety of albiglutide in the Harmony programme: A meta-analysis

Fisher, Miles, Petrie, Mark C., Ambery, Philip D., Donaldson, Jill, McMurray, John J. V. and Ye, June. (2015). Cardiovascular safety of albiglutide in the Harmony programme: A meta-analysis. The Lancet Diabetes & Endocrinology. 3(9), pp. 697 - 703. https://doi.org/10.1016/S2213-8587(15)00233-8

Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation? Results from the MAGGIC meta-analysis

Simpson, Joanne, Castagno, Davide, Doughty, Rob N., Poppe, Katrina K., Earle, Nikki, Squire, Iain, Richards, Mark, Andersson, Bert, Ezekowitz, Justin A., Komajda, Michel, Petrie, Mark C., McAlister, Finlay A., Gamble, Greg D., Whalley, Gillian A. and McMurray, John J. V.. (2015). Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation? Results from the MAGGIC meta-analysis. European Journal of Heart Failure. 17(11), pp. 1182 - 1191. https://doi.org/10.1002/ejhf.346

Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances

McMurray, John. (2015). Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances. European Journal of Heart Failure. 17(3), pp. 242 - 247. https://doi.org/10.1002/ejhf.250

Assessment and prevalence of pulmonary oedema in contemporary acute heart failure trials: A systematic review

Platz, Elke, Jhund, Pardeep S., Campbell, Ross T. and McMurray, John J. V.. (2015). Assessment and prevalence of pulmonary oedema in contemporary acute heart failure trials: A systematic review. European Journal of Heart Failure. 17(9), pp. 906 - 916. https://doi.org/10.1002/ejhf.321

Mortality following a cardiovascular or renal event in patients with type 2 diabetes in the ALTITUDE trial

Jhund, Pardeep S., McMurray, John J. V., Chaturvedi, Nish, Brunel, Patrick, Desai, Akshay S., Finn, Peter V., Haffner, Steven M., Solomon, Scott D., Weinrauch, Larry A., Claggett, Brian L. and Pfeffer, Marc A.. (2015). Mortality following a cardiovascular or renal event in patients with type 2 diabetes in the ALTITUDE trial. European Heart Journal. 36(36), pp. 2463 - 2469. https://doi.org/10.1093/eurheartj/ehv295

Loop diuretic dose adjustments after a hospitalization for heart failure: Insights from ASCEND-HF

DeVore, Adam D., Hasselblad, Vic, Mentz, Robert J., O'Connor, Christopher M., Armstrong, Paul W., McMurray, John J. V., Ezekowitz, Justin A., Tang, W. H. Wilson, Starling, Randall C., Voors, Adriaan A., Califf, Robert M. and Hernandez, Adrian F.. (2015). Loop diuretic dose adjustments after a hospitalization for heart failure: Insights from ASCEND-HF. European Journal of Heart Failure. 17(3), pp. 340 - 346. https://doi.org/10.1002/ejhf.235

Clinical characteristics and outcomes of patients with angina and heart failure in the CHARM (Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity) Programme

Badar, Athar A., Perez-Moreno, Ana C., Hawkins, Nathaniel M., Brunton, Alan P. T., Jhund, Pardeep S., Wong, Chih M., Solomon, Scott D., Granger, Christopher B., Yusuf, Salim, Pfeffer, Marc A., Swedberg, Karl, Gardner, Roy S., Petrie, Mark C. and McMurray, John J. V.. (2015). Clinical characteristics and outcomes of patients with angina and heart failure in the CHARM (Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity) Programme. European Journal of Heart Failure. 17(2), pp. 196 - 204. https://doi.org/10.1002/ejhf.221

Statistical Controversies in Reporting of Clinical Trials Part 2 of a 4-Part Series on Statistics for Clinical Trials

Pocock, Stuart J., McMurray, John J.V. and Collier, Timothy J.. (2015). Statistical Controversies in Reporting of Clinical Trials Part 2 of a 4-Part Series on Statistics for Clinical Trials. Journal of the American College of Cardiology. 66(23), pp. 2648 - 2662. https://doi.org/10.1016/j.jacc.2015.10.023

Improving outcomes in heart failure: a personal perspective

McMurray, John. (2015). Improving outcomes in heart failure: a personal perspective. European Heart Journal. 36(48), pp. 3467 - 3470. https://doi.org/10.1093/eurheartj/ehv565

The hospitalization burden and post-hospitalization mortality risk in heart failure with preserved ejection fraction: Results from the I-PRESERVE trial (irbesartan in heart failure and preserved ejection fraction)

Carson, Peter E., Anand, Inder S., Win, Sithu, Rector, Thomas S., Haass, Markus, Lopez-Sendon, Jose, Miller, Alan, Teerlink, John R., White, Michel, McKelvie, Robert S., Komajda, Michel, Zile, Michael R., McMurray, John J. and Massie, Barry. (2015). The hospitalization burden and post-hospitalization mortality risk in heart failure with preserved ejection fraction: Results from the I-PRESERVE trial (irbesartan in heart failure and preserved ejection fraction). JACC: Heart Failure. 3(6), pp. 429 - 441. https://doi.org/10.1016/j.jchf.2014.12.017

Clinical outcomes of patients with diabetes and atrial fibrillation treated with apixaban: Results from the ARISTOTLE trial

Ezekowitz, Justin A., Lewis, Basil S., Lopes, Renato D., Wojdyla, Daniel M., McMurray, John J. V., Hanna, Michael, Atar, Dan, Bahit, M. Cecilia, Keltai, Matyas, Lopez-Sendon, Jose L., Pais, Prem, Ruzyllo, Witold, Wallentin, Lars, Granger, Christopher B. and Alexander, John H.. (2015). Clinical outcomes of patients with diabetes and atrial fibrillation treated with apixaban: Results from the ARISTOTLE trial. European Heart Journal - Cardiovascular Pharmacotherapy. 1(2), pp. 86 - 94. https://doi.org/10.1093/ehjcvp/pvu024

Clinical outcomes according to QRS duration and morphology in the Eplerenone in Mild Patients: Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF)

Cannon, Jane A., Collier, Timothy J., Shen, Li, Swedberg, Karl, Krum, Henry, van Veldhuisen, Dirk J., Vincent, John, Pocock, Stuart J., Pitt, Bertram, Zannad, Faiez and McMurray, John J. V.. (2015). Clinical outcomes according to QRS duration and morphology in the Eplerenone in Mild Patients: Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). European Journal of Heart Failure. 17(7), pp. 707 - 716. https://doi.org/10.1002/ejhf.303

Race and ethnicity influences on cardiovascular and renal events in patients with diabetes mellitus

Lewis, Eldrin F., Claggett, Brian L., Parfrey, Patrick S., Burdmann, Emmanuel A., McMurray, John J.V, Solomon, Scott D., Levey, Andrew S., Ivanovich, Peter, Eckardt, Kai-Uwe, Kewalramani, Reshma, Toto, Robert and Pfeffer, Marc A.. (2015). Race and ethnicity influences on cardiovascular and renal events in patients with diabetes mellitus. American Heart Journal. 170(2), pp. 322 - 329. https://doi.org/10.1016/j.ahj.2015.05.008

Characterization of subgroups of heart failure patients with preserved ejection fraction with possible implications for prognosis and treatment response

Kao, David P., Lewsey, James D., Anand, Inder S., Massie, Barry M., Zile, Michael R., Carson, Peter E., McKelvie, Robert S., Komajda, Michel, McMurray, John J. V. and Lindenfeld, JoAnn. (2015). Characterization of subgroups of heart failure patients with preserved ejection fraction with possible implications for prognosis and treatment response. European Journal of Heart Failure. 17(9), pp. 925 - 935. https://doi.org/10.1002/ejhf.327

Predictors of clinical outcomes in acute decompensated heart failure: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure outcome models

Khazanie, Prateeti, Heizer, Gretchen M., Hasselblad, Vic, Armstrong, P. W., Califf, Robert M., Ezekowitz, Justin, Dickstein, Kenneth, Levy, Wayne C., McMurray, John J.V., Metra, Marco, Tang, W. H. Wilson, Teerlink, John R., Voors, Adriaan A., O'Connor, Christopher M., Hernandez, Adrian F. and Starling, Randall C.. (2015). Predictors of clinical outcomes in acute decompensated heart failure: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure outcome models. American Heart Journal. 170(2), pp. 290 - 297. https://doi.org/10.1016/j.ahj.2015.04.006

Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure

Packer, Milton, McMurray, John J. V., Desai, Akshay S., Gong, Jianjian, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R., Andersen, Karl, Arango, Juan Luis, Arnold, J. Malcolm, Belohlávek, Jan, Bohm, Michael, Boytsov, Sergey, Burgess, Lesley J., Cabrera, Walter, ... Wong, Raymond Ching-Chiew. (2015). Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure. Circulation. 131(1), pp. 54 - 61. https://doi.org/10.1161/CIRCULATIONAHA.114.013748

Cause of Death in Patients with Diabetic CKD Enrolled in the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT)

Charytan, David M., Lewis, E. F., Desai, Akshay S., Weinrauch, Larry A., Ivanovich, Peter, Toto, Robert D., Claggett, Brian L., Liu, Jiankang, Hartley, L. Howard, Finn, Peter, Singh, Ajay K., Levey, Andrew S., Pfeffer, Marc A., McMurray, John and Solomon, Scott. (2015). Cause of Death in Patients with Diabetic CKD Enrolled in the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT). American Journal of Kidney Diseases. 66(3), pp. 429 - 440. https://doi.org/10.1053/j.ajkd.2015.02.324

Changes in N-terminal pro-B-type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: An analysis of the I-Preserve study

Jhund, Pardeep S., Anand, Inder S., Komajda, Michel, Claggett, Brian L., McKelvie, Robert S., Zile, Michael R., Carson, Peter E. and McMurray, John J. V.. (2015). Changes in N-terminal pro-B-type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: An analysis of the I-Preserve study. European Journal of Heart Failure. 17(8), pp. 809 - 817. https://doi.org/10.1002/ejhf.274

Prognostic importance of temporal changes in resting heart rate in heart failure patients: An analysis of the CHARM program

Vazir, Ali, Claggett, Brian L., Jhund, Pardeep, Castagno, Davide, Skali, Hicham, Yusuf, Salim, Swedberg, Karl, Granger, Christopher B., McMurray, John J. V., Pfeffer, Marc A. and Solomon, Scott D.. (2015). Prognostic importance of temporal changes in resting heart rate in heart failure patients: An analysis of the CHARM program. European Heart Journal. 36(11), pp. 669 - 675. https://doi.org/10.1093/eurheartj/ehu401

Prospective relationships between body weight and physical activity: An observational analysis from the NAVIGATOR study

Preiss, David, Thomas, Laine E., Wojdyla, Daniel M., Haffner, Steven M., Gill, Jason M. R., Yates, Thomas, Davies, Melanie J., Holman, Rury R., McMurray, John J., Califf, Robert M. and Kraus, William E.. (2015). Prospective relationships between body weight and physical activity: An observational analysis from the NAVIGATOR study. BMJ Open. 5(8), pp. 1 - 7. https://doi.org/10.1136/bmjopen-2015-007901

Temporal trends and risk factors for readmission for infections, gastrointestinal and immobility complications after an incident hospitalisation for stroke in Scotland between 1997 and 2005

Lewsey, James, Ebueku, Osaretin, Jhund, Pardeep S., Gillies, Michelle, Chalmers, Jim WT, Redpath, Adam, Briggs, Andrew, Walters, Matthew, Langhorne, Peter, Capewell, Simon, McMurray, John JV and MacIntyre, Kate. (2015). Temporal trends and risk factors for readmission for infections, gastrointestinal and immobility complications after an incident hospitalisation for stroke in Scotland between 1997 and 2005. BMC Neurology. 15(3), pp. 1 - 8. https://doi.org/10.1186/s12883-014-0257-1

The emerging potential of the apelin-APJ system in heart failure

Dalzell, Jonathan R., Rocchiccioli, John P., Weir, Robin A. P., Jackson, Colette E., Padmanabhan, Neal, Gardner, Roy S., Petrie, Mark C. and McMurray, John J. V.. (2015). The emerging potential of the apelin-APJ system in heart failure. Journal of Cardiac Failure. 21(6), pp. 489 - 498. https://doi.org/10.1016/j.cardfail.2015.03.007

Acute heart failure in the elderly: Differences in clinical characteristics, outcomes, and prognostic factors in the Veritas study

Metra, Marco, Cotter, Gad, El-Khorazaty, Jill, Davison, Beth A., Milo, Olga, Carubelli, Valentina, Bourge, Robert C., Cleland, John G. F., Jondeau, Guillaume, Krum, Henry, O'Connor, Christopher M., Parker, John D., Torre-Amione, Guillermo, van Veldhuisen, Dirk J., Rainisio, Maurizio, Kobrin, Isaac, McMurray, John J. V. and Teerlink, John R.. (2015). Acute heart failure in the elderly: Differences in clinical characteristics, outcomes, and prognostic factors in the Veritas study. Journal of Cardiac Failure. 21(3), pp. 179 - 188. https://doi.org/10.1016/j.cardfail.2014.12.012

Recommendations on pre-hospital & early hospital management of acute heart failure: A consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine

Mebazaa, Alexandre, Yilmaz, M. B., Levy, Phillip, Ponikowski, Piotr P., Peacock, W. F., Laribi, Said, Ristic, Arsen D., Lambrinou, Ekaterini, Masip, J., Riley, Jillian P., McDonagh, Theresa, Mueller, Christian, Defilippi, Christopher, Harjola, Veli-Pekka, Thiele, Holger, Piepoli, Massimo F., Metra, Marco, Maggioni, Aldo, McMurray, John, ... Filippatos, Gerasimos S.. (2015). Recommendations on pre-hospital & early hospital management of acute heart failure: A consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine. European Journal of Heart Failure. 17(6), pp. 544 - 548. https://doi.org/10.1002/ejhf.289

Comparative assessment of short-term adverse events in acute heart failure withcystatin C and other estimates of renal function: Results from the ASCEND-HF trial

Tang, W. H. Wilson, Dupont, Matthias, Hernandez, Adrian F., Voors, Adriaan A., Hsu, Amy P., Felker, G. Michael, Butler, Javed, Metra, Marco, Anker, Stefan D., Troughton, Richard W., Gottlieb, Stephen S., McMurray, John J., Armstrong, Paul W., Massie, Barry M., Califf, Robert M., O'Connor, Christopher M. and Starling, Randall C.. (2015). Comparative assessment of short-term adverse events in acute heart failure withcystatin C and other estimates of renal function: Results from the ASCEND-HF trial. JACC: Heart Failure. 3(1), pp. 40 - 49. https://doi.org/10.1016/j.jchf.2014.06.014

Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: Results from the MAGGIC individual patient meta-analysis

Jackson, Colette E., Castagno, Davide, Maggioni, Aldo Pietro, Køber, Lars, Squire, Iain B., Swedberg, Karl, Andersson, Bert, Richards, A. Mark, Bayes-Genis, Antoni, Tribouilloy, Christophe, Dobson, Joanna, Ariti, Cono A., Poppe, Katrina K., Earle, Nikki, Whalley, Gillian A., Pocock, Stuart J., Doughty, Rob N. and McMurray, John J. V.. (2015). Differing prognostic value of pulse pressure in patients with heart failure with reduced or preserved ejection fraction: Results from the MAGGIC individual patient meta-analysis. European Heart Journal. 36(18), pp. 1106 - 1114. https://doi.org/10.1093/eurheartj/ehu490

Relative importance of history of heart failure hospitalization and n-terminal pro-b-type natriuretic peptide level as predictors of outcomes in patients with heart failure and preserved ejection fraction

Kristensen, Søren L., Jhund, Pardeep, Kober, Lars, McKelvie, Robert, Zile, Michael R., Anand, Inder S., Komajda, Michel, Cleland, John G. F., Carson, Peter E. and McMurray, John. (2015). Relative importance of history of heart failure hospitalization and n-terminal pro-b-type natriuretic peptide level as predictors of outcomes in patients with heart failure and preserved ejection fraction. JACC: Heart Failure. 3(6), pp. 478 - 486. https://doi.org/10.1016/j.jchf.2015.01.014

'Hearts and minds': Association, causation and implication of cognitive impairment in heart failure

Cannon, Jane A., McMurray, John J. V. and Quinn, Terry J.. (2015). 'Hearts and minds': Association, causation and implication of cognitive impairment in heart failure. Alzheimer's Research and Therapy. 7(1), pp. 1 - 18. https://doi.org/10.1186/s13195-015-0106-5

Do statins reduce the risk of myocardial infarction in patients with heart failure? A pooled individual-level reanalysis of CORONA and GISSI-HF

Feinstein, Matthew J., Jhund, Pardeep, Kang, Joseph, Ning, Hongyan, Maggioni, Aldo Pietro, Wikstrand, John, Kjekshus, John, Tavazzi, Luigi, McMurray, John J. V. and Lloyd-Jones, Donald M.. (2015). Do statins reduce the risk of myocardial infarction in patients with heart failure? A pooled individual-level reanalysis of CORONA and GISSI-HF. European Journal of Heart Failure. 17(4), pp. 434 - 441. https://doi.org/10.1002/ejhf.247

Increased risk of stroke with Darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease

Bello, Natalie A., Lewis, Eldrin F., Desai, Akshay S., Anand, Inder S., Krum, Henry, McMurray, John J. V., Olson, Kurt, Solomon, Scott D., Swedberg, Karl, van Veldhuisen, Dirk J., Young, James B. and Pfeffer, Marc A.. (2015). Increased risk of stroke with Darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease. European Journal of Heart Failure. 17(11), pp. 1201 - 1207. https://doi.org/10.1002/ejhf.412

The effect of statin therapy on heart failure events: A collaborative meta-analysis of unpublished data from major randomized trials

Preiss, David, Campbell, Ross T., Murray, Heather M., Ford, Ian, Packard, Chris J., Sattar, Naveed, Rahimi, Kazem, Colhoun, Helen M., Waters, David D., LaRosa, John C., Amarenco, Pierre, Pedersen, Terje R., Tikkanen, Matti J., Koren, Michael J., Poulter, Neil R., Sever, Peter S., Ridker, Paul M., MacFadyen, Jean G., Solomon, Scott D., ... McMurray, John J. V.. (2015). The effect of statin therapy on heart failure events: A collaborative meta-analysis of unpublished data from major randomized trials. European Heart Journal. 36(24), pp. 1536 - 1546. https://doi.org/10.1093/eurheartj/ehv072

Risk of stroke in chronic heart failure patients without atrial fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials

Abdul-Rahim, Azmil H., Perez, Ana Cristina, Fulton, Rachael L., Jhund, Pardeep, Latini, Roberto, Tognoni, Gianni, Wikstrand, John, Kjekshus, John, Lip, Gregory Y. H., Maggioni, Aldo Pietro, Tavazzi, Luigi, Lees, Kennedy R. and McMurray, John. (2015). Risk of stroke in chronic heart failure patients without atrial fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials. Circulation. 131(17), pp. 1486 - 1494. https://doi.org/10.1161/CIRCULATIONAHA.114.013760

Comparison of outcomes after hospitalization for worsening heart failure, myocardial infarction, and stroke in patients with heart failure and reduced and preserved ejection fraction

Kristensen, Søren L., Jhund, Pardeep S., Kober, Lars, Preiss, David, Kjekshus, John, McKelvie, Robert S., Zile, Michael R., Anand, Inder S., Wikstrand, John, Wedel, Hans, Komajda, Michel, Carson, Peter E., Cleland, John G. F. and McMurray, John J. V.. (2015). Comparison of outcomes after hospitalization for worsening heart failure, myocardial infarction, and stroke in patients with heart failure and reduced and preserved ejection fraction. European Journal of Heart Failure. 17(2), pp. 169 - 176. https://doi.org/10.1002/ejhf.211

Associations of chronic heart failure with outcome in acute ischaemic stroke patients who received systemic thrombolysis: Analysis from VISTA

Abdul-Rahim, Azmil H., Fulton, Rachael L., Frank, B., McMurray, John J. V., Lees, K. R., Alexandrov, Andrei V., Bath, P. W., Bluhmki, E., Claesson, L., Curram, J., Davis, Stephen M., Donnan, Geoffrey, Diener, Hans Christoph, Fisher, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M. G., Hommel, M., ... Weimar, C.. (2015). Associations of chronic heart failure with outcome in acute ischaemic stroke patients who received systemic thrombolysis: Analysis from VISTA. European Journal of Neurology. 22(1), pp. 163 - 169. https://doi.org/10.1111/ene.12548

Making Sense of Statistics in Clinical Trial Reports Part 1 of a 4-Part Series on Statistics for Clinical Trials

Pocock, Stuart J., McMurray, John J.V. and Collier, Timothy J.. (2015). Making Sense of Statistics in Clinical Trial Reports Part 1 of a 4-Part Series on Statistics for Clinical Trials. Journal of the American College of Cardiology. 66(22), pp. 2536 - 2549. https://doi.org/10.1016/j.jacc.2015.10.014

Circulating kidney injury molecule-1 levels in acute heart failure. Insights from the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure)

Grodin, Justin L., Perez, Antonio L., Wu, Yuping, Hernandez, Adrian F., Butler, Javed, Metra, Marco, Felker, G. Michael, Voors, Adriaan A., McMurray, John, Armstrong, P. W., Califf, Robert M., Starling, Randall C., O'Connor, Christopher M. and Tang, W. H. Wilson. (2015). Circulating kidney injury molecule-1 levels in acute heart failure. Insights from the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure). JACC: Heart Failure. 3(10), pp. 777 - 785. https://doi.org/10.1016/j.jchf.2015.06.006

Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction

Voors, Adriaan A., Gori, Mauro, Liu, Licette C. Y., Claggett, Brian L., Zile, Michael R., Pieske, Burkert, McMurray, John J. V., Packer, Milton, Shi, Victor C., Lefkowitz, Martin P. and Solomon, Scott D.. (2015). Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction. European Journal of Heart Failure. 17(5), pp. 510 - 517. https://doi.org/10.1002/ejhf.232

Sex differences in clinical characteristics and outcomes after myocardial infarction: Insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT)

Lam, Carolyn S. P., McEntegart, Margaret, Claggett, Brian L., Liu, Jiankang, Skali, Hicham, Lewis, Eldrin F., Kober, Lars, Rouleau, Jean L., Velazquez, Eric J., Califf, Rob M., McMurray, John J. V., Pfeffer, Marc A. and Solomon, Scott D.. (2015). Sex differences in clinical characteristics and outcomes after myocardial infarction: Insights from the Valsartan in Acute Myocardial Infarction Trial (VALIANT). European Journal of Heart Failure. 17(3), pp. 301 - 312. https://doi.org/10.1002/ejhf.238

Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients

Desai, Akshay S., McMurray, John J. V., Packer, Milton, Swedberg, Karl, Rouleau, Jean L., Chen, Fabian, Gong, Jianjian, Rizkala, Adel R., Brahimi, Abdel, Claggett, Brian L., Finn, Peter V., Hartley, Loren Howard, Liu, Jiankang, Lefkowitz, Martin, Shi, Victor C., Zile, Michael R. and Solomon, Scott D.. (2015). Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients. European Heart Journal. 36(30), pp. 1990 - 1997. https://doi.org/10.1093/eurheartj/ehv186

Novel extracellular matrix biomarkers as predictors of adverse outcome in chronic heart failure: Association between biglycan and response to statin therapy in the CORONA trial

Ueland, Thor, Aukrust, Pål, Nymo, Ståle H., Kjekshus, John, McMurray, John J. V., Wikstrand, John, Block, Dirk, Zaugg, Christian and Gullestad, Lars. (2015). Novel extracellular matrix biomarkers as predictors of adverse outcome in chronic heart failure: Association between biglycan and response to statin therapy in the CORONA trial. Journal of Cardiac Failure. 21(2), pp. 153 - 159. https://doi.org/10.1016/j.cardfail.2014.10.016

Combined free light chains are novel predictors of prognosis in heart failure

Jackson, Colette E., Haig, Caroline, Welsh, Paul, Dalzell, Jonathan R., Tsorlalis, Ioannis K., McConnachie, Alex, Preiss, David, McInnes, Iain B., Sattar, Naveed, Petrie, Mark C., Gardner, Roy S. and McMurray, John. (2015). Combined free light chains are novel predictors of prognosis in heart failure. JACC: Heart Failure. 3(8), pp. 618 - 625. https://doi.org/10.1016/j.jchf.2015.03.014

Predictive value of endostatin in chronic heart failure patients with poor kidney function

Ueland, Thor, Aukrust, Pål, Nymo, Ståle H., Kjekshus, John, McMurray, John J.V., Wikstrand, John, Wienhues-Thelen, Ursula-Henrike, Block, Dirk, Zaugg, Christian and Gullestad, Lars. (2015). Predictive value of endostatin in chronic heart failure patients with poor kidney function. Cardiology. 130(1), pp. 17 - 22. https://doi.org/10.1159/000368220

Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: Insights from PARADIGM-HF

Jhund, Pardeep S., Fu, Michael, Bayram, Edmundo, Chen, -Huan Chen, Negrusz-Kawecka, Marta, Rosenthal, Arvo, Desai, Akshay S., Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R., McMurray, John J. V. and Packer, Milton. (2015). Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: Insights from PARADIGM-HF. European Heart Journal. 36(38), pp. 2576 - 2584. https://doi.org/10.1093/eurheartj/ehv330

Lixisenatide in patients with type 2 diabetes and acute coronary syndrome

Pfeffer, Marc A., Claggett, Brian L., Diaz, Rafael, Dickstein, Kenneth, Gerstein, Hertzel C., Kober, Lars V., Lawson, Francesca C., Ping, Lin, Wei, Xiaodan, Lewis, Eldrin F., Maggioni, Aldo Pietro, McMurray, John J. V., Probstfield, Jeffrey L., Riddle, Matthew C., Solomon, Scott D. and Tardif, Jean Claude. (2015). Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. New England Journal of Medicine. 373(23), pp. 2247 - 2257. https://doi.org/10.1056/NEJMoa1509225

The Aliskiren Trial to Minimize OutcomeS in Patients with HEart failure trial (ATMOSPHERE): Revised statistical analysis plan and baseline characteristics

Krum, Henry, McMurray, John J. V., Abraham, William T., Dickstein, Kenneth, Køber, Lars, Desai, Akshay S., Solomon, Scott D., Chiang, Yanntong, Gimpelewicz, Claudio, Reimund, Bernard, Ali, M. Atif, Tarnesby, Georgia and Massie, Barry M.. (2015). The Aliskiren Trial to Minimize OutcomeS in Patients with HEart failure trial (ATMOSPHERE): Revised statistical analysis plan and baseline characteristics. European Journal of Heart Failure. 17(10), pp. 1075 - 1083. https://doi.org/10.1002/ejhf.408

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials

Swerdlow, Daniel I., Preiss, David, Kuchenbaecker, Karoline B., Holmes, Michael V., Engmann, Jorgen E. L., Shah, Tina, Sofat, Reecha, Stender, Stefan, Johnson, Paul C. D., Scott, Robert A., Leusink, Maarten, Verweij, Niek, Sharp, Stephen J., Guo, Yiran, Giambartolomei, Claudia, Chung, Christina, Peasey, Anne, Amuzu, Antoinette, Li, KaWah, ... InterAct Consortium. (2015). HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: Evidence from genetic analysis and randomised trials. The Lancet. 385(9965), pp. 351 - 361. https://doi.org/10.1016/S0140-6736(14)61183-1

Palliative care needs in patients hospitalized with heart failure (PCHF) study: Rationale and design

Campbell, Ross T., Jackson, Colette E., Wright, Ann, Gardner, Roy S., Ford, Ian, Davidson, Patricia M., Denvir, Martin A., Hogg, Karen J., Johnson, Miriam J., Petrie, Mark C. and McMurray, John J. V.. (2015). Palliative care needs in patients hospitalized with heart failure (PCHF) study: Rationale and design. ESC Heart Failure. 2(1), pp. 25 - 36. https://doi.org/10.1002/ehf2.12027

International geographic variation in event rates in trials of heart failure with preserved and reduced ejection fraction

Kristensen, Søren L., Kober, Lars, Jhund, Pardeep, Solomon, Scott, Kjekshus, John, McKelvie, Robert, Zile, Michael R., Granger, Christopher B., Wikstrand, John, Komajda, Michel, Carson, Peter E., Pfeffer, Marc A., Swedberg, Karl, Wedel, Hans, Yusuf, Salim and McMurray, John. (2015). International geographic variation in event rates in trials of heart failure with preserved and reduced ejection fraction. Circulation. 131(1), pp. 43 - 53. https://doi.org/10.1161/CIRCULATIONAHA.114.012284

Clinical benefits of eplerenone in patients with systolic heart failure and mild symptoms when initiated shortly after hospital discharge: Analysis from the EMPHASIS-HF trial

Girerd, Nicolas, Collier, Tim J., Pocock, Stuart J., Krum, Henry, McMurray, John J. V., Swedberg, Karl, Van Veldhuisen, Dirk J., Vincent, John, Pitt, Bertram and Zannad, Faiez. (2015). Clinical benefits of eplerenone in patients with systolic heart failure and mild symptoms when initiated shortly after hospital discharge: Analysis from the EMPHASIS-HF trial. European Heart Journal. 36(34), pp. 2310 - 2317. https://doi.org/10.1093/eurheartj/ehv273

The diagnostic accuracy of the natriuretic peptides in heart failure: Systematic review and diagnostic meta-analysis in the acute care setting

Roberts, Emmert, Ludman, Andrew J., Dworzynski, Katharina, Al-Mohammad, Abdallah, Cowie, Martin R., McMurray, John J V and Mant, Jonathan. (2015). The diagnostic accuracy of the natriuretic peptides in heart failure: Systematic review and diagnostic meta-analysis in the acute care setting. BMJ. 350(4), pp. 1 - 16. https://doi.org/10.1136/bmj.h910

Meta-analysis of large-scale randomized trials to determine the effectiveness of inhibition of the renin-angiotensin aldosterone system in heart failure

Emdin, Connor A., Callender, Tom, Cao, Jun, McMurray, John J. V. and Rahimi, Kazem. (2015). Meta-analysis of large-scale randomized trials to determine the effectiveness of inhibition of the renin-angiotensin aldosterone system in heart failure. American Journal of Cardiology. 116(1), pp. 155 - 161. https://doi.org/10.1016/j.amjcard.2015.03.052

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): A randomised controlled trial

Preiss, David, Lloyd, Suzanne M., Ford, Ian, McMurray, John J. V., Holman, Rury R., Welsh, Paul, Fisher, Miles, Packard, Chris J. and Sattar, Naveed. (2014). Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): A randomised controlled trial. The Lancet Diabetes & Endocrinology. 2(2), pp. 116 - 124. https://doi.org/10.1016/S2213-8587(13)70152-9

A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction

Adabag, Selcuk, Rector, Thomas S., Anand, Inder S., McMurray, John J. V., Zile, Michael R., Komajda, Michel, McKelvie, Robert S., Massie, Barry M. and Carson, Peter E.. (2014). A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction. European Journal of Heart Failure. 16(11), pp. 1175 - 1182. https://doi.org/10.1002/ejhf.172

Angiotensin-neprilysin inhibition versus enalapril in heart failure

McMurray, John J. V., Packer, Milton, Desai, Akshay S., Gong, Jianjian, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl and Zile, Michael R.. (2014). Angiotensin-neprilysin inhibition versus enalapril in heart failure. New England Journal of Medicine. 371(11), pp. 993 - 1004. https://doi.org/10.1056/NEJMoa1409077

Acute decompensated heart failure patients admitted to critical care units: Insights from ASCEND-HF

Van Diepen, Sean, Podder, Mohua, Hernandez, Adrian F., Westerhout, Cynthia M., Armstong, Paul W., McMurray, John J.V., Eapen, Zubin J., Califf, Robert M., Starling, Randall C., O'Connor, Christopher M. and Ezekowitz, Justin A.. (2014). Acute decompensated heart failure patients admitted to critical care units: Insights from ASCEND-HF. International Journal of Cardiology. 177(3), pp. 840 - 846. https://doi.org/10.1016/j.ijcard.2014.11.007

Heart failure: A cardiovascular outcome in diabetes that can no longer be ignored

McMurray, John J. V., Gerstein, Hertzel C., Holman, Rury R. and Pfeffer, Marc A.. (2014). Heart failure: A cardiovascular outcome in diabetes that can no longer be ignored. The Lancet Diabetes & Endocrinology. 2(10), pp. 843 - 851. https://doi.org/10.1016/S2213-8587(14)70031-2

Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: Insights from the ARISTOTLE trial

Alexander, John H., Lopes, Renato D., Thomas, Laine, Alings, Marco, Atar, Dan, Aylward, Philip, Goto, Shinya, Hanna, Michael, Huber, Kurt, Husted, Steen, Lewis, Basil S., McMurray, John J. V., Pais, Prem, Pouleur, Hubert, Steg, Philippe Gabriel, Verheugt, Freek W. A., Wojdyla, Daniel M., Granger, Christopher B. and Wallentin, Lars. (2014). Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: Insights from the ARISTOTLE trial. European Heart Journal. 35(4), pp. 224 - 232. https://doi.org/10.1093/eurheartj/eht445

Prognostic effect of high-sensitive troponin t assessment in elderly patients with chronic heart failure : results from the CORONA Trial

Gravning, Jørgen, Askevold, Erik Tandberg, Nymo, Ståle, Ueland, Thor, Wikstrand, John, McMurray, John, Aukrust, Pål, Gullestad, Lars and Kjekshus, John. (2014). Prognostic effect of high-sensitive troponin t assessment in elderly patients with chronic heart failure : results from the CORONA Trial. Circulation: Heart Failure. 7(1), pp. 96 - 103. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000450

Association between change in daily ambulatory activity and cardiovascular events in people with impaired glucose tolerance (NAVIGATOR trial): A cohort analysis

Yates, Thomas, Haffner, Steven M., Schulte, Phillip J., Thomas, Laine, Huffman, Kim M., Bales, Connie W., Califf, Robert M., Holman, Rury R., McMurray, John J. V., Bethel, M. Angelyn, Tuomilehto, Jaako, Davies, Melanie J. and Kraus, William E.. (2014). Association between change in daily ambulatory activity and cardiovascular events in people with impaired glucose tolerance (NAVIGATOR trial): A cohort analysis. The Lancet. 383(9922), pp. 1059 - 1066. https://doi.org/10.1016/S0140-6736(13)62061-9

Influence of hospitalization for cardiovascular versus noncardiovascular reasons on subsequent mortality in patients with chronic heart failure across the spectrum of ejection fraction

Desai, Akshay S., Claggett, Brian L., Pfeffer, Marc A., Bello, Natalie, Finn, Peter, Granger, Christopher B., McMurray, John, Pocock, Stuart J., Swedberg, Karl, Yusuf, Salim and Solomon, Scott. (2014). Influence of hospitalization for cardiovascular versus noncardiovascular reasons on subsequent mortality in patients with chronic heart failure across the spectrum of ejection fraction. Circulation: Heart Failure. 7(6), pp. 895 - 902. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001567

Impaired systolic function by strain imaging in heart failure with preserved ejection fraction

Kraigher-Krainer, Elisabeth, Shah, Amil M., Gupta, Deepak K., Santos, Angela, Claggett, Brian, Pieske, Burkert, Zile, Michael R., Voors, Adriaan A., Lefkowitz, Martin P., Packer, Milton, McMurray, John J.V. and Solomon, Scott D.. (2014). Impaired systolic function by strain imaging in heart failure with preserved ejection fraction. Journal of the American College of Cardiology. 63(5), pp. 447 - 456. https://doi.org/10.1016/j.jacc.2013.09.052

Worsening renal function and outcome in heart failure patients with preserved ejection fraction and the impact of angiotensin receptor blocker treatment

Damman, Kevin, Perez, Ana C., Anand, Inder S., Komajda, Michel, McKelvie, Robert S., Zile, Michael R., Massie, Barrie, Carson, Peter E. and McMurray, John J.V.. (2014). Worsening renal function and outcome in heart failure patients with preserved ejection fraction and the impact of angiotensin receptor blocker treatment. Journal of the American College of Cardiology. 64(11), pp. 1106 - 1113. https://doi.org/10.1016/j.jacc.2014.01.087

Baseline characteristics and treatment of patients in Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure trial (PARADIGM-HF)

McMurray, John J. V., Packer, Milton, Desai, Akshay S., Gong, Jianjian, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl and Zile, Michael R.. (2014). Baseline characteristics and treatment of patients in Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure trial (PARADIGM-HF). European Journal of Heart Failure. 16(7), pp. 817 - 825. https://doi.org/10.1002/ejhf.115

Heart failure in younger patients: The meta-analysis global group in chronic heart failure (MAGGIC)

Wong, Chih M., Hawkins, Nathaniel M., Petrie, Mark C., Jhund, Pardeep, Gardner, Roy S., Ariti, Cono A., Poppe, Katrina K., Earle, Nikki, Whalley, Gillian A., Squire, Iain, Doughty, Robert N. and McMurray, John J. V.. (2014). Heart failure in younger patients: The meta-analysis global group in chronic heart failure (MAGGIC). European Heart Journal. 35(39), pp. 2714 - 2721. https://doi.org/10.1093/eurheartj/ehu216

The association between meteorological events and acute heart failure: New insights from ASCEND-HF

Das, Debraj, Bakal, Jeffery A., Westerhout, Cynthia M., Hernandez, Adrian F., O'Connor, Christopher M., Atar, Dan, McMurray, John J.V., Armstrong, Paul W. and Ezekowitz, Justin A.. (2014). The association between meteorological events and acute heart failure: New insights from ASCEND-HF. International Journal of Cardiology. 177(3), pp. 819 - 824. https://doi.org/10.1016/j.ijcard.2014.11.066

High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin

Hijazi, Ziyad, Wallentin, Lars, Siegbahn, Agneta, Andersson, Ulrika, Alexander, John H., Atar, Dan, Gersh, Bernard J., Hanna, Michael, Harjola, Veli-Pekka, Horowitz, John D., Husted, Steen, Hylek, Elaine M., Lopes, Renato D., McMurray, John J.V. and Granger, Christopher B.. (2014). High-sensitivity troponin T and risk stratification in patients with atrial fibrillation during treatment with apixaban or warfarin. Journal of the American College of Cardiology. 63(1), pp. 52 - 61. https://doi.org/10.1016/j.jacc.2013.07.093

Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction

Bello, Natalie A., Claggett, Brian L., Desai, Akshay S., McMurray, John, Granger, Christopher B., Yusuf, Salim, Swedberg, Karl, Pfeffer, Marc A. and Solomon, Scott. (2014). Influence of previous heart failure hospitalization on cardiovascular events in patients with reduced and preserved ejection fraction. Circulation: Heart Failure. 7(4), pp. 590 - 595. https://doi.org/10.1161/CIRCHEARTFAILURE.113.001281

Analysing recurrent hospitalizations in heart failure: A review of statistical methodology, with application to CHARM-preserved

Rogers, Jennifer K., Pocock, Stuart J., McMurray, John J. V., Granger, Christopher B., Michelson, Eric L., Ostergren, Jan, Pfeffer, Marc A., Solomon, Scott D., Swedberg, Karl and Yusuf, Salim. (2014). Analysing recurrent hospitalizations in heart failure: A review of statistical methodology, with application to CHARM-preserved. European Journal of Heart Failure. 16(1), pp. 33 - 40. https://doi.org/10.1002/ejhf.29

Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial

Holman, Rury R., Bethel, Mary A., Chan, Juliana C. N., Chiasson, Jean Louis, Doran, Zoë, Ge, Junbo, Gerstein, Hertzel C., Huo, Yong, McMurray, John J., Ryden, Lars, Liyanage, Winitha, Schröder, Stefan, Tendera, Michal, Theodorakis, Michael J., Tuomilehto, Jaakko, Yang, Wenying, Hu, Dayi and Pan, Changyu. (2014). Rationale for and design of the Acarbose Cardiovascular Evaluation (ACE) trial. American Heart Journal. 168(1), pp. 23 - 29. https://doi.org/10.1016/j.ahj.2014.03.021

Risk prediction in patients with heart failure: A systematic review and analysis

Rahimi, Kazem, Bennett, Derrick A., Conrad, Nathalie, Williams, Timothy M., Basu, Joyee, Dwight, Jeremy, Woodward, Mark, Patel, Anushka, McMurray, John and Macmahon, Stephen. (2014). Risk prediction in patients with heart failure: A systematic review and analysis. JACC: Heart Failure. 2(5), pp. 440 - 446. https://doi.org/10.1016/j.jchf.2014.04.008

Current evidence on treatment of patients with chronic systolic heart failure and renal insufficiency: Practical considerations from published data

Damman, Kevin, Tang, W. H. Wilson, Felker, G. Michael, Lassus, Johan, Zannad, Faiez, Krum, Henry and McMurray, John J.V.. (2014). Current evidence on treatment of patients with chronic systolic heart failure and renal insufficiency: Practical considerations from published data. Journal of the American College of Cardiology. 63(9), pp. 853 - 871. https://doi.org/10.1016/j.jacc.2013.11.031

Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction

Gori, Mauro, Lam, Carolyn S. P., Gupta, Deepak K., Santos, Angela B. S., Cheng, Susan, Shah, Amil M., Claggett, Brian L., Zile, Michael R., Kraigher-Krainer, Elisabeth, Pieske, Burkert, Voors, Adriaan A., Packer, Milton, Bransford, Toni, Lefkowitz, Martin P., McMurray, John J. V. and Solomon, Scott D.. (2014). Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction. European Journal of Heart Failure. 16(5), pp. 535 - 542. https://doi.org/10.1002/ejhf.67

Relationship between angina pectoris and outcomes in patients with heart failure and reduced ejection fraction: An analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)

Badar, Athar A., Perez-Moreno, Ana-Cristina, Jhund, Pardeep S., Wong, Chih M., Hawkins, Nathaniel M., Cleland, John G. F., van Veldhuisen, Dirk J., Wikstrand, John, Kjekshus, John, Wedel, Hans, Watkins, Stuart, Gardner, Roy S., Petrie, Mark C. and McMurray, John J. V.. (2014). Relationship between angina pectoris and outcomes in patients with heart failure and reduced ejection fraction: An analysis of the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). European Heart Journal. 35(48), pp. 3426 - 3433. https://doi.org/10.1093/eurheartj/ehu342

Fatigue as a predictor of outcome in patients with heart failure: Analysis of CORONA (Controlled rosuvastatin multinational trial in heart failure)

Perez-Moreno, Ana Cristina, Jhund, Pardeep S., Macdonald, Michael R., Petrie, Mark C., Cleland, John G. F., Böhm, Michael, van Veldhuisen, Dirk J., Gullestad, Lars, Wikstrand, John, Kjekshus, John, Lewsey, James D. and McMurray, John J.V.. (2014). Fatigue as a predictor of outcome in patients with heart failure: Analysis of CORONA (Controlled rosuvastatin multinational trial in heart failure). JACC: Heart Failure. 2(2), pp. 187 - 197. https://doi.org/10.1016/j.jchf.2014.01.001

The impact of kidney function on outcomes following high risk myocardial infarction: Findings from 27 610 patients

Moukarbel, George V., Yu, Zi-Fan, Dickstein, Kenneth, Hou, Yingxin, Wittes, Janet T., McMurray, John J. V., Pitt, Bertram, Zannad, Faiez, Pfeffer, Marc A. and Solomon, Scott D.. (2014). The impact of kidney function on outcomes following high risk myocardial infarction: Findings from 27 610 patients. European Journal of Heart Failure. 16(3), pp. 289 - 299. https://doi.org/10.1002/ejhf.11

Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl

Chin, Melanie P., Wrolstad, Danielle, Bakris, George L., Chertow, Glenn M., de Zeeuw, Dick, Goldsberry, Angie, Linde, Peter G., McCullough, Peter A., McMurray, John J. V., Wittes, Janet T. and Meyer, Colin J.. (2014). Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl. Journal of Cardiac Failure. 20(12), pp. 953 - 958. https://doi.org/10.1016/j.cardfail.2014.10.001

Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: Results from the eplerenone in mild patients hospitalization and survival study in heart failure (EMPHASIS-HF)

Rossignol, Patrick, Dobre, Daniela, McMurray, John, Swedberg, Karl, Krum, Henry, van Veldhuisen, Dirk J., Shi, Harry, Messig, Michael, Vincent, John, Girerd, Nicolas, Bakris, G., Pitt, Bertram and Zannad, Faiez. (2014). Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: Results from the eplerenone in mild patients hospitalization and survival study in heart failure (EMPHASIS-HF). Circulation: Heart Failure. 7(1), pp. 51 - 58. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000792

Left ventricular dyssynchrony in patients with heart failure and preserved ejection fraction

Santos, Angela B. S., Kraigher-Krainer, Elisabeth, Bello, Natalie, Claggett, Brian L., Zile, Michael R., Pieske, Burkert, Voors, Adriaan A., McMurray, John J. V., Packer, Milton, Bransford, Toni, Lefkowitz, Marty P., Shah, Amil M. and Solomon, Scott D.. (2014). Left ventricular dyssynchrony in patients with heart failure and preserved ejection fraction. European Heart Journal. 35(1), pp. 42 - 47. https://doi.org/10.1093/eurheartj/eht427

Relationship between heart rate and mortality and morbidity in the irbesartan patients with heart failure and preserved systolic function trial (I-Preserve)

Bohm, Michael, Perez, Ana-Cristina, Jhund, Pardeep S., Reil, Jan C., Komajda, Michel, Zile, Michael R., McKelvie, Robert S., Anand, Inder S., Massie, Barry M., Carson, Peter E. and McMurray, John J. V.. (2014). Relationship between heart rate and mortality and morbidity in the irbesartan patients with heart failure and preserved systolic function trial (I-Preserve). European Journal of Heart Failure. 16(7), pp. 778 - 787. https://doi.org/10.1002/ejhf.85

Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: An analysis of the PARAMOUNT trial

Jhund, Pardeep S., Claggett, Brian L., Packer, Milton, Zile, Michael R., Voors, Adriaan A., Pieske, Burkert, Lefkowitz, Martin P., Shi, Victor C., Bransford, Toni, McMurray, John J. V. and Solomon, Scott D.. (2014). Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: An analysis of the PARAMOUNT trial. European Journal of Heart Failure. 16(6), pp. 671 - 677. https://doi.org/10.1002/ejhf.76

Elevation in high-sensitivity troponin t in heart failure and preserved ejection fraction and influence of treatment with the angiotensin receptor neprilysin inhibitor LCZ696

Jhund, Pardeep, Claggett, Brian L., Voors, Adriaan A., Zile, Michael R., Packer, Milton, Pieske, Burkert, Kraigher-Krainer, Elisabeth, Shah, Amil, Prescott, Margaret F., Shi, Victor C., Lefkowitz, Marty P., McMurray, John and Solomon, Scott. (2014). Elevation in high-sensitivity troponin t in heart failure and preserved ejection fraction and influence of treatment with the angiotensin receptor neprilysin inhibitor LCZ696. Circulation: Heart Failure. 7(6), pp. 953 - 959. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001427

High-sensitivity C-reactive protein in acute heart failure: Insights from the ASCEND-HF trial

Kalogeropoulos, Andreas P., Tang, W. H. Wilson, Hsu, Amy, Felker, G. Michael, Hernandez, Adrian F., Troughton, Richard W., Voors, Adriaan A., Anker, Stefan D., Metra, Marco, McMurray, John J. V., Massie, Barry M., Ezekowitz, Justin A., Califf, Robert M., O'Connor, Christopher M., Starling, Randall C. and Butler, Javed. (2014). High-sensitivity C-reactive protein in acute heart failure: Insights from the ASCEND-HF trial. Journal of Cardiac Failure. 20(5), pp. 319 - 326. https://doi.org/10.1016/j.cardfail.2014.02.002

Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction

Gori, Mauro, Senni, Michele, Gupta, Deepak K., Charytan, David M., Kraigher-Krainer, Elisabeth, Pieske, Burkert, Claggett, Brian L., Shah, Amil M., Santos, Angela B. S., Zile, Michael R., Voors, Adriaan A., McMurray, John J. V., Packer, Milton, Bransford, Toni, Lefkowitz, Martin and Solomon, Scott D.. (2014). Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction. European Heart Journal. 35(48), pp. 3442 - 3451. https://doi.org/10.1093/eurheartj/ehu254

Cost-effectiveness of eplerenone in patients with systolic heart failure and mild symptoms

Lee, Dawn, Wilson, Koo, Akehurst, Ron, Cowie, Martin R., Zannad, Faiez, Krum, Henry, van Veldhuisen, Dirk J., Vincent, John, Pitt, Bertram and McMurray, John J. V.. (2014). Cost-effectiveness of eplerenone in patients with systolic heart failure and mild symptoms. Heart. 100(21), pp. 1681 - 1687. https://doi.org/10.1136/heartjnl-2014-305673

Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): A large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia

MacDonald, Thomas M., Ford, Ian, Nuki, George, Mackenzie, Isla S., De Caterina, Raffaele, Findlay, Evelyn, Hallas, Jesper, Hawkey, Christopher J., Ralston, Stuart, Walters, Matthew, Webster, John, McMurray, John, Ruiz, Fernando Perez and Jennings, Claudine G.. (2014). Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): A large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia. BMJ Open. 4(7), pp. 1 - 7. https://doi.org/10.1136/bmjopen-2014-005354

High-sensitivity troponin I for risk assessment in patients with atrial fibrillation: Insights from the apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial

Hijazi, Ziad M., Siegbahn, Agneta, Andersson, Ulrika, Granger, Christopher B., Alexander, John H., Atar, Dan, Gersh, Bernard J., Mohan, Puneet, Harjola, Veli-Pekka, Horowitz, John, Husted, Steen, Hylek, Elaine, Lopes, Renato D., McMurray, John and Wallentin, Lars. (2014). High-sensitivity troponin I for risk assessment in patients with atrial fibrillation: Insights from the apixaban for reduction in stroke and other thromboembolic events in atrial fibrillation (ARISTOTLE) trial. Circulation. 129(6), pp. 625 - 634. https://doi.org/10.1161/CIRCULATIONAHA.113.006286

Thyroid-stimulating hormone and clinical outcomes: The CORONA trial (controlled rosuvastatin multinational study in heart failure)

Perez, Ana Cristina, Jhund, Pardeep S., Stott, David S., Gullestad, Lars, Cleland, John G. F., van Veldhuisen, Dirk J., Wikstrand, John, Kjekshus, John and McMurray, John. (2014). Thyroid-stimulating hormone and clinical outcomes: The CORONA trial (controlled rosuvastatin multinational study in heart failure). JACC: Heart Failure. 2(1), pp. 35 - 40. https://doi.org/10.1016/j.jchf.2013.07.008

Impaired left atrial function in heart failure with preserved ejection fraction

Santos, Angela B. S., Kraigher-Krainer, Elisabeth, Gupta, Deepak K., Claggett, Brian L., Zile, Michael R., Pieske, Burkert, Voors, Adriaan A., Lefkowitz, Marty P., Bransford, Toni, Shi, Victor C., Packer, Milton, McMurray, John J. V., Shah, Amil M. and Solomon, Scott D.. (2014). Impaired left atrial function in heart failure with preserved ejection fraction. European Journal of Heart Failure. 16(10), pp. 1096 - 1103. https://doi.org/10.1002/ejhf.147

The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: A meta-analysis of individual patient data

Padwal, R., McAlister, Finlay A., McMurray, John J.V., Cowie, M. R., Rich, Michael W., Pocock, Stuart J., Swedberg, Karl, Maggioni, Aldo Pietro, Gamble, Greg D., Ariti, Cono A., Earle, Nikki, Whalley, Gillian A., Poppe, Katrina K., Doughty, Robert N. and Bayes-Genis, Antoni. (2014). The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: A meta-analysis of individual patient data. International Journal of Obesity. 38, pp. 1110 - 1114. https://doi.org/10.1038/ijo.2013.203

Retinopathy and clinical outcomes in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia

Bello, Natalie A., Pfeffer, Marc A., Skali, Hicham, McGill, Janet B., Rossert, Jerome, Olson, Kurt A., Weinrauch, Larry, Cooper, Mark E., de Zeeuw, Dick, Rossing, Peter, McMurray, John J. V. and Solomon, Scott D.. (2014). Retinopathy and clinical outcomes in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia. BMJ Open Diabetes Research and Care. 2(1), pp. 1 - 8. https://doi.org/10.1136/bmjdrc-2013-000011

Impact of baseline physical activity and diet behavior on metabolic syndrome in a pharmaceutical trial: Results from NAVIGATOR

Huffman, Kim M., Sun, Jie-Lena, Thomas, Laine, Bales, Connie W., Califf, Robert M., Yates, Thomas, Davies, Melanie J., Holman, Rury R., McMurray, John J. V., Bethel, M. Angelyn, Tuomilehto, Jaakko, Haffner, Steven M. and Kraus, William E.. (2014). Impact of baseline physical activity and diet behavior on metabolic syndrome in a pharmaceutical trial: Results from NAVIGATOR. Metabolism. 63(4), pp. 554 - 561. https://doi.org/10.1016/j.metabol.2014.01.002

Comorbidities and differential diagnosis in heart failure with preserved ejection fraction

Campbell, Ross T. and McMurray, John J. V.. (2014). Comorbidities and differential diagnosis in heart failure with preserved ejection fraction. Heart Failure Clinics. 10(3), pp. 481 - 501. https://doi.org/10.1016/j.hfc.2014.04.009

Effect of rosuvastatin on repeat heart failure hospitalizations: The CORONA trial (controlled rosuvastatin multinational trial in heart failure)

Rogers, Jennifer K., Jhund, Pardeep S., Perez, Ana-Cristina, Böhm, Michael, Cleland, John G., Gullestad, Lars, Kjekshus, John, van Veldhuisen, Dirk J., Wikstrand, John, Wedel, Hans, McMurray, John J.V. and Pocock, Stuart J.. (2014). Effect of rosuvastatin on repeat heart failure hospitalizations: The CORONA trial (controlled rosuvastatin multinational trial in heart failure). JACC: Heart Failure. 2(3), pp. 289 - 297. https://doi.org/10.1016/j.jchf.2013.12.007

Up-titration of allopurinol in patients with gout

Jennings, Claudine G., Mackenzie, Isla S., Flynn, Rob, Ford, Ian, Nuki, George, De Caterina, Raffaele, Riches, Philip L., Ralston, Stuart H., MacDonald, Thomas M., Ralston, Stuart, Findlay, Evelyn, Hallas, Jesper, Hawkey, Chris J., Walters, Matthew, Webster, John, McMurray, John J. V., Ruiz, Fernando Perez and Harvie, John. (2014). Up-titration of allopurinol in patients with gout. Seminars in Arthritis and Rheumatism. 44(1), pp. 25 - 30. https://doi.org/10.1016/j.semarthrit.2014.01.004

Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality : Findings from ASCEND-HF

Patel, Priyesh A., Heizer, Gretchen M., O'Connor, Christopher M., Schulte, Phillip J., Dickstein, Kenneth, Ezekowitz, Justin A., Armstrong, P W., Hasselblad, Vic, Mills, Roger M., McMurray, John, Starling, Randall C., Tang, W. H. Wilson, Califf, Robert M. and Hernandez, Adrian F.. (2014). Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality : Findings from ASCEND-HF. Circulation: Heart Failure. 7(6), pp. 918 - 925. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000872

Inflammatory cytokines in chronic heart failure: Interleukin-8 is associated with adverse outcome. Results from CORONA

Nymo, Ståle H., Hulthe, Johannes, Ueland, Thor, McMurray, John J. V., Wikstrand, John, Askevold, Erik Tandberg, Yndestad, Arne, Gullestad, Lars and Aukrust, Pål. (2014). Inflammatory cytokines in chronic heart failure: Interleukin-8 is associated with adverse outcome. Results from CORONA. European Journal of Heart Failure. 16(1), pp. 68 - 75. https://doi.org/10.1093/eurjhf/hft125

Effects of neutral endopeptidase (Neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: Studies with thiorphan and omapatrilat

Dalzell, Jonathan R., Seed, Alison, Berry, Colin, Whelan, Carol J., Petrie, Mark C., Padmanabhan, Neal, Clarke, Amanda, Biggerstaff, Fiona, Hillier, Christopher and McMurray, John J.V.. (2014). Effects of neutral endopeptidase (Neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: Studies with thiorphan and omapatrilat. Cardiovascular Therapeutics. 32(1), pp. 13 - 18. https://doi.org/10.1111/1755-5922.12053

History of atrial fibrillation as a risk factor in patients with heart failure and preserved ejection fraction

Oluleye, Oludamilola W., Rector, Thomas S., Win, Sithu, McMurray, John, Zile, Michael R., Komajda, Michel, McKelvie, Robert, Massie, Barry, Carson, Peter E. and Anand, Inder S.. (2014). History of atrial fibrillation as a risk factor in patients with heart failure and preserved ejection fraction. Circulation: Heart Failure. 7(6), pp. 960 - 966. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001523

Digitalis for treatment of heart failure in patients in sinus rhythm

Hood, William B., Dans, Antonio L., Guyatt, Gordon H., Jaeschke, Roman and McMurray, John J. V.. (2014). Digitalis for treatment of heart failure in patients in sinus rhythm. The Cochrane Database of Systematic Reviews. 4, pp. 1 - 33. https://doi.org/10.1002/14651858.CD002901.pub3

The large-scale placebo-controlled beta-blocker studies in systolic heart failure revisited: Results from CIBIS-II, COPERNICUS and SENIORS-SHF compared with stratified subsets from MERIT-HF

Wikstrand, John, Wedel, H., Castagno, Davide and McMurray, John J. V.. (2014). The large-scale placebo-controlled beta-blocker studies in systolic heart failure revisited: Results from CIBIS-II, COPERNICUS and SENIORS-SHF compared with stratified subsets from MERIT-HF. Journal of Internal Medicine. 275(2), pp. 134 - 143. https://doi.org/10.1111/joim.12141

Nesiritide, renal function, and associated outcomes during hospitalization for acute decompensated heart failure: Results from the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure (ASCEND-HF).

van Dersen, Vincent M., Hernandez, Adrian F., Stebbins, Amanda, Hasselblad, Vic, Ezekowitz, Justin A., Califf, Robert M., Gottlieb, Stephen S., O'Connor, Christopher M., Starling, Randall C., Tang, W. H. Wilson, McMurray, John, Dickstein, Kenneth and Voors, Adriaan A.. (2014). Nesiritide, renal function, and associated outcomes during hospitalization for acute decompensated heart failure: Results from the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure (ASCEND-HF). Circulation. 130(12), pp. 958 - 965. https://doi.org/10.1161/CIRCULATIONAHA.113.003046

Microvolt T-wave alternans testing in patients recently hospitalized with decompensated heart failure: Reply

Jackson, Colette E., Myles, Rachel C. and McMurray, John. (2014). Microvolt T-wave alternans testing in patients recently hospitalized with decompensated heart failure: Reply. European Journal of Heart Failure. 16(1), pp. 113 - 113. https://doi.org/10.1111/ejhf.45

Developing therapies for heart failure with preserved ejection fraction: Current state and future directions

Butler, Javed, Fonarow, Gregg C., Zile, Michael R., Lam, Carolyn S., Roessig, Lothar, Schelbert, Erik B., Shah, Sanjiv J., Ahmed, Ali, Bonow, Robert O., Cleland, John G. F., Cody, Robert J., Chioncel, Ovidiu, Collins, Sean P., Dunnmon, Preston M., Filippatos, Gerasimos S., Lefkowitz, Martin P., Marti, Catherine N., McMurray, John J., Misselwitz, Frank, ... Gheorghiade, Mihai. (2014). Developing therapies for heart failure with preserved ejection fraction: Current state and future directions. JACC: Heart Failure. 2(2), pp. 97 - 112. https://doi.org/10.1016/j.jchf.2013.10.006

Worsening heart failure, a critical event during hospital admission for acute heart failure: Results from the VERITAS study

Cotter, Gad, Metra, Marco, Davison, Beth A., Senger, Stefanie, Bourge, Robert C., Cleland, John G. F., Jondeau, Guillaume, Krum, Henry, O'Connor, Christopher M., Parker, John D., Torre-Amione, Guillermo, van Veldhuisen, Dirk J., Milo, Olga, Kobrin, Isaac, Rainisio, Maurizio, McMurray, John J. V. and Teerlink, John R.. (2014). Worsening heart failure, a critical event during hospital admission for acute heart failure: Results from the VERITAS study. European Journal of Heart Failure. 16(12), pp. 1362 - 1371. https://doi.org/10.1002/ejhf.186

CCL21 is associated with fatal outcomes in chronic heart failure: Data from CORONA and GISSI-HF trials

Ueland, Thor, Nymo, Ståle H., Latini, Roberto, McMurray, John J. V., Kjekshus, John, Yndestad, Arne, Fucili, Alessandro, Grosu, Aurelia, Masson, Serge, Maggioni, Aldo Pietro, Gullestad, Lars and Aukrust, Pål. (2013). CCL21 is associated with fatal outcomes in chronic heart failure: Data from CORONA and GISSI-HF trials. European Journal of Heart Failure. 15(7), pp. 747 - 755. https://doi.org/10.1093/eurjhf/hft031

Iron status in patients with chronic heart failure

Jankowska, Ewa A., Malyszko, Jolanta, Ardehali, Hossein, Koc-Zorawska, Ewa, Banasiak, Waldemar, von Haehling, Stephan, MacDougall, Iain C., Weiss, Guenter, McMurray, John J. V., Anker, Stefan D., Gheorghiade, Mihai and Ponikowski, Piotr P.. (2013). Iron status in patients with chronic heart failure. European Heart Journal. 34(11), pp. 827 - 834. https://doi.org/10.1093/eurheartj/ehs377

Spectral microvolt T-Wave alternans testing has no prognostic value in patients recently hospitalized with decompensated heart failure

Jackson, Colette E., Myles, Rachel C., Tsorlalis, Ioannis K., Dalzell, Jonathan R., Rocchiccioli, John P., Rodgers, John R., Spooner, Richard J., Greenlaw, Nicola, Ford, Ian, Gardner, Roy S., Cobbe, Stuart M., Petrie, Mark C. and McMurray, John J. V.. (2013). Spectral microvolt T-Wave alternans testing has no prognostic value in patients recently hospitalized with decompensated heart failure. European Journal of Heart Failure. 15(11), pp. 1253 - 1261. https://doi.org/10.1093/eurjhf/hft085

Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for Stroke prevention in atrial fibrillation

Wallentin, Lars, Lopes, Renato D., Hanna, Michael, Thomas, Laine, Hellkamp, Anne, Nepal, Sunil, Hylek, Elaine, Al-Khatib, Sana M., Alexander, John H., Alings, Marco, Amerena, John, Ansell, Jack, Aylward, Philip, Bartunek, Jozef, Commerford, Patrick, De Caterina, Raffaele, Erol, Çetin, Harjola, Veli-Pekka, Held, Claes, ... Granger, Christopher B.. (2013). Efficacy and safety of apixaban compared with warfarin at different levels of predicted international normalized ratio control for Stroke prevention in atrial fibrillation. Circulation. 127(22), pp. 2166 - 2176. https://doi.org/10.1161/CIRCULATIONAHA.112.142158

Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy : Analysis of the EMPHASIS-HF study

Krum, Henry, Shi, Harry, Pitt, Bertram, McMurray, John, Swedberg, Karl, van Veldhuisen, Dirk J., Vincent, John, Pocock, Stuart J. and Zannad, Faiez. (2013). Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy : Analysis of the EMPHASIS-HF study. Circulation: Heart Failure. 6(4), pp. 711 - 718. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000173

Angina and intermittent claudication in 7403 participants of the 2003 Scottish Health Survey : impact on general and mental health, quality of life and five-year mortality

Inglis, Sally, Lewsey, James, Lowe, Gordon, Jhund, Pardeep, Gillies, Michelle, Capewell, S, MacIntyre, Kate and McMurray, J. (2013). Angina and intermittent claudication in 7403 participants of the 2003 Scottish Health Survey : impact on general and mental health, quality of life and five-year mortality. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.05.099

Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation : insights from the ARISTOTLE trial

McMurray, John, Ezekowitz, Justin A., Lewis, Basil S., Gersh, Bernard J., Van Diepen, Sean, Amerena, John, Bartunek, Jozef, Commerford, Patrick, Oh, Byung Hee, Harjola, Veli-Pekka, Al-Khatib, Sana M., Hanna, Michael, Alexander, John H., Lopes, Renato D., Wojdyla, Daniel M., Wallentin, Lars and Granger, Christopher B.. (2013). Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation : insights from the ARISTOTLE trial. Circulation: Heart Failure. 6(3), pp. 451 - 460. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000143

Baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF)

McMurray, John J. V., Anand, Inder S., Diaz, Rafael, Maggioni, Aldo Pietro, O'Connor, Christopher M., Pfeffer, Marc A., Solomon, Scott D., Tendera, Michal, van Veldhuisen, Dirk J., Albizem, Moetaz, Cheng, Sunfa, Scarlata, Debra, Swesberg, Karl and Young, James B.. (2013). Baseline characteristics of patients in the Reduction of Events with Darbepoetin alfa in Heart Failure trial (RED-HF). European Journal of Heart Failure. 15(3), pp. 334 - 341. https://doi.org/10.1093/eurjhf/hfs204

Predicting survival in heart failure: A risk score based on 39 372 patients from 30 studies

Pocock, Stuart J., Ariti, Cono A., McMurray, John J. V., Maggioni, Aldo Pietro, Kober, Lars, Squire, Iain B., Swedberg, Karl, Dobson, Joanna, Poppe, Katrina K., Whalley, Gillian A. and Doughty, Rob N.. (2013). Predicting survival in heart failure: A risk score based on 39 372 patients from 30 studies. European Heart Journal. 34(19), pp. 1404 - 1413. https://doi.org/10.1093/eurheartj/ehs337

Known and missing left ventricular ejection fraction and survival in patients with heart failure: A MAGGIC meta-analysis report

Poppe, Katrina K., Squire, Iain B., Whalley, Gillian A., Kober, Lars, McAlister, Finlay A., McMurray, John J. V., Pocock, Stuart J., Earle, Nikki J., Berry, Colin and Doughty, Robert N.. (2013). Known and missing left ventricular ejection fraction and survival in patients with heart failure: A MAGGIC meta-analysis report. European Journal of Heart Failure. 15(11), pp. 1220 - 1227. https://doi.org/10.1093/eurjhf/hft101

Incidence of atrial fibrillation in a population with impaired glucose tolerance: The contribution of glucose metabolism and other risk factors. A post hoc analysis of the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research tria

Latini, Roberto, Staszewsky, Lidia, Sun, Jie Lena, Bethel, M. A., Disertori, Marcello, Haffner, S. M., Holman, Rury R., Chang, Futien, Giles, Thomas D., Maggioni, Aldo Pietro, Rutten, Guy E. H. M., Standl, Eberhard, Thomas, Laine, Tognoni, Gianni, Califf, Robert M. and McMurray, John J. V.. (2013). Incidence of atrial fibrillation in a population with impaired glucose tolerance: The contribution of glucose metabolism and other risk factors. A post hoc analysis of the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research tria. American Heart Journal. 166(5), pp. 935 - 940. https://doi.org/10.1016/j.ahj.2013.08.012

Profile and burden of an evolving epidemic in the 21st century

Ball, Jocasta, Carrington, Melinda, McMurray, J and Stewart, Simon. (2013). Profile and burden of an evolving epidemic in the 21st century. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.12.093

The past, present and future of renin-angiotensin aldosterone system inhibition

Mentz, Robert J., Bakris, George L., Waeber, Bernard, McMurray, John J.V., Gheorghiade, Mihai, Ruilope, Luis Miguel, Maggioni, Aldo Pietro, Swedberg, Karl, Pina, Ileana L., Fiuzat, Mona, O'Connor, Christopher M., Zannad, Faiez and Pitt, Bertram. (2013). The past, present and future of renin-angiotensin aldosterone system inhibition. International Journal of Cardiology. 167(5), pp. 1677 - 1687. https://doi.org/10.1016/j.ijcard.2012.10.007

Safety and efficacy of eplerenone in patients at high risk for hyperkalemia and/or worsening renal function: Analyses of the EMPHASIS-HF study subgroups (eplerenone in mild patients hospitalization and survival study in heart failure)

Eschalier, Romain, McMurray, John J.V., Sweberg, Karl, van Veldhuisen, Dirk J., Krum, Henry, Pocock, Stuart J., Shi, Harry, Vincent, John, Rossignol, Patrick, Zannad, Faiez and Pitt, Bertram. (2013). Safety and efficacy of eplerenone in patients at high risk for hyperkalemia and/or worsening renal function: Analyses of the EMPHASIS-HF study subgroups (eplerenone in mild patients hospitalization and survival study in heart failure). Journal of the American College of Cardiology. 62(17), pp. 1585 - 1593. https://doi.org/10.1016/j.jacc.2013.04.086

Beta-blockers and outcome in heart failure and atrial fibrillation: A meta-analysis

Rienstra, Michiel, Damman, Kevin, Mulder, Bart A., van Gelder, Isabelle C., McMurray, John J.V. and van Veldhuisen, Dirk J.. (2013). Beta-blockers and outcome in heart failure and atrial fibrillation: A meta-analysis. JACC: Heart Failure. 1(1), pp. 21 - 28. https://doi.org/10.1016/j.jchf.2012.09.002

Organization of heart failure management in European Society of Cardiology member countries: Survey of the Heart Failure Association of the European Society of Cardiology in collaboration with the Heart Failure National Societies/Working Groups

Seferovic, Petar M., Stoerk, Stefan, Filippatos, Gerasimos S., Mareev, Viacheslav, Kavoliuniene, Ausra, Ristic, Arsen D., Ponikowski, Piotr P., McMurray, John J. V., Maggioni, Aldo Pietro, Ruschitzka, Frank, van Veldhuisen, Dirk J., Coats, Andrew J. S., Piepoli, Massimo F., McDonagh, Theresa, Riley, Jillian P., Hoes, Arno W., Pieske, Burkert, Dobric´, Milan, Papp, Zoltan, ... Anker, Stefan D.. (2013). Organization of heart failure management in European Society of Cardiology member countries: Survey of the Heart Failure Association of the European Society of Cardiology in collaboration with the Heart Failure National Societies/Working Groups. European Journal of Heart Failure. 15(9), pp. 947 - 959. https://doi.org/10.1093/eurjhf/hft092

Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: The Occurrence of renal eveNts (BEACON) trial

Lambers Heerspink, Hiddo J., Chertow, Glenn M., Akizawa, Tadao, Audhya, Paul, Bakris, George L., Goldsberry, Angie, Krauth, Melissa, Linde, Peter G., McMurray, John J. V., Meyer, Colin J., Parving, Hans-Henrik, Remuzzi, Guiseppe, Christ-Schmidt, Heidi, Toto, Robert D., Vaziri, Nosratola D., Wanner, Christoph, Wittes, Janet T., Wrolstad, Danielle and de Zeeuw, Dick. (2013). Baseline characteristics in the Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes mellitus: The Occurrence of renal eveNts (BEACON) trial. Nephrology Dialysis Transplantation. 28(11), pp. 2841 - 2850. https://doi.org/10.1093/ndt/gft445

Peripheral artery disease and outcomes after myocardial infarction: An individual-patient meta-analysis of 28,771 patients in CAPRICORN, EPEHESUS, OPTIMAAL and VALIANT

Inglis, Sally C., Bebchuk, Judith, Al-Suhaim, Sultan A., Case, Jessica, Pfeffer, Marc A., Solomon, Scott D., Hou, Yingxin Rachel, Pitt, Bertram, Dargie, Henry J., Ford, Ian, Kjekshus, John, Zannad, Faiez, Dickstein, Kenneth and McMurray, John J.V.. (2013). Peripheral artery disease and outcomes after myocardial infarction: An individual-patient meta-analysis of 28,771 patients in CAPRICORN, EPEHESUS, OPTIMAAL and VALIANT. International Journal of Cardiology. 168(2), pp. 1094 - 1101. https://doi.org/10.1016/j.ijcard.2012.11.033

Angina and intermittent claudication in 7403 participants of the 2003 Scottish Health Survey : impact on general and mental health, quality of life and five-year mortality

Rationale and trial design of bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes: The occurrence of renal events (BEACON)

Zeeuw, Dick de, Akizawa, Tadao, Agarwal, Rajiv, Audhya, Paul, Bakris, George L., Chin, Melanie P., Krauth, Melissa, Lambers Heerspink, Hiddo J., Meyer, Colin J., McMurray, John J.V., Parving, Hans-Henrick, Pergola, Pablo E., Remuzzi, Guiseppe, Toto, Robert D., Vaziri, Nosratola D., Wanner, Christoph, Warnock, David G., Wittes, Janet T. and Chertow, Glenn M.. (2013). Rationale and trial design of bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes: The occurrence of renal events (BEACON). American Journal of Nephrology. 37(3), pp. 212 - 222. https://doi.org/10.1159/000346948

Atrial fibrillation : Profile and burden of an evolving epidemic in the 21st century

Ball, Jocasta, Carrington, Melinda, McMurray, J and Stewart, Simon. (2013). Atrial fibrillation : Profile and burden of an evolving epidemic in the 21st century. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2012.12.093

Digoxin reduces 30-day all-cause hospital admission in older patients with chronic systolic heart failure

Bourge, Robert C., Fleg, Jerome L., Fonarow, Gregg C., Cleland, John G. F., McMurray, John J.V., van Veldhuisen, Dirk J., Gheorghiade, Mihai, Patel, Kanan, Aban, Inmaculada B., Allman, Richard M., White-Willia, Connie, White, Michel, Filippatos, Gerasimos S., Anker, Stefan D. and Ahmed, Ali. (2013). Digoxin reduces 30-day all-cause hospital admission in older patients with chronic systolic heart failure. American Journal of Medicine. 126(8), pp. 701 - 708. https://doi.org/10.1016/j.amjmed.2013.02.001

The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: Insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial

Collier, Timothy J., Pocock, Stuart J., McMurray, John J. V., Zannad, Faiez, Krum, Henry, van Veldhuisen, Dirk J., Swedberg, Karl, Shi, Harry, Vincent, John and Pitt, Bertram. (2013). The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: Insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial. European Heart Journal. 34(36), pp. 2823 - 2829. https://doi.org/10.1093/eurheartj/eht247

Clinical characteristics and outcomes of young and very young adults with heart failure: The CHARM programme (candesartan in heart failure assessment of reduction in mortality and morbidity)

Wong, Chih M., Hawkins, Nathaniel M., Jhund, Pardeep S., Macdonald, Michael R., Solomon, Scott D., Granger, Christopher B., Yusuf, Salim, Pfeffer, Marc A., Sweberg, Karl, Petrie, Mark C. and McMurray, John J.V.. (2013). Clinical characteristics and outcomes of young and very young adults with heart failure: The CHARM programme (candesartan in heart failure assessment of reduction in mortality and morbidity). Journal of the American College of Cardiology. 62(20), pp. 1845 - 1854. https://doi.org/10.1016/j.jacc.2013.05.072

Hemoglobin stability in patients with anemia, CKD, and type 2 diabetes: An analysis of the TREAT (trial to reduce cardiovascular events with aranesp therapy) placebo arm

Skali, Hicham, Lin, Julie, Pfeffer, Marc A., Chen, Chao Yin, Cooper, Mark E., McMurray, John, Nissenson, Allen R., Remuzzi, Guiseppe, Rossert, Jerome, Parfrey, Patrick, Scott-Douglas, Nairne W., Singh, Ajay K., Toto, Robert D., Uno, Hajime and Ivanovich, Peter. (2013). Hemoglobin stability in patients with anemia, CKD, and type 2 diabetes: An analysis of the TREAT (trial to reduce cardiovascular events with aranesp therapy) placebo arm. American Journal of Kidney Diseases. 61(2), pp. 238 - 246. https://doi.org/10.1053/j.ajkd.2012.08.043

Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: Rationale for and design of the Prospective comparison of ARNI with ACEI to Determine I

McMurray, John J. V., Packer, Milton, Desai, Akshay S., Gong, Jim, Lefkowitz, Martin P., Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl and Zile, Michael R.. (2013). Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: Rationale for and design of the Prospective comparison of ARNI with ACEI to Determine I. European Journal of Heart Failure. 15(9), pp. 1062 - 1073. https://doi.org/10.1093/eurjhf/hft052

Methodology of a reevaluation of cardiovascular outcomes in the RECORD trial: Study design and conduct

Lopes, Renato D., Dickerson, Sheila, Hafley, Gail, Burns, Shana, Tourt-Uhlig, Sandra, White, Jennifer, Newby, L. Kristin, Komajda, Michel, McMurray, John, Bigelow, Robert, Home, Philip D. and Mahaffey, Kenneth W.. (2013). Methodology of a reevaluation of cardiovascular outcomes in the RECORD trial: Study design and conduct. American Heart Journal. 166(2), pp. 208 - 216. https://doi.org/10.1016/j.ahj.2013.05.005

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease

de Zeeuw, Dick, Akizawa, Tadao, Audhya, Paul, Bakris, George L., Chin, Melanie P., Christ-Schmidt, Heidi, Goldsberry, Angie, Houser, Mark, Krauth, Melissa, Lambers Heerspink, Hiddo J., McMurray, John J. V., Meyer, Colin J., Parving, Hans-Henrik, Remuzzi, Guiseppe, Toto, Robert D., Vaziri, Nosratola D., Wanner, Christoph, Wittes, Janet T., Wrolstad, Danielle and Chertow, Glenn M.. (2013). Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. New England Journal of Medicine. 369(26), pp. 2492 - 2503. https://doi.org/10.1056/NEJMoa1306033

Galectin-3 and cardiac function in survivors of acute myocardial infarction

Weir, Robin A. P., Petrie, Colin J., Murphy, C. Aengus, Clements, Suzanne, Steedman, Tracey, Miller, Ashley M., McInnes, Iain B., Squire, Iain, Ng, Leong L., Dargie, H. J. and McMurray, John. (2013). Galectin-3 and cardiac function in survivors of acute myocardial infarction. Circulation: Heart Failure. 6(3), pp. 492 - 498. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000146

Effect of oral digoxin in high-risk heart failure patients: A pre-specified subgroup analysis of the DIG trial

Gheorghiade, Mihai, Patel, Kanan, Filippatos, Gerasimos S., Anker, Stefan D., van Veldhuisen, Dirk J., Cleland, John G. F., Metra, Marco, Aban, Inmaculada B., Greene, Stephen J., Adams, Kirkwood F., McMurray, John J. V. and Ahmed, Ali. (2013). Effect of oral digoxin in high-risk heart failure patients: A pre-specified subgroup analysis of the DIG trial. European Journal of Heart Failure. 15(5), pp. 551 - 559. https://doi.org/10.1093/eurjhf/hft010

Atrial fibrillation : Profile and burden of an evolving epidemic in the 21st century

Predictors of stroke in patients with impaired glucose tolerance: Results from the nateglinide and valsartan in impaired glucose tolerance outcomes research trial

Preiss, David, Giles, Thomas D., Thomas, Laine E., Sun, Jie-Lena, Haffner, Steven M., Holman, Rury R., Standl, Eberhard, Mazzone, Theodore, Rutten, Guy E. H. M., Tognoni, Gianni, Chiang, Fu-Tien, McMurray, John J. V. and Califf, Robert M.. (2013). Predictors of stroke in patients with impaired glucose tolerance: Results from the nateglinide and valsartan in impaired glucose tolerance outcomes research trial. Stroke. 44(9), pp. 2590 - 2593. https://doi.org/10.1161/STROKEAHA.113.001177

N-terminal pro-B-type natriuretic peptide for risk assessment in patients with atrial fibrillation: Insights from the aristotle trial (apixaban for the prevention of stroke in subjects with atrial fibrillation)

Hijazi, Ziyad, Wallentin, Lars, Siegbahn, Agneta, Andersson, Ulrika, Christersson, Christina, Ezekowitz, Justin, Gersh, Bernard J., Hanna, Michael, Hohnloser, Stefan, Horowitz, John, Huber, Kurt, Hylek, Elaine M., Lopes, Renato D., McMurray, John J.V. and Granger, Christopher B.. (2013). N-terminal pro-B-type natriuretic peptide for risk assessment in patients with atrial fibrillation: Insights from the aristotle trial (apixaban for the prevention of stroke in subjects with atrial fibrillation). Journal of the American College of Cardiology. 61(22), pp. 2274 - 2284. https://doi.org/10.1016/j.jacc.2012.11.082

Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure : Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA)

Askevold, Erik Tandberg, Nymo, Ståle, Ueland, Thor, Gravning, Jørgen, Wergeland, Ragnhild, Kjekshus, John, Yndestad, Arne, Cleland, John G. F., McMurray, John, Aukrust, Pål and Gullestad, Lars. (2013). Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure : Analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA). Circulation: Heart Failure. 6(1), pp. 91 - 98. https://doi.org/10.1161/CIRCHEARTFAILURE.112.972653

Results of a reevaluation of cardiovascular outcomes in the RECORD trial

Mahaffey, Kenneth W., Hafley, Gail, Dickerson, Sheila, Burns, Shana, Tourt-Uhlig, Sandra, White, Jennifer, Newby, L. Kristin, Komajda, Michel, McMurray, John, Bigelow, Robert, Home, Philip D. and Lopes, Renato D.. (2013). Results of a reevaluation of cardiovascular outcomes in the RECORD trial. American Heart Journal. 166(2), pp. 240 - 249. https://doi.org/10.1016/j.ahj.2013.05.004

Antithrombotic outcome trials in acute coronary syndromes: Seeking the optimal balance between safety and efficacy

Verheugt, Freek W. A., Clemmensen, Peter, Mehran, Roxana, Agewall, Stefan, Pocock, Stuart J., Goldstein, Sidney, Torp-Pedersen, Christian, Simoons, Maarten L., Borer, Jeffrey S., Khder, Yasser M., Burton, Paul, Deliargyris, Efthymios, McMurray, John J. V., Berkowitz, Scott D., Stough, Wendy Gattis and Zannad, Faiez. (2013). Antithrombotic outcome trials in acute coronary syndromes: Seeking the optimal balance between safety and efficacy. European Heart Journal. 34(22), pp. 1621 - 1629. https://doi.org/10.1093/eurheartj/eht013

Do countries or hospitals with longer hospital stays for acute heart failure have lower readmission rates? : Findings from ASCEND-HF

Eapen, Zubin J., Reed, Shelby D., Li, Yanhong, Kociol, Robb D., Armstrong, P W., Starling, Randall C., McMurray, John, Massie, Barry M., Swedberg, Karl, Ezekowitz, Justin A., Fonarow, Gregg C., Teerlink, John R., Metra, Marco, Whellan, David J., O'Connor, Christopher M., Califf, Robert M. and Hernandez, Adrian F.. (2013). Do countries or hospitals with longer hospital stays for acute heart failure have lower readmission rates? : Findings from ASCEND-HF. Circulation: Heart Failure. 6(4), pp. 727 - 732. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000265

A novel risk classification paradigm for patients with impaired glucose tolerance and high cardiovascular risk

Bethel, M. Angelyn, Chacra, Antonio R., Deedwania, Prakash, Fulcher, Gregory R., Holman, Rury R., Jenssen, Trond, Kahn, Steven E., Levitt, Naomi S., McMurray, John J.V., Califf, Robert M., Raptis, Sotirios A., Thomas, Laine, Sun, Jie-Lena and Haffner, Steven M.. (2013). A novel risk classification paradigm for patients with impaired glucose tolerance and high cardiovascular risk. American Journal of Cardiology. 112(2), pp. 231 - 237. https://doi.org/10.1016/j.amjcard.2013.03.019

Predictors of incident heart failure hospitalizations among patients with impaired glucose tolerance : insight from the nateglinide and valsartan in impaired glucose tolerance outcomes research study

Wong, Yee Weng, Thomas, Laine, Sun, Jie Lena, McMurray, John, Krum, Henry, Hernandez, Adrian F., Rutten, Guy E. H. M., Leiter, Lawrence A., Standl, Eberhard, Haffner, S. M., Mazzone, Theodore, Martinez, Felipe, Tognoni, Gianni, Giles, Thomas D. and Califf, Robert M.. (2013). Predictors of incident heart failure hospitalizations among patients with impaired glucose tolerance : insight from the nateglinide and valsartan in impaired glucose tolerance outcomes research study. Circulation: Heart Failure. 6(2), pp. 203 - 210. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000086

Role of diuretics, ß blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study

Shen, Lan, Shah, Bimal R., Reyes, Eric M., Thomas, Laine, Wojdyla, Daniel, Diem, Peter, Leiter, Lawrence A., Charbonnel, Bernard, Mareev, Viacheslav, Horton, Edward S., Haffner, Steven M., Soska, Vladimir, Holman, Rury, Bethel, M. Angelyn, Schaper, Frank, Sun, Jie Lena, McMurray, John JV, Califf, Robert M. and Krum, Henry. (2013). Role of diuretics, ß blockers, and statins in increasing the risk of diabetes in patients with impaired glucose tolerance: reanalysis of data from the NAVIGATOR study. BMJ. 347, pp. 1 - 10. https://doi.org/10.1136/bmj.f6745

Treatment of anemia with darbepoetin alfa in systolic heart failure

Swedberg, Karl, Young, James B., Anand, Inder S., Cheng, Sunfa, Desai, Akshay S., Diaz, Rafael, Maggioni, Aldo Pietro, McMurray, John J. V., O'Connor, Christopher M., Pfeffer, Marc A., Solomon, Scott D., Sun, Yan, Tendera, Michal and van Veldhuisen, Dirk J.. (2013). Treatment of anemia with darbepoetin alfa in systolic heart failure. New England Journal of Medicine. 368(13), pp. 1210 - 1219. https://doi.org/10.1056/NEJMoa1214865

Pharmacological treatment of heart failure with preserved ejection fraction: A glimpse of light at the end of the tunnel?

van Veldhuisen, Dirk J. and McMurray, John J. V.. (2013). Pharmacological treatment of heart failure with preserved ejection fraction: A glimpse of light at the end of the tunnel? European Journal of Heart Failure. 15(1), pp. 5 - 8. https://doi.org/10.1093/eurjhf/hfs194

Cardiovascular risks with azithromycin

McMurray, John J. V. and Jhund, Pardeep S.. (2013). Cardiovascular risks with azithromycin. New England Journal of Medicine. 369(6), pp. 579 - 580. https://doi.org/10.1056/NEJMc1306999

Assessment of long-term effects of irbesartan on heart failure with preserved ejection fraction as measured by the Minnesota living with heart failure questionnaire in the irbesartan in heart failure with preserved systolic function (I-PRESERVE) trial

Rector, Thomas S., Carson, Peter E., Anand, Inder S., McMurray, John, Zile, Michael R., McKelvie, Robert, Komajda, Michel, Kuskowski, Michael and Massie, Barry M.. (2012). Assessment of long-term effects of irbesartan on heart failure with preserved ejection fraction as measured by the Minnesota living with heart failure questionnaire in the irbesartan in heart failure with preserved systolic function (I-PRESERVE) trial. Circulation: Heart Failure. 5(2), pp. 217 - 225. https://doi.org/10.1161/CIRCHEARTFAILURE.111.964221

Diabetes clinical trials: Helped or hindered by the current shift in regulatory requirements?

Zannad, Faiez, Stough, Wendy Gattis, Pocock, Stuart J., Sleight, Peter, Cushman, William C., Cleland, John G. F., McMurray, John J. V., Lonn, Eva M., Geller, Nancy L., Wedel, Hans, Abadie, Eric, Alonso-Garcia, Angeles and Pitt, Bertram. (2012). Diabetes clinical trials: Helped or hindered by the current shift in regulatory requirements? European Heart Journal. 33(9), pp. 1049 - 1057. https://doi.org/10.1093/eurheartj/ehr437

Eplerenone in patients with systolic heart failure and mild symptoms: Analysis of repeat hospitalizations

Rogers, Jennifer K., McMurray, John, Pocock, Stuart J., Zannad, Faiez, Krum, Henry, van Veldhuisen, Dirk J., Swedberg, Karl, Shi, Harry, Vincent, John and Pitt, Bertram. (2012). Eplerenone in patients with systolic heart failure and mild symptoms: Analysis of repeat hospitalizations. Circulation. 126(19), pp. 2317 - 2323. https://doi.org/10.1161/CIRCULATIONAHA.112.110536

B-type natriuretic peptide and glycaemia: An emerging cardiometabolic pathway?

Welsh, Paul and McMurray, John J. V.. (2012). B-type natriuretic peptide and glycaemia: An emerging cardiometabolic pathway? Diabetologia. 55(5), pp. 1240 - 1243. https://doi.org/10.1007/s00125-012-2515-3

The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: A phase 2 double-blind randomised controlled trial

Solomon, Scott D., Zile, Michael R., Pieske, Burkert, Voors, Adriaan A., Shah, Amil, Kraigher-Krainer, Elisabeth, Shi, Victor C., Bransford, Toni, Takeuchi, Madoka, Gong, Jianjian, Lefkowitz, Martin P., Packer, Milton and McMurray, John J. V.. (2012). The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: A phase 2 double-blind randomised controlled trial. The Lancet. 380(9851), pp. 1387 - 1395. https://doi.org/10.1016/S0140-6736(12)61227-6

Eplerenone and atrial fibrillation in mild systolic heart failure: Results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure) study

Sweberg, Karl, Zannad, Faiez, McMurray, John J.V., Krum, Henry, van Veldhuisen, Dirk J., Shi, Harry, Vincent, John and Pitt, Bertram. (2012). Eplerenone and atrial fibrillation in mild systolic heart failure: Results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure) study. Journal of the American College of Cardiology. 59(18), pp. 1598 - 1603. https://doi.org/10.1016/j.jacc.2011.11.063

When to stop a clinical trial early for benefit: Lessons learned and future approaches

Zannad, Faiez, Stough, Wendy Gattis, McMurray, John, Remme, Willem J., Pitt, Bertram, Borer, Jeffrey S., Geller, Nancy L. and Pocock, Stuart J.. (2012). When to stop a clinical trial early for benefit: Lessons learned and future approaches. Circulation: Heart Failure. 5(2), pp. 294 - 302. https://doi.org/10.1161/CIRCHEARTFAILURE.111.965707

Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: A secondary analysis of a randomised controlled trial

Lopes, Renato D., Al-Khatib, Sana M., Wallentin, Lars, Yang, Hongqiu, Ansell, Jack, Bahit, Maria C., De Caterina, Raffaele, Dorian, Paul, Easton, J. Donald, Erol, Çetin, Ezekowitz, Justin A., Gersh, Bernard J., Granger, Christopher B., Hohnloser, Stefan H., Horowitz, John, Hylek, Elaine M., McMurray, John J. V., Mohan, Puneet, Vinereanu, Dragos and Alexander, John H.. (2012). Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: A secondary analysis of a randomised controlled trial. The Lancet. 380(9855), pp. 1749 - 1758. https://doi.org/10.1016/S0140-6736(12)60986-6

European Guidelines on Cardiovascular Diseases prevention in clinical practice (version 2012)

Perk, Joep, De Backer, Guy, Gohlke, Helmut, Graham, Ian, Reiner, Zeljko, Verschuren, Monique, Albus, Christian, Benlian, Pascale, Boysen, Gudrun, Cifkova, Renata, Deaton, Christi, Ebrahim, Shah, Fisher, Miles, Germano, Giuseppe, Hobbs, Richard, Hoes, Arno W., Karadeniz, Sehnaz, Mezzani, Alessandro, Prescott, Eva, ... Wolpert, Christian. (2012). European Guidelines on Cardiovascular Diseases prevention in clinical practice (version 2012). European Heart Journal. 33(13), pp. 1635 - 1701. https://doi.org/10.1093/eurheartj/ehs092

Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure

Castagno, Davide, Petrie, Mark C., Claggett, Brian L. and McMurray, John J. V.. (2012). Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure. European Heart Journal. 33(9), pp. 1137 - 1141. https://doi.org/10.1093/eurheartj/ehs004

Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction

Lowrie, Richard, Mair, Frances S., Greenlaw, Nicola, Forsyth, Paul, Jhund, Pardeep S., McConnachie, Alex, Rae, Brian and McMurray, John J. V.. (2012). Pharmacist intervention in primary care to improve outcomes in patients with left ventricular systolic dysfunction. European Heart Journal. 33(3), pp. 314 - 324. https://doi.org/10.1093/eurheartj/ehr433

Effect of statins on venous thromboembolic events: A meta-analysis of published and unpublished evidence from randomised controlled trials

Rahimi, Kazem, Bhala, Neeraj, Kamphuisen, Pieter, Emberson, Jonathan, Biere-Rafi, Sara, Krane, Vera, Robertson, Michele, Wikstrand, John and McMurray, John. (2012). Effect of statins on venous thromboembolic events: A meta-analysis of published and unpublished evidence from randomised controlled trials. PLoS Medicine. 9(9), pp. 1 - 13. https://doi.org/10.1371/journal.pmed.1001310

Mechanisms and predictors of mitral regurgitation after high-risk myocardial infarction

Meris, Alessandra, Amigoni, Maria, Verma, Anil, Thune, Jens Jakob, Kober, Lars, Velazquez, Eric J., McMurray, John, Pfeffer, Marc A., Califf, Robert M., Levine, Robert A. and Solomon, Scott. (2012). Mechanisms and predictors of mitral regurgitation after high-risk myocardial infarction. Journal of the American Society of Echocardiography. 25(5), pp. 535 - 542. https://doi.org/10.1016/j.echo.2012.01.006

Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: Integrating evidence into clinical practice

Zannad, Faiez, Stough, Wendy Gattis, Rossignol, Patrick, Bauersachs, Johann, McMurray, John J. V., Swedberg, Karl, Struthers, Allan D., Voors, Adriaan A., Ruilope, Luis Miguel, Bakris, George L., O'Connor, Christopher M., Gheorghiade, Mihai, Mentz, Robert J., Cohen-Solal, Alain, Maggioni, Aldo Pietro, Beygui, Farzin, Filippatos, Gerasimos S., Massy, Ziad A., Pathak, Atul, ... Pitt, Bertram. (2012). Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: Integrating evidence into clinical practice. European Heart Journal. 33(22), pp. 2782 - 2795. https://doi.org/10.1093/eurheartj/ehs257

Troponin i in acute decompensated heart failure: Insights from the ASCEND-HF study

Felker, G. Michael, Hasselblad, Vic, Tang, W. H. Wilson, Hernandez, Adrian F., Armstrong, Paul W., Fonarow, Gregg C., Voors, Adriaan A., Metra, Marco, McMurray, John J. V., Butler, Javed, Heizer, Gretchen M., Dickstein, Kenneth, Massie, Barry M., Atar, Dan, Troughton, Richard W., Anker, Stefan D., Califf, Robert M., Starling, Randall C. and O'Connor, Christopher M.. (2012). Troponin i in acute decompensated heart failure: Insights from the ASCEND-HF study. European Journal of Heart Failure. 14(11), pp. 1257 - 1264. https://doi.org/10.1093/eurjhf/hfs110

Heart failure in 2011: Heart failure therapy - Technology to the fore

McMurray, John J. V.. (2012). Heart failure in 2011: Heart failure therapy - Technology to the fore. Nature Reviews Cardiology. 9(2), pp. 73 - 74. https://doi.org/10.1038/nrcardio.2011.212

Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology

Broch, Kaspar, Ueland, Thor, Nymo, Ståle H., Kjekshus, John, Hulthe, Johannes, Muntendam, Pieter, McMurray, John J. V., Wikstrand, John, Cleland, John G. F., Aukrust, Pål and Gullestad, Lars. (2012). Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology. European Journal of Heart Failure. 14(3), pp. 268 - 277. https://doi.org/10.1093/eurjhf/hfs006

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans

Seed, Alison, Kuc, Rhoda E., Maguire, Janet J., Hillier, Christopher, Johnston, Fiona, Essers, Hans, de Voogd, Hanka J., McMurray, John and Davenport, Anthony P.. (2012). The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sciences. 91(13-14), pp. 743 - 748. https://doi.org/10.1016/j.lfs.2012.03.022

Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE)

Parving, Hans Henrik, Brenner, Barry M., McMurray, John J.V., de Zeeuw, Dick, Haffner, Steven M., Solomon, Scott D., Chaturvedi, Nish, Persson, Frederik, Nicolaides, Maria, Richard, Alexia, Xiang, Zhihua, Armbrecht, Juergen and Pfeffer, Marc A.. (2012). Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE). Journal of the Renin-Angiotensin-Aldosterone System. 13(3), pp. 387 - 393. https://doi.org/10.1177/1470320311434818

Effects of dalcetrapib in patients with a recent acute coronary syndrome

Schwartz, Gregory G., Olsson, Anders G., Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J. V., Mundl, Hardi, Nicholls, Stephen J., Shah, Prediman K., Tardif, Jean Claude and Wright, R. Scott. (2012). Effects of dalcetrapib in patients with a recent acute coronary syndrome. New England Journal of Medicine. 367(22), pp. 2089 - 2099. https://doi.org/10.1056/NEJMoa1206797

Gender and survival in patients with heart failure: Interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis

Martinez-Selles, Manuel, Doughty, Robert N., Poppe, Katrina K., Whalley, Gillian A., Tribouilloy, Christophe, McMurray, John J. V., Swedberg, Karl, Kober, Lars, Berry, Colin and Squire, Iain. (2012). Gender and survival in patients with heart failure: Interactions with diabetes and aetiology. Results from the MAGGIC individual patient meta-analysis. European Journal of Heart Failure. 14(5), pp. 473 - 479. https://doi.org/10.1093/eurjhf/hfs026

Thrombo-embolism and antithrombotic therapy for heart failure in sinus rhythm. A Joint Consensus Document from the ESC Heart Failure Association and the ESC Working Group on Thrombosis

Lip, Gregory Y. H., Ponikowski, Piotr P., Andreotti, Felicita, Anker, Stefan D., Filippatos, Gerasimos S., Homma, Shunichi, Morais, Joao, Pullicino, Patrick, Rasmussen, Lars H., Marin, Francisco, Lane, Deirdre A., McMurray, John J. V., Hoes, Arno W., Berg, Jurrien Ten, De Caterina, Raffaele, Kristensen, Steen and Zeymer, Uwe. (2012). Thrombo-embolism and antithrombotic therapy for heart failure in sinus rhythm. A Joint Consensus Document from the ESC Heart Failure Association and the ESC Working Group on Thrombosis. European Journal of Heart Failure. 14(7), pp. 681 - 695. https://doi.org/10.1093/eurjhf/hfs073

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012

McMurray, John J. V., Stamatis,, Anker, Stefen D., Auricchio, Angelo, Boḧm, Michael, Dickstein, Kenneth, Falk, Volkmar, Filippatos, Gerasimos, Fonseca, Cândida, Gomez-Sanchez, Miguel Angel, Jaarsma, Tiny, Køber, Lars, Lip, Gregory Y. H., Maggioni, Aldo Pietro, Parkhomenko, Alexander, Pieske, Burkert M., Popescu, Bogdan A., Rønnevik, K., Rutten, Frans H., ... Zeiher, Andreas. (2012). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. European Heart Journal. 33, pp. 1787 - 1847. https://doi.org/10.1093/eurheartj/ehs104b

Interleukin-21 - A biomarker of importance in predicting myocardial function following acute infarction?

Weir, Robin A. P., Miller, Ashley M., Petrie, Colin J., Clements, Suzanne, Steedman, Tracey, Dargie, Henry J., Squire, Iain B., Ng, Leong L., McInnes, Iain B. and McMurray, John J. V.. (2012). Interleukin-21 - A biomarker of importance in predicting myocardial function following acute infarction? Cytokine. 60(1), pp. 220 - 225. https://doi.org/10.1016/j.cyto.2012.06.002

Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: An observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial

Preiss, David, Thomas, Laine E., Sun, Jie-Lena, Haffner, Steven M., Holman, Rury R., Standl, Eberhard, Leiter, Lawrence A., Mazzone, Theodore, Rutten, Guy E., Tognoni, Gianni, Martinez, Felipe A., Chiang, Fu-Tien, Califf, Robert M. and McMurray, John J.. (2012). Predictors of cardiovascular events in a contemporary population with impaired glucose tolerance: An observational analysis of the Nateglinide and Valsartan in impaired glucose tolerance outcomes research (NAVIGATOR) trial. BMJ Open. 2(6), pp. 1 - 10. https://doi.org/10.1136/bmjopen-2012-001925

Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure

Jackson, Colette E., Myles, Rachel C., Tsorlalis, Ioannis K., Dalzell, Jonathan R., Spooner, Richard J., Rodgers, John R., Bezlyak, Vladimir, Greenlaw, Nicola, Ford, Ian, Cobbe, Stuart M., Petrie, Mark C. and McMurray, John J. V.. (2012). Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure. 14(4), pp. 377 - 386. https://doi.org/10.1093/eurjhf/hfs010

The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: Results from CORONA

Nymo, Ståle H., Ueland, Thor, Askevold, Erik Tandberg, Flo, T. H., Kjekshus, John, Hulthe, Johannes, Wikstrand, John, McMurray, John J. V., van Veldhuisen, Dirk J., Gullestad, Lars, Aukrust, Pål and Yndestad, Arne. (2012). The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: Results from CORONA. Journal of Internal Medicine. 271(5), pp. 436 - 443. https://doi.org/10.1111/j.1365-2796.2011.02503.x

Heart failure and socioeconomic status: Accumulating evidence of inequality

Hawkins, Nathaniel M., Jhund, Pardeep S., McMurray, John J. V. and Capewell, Simon. (2012). Heart failure and socioeconomic status: Accumulating evidence of inequality. European Journal of Heart Failure. 14(2), pp. 138 - 146. https://doi.org/10.1093/eurjhf/hfr168

Sex differences in clinical characteristics and outcomes in elderly patients with heart failure and preserved ejection fraction: The irbesartan in heart failure with preserved ejection fraction (I-PRESERVE) trial

Lam, Carolyn S. P., Carson, Peter E., Anand, Inder S., Rector, Thomas S., Kuskowski, Michael, Komajda, Michel, McKelvie, Robert, McMurray, John, Zile, Michael R., Massie, Barry M. and Kitzman, Dalane W.. (2012). Sex differences in clinical characteristics and outcomes in elderly patients with heart failure and preserved ejection fraction: The irbesartan in heart failure with preserved ejection fraction (I-PRESERVE) trial. Circulation: Heart Failure. 5(5), pp. 571 - 578. https://doi.org/10.1161/CIRCHEARTFAILURE.112.970061

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012

McMurray, John, Adamopoulos, Stamatis, Anker, Stefan D., Auricchio, Angelo, Bohm, Michael, Dickstein, Kenneth, Falk, Volkmar, Filippatos, Gerasimos S., Fonseca, Candida, Gomez-Sanchez, Miguel Angel, Jaarsma, Tiny, Kober, Lars, Lip, Gregory Y. H., Maggioni, Aldo Pietro, Parkhomenko, Alexander, Pieske, Burkert, Popescu, Bogdan A., Ronnevik, Per K., Rutten, Frans H., ... Ceconi, Claudio. (2012). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. European Journal of Heart Failure. 14(8), pp. 803 - 869. https://doi.org/10.1093/eurjhf/hfs105

Lipid-modifying therapies and risk of pancreatitis: A meta-analysis

Preiss, David, Tikkanen, Matti J., Welsh, Paul, Ford, Ian, Lovato, Laura C., Elam, Marshall B., LaRosa, John C., DeMicco, David A., Colhoun, Helen M., Goldenberg, Ilan, Murphy, Michael J., MacDonald, Thomas M., Pedersen, Terje R., Keech, Anthony C., Ridker, Paul M., Kjekshus, John, Sattar, Naveed and McMurray, John J.V.. (2012). Lipid-modifying therapies and risk of pancreatitis: A meta-analysis. Journal of the American Medical Association. 308(8), pp. 804 - 811. https://doi.org/10.1001/jama.2012.8439

Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)

Gullestad, Lars, Ueland, Thor, Kjekshus, John, Nymo, Ståle H., Hulthe, Johannes, Muntendam, Pieter, Adourian, Aram, Bohm, Michael, van Veldhuisen, Dirk J., Komajda, Michel, Cleland, John G. F., Wikstrand, John, McMurray, John J. V. and Aukrust, Pål. (2012). Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). European Heart Journal. 33(18), pp. 2290 - 2296. https://doi.org/10.1093/eurheartj/ehs077

Association of heart rate and outcomes in a broad spectrum of patients with chronic heart failure: Results from the CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and morbidity) program

Castagno, Davide, Skali, Hicham, Takeuchi, Madoka, Sweberg, Karl, Yusuf, Salim, Granger, Christopher B., Michelson, Eric L., Pfeffer, Marc A., McMurray, John J.V. and Solomon, Scott D.. (2012). Association of heart rate and outcomes in a broad spectrum of patients with chronic heart failure: Results from the CHARM (Candesartan in Heart Failure: Assessment of Reduction in Mortality and morbidity) program. Journal of the American College of Cardiology. 59(20), pp. 1785 - 1795. https://doi.org/10.1016/j.jacc.2011.12.044

Eplerenone and new-onset diabetes in patients with mild heart failure: Results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF)

Preiss, David, van Veldhuisen, Dirk J., Sattar, Naveed, Krum, Henry, Swedberg, Karl, Shi, Harry, Vincent, John, Pocock, Stuart J., Pitt, Bertram, Zannad, Faiez and McMurray, John J. V.. (2012). Eplerenone and new-onset diabetes in patients with mild heart failure: Results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). European Journal of Heart Failure. 14(8), pp. 909 - 915. https://doi.org/10.1093/eurjhf/hfs067

How small is too small? A systematic review of center volume and outcome after cardiac transplantation

Pettit, Stephen J., Jhund, Pardeep, Hawkins, Nathaniel M., Gardner, Roy S., Haj-Yahia, Saleem, McMurray, John and Petrie, Mark C.. (2012). How small is too small? A systematic review of center volume and outcome after cardiac transplantation. Circulation: Cardiovascular Quality and Outcomes. 5(6), pp. 783 - 790. https://doi.org/10.1161/CIRCOUTCOMES.112.966630

Cardiorenal end points in a trial of aliskiren for type 2 diabetes

Parving, Hans-Henrik, Brenner, Barry M., McMurray, John J. V., de Zeeuw, Dick, Haffner, Steven M., Solomon, Scott D., Chaturvedi, Nish, Persson, Frederik, Desai, Akshay S., Nicolaides, Maria, Richard, Alexia, Xiang, Zhihua, Brunel, Patrick and Pfeffer, Marc A.. (2012). Cardiorenal end points in a trial of aliskiren for type 2 diabetes. New England Journal of Medicine. 367(23), pp. 2204 - 2213. https://doi.org/10.1056/NEJMoa1208799

Assessment of dyspnea in acute decompensated heart failure: Insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) on the contributions of peak expiratory flow

Ezekowitz, Justin A., Hernandez, Adrian F., O'Connor, Christopher M., Starling, Randall C., Proulx, Guy, Weiss, Mason H., Bakal, Jeffery A., Califf, Robert M., McMurray, John J.V. and Armstrong, P. W.. (2012). Assessment of dyspnea in acute decompensated heart failure: Insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) on the contributions of peak expiratory flow. Journal of the American College of Cardiology. 59(16), pp. 1441 - 1448. https://doi.org/10.1016/j.jacc.2011.11.061

The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA)

Gullestad, Lars, Ueland, Thor, Kjekshus, John, Nymo, Ståle H., Hulthe, Johannes, Muntendam, Pieter, McMurray, John J.V., Wikstrand, John and Aukrust, Pål. (2012). The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). American Heart Journal. 164(6), pp. 878 - 883. https://doi.org/10.1016/j.ahj.2012.08.021

Left ventricular systolic and diastolic function, remodelling, and clinical outcomes among patients with diabetes following myocardial infarction and the influence of direct renin inhibition with aliskiren

Shah, Amil M., Shin, Sung Hee, Takeuchi, Madoka, Skali, Hicham, Desai, Akshay S., Kober, Lars, Maggioni, Aldo Pietro, Rouleau, Jean L., Kelly, Roxzana Y., Hester, Allen, Keefe, Deborah, McMurray, John J. V., Pfeffer, Marc A. and Solomon, Scott D.. (2012). Left ventricular systolic and diastolic function, remodelling, and clinical outcomes among patients with diabetes following myocardial infarction and the influence of direct renin inhibition with aliskiren. European Journal of Heart Failure. 14(2), pp. 185 - 192. https://doi.org/10.1093/eurjhf/hfr125

Kidney disease: Improving global outcomes (KDIGO) anemia work group. KDIGO clinical practice guideline for anemia in chronic kidney disease

McMurray, John, Parfrey, Patrick, Adamson, John W., Aljama, Pedro, Berns, Jeffrey S., Bohlius, Julia, Drüeke, Tilman B., Finkelstein, Fredric O., Fishbane, Steven, Ganz, Tomas, MacDougall, Iain C., McDonald, Ruth A., McMahon, Lawrence P., Obrador, Gregorio T., Strippoli, Giovanni F. M., Weiss, Günnter and Wi¿cek, Andrzej. (2012). Kidney disease: Improving global outcomes (KDIGO) anemia work group. KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney International Supplements. 2(4), pp. 279 - 335. https://doi.org/10.1038/kisup.2012.37

Time to move on from 'time-to-first': Should all events be included in the analysis of clinical trials?

Anker, Stefan D. and McMurray, John J. V.. (2012). Time to move on from 'time-to-first': Should all events be included in the analysis of clinical trials? European Heart Journal. 33(22), pp. 2764 - 2765. https://doi.org/10.1093/eurheartj/ehs277

Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction : findings from the I-PRESERVE trial

Anand, Inder S., Rector, Thomas S., Cleland, John GF, Kuskowski, Michael, McKelvie, Robert, Persson, Hans, McMurray, John, Zile, Michael R., Komajda, Michel, Massie, Barry M. and Carson, Peter E.. (2011). Prognostic value of baseline plasma amino-terminal pro-brain natriuretic peptide and its interactions with irbesartan treatment effects in patients with heart failure and preserved ejection fraction : findings from the I-PRESERVE trial. Circulation: Heart Failure. 4(5), pp. 569 - 577. https://doi.org/10.1161/CIRCHEARTFAILURE.111.962654

Clinical trials update AHA Congress 2010

Horowitz, John D., Rosenson, Robert S., McMurray, John J. V., Marx, Nikolaus and Remme, Willem J.. (2011). Clinical trials update AHA Congress 2010. Clinical Reports sessions of the American Heart Association Congress, 2010, Chicago.. United States of America: Springer, New York. pp. 69 - 76 https://doi.org/10.1007/s10557-011-6285-9

Intensive glycemic control has no impact on the risk of heart failure in type 2 diabetic patients: Evidence from a 37,229 patient meta-analysis

Castagno, Davide, Baird-Gunning, Jonathan, Jhund, Pardeep S., Biondi-Zoccai, Giuseppe, MacDonald, Michael R., Petrie, Mark C., Gaita, Fiorenzo and McMurray, John J.V. (2011). Intensive glycemic control has no impact on the risk of heart failure in type 2 diabetic patients: Evidence from a 37,229 patient meta-analysis. American Heart Journal. 162(5), pp. 938 - 948. https://doi.org/10.1016/j.ahj.2011.07.030

Effect of aliskiren in patients with heart failure according to background dose of ACE inhibitor: A retrospective analysis of the Aliskiren Observation of Heart Failure Treatment (ALOFT) trial

Sidik, Novalia P., Solomon, Scott D., Latini, Roberto, Maggioni, Aldo P., Wright, Melanie, Gimpelewicz, Claudio R., Pitt, Bertram and McMurray, John J.V.. (2011). Effect of aliskiren in patients with heart failure according to background dose of ACE inhibitor: A retrospective analysis of the Aliskiren Observation of Heart Failure Treatment (ALOFT) trial. Cardiovascular Drugs and Therapy. 25(4), pp. 315 - 321. https://doi.org/10.1007/s10557-011-6319-3

Relation of peripheral collagen markers to death and hospitalization in patients with heart failure and preserved ejection fraction : results of the I-PRESERVE collagen substudy

Krum, Henry, Elsik, Maros, Schneider, Hans G., Ptaszynska, Agata, Black, Marion, Carson, Peter E., Komajda, Michel, Massie, Barry, McKelvie, Robert, McMurray, John, Zile, Michael R. and Anand, Inder S.. (2011). Relation of peripheral collagen markers to death and hospitalization in patients with heart failure and preserved ejection fraction : results of the I-PRESERVE collagen substudy. Circulation: Heart Failure. 4(5), pp. 561 - 568. https://doi.org/10.1161/CIRCHEARTFAILURE.110.960716

Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD

Desai, Akshay S., Toto, Robert D., Jarolim, Petr, Uno, Hajime, Eckardt, Kai Uwe, Kewalramani, Reshma, Levey, Andrew S., Lewis, E. F., McMurray, John, Parving, Hans Henrik, Solomon, Scott and Pfeffer, Marc A.. (2011). Association between cardiac biomarkers and the development of ESRD in patients with type 2 diabetes mellitus, anemia, and CKD. American Journal of Kidney Diseases. 58(5), pp. 717 - 728. https://doi.org/10.1053/j.ajkd.2011.05.020

Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction

Thune, Jens Jakob, Signorovitch, James E., Kober, Lars, McMurray, John J. V., Swedberg, Karl, Rouleau, Jean L., Maggioni, Aldo Pietro, Velazquez, Eric J., Califf, Robert M., Pfeffer, Marc A. and Solomon, Scott D.. (2011). Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction. European Journal of Heart Failure. 13(2), pp. 148 - 153. https://doi.org/10.1093/eurjhf/hfq194

Focused Update Recommendation European Society of Cardiology instrumentation for use in heart failure therapy, 2010

Dickstein, Kenneth, Vardas, Panagiotis, Auricchio, Angelo, Daubert, Jean Claude, Linde, Cecilia, McMurray, John, Ponikowski, Piotr P., Priori, Silvia G., Sutton, Richard and van Veldhuisen, Dirk J.. (2011). Focused Update Recommendation European Society of Cardiology instrumentation for use in heart failure therapy, 2010. Cardiology Letters. 20(3), pp. 246 - 253.

Plasma TIMP-4 predicts left ventricular remodeling after acute myocardial infarction

Weir, Robin A. P., Clements, Suzanne, Steedman, Tracey, Dargie, Henry J., McMurray, John J. V., Squire, Iain B. and Ng, Leong L.. (2011). Plasma TIMP-4 predicts left ventricular remodeling after acute myocardial infarction. Journal of Cardiac Failure. 17(6), pp. 465 - 471. https://doi.org/10.1016/j.cardfail.2011.02.002

Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with darbepoetin alfa: The trial to reduce cardiovascular events with aranesp therapy (TREAT) experience

Skali, Hicham, Parving, Hans Henrik, Parfrey, Patrick, Burdmann, Emmanuel A., Lewis, E. F., Ivanovich, Peter, Keithi-Reddy, Sai Ram, McGill, Janet B., McMurray, John, Singh, Ajay K., Solomon, Scott, Uno, Hajime and Pfeffer, Marc A.. (2011). Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with darbepoetin alfa: The trial to reduce cardiovascular events with aranesp therapy (TREAT) experience. Circulation. 124(25), pp. 2903 - 2908. https://doi.org/10.1161/CIRCULATIONAHA.111.030411

Cardiac structure and function, remodeling, and clinical outcomes among patients with diabetes after myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both

Shah, Amil M., Hung, Chung-Lieh, Shin, Sung Hee, Skali, Hicham, Verma, Anil, Ghali, Jalal K., Kober, Lars, Velazquez, Eric J., Rouleau, Jean L., McMurray, John J.V., Pfeffer, Marc A. and Solomon, Scott D.. (2011). Cardiac structure and function, remodeling, and clinical outcomes among patients with diabetes after myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both. American Heart Journal. 162(4), pp. 685 - 691. https://doi.org/10.1016/j.ahj.2011.07.015

Darbepoetin Alfa impact on health status in diabetes patients with kidney disease: A randomized trial

Lewis, Eldrin F., Pfeffer, Marc A., Feng, Amy, Uno, Hajime, McMurray, John J. V., Toto, Robert D., Gandra, Shravanthi R., Solomon, Scott D., Moustafa, Moustafa, MacDougall, Iain C., Locatelli, Francesco and Parfrey, Patrick S.. (2011). Darbepoetin Alfa impact on health status in diabetes patients with kidney disease: A randomized trial. Clinical Journal of the American Society of Nephrology. 6(4), pp. 845 - 855. https://doi.org/10.2215/CJN.06450710

Incidence and prevalence of unrecognized myocardial infarction in people with diabetes: A substudy of the Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of glycemia in Diabetes (RECORD) study

Macdonald, Michael R., Petrie, Mark C., Home, Philip D., Komajda, Michel, Jones, Nigel P., Beck-Nielsen, Henning, Gomis, Ramon, Hanefeld, Markolf, Pocock, Stuart J., Curtis, Paula S. and McMurray, John J. V.. (2011). Incidence and prevalence of unrecognized myocardial infarction in people with diabetes: A substudy of the Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of glycemia in Diabetes (RECORD) study. Diabetes Care. 34(6), pp. 1394 - 1396. https://doi.org/10.2337/dc10-2398

Circumstances and outcomes of sudden unexpected death in patients with high-risk myocardial infarction: Implications for prevention

Ye, Siqin, Grunnert, Matthew, Thune, Jens Jakob, Stephenson, Kent M., Uno, Hajime, Finn, Peter V., McMurray, John J. V., Velazquez, Eric J., Califf, Robert, Pfeffer, Marc A. and Solomon, Scott D.. (2011). Circumstances and outcomes of sudden unexpected death in patients with high-risk myocardial infarction: Implications for prevention. Circulation. 123(23), pp. 2674 - 2680. https://doi.org/10.1161/CIRCULATIONAHA.110.990655

Associations of albuminuria in patients with chronic heart failure: Findings in the ALiskiren Observation of heart Failure Treatment study

Jackson, Colette E., Macdonald, Michael R., Petrie, Mark C., Solomon, Scott D., Pitt, Bertram, Latini, Roberto, Maggioni, Aldo Pietro, Smith, Beverly A., Prescott, Margaret F., Lewsey, Jim D. and McMurray, John J. V.. (2011). Associations of albuminuria in patients with chronic heart failure: Findings in the ALiskiren Observation of heart Failure Treatment study. European Journal of Heart Failure. 13(7), pp. 746 - 754. https://doi.org/10.1093/eurjhf/hfr031

Radiofrequency ablation for persistent atrial fibrillation in patients with advanced heart failure and severe left ventricular systolic dysfunction: A randomised controlled trial

Macdonald, Michael R., Connelly, Derek T., Hawkins, Nathaniel M., Steedman, Tracey, Payne, John, Shaw, Morag, Denvir, Martin, Bhagra, Sai, Small, Sandy, Martin, William, McMurray, John J. V. and Petrie, Mark C.. (2011). Radiofrequency ablation for persistent atrial fibrillation in patients with advanced heart failure and severe left ventricular systolic dysfunction: A randomised controlled trial. Heart. 97(9), pp. 740 - 747. https://doi.org/10.1136/hrt.2010.207340

ESC Guidelines on the diagnosis and treatment of peripheral artery diseases

Tendera, Michal, Aboyans, Victor, Bartelink, Marie-Louise, Baumgartner, Iris, Clement, Denis, Collet, Jean-Philippe, Cremonesi, Alberto, De Carlo, Marco, Erbel, Raimund, Fowkes, F. Gerry R., Heras, Magda, Kownator, Serge, Minar, Erich, Ostergren, Jan, Poldermans, Don, Riambau, Vincent, Roffi, Marco, Rother, Joachim, Sievert, Horst, ... Van Damme, Hendrik. (2011). ESC Guidelines on the diagnosis and treatment of peripheral artery diseases. European Heart Journal. 32(22), pp. 2851 - 2906. https://doi.org/10.1093/eurheartj/ehr211

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: A double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

Cleland, John G. F., Teerlink, John R., Senior, Roxy, Nifontov, Evgeny M., McMurray, John J. V., Lang, Chim C., Tsyrlin, Vitaly A., Greenberg, Barry H., Mayet, Jamil, Francis, Darrel P., Shaburishvili, Tamaz, Monaghan, Mark, Saltzberg, Mitchell, Neyses, Ludwig, Wasserman, Scott M., Lee, Jacqueline H., Saikali, Khalil G., Clarke, Cyril P., Goldman, Jonathan H., ... Malik, Fady I.. (2011). The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: A double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial. The Lancet. 378(9792), pp. 676 - 683. https://doi.org/10.1016/S0140-6736(11)61126-4

Effect of nesiritide in patients with acute decompensated heart failure

O'Connor, M., Starling, Randall C., Hernandez, Adrian F., Armstrong, P. W., Dickstein, Kenneth, Hasselblad, Vic, Heizer, Gretchen M., Komajda, Michel, Massie, Barrie M., McMurray, John J. V., Nieminen, Markku S., Reist, C. J., Rouleau, Jean L., Sweberg, Karl, Adams, Kirkwood F., Anker, Stefan D., Atar, Dan, Battler, A., Botero, R., ... Califf, R.M.. (2011). Effect of nesiritide in patients with acute decompensated heart failure. New England Journal of Medicine. 365, pp. 32 - 43. https://doi.org/10.1056/NEJMoa1100171

Neurohumoral effects of aliskiren in patients with symptomatic heart failure receiving a mineralocorticoid receptor antagonist: The Aliskiren Observation of Heart Failure Treatment study

Pitt, Bertram, Latini, Roberto, Maggioni, Aldo Pietro, Solomon, Scott D., Smith, Beverly A., Wright, Melanie, Prescott, Margaret F. and McMurray, John J. V.. (2011). Neurohumoral effects of aliskiren in patients with symptomatic heart failure receiving a mineralocorticoid receptor antagonist: The Aliskiren Observation of Heart Failure Treatment study. European Journal of Heart Failure. 13(7), pp. 755 - 764. https://doi.org/10.1093/eurjhf/hfr034

Eplerenone in patients with systolic heart failure and mild symptoms

Zannad, Faiez, McMurray, John J. V., Krum, Henry, van Veldhuisen, Dirk J., Swedberg, Karl, Shi, Harry, Vincent, John, Pocock, Stuart J. and Pitt, Bertram. (2011). Eplerenone in patients with systolic heart failure and mild symptoms. New England Journal of Medicine. 364(1), pp. 11 - 21. https://doi.org/10.1056/NEJMoa1009492

Aldosterone and cortisol predict medium-term left ventricular remodelling following myocardial infarction

Weir, Robin A. P., Tsorlalis, Ioannis K., Steedman, Tracey, Dargie, Henry J., Fraser, Robert, McMurray, John J. V. and Connell, John M. C.. (2011). Aldosterone and cortisol predict medium-term left ventricular remodelling following myocardial infarction. European Journal of Heart Failure. 13(12), pp. 1305 - 1313. https://doi.org/10.1093/eurjhf/hfr129

Self-care management of heart failure :Practical recommendations from the patient care committee of the heart failure association of the European society of cardiology

Lainscak, Mitja, Blue, Lynda, Andrew, Clark, Dahlstrom, Ulf, Dickstein, Kenneth, Ekman, Inger, McDonagh, Theresa, McMurray, J, Ryder, Mary, Stromberg, Anna and Jaarsma, Tiny. (2011). Self-care management of heart failure :Practical recommendations from the patient care committee of the heart failure association of the European society of cardiology. European Journal of Heart Failure. 13(2), pp. 115 - 126. https://doi.org/10.1093/eurjhf/hfq219

Heart failure and chronic obstructive pulmonary disease: The quandary of beta-blockers and beta-agonists

Hawkins, Nathaniel M., Petrie, Mark C., MacDonald, Michael R., Jhund, Pardeep S., Fabbri, Leonardo M., Wikstrand, John and McMurray, John J.V.. (2011). Heart failure and chronic obstructive pulmonary disease: The quandary of beta-blockers and beta-agonists. Journal of the American College of Cardiology. 57(21), pp. 2137 - 2138. https://doi.org/10.1016/j.jacc.2011.02.020

Incremental value of echocardiographic assessment beyond clinical evaluation for prediction of death and development of heart failure after high-risk myocardial infarction

Verma, Anil, Pfeffer, Marc A., Skali, Hicham, Rouleau, Jean, Maggioni, Aldo, McMurray, John J.V, Califf, Robert M., Velazquez, Eric J. and Solomon, Scott D.. (2011). Incremental value of echocardiographic assessment beyond clinical evaluation for prediction of death and development of heart failure after high-risk myocardial infarction. American Heart Journal. 161(6), pp. 1156 - 1162. https://doi.org/10.1016/j.ahj.2011.03.024

CONSENSUS to EMPHASIS: The overwhelming evidence which makes blockade of the reninangiotensinaldosterone system the cornerstone of therapy for systolic heart failure

McMurray, John J. V.. (2011). CONSENSUS to EMPHASIS: The overwhelming evidence which makes blockade of the reninangiotensinaldosterone system the cornerstone of therapy for systolic heart failure. European Journal of Heart Failure. 13(9), pp. 929 - 936. https://doi.org/10.1093/eurjhf/hfr093

Days alive and out of hospital and the patient journey in patients with heart failure: Insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program

Ariti, Cono A., Cleland, John G. F., Pocock, Stuart J., Pfeffer, Marc A., Swedberg, Karl, Granger, Christopher B., McMurray, John J.V., Michelson, Eric L., Ostergren, Jan and Yusuf, Salim. (2011). Days alive and out of hospital and the patient journey in patients with heart failure: Insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. American Heart Journal. 162(5), pp. 900 - 906. https://doi.org/10.1016/j.ahj.2011.08.003

Clinical development of pharmacologic agents for acute heart failure syndromes: A proposal for a mechanistic translational phase

Gheorghiade, Mihai, Pang, Peter S., O'Connor, Christopher M., Prasad, Krishna, McMurray, John, Teerlink, John R., Fiuzat, Mona, Sabbah, Hani and Komajda, Michel. (2011). Clinical development of pharmacologic agents for acute heart failure syndromes: A proposal for a mechanistic translational phase. American Heart Journal. 161(2), pp. 224 - 232. https://doi.org/10.1016/j.ahj.2010.10.023

Heart failure: Acute ischemic events in HF-should we include sudden death?

McMurray, John J. V.. (2011). Heart failure: Acute ischemic events in HF-should we include sudden death? Nature Reviews Cardiology. 8(4), pp. 192 - 193. https://doi.org/10.1038/nrcardio.2011.22

Apixaban versus warfarin in patients with atrial fibrillation

Granger, Christopher B., Alexander, John H., McMurray, John J. V., Lopes, Renato D., Hylek, Elaine M., Hanna, Michael, Al-Khalidi, Hussein R., Ansell, Jack, Atar, Dan, Avezum, Alvaro, Bahit, Maria Cecilia, Diaz, Rafael, Easton, J. Donald, Ezekowitz, Justin A., Flaker, Greg, Garcia, David, Geraldes, Margarida, Gersh, Bernard J., Golitsyn, Sergey, ... Wallentin, Lars. (2011). Apixaban versus warfarin in patients with atrial fibrillation. New England Journal of Medicine. 365(11), pp. 981 - 992. https://doi.org/10.1056/NEJMoa1107039

A systematic review of event rates in clinical trials in diabetes mellitus: The importance of quantifying baseline cardiovascular disease history and proteinuria and implications for clinical trial design

Preiss, David, Sattar, Naveed and McMurray, John J.. (2011). A systematic review of event rates in clinical trials in diabetes mellitus: The importance of quantifying baseline cardiovascular disease history and proteinuria and implications for clinical trial design. American Heart Journal. 161(1), pp. 210 - 219. https://doi.org/10.1016/j.ahj.2010.10.019

Predictors of fatal and nonfatal cardiovascular events in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia: An analysis of the Trial to Reduce cardiovascular Events with Aranesp (darbepoetin-alfa) Therapy (TREAT)

McMurray, John J.V., Uno, Hajime, Jarolim, Petr, Desai, Akshay S., de Zeeuw, D., Eckardt, Kai-Uwe, Ivanovich, Peter, Levey, Andrew S., Lewis, E. F., McGill, Janet B., Parfrey, Patrick, Parving, Hans-Henrik, Toto, Robert M., Solomon, Scott D. and Pfeffer, Marc A.. (2011). Predictors of fatal and nonfatal cardiovascular events in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia: An analysis of the Trial to Reduce cardiovascular Events with Aranesp (darbepoetin-alfa) Therapy (TREAT). American Heart Journal. 162(4), pp. 748 - 755. https://doi.org/10.1016/j.ahj.2011.07.016

Trends in incidence and in short term survival following a subarachnoid haemorrhage in Scotland, 1986 - 2005: A retrospective cohort study

Macpherson, Karen J., Lewsey, James D., Jhund, Pardeep S., Gillies, Michelle, Chalmers, Jim WT, Redpath, Adam, Briggs, Andrew, Walters, Matthew, Langhorne, Peter, Capewell, Simon, McMurray, John JV and MacIntyre, Kate. (2011). Trends in incidence and in short term survival following a subarachnoid haemorrhage in Scotland, 1986 - 2005: A retrospective cohort study. BMC Neurology. 11(38), pp. 1 - 7. https://doi.org/10.1186/1471-2377-11-38

Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction

Zile, Michael R., Gottdiener, John S., Hetzel, Scott J., McMurray, John, Komajda, Michel, McKelvie, Robert, Baicu, Catalin F., Massie, Barry M. and Carson, Peter E.. (2011). Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction. Circulation. 124(23), pp. 2491 - 2501. https://doi.org/10.1161/CIRCULATIONAHA.110.011031

The Heart failure and Optimal Outcomes from Pharmacy Study (HOOPS): Rationale, design, and baseline characteristics

Lowrie, Richard, Mair, Frances S., Greenlaw, Nicola, Forsyth, Paul, McConnachie, Alex, Richardson, Janice, Khan, Nina, Morrison, Deborah, Messow, Claudia-Martina, Rae, Brian and McMurray, John J. V.. (2011). The Heart failure and Optimal Outcomes from Pharmacy Study (HOOPS): Rationale, design, and baseline characteristics. European Journal of Heart Failure. 13(8), pp. 917 - 924. https://doi.org/10.1093/eurjhf/hfr083

Neurohormonal activation in acute heart failure: Results from VERITAS

Milo-Cotter, Olga, Cotter-Davison, Beth, Lombardi, Carlo, Sun, Hengrui, Bettari, Luca, Bugatti, Silvia, Rund, Michele, Metra, Marco, Kaluski, Edo, Kobrin, Isaac, Frey, Aline, Rainisio, Maurizio, McMurray, John J.V., Teerlink, John R. and Cotter-Davison, Gad. (2011). Neurohormonal activation in acute heart failure: Results from VERITAS. Cardiology. 119(2), pp. 96 - 105. https://doi.org/10.1159/000330409

Heart failure: Not enough pump iron?

McMurray, John J. V. and Ponikowski, Piotr P.. (2011). Heart failure: Not enough pump iron? Journal of the American College of Cardiology. 58(5), pp. 481 - 482. https://doi.org/10.1016/j.jacc.2011.02.066

Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

Solomon, Scott D., Shin, Sung Hee, Shah, Amil, Skali, Hicham, Desai, Akshay S., Kober, Lars, Maggioni, Aldo Pietro, Rouleau, Jean L., Kelly, Roxzana Y., Hester, Allen, McMurray, John J. V. and Pfeffer, Marc A.. (2011). Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. European Heart Journal. 32(10), pp. 1227 - 1234. https://doi.org/10.1093/eurheartj/ehq522

Evaluation of the functional status questionnaire in heart failure: A sub-study of the second Cardiac Insufficiency Bisoprolol Survival Study (CIBIS-II)

Gallanagh, Siobhan, Castagno, Davide, Wilson, Ben, Erdmann, Erland, Zannad, Faiez, Remme, Willem J., Lopez-Sendon, Jose L., Lechat, Philippe, Follath, Ferenc, Höglund, Christer, Mareev, Viacheslav, Sadowski, Zygmunt, Seabra-Gomes, Ricardo J., Dargie, Henry J. and McMurray, John J.V.. (2011). Evaluation of the functional status questionnaire in heart failure: A sub-study of the second Cardiac Insufficiency Bisoprolol Survival Study (CIBIS-II). Cardiovascular Drugs and Therapy. 25(1), pp. 77 - 85. https://doi.org/10.1007/s10557-011-6284-x

Calcium handling in the failing heart and SUMO -Weighing the evidence

McMurray, John J. V. and Smith, Godfrey L.. (2011). Calcium handling in the failing heart and SUMO -Weighing the evidence. New England Journal of Medicine. 365(18), pp. 1738 - 1739. https://doi.org/10.1056/NEJMcibr1110758

Factors associated with outcome in heart failure with preserved ejection fraction : Findings from the Irbesartan in heart failure with preserved ejection fraction study (I-PRESERVE)

Komajda, Michel, Carson, Peter E., Hetzel, Scott J., McKelvie, Robert, McMurray, John, Ptaszynska, Agata, Zile, Michael R., DeMets, David and Massie, Barry M.. (2011). Factors associated with outcome in heart failure with preserved ejection fraction : Findings from the Irbesartan in heart failure with preserved ejection fraction study (I-PRESERVE). Circulation: Heart Failure. 4(1), pp. 27 - 35. https://doi.org/10.1161/CIRCHEARTFAILURE.109.932996

Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: Rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study

Krum, Henry, Massie, Barry M., Abraham, William T., Dickstein, Kenneth, Kober, Lars, McMurray, John J. V., Desai, Ashkay, Gimpelewicz, Claudio, Kandra, Albert, Reimund, Bernard, Rattunde, Henning and Armbrecht, Juergen. (2011). Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: Rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study. European Journal of Heart Failure. 13(1), pp. 107 - 114. https://doi.org/10.1093/eurjhf/hfq212

What works in chronic care management: The case of heart failure

Sochalski, Julie, Jaarsma, Tiny, Krumholz, Harlan M., Laramee, Ann, McMurray, John J.V., Naylor, Mary D., Rich, Michael W., Riegel, Barbara and Stewart, Simon. (2009). What works in chronic care management: The case of heart failure. Health Affairs. 28(1), pp. 179 - 189. https://doi.org/10.1377/hlthaff.28.1.179

Long-term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003. A population study of 5.1 million people

Jhund, Pardeep S., MacIntyre, Kate, Simpson, Colin R., Lewsey, James D., Stewart, Simon, Redpath, Adam, Chalmers, James W.T., Capewell, Simon and McMurray, John J.V.. (2009). Long-term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003. A population study of 5.1 million people. Circulation. 119(4), pp. 515 - 523. https://doi.org/10.1161/CIRCULATIONAHA.108.812172

Predominance of heart failure in the heart of Soweto study cohort: Emerging challenges for urban African communities

Stewart, Simon, Wilkinson, David, Hansen, Craig, Vaghela, Vinesh, Mvungi, Robert, McMurray, John J. and Sliwa, Karen. (2008). Predominance of heart failure in the heart of Soweto study cohort: Emerging challenges for urban African communities. Circulation. 118(23), pp. 2360 - 2367. https://doi.org/10.1161/CIRCULATIONAHA.108.786244

Prognostic impact of pulmonary arterial hypertension: A population-based analysis

Carrington, Melinda Jane, Murphy, Niamh F., Strange, Geoff, Peacock, Andrew, McMurray, John J.V. and Stewart, Simon. (2008). Prognostic impact of pulmonary arterial hypertension: A population-based analysis. International Journal of Cardiology. 124(2), pp. 183 - 187. https://doi.org/10.1016/j.ijcard.2006.12.045

The complex nature of informal care in home-based heart failure management

Clark, Alexander Michael, Reid, Machar, Morrison, Caroline E., Capewell, Simon, Murdoch, David L. and McMurray, John J.. (2008). The complex nature of informal care in home-based heart failure management. Journal of Advanced Nursing. 61(4), pp. 373 - 383. https://doi.org/10.1111/j.1365-2648.2007.04527.x