Detection of motor changes in huntington's disease using dynamic causal modeling

Journal article


Minkova, Lora, Scheller, Elisa, Peter, Jessica, Abdulkadir, Ahmed, Kaller, Christoph P., Roos, Raymund A. C., Dürr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Kloppel, Stefan, Coleman, Allison J., Decolongon, J., Fan, M., Koren, T., Jauffret, Céline, Justo, Damian, Lehericy, Stephane, Nigaud, Kevin, Valabrègue, Romain, ... Mills, J.. (2015) Detection of motor changes in huntington's disease using dynamic causal modeling. Frontiers in Human Neuroscience. 9, pp. 1 - 13. https://doi.org/10.3389/fnhum.2015.00634
AuthorsMinkova, Lora, Scheller, Elisa, Peter, Jessica, Abdulkadir, Ahmed, Kaller, Christoph P., Roos, Raymund A. C., Dürr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Kloppel, Stefan, Coleman, Allison J., Decolongon, J., Fan, M., Koren, T., Jauffret, Céline, Justo, Damian, Lehericy, Stephane, Nigaud, Kevin, Valabrègue, Romain, Schoonderbeek, A., t'Hart, Ellen P., Crawford, H., Gregory, Sue, Hensman Moss, D., Johnson, Eileanoir, Read, Joy, Owen, Gail N., Papoutsi, Marina, Berna, C., Razi, Adeel, Rees, Gwyneth, Scahill, Rachael I., Craufurd, David I. O., Reilmann, R., Weber, Nathan, Stout, Julie C., Labuschagne, Izelle, Orth, M., Landwehrmeyer, G. Bernhard, Langbehn, Douglas R., Johnson, Hans, Long, Jane and Mills, J.
Abstract

Deficits in motor functioning are one of the hallmarks of Huntington's disease (HD), a genetically caused neurodegenerative disorder. We applied functional magnetic resonance imaging (fMRI) and dynamic causal modeling (DCM) to assess changes that occur with disease progression in the neural circuitry of key areas associated with executive and cognitive aspects of motor control. Seventy-seven healthy controls, 62 pre-symptomatic HD gene carriers (preHD), and 16 patients with manifest HD symptoms (earlyHD) performed a motor finger-tapping fMRI task with systematically varying speed and complexity. DCM was used to assess the causal interactions among seven pre-defined regions of interest, comprising primary motor cortex, supplementary motor area (SMA), dorsal premotor cortex, and superior parietal cortex. To capture heterogeneity among HD gene carriers, DCM parameters were entered into a hierarchical cluster analysis using Ward's method and squared Euclidian distance as a measure of similarity. After applying Bonferroni correction for the number of tests, DCM analysis revealed a group difference that was not present in the conventional fMRI analysis. We found an inhibitory effect of complexity on the connection from parietal to premotor areas in preHD, which became excitatory in earlyHD and correlated with putamen atrophy. While speed of finger movements did not modulate the connection from caudal to pre-SMA in controls and preHD, this connection became strongly negative in earlyHD. This second effect did not survive correction for multiple comparisons. Hierarchical clustering separated the gene mutation carriers into three clusters that also differed significantly between these two connections and thereby confirmed their relevance. DCM proved useful in identifying group differences that would have remained undetected by standard analyses and may aid in the investigation of between-subject heterogeneity.

KeywordsHuntington's disease; motor network; sequential finger tapping; fMRI; DCM; cluster analysis
Year2015
JournalFrontiers in Human Neuroscience
Journal citation9, pp. 1 - 13
PublisherFrontiers Media S.A.
ISSN1662-5161
Digital Object Identifier (DOI)https://doi.org/10.3389/fnhum.2015.00634
Scopus EID2-s2.0-84969325602
Open accessOpen access
Page range1 - 13
Research GroupSchool of Philosophy
Publisher's version
Additional information

Copyright © 2015 Minkova, Scheller, Peter, Abdulkadir, Kaller, Roos, Durr, Leavitt, Tabrizi, Klöppel and TrackOn-HD Investigators. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Place of publicationSwitzerland
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Crawford, Matthew R.. (2013) The Triumph of Pro-nicene Theology over Anti-Monarchian Exegesis: Cyril of Alexandria and Theodore of Heraclea on John 14.10-11. Journal of Early Christian Studies. 21(4), pp. 537 - 567. https://doi.org/10.1353/earl.2013.0047
Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease
Dumas, Eve M., Say, Miranda Julia, Jones, Rebecca D., Labuschagne, Izelle, O'Regan, Alison M., Hart, Ellen P., van den Bogaard, Simon J. A., Queller, Sarah, Justo, Damian, Coleman, Allison J., dar Santos, Rachelle C., Durr, Alexandra, Leavitt, Blair R., Tabrizi, Sarah J., Roos, Raymund A. C. and Stout, Julie C.. (2012) Visual working memory impairment in premanifest gene-carriers and early Huntington's Disease. Journal of Huntington's Disease. 1(1), pp. 97 - 106. https://doi.org/10.3233/JHD-2012-120010
Changing teachers' practice through critical reflection on pedagogy
Long, Janette. (2012) Changing teachers' practice through critical reflection on pedagogy. International Journal of Interdisciplinary Social Sciences. 6(4), pp. 145 - 159.
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Doug, Tabrizi, Sarah J. and Frost, Chris. (2012) Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
The role of partnerships in the delivery of transformational international service learning
Campbell, Matthew and Long, Jan. (2012) The role of partnerships in the delivery of transformational international service learning. In K E Zegwaard (Ed.). New Zealand Association for Cooperative Education 2012 Conference Proceedings - Nuturing Good Practice: Getting Stuck In Together. New Zealand: New Zealand Association for Cooperative Education. pp. 25 - 29
Collaborative partnerships and learning: Broadening the experiences for a community organization, school and pre-service teachers
Long, Janette and Campbell, Matthew. (2012) Collaborative partnerships and learning: Broadening the experiences for a community organization, school and pre-service teachers. Partnerships: a journal of service-learning and civic engagement. 3(2), pp. 99 - 119.
Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda, Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C., Nathan, Pradeep J. and Pradeep, . (2012) Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin. International Journal of Neuropsychopharmacology (print). 15(7), pp. 883 - 896. https://doi.org/10.1017/S1461145711001489
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Stout, Julie, Jones, Rebecca, Labuschagne, Izelle, O'Regan, Alison, Say, Miranda, Dumas, Eve, Queller, Sarah, Justo, Damian, Dar Santos, Rachelle, Coleman, Allison, Hart, Ellen, Durr, Alexandra, Leavitt, Blair, Roos, Raymund, Langbehn, Douglas, Tabrizi, Sarah J. and Frost, Chris. (2012) Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry. 83(7), pp. 687 - 694. https://doi.org/10.1136/jnnp-2011-301940
Teachers professional development and professional learning: An examination of the shift in meaning of these terms and practices
Long, Janette. (2012) Teachers professional development and professional learning: An examination of the shift in meaning of these terms and practices. Curriculum Perspectives. 32(1), pp. 45 - 49.
Critical analysis of teachers' practice in order to improve student learning outcomes: Quality teaching model
Long, Janette. (2011) Critical analysis of teachers' practice in order to improve student learning outcomes: Quality teaching model. International Journal of Knowledge, Culture and Change Management (print version). 11(1), pp. 73 - 91.
What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases
Labuschagne, Izelle, Castle, David and Rossell, Susan L.. (2011) What the cognitive deficits in body dysmorphic disorder tell us about the underlying neurobiology: An investigation of three cases. International Journal of Cognitive Therapy. 4(1), pp. 21 - 33. https://doi.org/10.1521/ijct.2011.4.1.21
Following the yellow brick road: Interdisciplinary practices in the land of oz
Long, Janette, Moran, Wendy and Harris, Joanne. (2010) Following the yellow brick road: Interdisciplinary practices in the land of oz. Issues in Integrative Studies: an interdisciplinary journal. 28(Special), pp. 28 - 68.
Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder
Labuschagne, Izelle, Phan, K. Luan, Wood, Amanda G., Angstadt, Mike, Chua, Phyllis, Heinrichs, Markus, Stout, Julie C. and Nathan, Pradeep. (2010) Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder. Neuropsychopharmacology. 35(12), pp. 2403 - 2413. https://doi.org/10.1038/npp.2010.123
Teacher educators respond to the New South Wales institute of teachers' professional teaching standards: A case study of a school-university partnership
Harris, Joanne, Moran, Wendy and Long, Janette. (2010) Teacher educators respond to the New South Wales institute of teachers' professional teaching standards: A case study of a school-university partnership. Journal of Catholic School Studies. 82(2), pp. 40 - 58.
Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation
Labuschagne, Izelle, Croft, Rodney, Phan, K. Luan and Nathan, Pradeep. (2010) Augmenting serotonin neurotransmission with citalopram modulates emotional expression decoding but not structural encoding of moderate intensity sad facial emotional stimuli: An event-related potential (ERP) investigation. Journal of Psychopharmacology. 24(8), pp. 1153 - 1164. https://doi.org/10.1177/0269881108097878
Executive function in body dysmorphic disorder
Dunai, Judith, Labuschagne, Izelle, Castle, David J., Kyrios, Michael and Rossell, Susan. (2010) Executive function in body dysmorphic disorder. Psychological Medicine. 40(9), pp. 1541 - 1548. https://doi.org/10.1017/S003329170999198X
The fatal attraction of mentoring: Mentoring for retention of beginning teachers
Long, Janette. (2010) The fatal attraction of mentoring: Mentoring for retention of beginning teachers. International Journal of Interdisciplinary Social Sciences. 5(2), pp. 265 - 274. https://doi.org/10.18848/1833-1882/CGP/v05i02/51560
An examination of delusional thinking and cognitive styles in body dysmorphic disorder
Labuschagne, Izelle, Castle, David J., Dunai, Judith, Kyrios, Michael and Rossell, Susan. (2010) An examination of delusional thinking and cognitive styles in body dysmorphic disorder. Australian and New Zealand Journal of Psychiatry. 44(8), pp. 706 - 712. https://doi.org/10.3109/00048671003671007
The Australian curriculum: The educational driver for change
Long, Janette. (2010) The Australian curriculum: The educational driver for change. Journal of Catholic School Studies. 82(1), pp. 69 - 79.
Teach our mob: Lessons learnt from an Aboriginal teacher education training program in Australia
Long, Janette and Labone, Elizabeth. (2010) Teach our mob: Lessons learnt from an Aboriginal teacher education training program in Australia. International Journal of Knowledge, Culture and Change Management. 10(5), pp. 21 - 34.
Insights into exploring scripture in the primary classroom: An evaluation of a religious education initiative
Long, Janette Adele, Nicholson, Marea Anne, Langford, Jenny and Hemmings, Maureen. (2009) Insights into exploring scripture in the primary classroom: An evaluation of a religious education initiative. Journal of Catholic School Studies.
Assisting beginning teachers and school communities to grow through extended and collaborative mentoring experiences
Long, Janette. (2009) Assisting beginning teachers and school communities to grow through extended and collaborative mentoring experiences. Mentoring and Tutoring: Partnership in Learning. 17(4), pp. 317 - 327. https://doi.org/10.1080/13611260903284390
Integrating professional teaching standards with teachers' professional learning
Long, Janette. (2009) Integrating professional teaching standards with teachers' professional learning. International Journal of Interdisciplinary Social Sciences. 4(3), pp. 85 - 95.
Evaluating broad based professional learning: A case study of a school system's implementation of quality teaching pedagogies
Long, Janette, Labone, Elizabeth and Nicholson, Marea. (2009) Evaluating broad based professional learning: A case study of a school system's implementation of quality teaching pedagogies. International Journal of Diversity in Organisations, Communities and Nations. 9(2), pp. 125 - 137.
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study
Kerestes, Rebecca, Labuschagne, Izelle, Croft, Rodney, O'Neill, Barry, Bhagwagar, Zubin M., Phan, K Luan and Nathan, Pradeep. (2009) Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: An event-related potential (ERP) study. Psychopharmacology. 202(4), pp. 621 - 634. https://doi.org/10.1007/s00213-008-1340-3
Pathways ventured, lessons learned: A sustained university-school partnership ten years on
Moran, Wendy, Harris, Joanne and Long, Janette. (2008) Pathways ventured, lessons learned: A sustained university-school partnership ten years on. Journal of Catholic School Studies. 80(2), pp. 63 - 77.
Enhanced teacher training through indigenous mentors: A program to improve Aboriginal educational outcomes
Long, Janette, Cavanagh, Paddy and Maskell, John. (2008) Enhanced teacher training through indigenous mentors: A program to improve Aboriginal educational outcomes. International Journal of Interdisciplinary Social Sciences. 3(4), pp. 7 - 16. https://doi.org/10.18848/1833-1882/CGP/v03i04/52577
Improving pre-graduate teachers' professional knowledge, practice and commitment :Evaluating a school-university collaboration
Harris, Jo-Anne Margaret, Moran, Wendy Kay, Long, Janette Adele and Ryan, Sophie. (2008) Improving pre-graduate teachers' professional knowledge, practice and commitment :Evaluating a school-university collaboration. In Peter L. Jeffery (Ed.). AARE 2007 International Education Research Conference Papers. Melbourne, Australia: Australian Association for Research in Education. pp. 1 - 21
Eyes wide open: Preservice teachers' reflection upon the culture and contexts of schools
Long, Janette, Moran, Wendy, Harris, Joanne and Ryan, Sophie. (2007) Eyes wide open: Preservice teachers' reflection upon the culture and contexts of schools. International Journal of Interdisciplinary Social Sciences. 2(2), pp. 171 - 177.
Primary religious education coordinators - going, going, gone!
Long, Janette and Hemmings, Maureen. (2007) Primary religious education coordinators - going, going, gone! Journal of Catholic School Studies. 78(1), pp. 38 - 50.
Teach our Mob :Meeting the challenge to making a difference
Long, Janette Adele, Cavanagh, Patrick and Nicholson, Marea Anne. (2007) Teach our Mob :Meeting the challenge to making a difference. In Michael Kompf (Ed.). ISATT 2007 - conference proceedings. St Catharines, Ontario,Canada: International Study Association on Teachers and Teaching. pp. 1 - 8
Balancing ideals with reality :universities and schools working together to bridge the gap
Ryan, Sophie, Long, Janette Adele, Harris, Jo-Anne Margaret and Moran, Wendy Kay. (2007) Balancing ideals with reality :universities and schools working together to bridge the gap. In Michael Kompf (Ed.). ISATT 2007 - conference proceedings. St Catherines, Ontario, Canada: International Study Association on Teachers and Teaching. pp. 1 - 13
The Teaching and Learning consortium :a field based model for preservice teacher education
White, Paul, Moran, Wendy Kay and Long, Janette Adele. (2006) The Teaching and Learning consortium :a field based model for preservice teacher education. In Ruth Jeffery, Elizabeth Wright and Rebecca Feldman (Ed.). Australian Association for Research in Education 2006 Conference Papers. Melbourne,Australia: Australian Association for Research in Education. pp. 1 - 9
Building community and professional capacity at the end of life: an evaluation of health promoting palliative care in the Australian Capital Territory (ACT)
Rosenberg, John and Mills, Jason. (2006) Building community and professional capacity at the end of life: an evaluation of health promoting palliative care in the Australian Capital Territory (ACT) [Dataset].
Where have all the religious educators gone?
Long, Janette Adele and Hemmings, Margaret. (2006) Where have all the religious educators gone? In Ruth Jeffery, Elizabeth Wright and Rebecca Feldman (Ed.). Australian Association for Research in Education 2006 Conference Papers. Victoria, Australia: Australian Association for Research in Education. pp. 1 - 12
Professional development and professional learning: What's the difference?
Long, Janette Adele. (2005) Professional development and professional learning: What's the difference? In J. Clarek and M. Maguire (Ed.). Challenges for the Profession: Perspectives and directions for teachers; teaching and teacher education. Sydney, Australia: International Study Association on Teachers and Teaching. pp. 15 - 22
From Vision to Reality :Capacity Building for System Change
Nicholson, Marea Anne, Long, Janette Adele and King, Michael. (2004) From Vision to Reality :Capacity Building for System Change. In Professor Tony d'Arbon (Ed.). Realising the Vision and Living the Reality; Issues and Challenges Facing Catholic Educational Leaders. Sydney,Australia: Australian Catholic University. pp. 1 - 11
Changing teacher education for a changing world
Moran, Wendy, Long, Janette and Nettle, Ted. (2002) Changing teacher education for a changing world. Catholic School Studies: A Journal of Catholic Education. 75(2), pp. 28 - 31.