Interventional strategies to combat muscle disuse atrophy in humans: Focus on neuromuscular electrical stimulation and dietary protein
Journal article
Dirks, Marlou L., Wall, Benjamin T. and van Loon, Luc. (2018). Interventional strategies to combat muscle disuse atrophy in humans: Focus on neuromuscular electrical stimulation and dietary protein. Journal of Applied Physiology. 125(3), pp. 850 - 861. https://doi.org/10.1152/japplphysiol.00985.2016
Authors | Dirks, Marlou L., Wall, Benjamin T. and van Loon, Luc |
---|---|
Abstract | Numerous situations, such as the recovery from illness or rehabilitation after injury, necessitate a period of muscle disuse in otherwise healthy individuals. Even a few days of immobilization or bed rest can lead to substantial loss of skeletal muscle tissue and compromise metabolic health. The decline in muscle mass is attributed largely to a decline in postabsorptive and postprandial muscle protein synthesis rates. Reintroduction of some level of muscle contraction by the application of neuromuscular electrical stimulation (NMES) can augment both postabsorptive and postprandial muscle protein synthesis rates and, as such, prevent or attenuate muscle loss during short-term disuse in various clinical populations. Whereas maintenance of habitual dietary protein consumption is a prerequisite for muscle mass maintenance, supplementing dietary protein above habitual intake levels does not prevent muscle loss during disuse in otherwise healthy humans. Combining the anabolic properties of physical activity (or surrogates) with appropriate nutritional support likely further increases the capacity to preserve skeletal muscle mass during a period of disuse. Therefore, effective interventional strategies to prevent or alleviate muscle disuse atrophy should include both exercise (mimetics) and appropriate nutritional support. |
Keywords | protein; neuromuscular electrical stimulation; protein balance; nutrition |
Year | 2018 |
Journal | Journal of Applied Physiology |
Journal citation | 125 (3), pp. 850 - 861 |
Publisher | American Physiological Society |
ISSN | 8750-7587 |
Digital Object Identifier (DOI) | https://doi.org/10.1152/japplphysiol.00985.2016 |
Scopus EID | 2-s2.0-85053834772 |
Page range | 850 - 861 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/88q72/interventional-strategies-to-combat-muscle-disuse-atrophy-in-humans-focus-on-neuromuscular-electrical-stimulation-and-dietary-protein
Restricted files
Publisher's version
94
total views0
total downloads1
views this month0
downloads this month