The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia

Journal article


Hui, Li, Zhang, Xuan, Huang, Xu Feng, Han, Mei, Fernandez, Francesca, Yu, Yaqin, Sun, ShiLong, Li, Wenjun, Chen, Da Chun, Xiu, Mei Hong, Kosten, Thomas R. and Zhang, Xiang Yang. (2012). The dopamine b-hydroxylase 19 bp insertion/deletion polymorphism was associated with first-episode but not medicated chronic schizophrenia. Journal of Psychiatric Research. 46(6), pp. 733 - 737. https://doi.org/10.1016/j.jpsychires.2012.02.016
AuthorsHui, Li, Zhang, Xuan, Huang, Xu Feng, Han, Mei, Fernandez, Francesca, Yu, Yaqin, Sun, ShiLong, Li, Wenjun, Chen, Da Chun, Xiu, Mei Hong, Kosten, Thomas R. and Zhang, Xiang Yang
Abstract

Background: Numerous studies report dysfunctional dopaminergic and noradrenergic neurotransmission in the pathogenesis of schizophrenia. Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline. Functional polymorphisms have been reported in the promoter region of DBH gene, including a 19 bp insertion/deletion polymorphism. The purpose of this study was to investigate whether there was an association between the functional polymorphism (DBH5′-Ins/Del) and schizophrenia in a Han Chinese population. Methods: This polymorphism was genotyped in 221 first-episode schizophrenics, 360 chronic schizophrenics and 318 healthy controls using a case-control design. We assessed their psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We showed that the DBH5′-Ins/Del deletion (Del) allelic and genotypic frequencies were significantly lower in controls than first-episode of schizophrenics (FES) (both p < 0.001), but controls were not different from chronic schizophrenics. Furthermore, the PANSS positive symptom and total scores were significantly higher in FES with the Del/Del genotype than those with Ins/Del and Ins/Ins genotypes (all p < 0.05). Conclusions: The DBH5′-Ins/Del polymorphism may play a role in susceptibility to the positive symptoms of FES and to these FES not progressing on to chronic schizophrenia.

Keywordsfirst-episode schizophrenia; chronic schizophrenia; case-control association; dopamine beta-hydroxylase polymorphism
Year2012
JournalJournal of Psychiatric Research
Journal citation46 (6), pp. 733 - 737
PublisherPergamon Press Ltd.
ISSN0022-3956
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jpsychires.2012.02.016
Scopus EID2-s2.0-84862791804
Page range733 - 737
Research GroupSchool of Behavioural and Health Sciences
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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