The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: A randomized controlled
Journal article
Hagstrom, Amanda D., Marshall, Paul W. M., Lonsdale, Chris, Papalia, Shona, Cheema, Birinder S., Toben, Catherine, Baune, Bernhard T., Fiatarone Singh, Maria A. and Green, Simon. (2016). The effect of resistance training on markers of immune function and inflammation in previously sedentary women recovering from breast cancer: A randomized controlled. Breast Cancer Research and Treatment. 155(3), pp. 471 - 482. https://doi.org/10.1007/s10549-016-3688-0
Authors | Hagstrom, Amanda D., Marshall, Paul W. M., Lonsdale, Chris, Papalia, Shona, Cheema, Birinder S., Toben, Catherine, Baune, Bernhard T., Fiatarone Singh, Maria A. and Green, Simon |
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Abstract | The purpose of this randomized controlled trial was to determine the effects of resistance training (RT) on markers of inflammation and immune function in breast cancer survivors. Thirty-nine breast cancer survivors were randomly assigned to a RT (n = 20) or control (n = 19) group. RT performed supervized exercise three times per week. Natural killer cell (NK) and natural killer T-cell (NKT) function, and markers of inflammation (serum TNF-α, IL-6, IL-10, and CRP) were measured before and after training. Changes in NK and NKT cell function were analyzed using ANCOVA, with the change score the dependent variable, and the baseline value of the same variable the covariate. Effect sizes (ES) were calculated via partial eta-squared. We found a significant reduction, and large associated ESs, in the RT group compared to the control group for change in NK cell expression of TNF-α (p = 0.005, ES = 0.21) and NKT cell expression of TNF-α (p = 0.04, ES = 0.12). No differences were observed in any serum marker. Significant improvements in all measurements of strength were found in RT compared to control (p < 0.001; large ESs ranging from 0.32 to 0.51). These data demonstrate that RT has a beneficial effect on the NK and NKT cell expression of TNF-α indicating that RT may be beneficial in improving the inflammatory profile in breast cancer survivors. |
Keywords | resistance training; immune function; inflammation; breast cancer survivors |
Year | 2016 |
Journal | Breast Cancer Research and Treatment |
Journal citation | 155 (3), pp. 471 - 482 |
Publisher | Springer New York LLC |
ISSN | 0167-6806 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s10549-016-3688-0 |
Scopus EID | 2-s2.0-84959121022 |
Page range | 471 - 482 |
Research Group | Institute for Positive Psychology and Education |
Publisher's version | File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/88ww8/the-effect-of-resistance-training-on-markers-of-immune-function-and-inflammation-in-previously-sedentary-women-recovering-from-breast-cancer-a-randomized-controlled
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