Body position modulates gastric emptying and affects the post-prandial rise in plasma amino acid concentrations following protein ingestion in humans

Journal article


Holwerda, Andrew M., Lenaerts, Kaatje, Bierau, Jörgen and van Loon, Luc J.C.. (2016). Body position modulates gastric emptying and affects the post-prandial rise in plasma amino acid concentrations following protein ingestion in humans. Nutrients. 8(4), pp. 1 - 11. https://doi.org/10.3390/nu8040221
AuthorsHolwerda, Andrew M., Lenaerts, Kaatje, Bierau, Jörgen and van Loon, Luc J.C.
Abstract

Dietary protein digestion and amino acid absorption kinetics determine the post-prandial muscle protein synthetic response. Body position may affect gastrointestinal function and modulate the post-prandial rise in plasma amino acid availability. We aimed to assess the impact of body position on gastric emptying rate and the post-prandial rise in plasma amino acid concentrations following ingestion of a single, meal-like amount of protein. In a randomized, cross-over design, eight healthy males (25 ± 2 years, 23.9 ± 0.8 kg·m−2) ingested 22 g protein and 1.5 g paracetamol (acetaminophen) in an upright seated position (control) and in a −20° head-down tilted position (inversion). Blood samples were collected during a 240-min post-prandial period and analyzed for paracetamol and plasma amino acid concentrations to assess gastric emptying rate and post-prandial amino acid availability, respectively. Peak plasma leucine concentrations were lower in the inversion compared with the control treatment (177 ± 15 vs. 236 ± 15 mmol·L−1, p < 0.05), which was accompanied by a lower plasma essential amino acid (EAA) response over 240 min (31,956 ± 6441 vs. 50,351 ± 4015 AU; p < 0.05). Peak plasma paracetamol concentrations were lower in the inversion vs. control treatment (5.8 ± 1.1 vs. 10.0 ± 0.6 mg·L−1, p < 0.05). Gastric emptying rate and post-prandial plasma amino acid availability are significantly decreased after protein ingestion in a head-down tilted position. Therefore, upright body positioning should be considered when aiming to augment post-prandial muscle protein accretion in both health and disease

Keywordsprotein; body position; digestion; gastric emptying
Year2016
JournalNutrients
Journal citation8 (4), pp. 1 - 11
PublisherMDPI AG
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu8040221
Scopus EID2-s2.0-84963782038
Page range1 - 11
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationSwitzerland
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