A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders
Journal article
Andrews, Jessica L. and Fernandez, Francesca Elizabeth. (2015). A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders. Neuroscience and Biobehavioral Reviews. 56, pp. 97 - 114. https://doi.org/10.1016/j.neubiorev.2015.06.009
Authors | Andrews, Jessica L. and Fernandez, Francesca Elizabeth |
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Abstract | Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of neuron and oligodendrocyte survival, neurite extension, axon regeneration, oligodendrocyte differentiation, axonal myelination and functional recovery; all processes highly implicated in numerous brain-related functions. Although playing a major role in developmental brain functions, the potential application of Lingo-1 as a therapeutic target for the treatment of neurological disorders has so far been under-estimated. A number of preclinical studies have shown that various methods of antagonizing Lingo-1 results in neuronal and oligodendroglial survival, axonal growth and remyelination; however to date literature has only detailed applications of Lingo-1 targeted therapeutics with a focus primarily on myelination disorders such as multiple sclerosis and spinal cord injury; omitting important information regarding Lingo-1 signaling co-factors. Here, we provide for the first time a complete and thorough review of the implications of Lingo-1 signaling in a wide range of neurological and psychiatric disorders, and critically examine its potential as a novel therapeutic target for these disorders. |
Keywords | lingo-1 signaling; gene expression; neurological pathologies; psychiatric disorders; therapeutic strategies |
Year | 2015 |
Journal | Neuroscience and Biobehavioral Reviews |
Journal citation | 56, pp. 97 - 114 |
Publisher | Pergamon Press |
ISSN | 0149-7634 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.neubiorev.2015.06.009 |
Page range | 97 - 114 |
Research Group | School of Behavioural and Health Sciences |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/88yw2/a-decade-from-discovery-to-therapy-lingo-1-the-dark-horse-in-neurological-and-psychiatric-disorders
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