Thrombolysis ImPlementation in Stroke (TIPS) : Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care

Journal article


Paul, Christine L., Levi, Christopher R., D'Este, Catherine, Parsons, Mark W., Bladin, Christopher F., Lindley, Richard I., Attia, John R., Henskens, Frans, Lalor, Erin, Longworth, Mark, Middleton, Sandy, Ryan, Annika, Kerr, Erin and Sanson-Fisher, Robert W. 2014. Thrombolysis ImPlementation in Stroke (TIPS) : Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care. Implementation Science. 9 (38), pp. 1 - 13. https://doi.org/10.1186/1748-5908-9-38
AuthorsPaul, Christine L., Levi, Christopher R., D'Este, Catherine, Parsons, Mark W., Bladin, Christopher F., Lindley, Richard I., Attia, John R., Henskens, Frans, Lalor, Erin, Longworth, Mark, Middleton, Sandy, Ryan, Annika, Kerr, Erin and Sanson-Fisher, Robert W.
Abstract

Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke. Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months. Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mRS

Year2014
JournalImplementation Science
Journal citation9 (38), pp. 1 - 13
PublisherBiomed Central Ltd
ISSN1748-5908
Digital Object Identifier (DOI)https://doi.org/10.1186/1748-5908-9-38
Web address (URL)http://dx.doi.org/10.1186/1748-5908-9-38
Open accessOpen access
Page range1 - 13
Research GroupNursing Research Institute
Publisher's version
License
Grant IDnhmrc/569328
Place of publicationUnited Kingdom
EditorsA. Sales
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https://acuresearchbank.acu.edu.au/item/88z13/thrombolysis-implementation-in-stroke-tips-evaluating-the-effectiveness-of-a-strategy-to-increase-the-adoption-of-best-evidence-practice-protocol-for-a-cluster-randomised-controlled-trial-in-acute

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