The exposome in practice: design of the EXPOsOMICS project
Journal article
Vineis, Paolo, Chadeau-Hyam, Marc, Gmuender, H., Gulliver, John, Herceg, Z., Kleinjans, J., Kogevinas, Manolis, Kyrtopoulos, Soterios, Nieuwenhuijsen, Mark, Phillips, David H., Probst-Hensch, Nicole, Scalbert, A., Vermeulen, Roel and Wild, Christopher. (2017). The exposome in practice: design of the EXPOsOMICS project. International Journal of Hygiene and Environmental Health. 220(2), pp. 142 - 151. https://doi.org/10.1016/j.ijheh.2016.08.001
Authors | Vineis, Paolo, Chadeau-Hyam, Marc, Gmuender, H., Gulliver, John, Herceg, Z., Kleinjans, J., Kogevinas, Manolis, Kyrtopoulos, Soterios, Nieuwenhuijsen, Mark, Phillips, David H., Probst-Hensch, Nicole, Scalbert, A., Vermeulen, Roel and Wild, Christopher |
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Abstract | EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple “omic” technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of “next generation exposure assessment” for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as ‘exposome-wide association studies’ (EWAS). |
Year | 2017 |
Journal | International Journal of Hygiene and Environmental Health |
Journal citation | 220 (2), pp. 142 - 151 |
Publisher | Elsevier GmbH - Urban und Fischer |
ISSN | 1438-4639 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.ijheh.2016.08.001 |
Scopus EID | 2-s2.0-84994468982 |
Open access | Open access |
Page range | 142 - 151 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | License |
Place of publication | Germany |
Editors | A. Calafat and H. Koch |
https://acuresearchbank.acu.edu.au/item/88zqq/the-exposome-in-practice-design-of-the-exposomics-project
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