Inflammatory biomarkers as risk factors for future atrial fibrillation. An eleven-year follow-up of 6315 men and women: The Tromso Study

Journal article


Nyrnes, Audhild, Njolstad, I., Mathiesen, E. B., Wilsgaard, Tom, Hansen, John-Bjarne, Skjelbakken, Tove, Jorgensen, Lone and Loechen, Maja-Lisa. (2012). Inflammatory biomarkers as risk factors for future atrial fibrillation. An eleven-year follow-up of 6315 men and women: The Tromso Study. Gender Medicine. 9(6), pp. 536 - 547. https://doi.org/10.1016/j.genm.2012.09.001
AuthorsNyrnes, Audhild, Njolstad, I., Mathiesen, E. B., Wilsgaard, Tom, Hansen, John-Bjarne, Skjelbakken, Tove, Jorgensen, Lone and Loechen, Maja-Lisa
Abstract

Background Inflammatory biomarkers are reported as risk factors for atrial fibrillation (AF), but their impact is uncertain. Objective We investigated the associations between inflammatory biomarkers and future AF in a large general cohort. Methods Available markers were white blood cells (WBCs) with subgroups, fibrinogen, high-sensitivity C-reactive protein (hs-CRP), and osteoprotegerin (OPG). A total of 6315 men and women from a population survey in Tromsø, Norway in 1994 to 1995 were followed for a mean of 10.9 years. Mean age at baseline was 60 years. Measurements of height, weight, blood pressure, heart rate, total cholesterol, high-density lipoprotein (HDL) cholesterol, WBC count, and information on diabetes, angina, myocardial infarction, and antihypertensive treatment, were obtained at baseline. Fibrinogen, hs-CRP, and OPG were obtained at a follow-up visit. The outcome measure was first-ever AF, documented on an electrocardiogram. The Cox proportional hazards regression model was used to estimate hazard ratios of AF. Results In the multivariable analysis, adjusted for traditional cardiovascular risk factors and other inflammatory biomarkers, hs-CRP was associated with AF in men only (hazard ratio = 1.14 for a 1 SD increase; 95% CI, 1.02–1.28). There was a significant increase in AF across quartiles of WBCs in men (P = 0.007) and in the total study population (P = 0.004). OPG was associated with AF in patients free of coronary heart disease at baseline. Fibrinogen and subgroups of WBCs showed no significant association with AF. Conclusion This population-based cohort study showed that hs-CRP was independently associated with AF in men, but apparently not in women, and that patients with WBCs in the upper quartile had increased risk of AF.

Keywordsatrial fibrillation; cohort study; gender; inflammation; risk factors
Year2012
JournalGender Medicine
Journal citation9 (6), pp. 536 - 547
PublisherExcerpta Medica, Inc.
ISSN1550-8579
Digital Object Identifier (DOI)https://doi.org/10.1016/j.genm.2012.09.001
Scopus EID2-s2.0-84870558451
Page range536 - 547
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States
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