Impact of denosumab on the peripheral skeleton of postmenopausal women with osteoporosis: Bone density, mass, and strength of the radius, and wrist fracture

Journal article


Simon, James A., Recknor, Christopher, Moffett, Alfred H., Adachi, Jonathan D., Franek, Edward, Lewiecki, E. Michael, McClung, Michael R., Mautalen, Carlos A., Ragi-Eis, Sergio, Nicholson, Geoffrey Charles, Muschitz, Christian, Nuti, Ranuccio, Torring, Ove, Wang, Andrea and Libanati, Cesar 2013. Impact of denosumab on the peripheral skeleton of postmenopausal women with osteoporosis: Bone density, mass, and strength of the radius, and wrist fracture. Menopause. 20 (2), pp. 130 - 137. https://doi.org/10.1097/gme.0b013e318267f909
AuthorsSimon, James A., Recknor, Christopher, Moffett, Alfred H., Adachi, Jonathan D., Franek, Edward, Lewiecki, E. Michael, McClung, Michael R., Mautalen, Carlos A., Ragi-Eis, Sergio, Nicholson, Geoffrey Charles, Muschitz, Christian, Nuti, Ranuccio, Torring, Ove, Wang, Andrea and Libanati, Cesar
Abstract

Objective: The aim of this study was to report the effects of denosumab on radius cortical and trabecular bone density, mass, and strength, and wrist fracture incidence in the FREEDOM (Fracture REduction Evaluation of Denosumab in Osteoporosis every 6 Months) study. Methods: In the FREEDOM study, postmenopausal women with osteoporosis (N = 7,808) received placebo or 60 mg of denosumab every 6 months for 36 months. Radius bone mineral density (BMD), bone mineral content, and strength (polar moment of inertia) were evaluated in two prespecified substudies using dual-energy x-ray absorptiometry (placebo, n = 209; denosumab, n = 232) or quantitative CT (placebo, n = 48; denosumab, n = 62). Prespecified analysis assessed wrist fracture incidence in all FREEDOM participants (placebo, N = 3,906; denosumab, N = 3,902), and post hoc subgroup analyses evaluated those with higher fracture risk (baseline femoral neck T-score ≤−2.5; placebo, N = 1,406; denosumab, N = 1,384). Results: Denosumab significantly increased areal BMD (assessed by dual-energy x-ray absorptiometry) and volumetric BMD, bone mineral content, and polar moment of inertia (assessed by quantitative CT), compared with placebo, in radius cortical and trabecular bone at all time points evaluated (all P < 0.05). Wrist fracture incidence was 2.9% for placebo and 2.5% for denosumab (relative risk reduction, 16%; P = 0.21) on month 36. Participants with a femoral neck T-score of −2.5 or lower were at increased risk for wrist fracture, and denosumab significantly reduced wrist fracture incidence compared with placebo (placebo, 4.0%; denosumab, 2.4%; relative risk reduction, 40%; absolute risk reduction, 1.6%; P = 0.03). Conclusions: Denosumab significantly improves radius bone density, mass, and strength compared with placebo. In higher-risk women, denosumab significantly reduces wrist fracture risk.

Year2013
JournalMenopause
Journal citation20 (2), pp. 130 - 137
PublisherLippincott Williams & Wilkins Ltd.
ISSN1072-3714
Digital Object Identifier (DOI)https://doi.org/10.1097/gme.0b013e318267f909
Page range130 - 137
Research GroupInstitute for Health and Ageing
Place of publicationUnited States of America
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A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia''s Indigenous populations
Black, Emma B., Ranmuthugala, Geetha, Kondalsamy-Chennakesavan, Srinivas, Toombs, Maree R., Nicholson, Geoffrey C. and Kisely, Steve 2014. A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia''s Indigenous populations. Australian and New Zealand Journal of Psychiatry. 115 (5), pp. 518 - 524. https://doi.org/10.1177/0004867415569802
Bisphosphonate therapy for osteoporosis: Benefits, risks, and drug holiday
McClung, Michael R., Harris, Steven T., Miller, Paul D., Bauer, Doug C., Davison, K. Shawn, Dian, Larry, Hanley, David A., Kendler, David L., Yuen, Chui Kin and Lewiecki, E. Michael 2013. Bisphosphonate therapy for osteoporosis: Benefits, risks, and drug holiday. American Journal of Medicine. 126 (1), pp. 13 - 20. https://doi.org/10.1016/j.amjmed.2012.06.023
A novel monthly dosing regimen of risedronate for the treatment of postmenopausal Osteoporosis: 2-year data
McClung, Michael R., Benhamou, Claude-Laurent, Man, Zulema, Tlustochowicz, Witold, Zanchetta, Jose Ruben, Eusebio, Rachelle, Balske, Ana M., Matzkin, Ellen, Olszynski, Wojciech P., Recker, Robert R. and Delmas, Pierre D. 2013. A novel monthly dosing regimen of risedronate for the treatment of postmenopausal Osteoporosis: 2-year data. Calcified Tissue International. 92 (1), pp. 59 - 67. https://doi.org/10.1007/s00223-012-9668-4
Is high dose Vitamin D harmful?
Sanders, Kerrie, Nicholson, Geoffrey and Ebeling, Peter 2013. Is high dose Vitamin D harmful? Calcified Tissue International. 92 (2), pp. 191 - 206. https://doi.org/10.1007/s00223-012-9679-1
Calcaneal ultrasound reference ranges for Australian men and women: The Geelong Osteoporosis Study
Gould, Haslinda, Brennan, Sharon L., Nicholson, Geoffrey Charles, Kotowicz, Mark A., Henry, Margaret J. and Pasco, Julie A. 2013. Calcaneal ultrasound reference ranges for Australian men and women: The Geelong Osteoporosis Study. Osteoporosis International. 24 (4), pp. 1369 - 1377. https://doi.org/10.1007/s00198-012-2082-y
Efficacy and safety of risedronate 150-mg once a month in the treatment of postmenopausal osteoporosis: 2-year data
McClung, Michael R., Zanchetta, Jose Ruben, Racewicz, A., Roux, Christian, Benhamou, Claude-Laurent, Man, Zulema, Eusebio, Rachelle, Beary, J. F., Burgio, D.E., Matzkin, Ellen, Boonen, Steven and Delmas, P. D. 2013. Efficacy and safety of risedronate 150-mg once a month in the treatment of postmenopausal osteoporosis: 2-year data. Osteoporosis International. 24 (1), pp. 293 - 299. https://doi.org/10.1007/s00198-012-2056-0
Treatment of postmenopausal osteoporosis with delayed-release risedronate 35 mg weekly for 2 years
McClung, Michael R., Balske, Ana M., Burgio, D. E., Wenderoth, D. and Recker, Robert R. 2013. Treatment of postmenopausal osteoporosis with delayed-release risedronate 35 mg weekly for 2 years. Osteoporosis International. 24 (1), pp. 301 - 310. https://doi.org/10.1007/s00198-012-2175-7
Effects of pioglitazone on bone in postmenopausal women with impaired fasting glucose or impaired glucose tolerance: A randomized, double-Blind, placebo-controlled study
Bone, Henry G., Lindsay, Robert, McClung, Michael R., Perez, Alfonso T., Raanan, Marsha G. and Spanheimer, Robert G. 2013. Effects of pioglitazone on bone in postmenopausal women with impaired fasting glucose or impaired glucose tolerance: A randomized, double-Blind, placebo-controlled study. Journal of Clinical Endocrinology and Metabolism. 98 (12), pp. 4691 - 4701. https://doi.org/10.1210/jc.2012-4096
Controversies in osteoporosis management: Concerns about bisphosphonates and when are "drug holidays" required?
McClung, Michael R. 2013. Controversies in osteoporosis management: Concerns about bisphosphonates and when are "drug holidays" required? Clinical Obstetrics and Gynecology. 56 (4), pp. 743 - 748. https://doi.org/10.1097/GRF.0b013e3182a98295
Denosumab densitometric changes assessed by quantitative computed tomography at the spine and hip in postmenopausal women with osteoporosis
McClung, Michael R., Zanchetta, Jose Ruben, Høiseth, Arne, Kendler, David L., Yuen, Chui Kin, Brown, Jacques P., Stonkus, Sigtas, Goemaere, Stefan, Recknor, Christopher, Woodson, Grattan C., Bolognese, Michael A., Franek, Edward, Brandi, Maria Luisa, Wang, Andrea and Libanati, Cesar 2013. Denosumab densitometric changes assessed by quantitative computed tomography at the spine and hip in postmenopausal women with osteoporosis. Journal of Clinical Densitometry. 16 (2), pp. 250 - 256. https://doi.org/10.1016/j.jocd.2012.02.014
Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of a phase 2 clinical trial
McClung, Michael R., Lewiecki, E. Michael, Geller, M. L. and Bolognese, Michael A. 2013. Effect of denosumab on bone mineral density and biochemical markers of bone turnover: 8-year results of a phase 2 clinical trial. Osteoporosis International. 24 (1), pp. 227 - 235. https://doi.org/10.1007/s00198-012-2052-4
Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women
Gunardi, A. J., Brennan, Sharon L., Wang, Yuanyuan, Cicuttini, Flavia M., Pasco, Julie A., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Wluka, Anita E. 2013. Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women. International Journal of Obesity. 37 (12), pp. 1586 - 1589. https://doi.org/10.1038/ijo.2013.42
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
Zheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimäki, Terho, Bergström, Ulrica, Kähönen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lehtimäki, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, ... Lorentzon, Mattias 2012. WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genetics. 8 (7), pp. 1 - 13. https://doi.org/10.1371/journal.pgen.1002745
In Memoriam: Sergio Ragi-Eis, MD
McClung, Michael 2012. In Memoriam: Sergio Ragi-Eis, MD. Archives of Osteoporosis. 7 (43862), pp. 1 - 2. https://doi.org/10.1007/s11657-012-0081-4
Effect of denosumab treatment on the risk of fractures in subgroupsof women with postmenopausal osteoporosis
McClung, Michael R., Boonen, Steven, Torring, Ove, Roux, Christian, Rizzoli, Rene, Bone, Henry G., Benhamou, Claude-Laurent, Lems, Willem F., Minisola, Salvatore, Halse, Johan, Hoeck, Hans C., Eastell, Richard, Wang, Andrea, Siddhanti, Suresh and Cummings, Steven R. 2012. Effect of denosumab treatment on the risk of fractures in subgroupsof women with postmenopausal osteoporosis. Journal of Bone and Mineral Research. 27 (1), pp. 211 - 218. https://doi.org/10.1002/jbmr.536
In memoriam: Sergio Ragi-Eis, MD
McClung, Michael R. 2012. In memoriam: Sergio Ragi-Eis, MD. Journal of Clinical Densitometry. 23 (6), pp. 1651 - 1652. https://doi.org/10.1007/s00198-012-1980-3
Cross-sectional analysis of association between socioeconomic status and utilization of primary total hip joint replacements 2006-7: Australian Orthopaedic Association National Joint Replacement Registry
Brennan, Sharon L., Stanford, Tyman, Wluka, Anita E., Henry, Margaret J., Page, Richard S., Graves, Stephen E., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A. 2012. Cross-sectional analysis of association between socioeconomic status and utilization of primary total hip joint replacements 2006-7: Australian Orthopaedic Association National Joint Replacement Registry. BMC Musculoskeletal Disorders. 13 (63), pp. 63 - 69. https://doi.org/10.1186/1471-2474-13-63
Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women
Brennan, Sharon L., Cicuttini, Flavia M., Nicholson, Geoffrey Charles, Pasco, Julie A., Kotowicz, Mark A. and Wluka, Anita E. 2012. Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women. Annals of the Rheumatic Diseases. 71 (6), pp. 1000 - 1003. https://doi.org/10.1136/annrheumdis-2011-200957
Dietary selenium and major depression: A nested case-control study
Pasco, Julie A., Jacka, Felice N., Willia, Lana J., Evans-Cleverdon, Melinda, Brennan, Sharon L., Kotowicz, Mark A., Nicholson, Geoffrey Charles, Ball, Madeleine J. and Berk, Michael 2012. Dietary selenium and major depression: A nested case-control study. Complementary Therapies in Medicine. 20 (3), pp. 119 - 123. https://doi.org/10.1016/j.ctim.2011.12.008
Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: A systematic review
Brennan, Sharon, Wluka, Anita, Gould, Haslinda, Nicholson, Geoffrey, Leslie, William, Ebeling, Peter, Oldenburg, Brian, Kotowicz, Mark and Pasco, Julie 2012. Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: A systematic review. Journal of Clinical Densitometry. 15 (2), pp. 165 - 175. https://doi.org/10.1016/j.jocd.2011.12.005
In memoriam: Sergio Ragi-Eis, MD, CCD, CDT (April 8, 1962-February 22, 2012)
Bilezikian, John P., Zerbini, Cristiano, Lewiecki, E. Michael, Borges, Joao Lindolfo, Miller, Paul D., Hans, Didier, Camargos, Bruno Muzzi and McClung, Michael R. 2012. In memoriam: Sergio Ragi-Eis, MD, CCD, CDT (April 8, 1962-February 22, 2012). Osteoporosis International. 15 (3), pp. 257 - 259. https://doi.org/10.1016/j.jocd.2012.05.003
Revisiting the prevention of bone loss at menopause
McClung, Michael R. 2012. Revisiting the prevention of bone loss at menopause. Menopause. 19 (11), pp. 1173 - 1175. https://doi.org/10.1097/gme.0b013e318274fb1d
Utilisation of primary total knee joint replacements across socioeconomic status in the Barwon Statistical Division, Australia, 2006-2007: A cross-sectional study
Brennan, Sharon L., Stanford, Tyman, Wluka, Anita, Page, Richard S., Graves, Stephen E., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A. 2012. Utilisation of primary total knee joint replacements across socioeconomic status in the Barwon Statistical Division, Australia, 2006-2007: A cross-sectional study. BMJ Open. 2 (5), pp. 1 - 6. https://doi.org/10.1136/bmjopen-2012-001310
Femoral strength in osteoporotic women treated with teriparatide or alendronate
Keaveny, Tony M., McClung, Michael R., Wan, Xiaohai, Kopperdahl, David L., Mitlak, Bruce H. and Krohn, Kelly 2012. Femoral strength in osteoporotic women treated with teriparatide or alendronate. Bone. 50 (1), pp. 165 - 170. https://doi.org/10.1016/j.bone.2011.10.002
The epidemiology of the first wave of H1N1 influenza pandemic in Australia: A population-based study
Pasco, Julie A., Nicholson, Geoffrey Charles, Brennan, Sharon L., Bennett, Kathy E., Dobbins, Amelia Grace and Athan, Eugene 2012. The epidemiology of the first wave of H1N1 influenza pandemic in Australia: A population-based study. The Open Public Health Journal. 5, pp. 80 - 85. https://doi.org/10.2174/1874944501205010080
Prevalence of obesity and the relationship between the body mass index and body fat: Cross-sectional, population-based data
Pasco, Julie A., Nicholson, Geoffrey C., Brennan, Sharon L. and Kotowicz, Mark A. 2012. Prevalence of obesity and the relationship between the body mass index and body fat: Cross-sectional, population-based data. PLoS ONE. 7 (1), pp. 1 - 7. https://doi.org/10.1371/journal.pone.0029580
Incident hip fracture and social disadvantage in an Australian population aged 50 years or greater
Brennan, Sharon, Henry, Margaret, Kotowicz, Mark, Nicholson, Geoffrey, Zhang, Yu and Pasco, Julie 2011. Incident hip fracture and social disadvantage in an Australian population aged 50 years or greater. Bone. 48 (3), pp. 607 - 610. https://doi.org/10.1016/j.bone.2010.10.175
Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect
Eisman, John A., Bone, Henry G., Hosking, David J., McClung, Michael R., Reid, Ian R., Rizzoli, Rene, Resch, Heinrich, Verbruggen, Nadia, Hustad, Carolyn M., DaSilva, Carolyn, Petrovic, Romana, Santora, Arthur C., Ince, B. Avery and Lombardi, Antonio 2011. Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect. Journal of Bone and Mineral Research. 26 (2), pp. 242 - 251. https://doi.org/10.1002/jbmr.212
Fracture risk score and absolute risk of fracture
Henry, Margaret, Pasco, Julie, Merriman, Elizabeth, Zhang, Yu, Sanders, Kerrie, Kotowicz, Mark and Nicholson, Geoffrey 2011. Fracture risk score and absolute risk of fracture. Radiology. 259 (2), pp. 495 - 501. https://doi.org/10.1148/radiol.10101406
Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007
Pasco, Julie, Brennan, Sharon, Henry, Margaret, Nicholson, Geoffrey, Sanders, Kerrie, Zhang, Yu and Kotowicz, Mark 2011. Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007. Journal of Bone and Mineral Research. 26 (7), pp. 1648 - 1654. https://doi.org/10.1002/jbmr.393
Effects of denosumab on fracture and bone mineral density by level of kidney function
Jamal, Sophie A., Ljunggren, Östen, Stehman-Breen, Catherine, Cummings, Steven R., McClung, Michael R., Goemaere, Stefan, Ebeling, Peter R., Franek, Edward, Yang, Yu-ching, Egbuna, Ogo I., Boonen, Steven and Miller, Paul D. 2011. Effects of denosumab on fracture and bone mineral density by level of kidney function. Journal of Bone and Mineral Research. 26 (8), pp. 1829 - 1835. https://doi.org/10.1002/jbmr.403
Effects of denosumab on bone turnover markers in postmenopausal osteoporosis
Eastell, Richard, Christiansen, Claus, Grauer, Andreas, Kutilek, Stepan, Libanati, Cesar, McClung, Michael R., Reid, Ian R., Resch, Heinrich, Siris, Ethel, Uebelhart, Daniel, Wang, Andrea, Weryha, Georges and Cummings, Steven R. 2011. Effects of denosumab on bone turnover markers in postmenopausal osteoporosis. Journal of Bone and Mineral Research. 26 (3), pp. 530 - 537. https://doi.org/10.1002/jbmr.251
Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial
Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie, Nicholson, Geoffrey, Seibel, Markus, Salmon, Jo and Daly, Robin 2011. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial. Journal of Clinical Endocrinology and Metabolism. 96 (4), pp. 955 - 963. https://doi.org/10.1210/jc.2010-2284
Paracetamol (acetaminophen) use, fracture and bone mineral density
Williams, Lana, Pasco, Julie, Henry, Margaret, Sanders, Kerrie, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael 2011. Paracetamol (acetaminophen) use, fracture and bone mineral density. Bone. 48 (6), pp. 1277 - 1281. https://doi.org/10.1016/j.bone.2011.03.435
Osteoporosis update from the 2010 Santa Fe Bone Symposium
Lewiecki, E. Michael, Bilezikian, John P., Khosla, Sundeep, Marcus, Robert, McClung, Michael R., Miller, Paul D., Watts, Nelson B. and Maricic, Michael 2011. Osteoporosis update from the 2010 Santa Fe Bone Symposium. Journal of Clinical Densitometry. 14 (1), pp. 1 - 21. https://doi.org/10.1016/j.jocd.2010.12.001
Area-based socioeconomic status and mood disorders: Cross-sectional evidence from a cohort of randomly selected adult women
Williams, Lana, Brennan, Sharon, Henry, Margaret, Berk, Michael, Jacka, Felice, Nicholson, Geoffrey, Kotowicz, Mark and Pasco, Julie 2011. Area-based socioeconomic status and mood disorders: Cross-sectional evidence from a cohort of randomly selected adult women. Maturitas. 69 (2), pp. 173 - 178. https://doi.org/10.1016/j.maturitas.2011.03.015
Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk
Boonen, Steven, Adachi, Jonathan D., Man, Zulema, Cummings, Steven R., Lippuner, K., Torring, Ove, Gallagher, J.C., Farrerons, J., Wang, Andrea, Franchimont, N., San Martin, Javier, Grauer, Andreas and McClung, Michael R. 2011. Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk. Journal of Clinical Endocrinology and Metabolism. 96 (6), pp. 1727 - 1736. https://doi.org/10.1210/jc.2010-2784
Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: A need for international reference standards
Vasikaran, Samuel, Eastell, Richard, Bruyere, O., Foldes, A. J., Garnero, P., Griesmacher, Andrea, McClung, Michael R., Morris, Howard A., Silverman, S., Trenti, Tommaso, Wahl, D. A., Cooper, Cyrus and Kanis, John A. 2011. Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: A need for international reference standards. Osteoporosis International. 22 (2), pp. 391 - 420. https://doi.org/10.1007/s00198-010-1501-1
Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial
Sanders, Kerrie, Stuart, Amanda, Williamson, Elizabeth, Jacka, Felice, Dodd, Seetal, Nicholson, Geoff and Berk, Michael 2011. Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial. British Journal of Psychiatry. 198 (5), pp. 357 - 364. https://doi.org/10.1192/bjp.bp.110.087544
Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study
Brennan, Sharon, Pasco, Julie, Cicuttini, Flavia, Henry, Margaret, Kotowicz, Mark, Nicholson, Geoffrey and Wluka, Anita 2011. Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study. Bone. 49 (4), pp. 839 - 844. https://doi.org/10.1016/j.bone.2011.06.015
Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women
Cummings, Steven R., McClung, Michael R., Reginster, Jean-Yves, Cox, David, Mitlak, Bruce, Stock, John, Amewou-Atisso, Messan, Powles, Trevor, Miller, Paul, Zanchetta, Jose Ruben and Christiansen, Claus 2011. Arzoxifene for prevention of fractures and invasive breast cancer in postmenopausal women. Journal of Bone and Mineral Research. 26 (2), pp. 397 - 404. https://doi.org/10.1002/jbmr.191
Habitual physical activity and the risk for depressive and anxiety disorders among older men and women
Pasco, Julie, Williams, Lana, Jacka, Felice, Henry, Margaret, Coulson, Carolyn, Brennan, Sharon, Leslie, Eva, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael 2011. Habitual physical activity and the risk for depressive and anxiety disorders among older men and women. International Psychogeriatrics. 23 (2), pp. 292 - 298. https://doi.org/10.1017/S1041610210001833
Annual feedback is an effective tool for a sustained increase in calcium intake among older women
Sanders, Kerrie, Stuart, Amanda L., Kotowicz, Mark and Nicholson, Geoff 2010. Annual feedback is an effective tool for a sustained increase in calcium intake among older women. Nutrients. 2 (9), pp. 1018 - 1025. https://doi.org/10.3390/nu2091018
Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines
Coulson, Carolyn E., Williams, Lana J., Henry, Margaret, Berk, Michael, Lubman, Dan, Brennan-Olsen, Sharon, Nicholson, Geoff, Kotowicz, Mark, Korn, S and Pasco, Julie 2010. Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines. Australian and New Zealand Journal of Psychiatry. 44 (10), pp. 946 - 951. https://doi.org/10.3109/00048674.2010.495051
Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study
Brennan-Olsen, Sharon, Henry, Margaret, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie 2010. Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study. Journal of Men's Health. 7 (1), pp. 31 - 41. https://doi.org/10.1016/j.jomh.2009.10.004
Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?
Brennan-Olsen, Sharon, Cicuttini, Flavia, Pasco, Julie, Henry, Margaret, Wang, Yuanyuan, Kotowicz, Mark, Nicholson, Geoff and Wluka, Anita 2010. Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women? Arthritis Research and Therapy. 12 (4), pp. 1 - 7. https://doi.org/10.1186/ar3078
Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial
Sanders, Kerrie, Stuart, Amanda L., Williamson, Elizabeth J., Simpson, Julie A., Kotowicz, Mark, Young, Doris and Nicholson, Geoff 2010. Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA: Journal of the American Medical Association. 303 (18), pp. 1815 - 1822. https://doi.org/10.1001/jama.2010.594
Socioeconomic status and bone mineral density in a population-based sample of men
Brennan-Olsen, Sharon, Henry, Margaret, Wluka, Anita, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie 2010. Socioeconomic status and bone mineral density in a population-based sample of men. Bone. 46 (4), pp. 993 - 999. https://doi.org/10.1016/j.bone.2009.12.029