The effect of regular exercise on insulin sensitivity in type 2 diabetes mellitus: A systematic review and meta-analysis
Way, Kimberley L., Hackett, Daniel A., Baker, Michael Kevin and Johnson, Nathan A.. (2016) The effect of regular exercise on insulin sensitivity in type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes and Metabolism Journal. 40(4), pp. 253 - 269. https://doi.org/10.4093/dmj.2016.40.4.253
|Authors||Way, Kimberley L., Hackett, Daniel A., Baker, Michael Kevin and Johnson, Nathan A.|
The purpose of this study was to examine the effect of regular exercise training on insulin sensitivity in adults with type 2 diabetes mellitus ( T2DM ) using the pooled data available from randomised controlled trials. In addition, we sought to determine whether short-term periods of physical inactivity diminish the exercise-induced improvement in insulin sensitivity. Eligible trials included exercise interventions that involved ≥3 exercise sessions, and reported a dynamic measurement of insulin sensitivity. There was a significant pooled effect size ( ES ) for the effect of exercise on insulin sensitivity ( ES, –0.588; 95% confidence interval [CI], –0.816 to –0.359; P < 0.001 ). Of the 14 studies included for meta-analyses, nine studies reported the time of data collection from the last exercise bout. There was a significant improvement in insulin sensitivity in favour of exercise versus control between 48 and 72 hours after exercise ( ES, –0.702; 95% CI, –1.392 to –0.012; P=0.046 ); and this persisted when insulin sensitivity was measured more than 72 hours after the last exercise session ( ES, –0.890; 95% CI, –1.675 to –0.105; P=0.026 ). Regular exercise has a significant benefit on insulin sensitivity in adults with T2DM and this may persist beyond 72 hours after the last exercise session.
|Keywords||aerobic training; glucose tolerance test; hyperinsulinaemic euglycaemic clamp; insulin resistance; resistance training|
|Journal||Diabetes and Metabolism Journal|
|Journal citation||40 (4), pp. 253 - 269|
|Publisher||Korean Diabetes Association|
|Digital Object Identifier (DOI)||https://doi.org/10.4093/dmj.2016.40.4.253|
|Open access||Open access|
|Page range||253 - 269|
|Research Group||Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre|
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
|Place of publication||Korea, Republic of|
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