Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans
Journal article
Snijders, Tim, Nederveen, Joshua P., Verdijk, Lex B., Houben, Alfons J.H.M., Goossens, Gijs H., Parise, Gianna and Van Loon, Luc. (2017). Muscle fiber capillarization as determining factor on indices of insulin sensitivity in humans. Physiological Reports. 5(10), pp. 1 - 5. https://doi.org/10.14814/phy2.13278
Authors | Snijders, Tim, Nederveen, Joshua P., Verdijk, Lex B., Houben, Alfons J.H.M., Goossens, Gijs H., Parise, Gianna and Van Loon, Luc |
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Abstract | To investigate the association between muscle fiber capillarization and indices of insulin sensitivity in healthy older adults. A skeletal muscle biopsy was taken from the m. vastus lateralis of 22 healthy (nondiabetic) male older adults. In addition, all participants underwent an Oral Glucose Tolerance Test (OGTT). Muscle fiber capillarization was assessed by immunohistochemistry. Participants were divided into a group with relatively low (LOW) or high (HIGH) muscle fiber capillarization (capillary-to-fiber perimeter exchange (CFPE) index), based on the median value for the entire group. All participants were healthy, nonobese, and had a normal glucose tolerance, according to the individual OGTT results. Whereas no differences in blood glucose concentrations were observed between groups during the OGTT, the postprandial increase in plasma insulin concentrations was significantly greater in the LOW compared to the HIGH muscle fiber capillarizationgroup (P < 0.05). Skeletal muscle fiber capillarization may determine insulin sensitivity in humans. |
Keywords | ageing; oral glucose tolerance; skeletal muscle |
Year | 2017 |
Journal | Physiological Reports |
Journal citation | 5 (10), pp. 1 - 5 |
Publisher | John Wiley & Sons Ltd |
ISSN | 2051-817X |
Digital Object Identifier (DOI) | https://doi.org/10.14814/phy2.13278 |
Scopus EID | 2-s2.0-85020114675 |
Open access | Open access |
Page range | 1 - 5 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | License |
Place of publication | United Kingdom |
Editors | S. Wray |
https://acuresearchbank.acu.edu.au/item/896q8/muscle-fiber-capillarization-as-determining-factor-on-indices-of-insulin-sensitivity-in-humans
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Publisher's version
OA_Snijders_2017_Muscle_fiber_capillarization_as_determining_factor.pdf | |
License: CC BY 4.0 |
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