Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women : A cluster randomized controlled trial
Journal article
Daly, Robin, O'Connell, Stella, Mundell, Niamh, Grimes, Carley, Dunstan, David and Nowson, Caryl. (2014). Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women : A cluster randomized controlled trial. American Journal of Clinical Nutrition: A journal reporting the practical application of our world-wide knowledge of nutrition. 99(4), pp. 899 - 910. https://doi.org/10.3945/ajcn.113.064154
Authors | Daly, Robin, O'Connell, Stella, Mundell, Niamh, Grimes, Carley, Dunstan, David and Nowson, Caryl |
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Abstract | Background: Physical inactivity, inadequate dietary protein, and low-grade systemic inflammation contribute to age-related muscle loss, impaired function, and disability. Objective: We assessed the effects of progressive resistance training (PRT) combined with a protein-enriched diet facilitated through lean red meat on lean tissue mass (LTM), muscle size, strength and function, circulating inflammatory markers, blood pressure, and lipids in elderly women. Design: In a 4-mo cluster randomized controlled trial, 100 women aged 60–90 y who were residing in 15 retirement villages were allocated to receive PRT with lean red meat (∼160 g cooked) to be consumed 6 d/wk [resistance training plus lean red meat (RT+Meat) group; n = 53] or control PRT [1 serving pasta or rice/d; control resistance training (CRT) group; n = 47)]. All women undertook PRT 2 times/wk and received 1000 IU vitamin D3/d. Results: The mean (± SD) protein intake was greater in the RT+Meat group than in the CRT group throughout the study (1.3 ± 0.3 compared with 1.1 ± 0.3 g · kg−1 · d−1, respectively; P < 0.05). The RT+Meat group experienced greater gains in total body LTM (0.45 kg; 95% CI: 0.07, 0.84 kg), leg LTM (0.22 kg; 95% CI: 0.02, 0.42 kg), and muscle strength (18%; 95% CI: 0.03, 0.34) than did the CRT group (all P < 0.05). The RT+Meat group also experienced a 10% greater increase in serum insulin-like growth factor I (P < 0.05) and a 16% greater reduction in the proinflammatory marker interleukin-6 (IL-6) (P < 0.05) after 4 mo. There were no between-group differences for the change in blood lipids or blood pressure. Conclusion: A protein-enriched diet equivalent to ∼1.3 g · kg−1 · d−1 achieved through lean red meat is safe and effective for enhancing the effects of PRT on LTM and muscle strength and reducing circulating IL-6 concentrations in elderly women. This trial was registered at the Australian Clinical Trials Registry as ACTRN12609000223235. |
Year | 2014 |
Journal | American Journal of Clinical Nutrition: A journal reporting the practical application of our world-wide knowledge of nutrition |
Journal citation | 99 (4), pp. 899 - 910 |
ISSN | 0002-9165 |
Digital Object Identifier (DOI) | https://doi.org/10.3945/ajcn.113.064154 |
Page range | 899 - 910 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
https://acuresearchbank.acu.edu.au/item/89714/protein-enriched-diet-with-the-use-of-lean-red-meat-combined-with-progressive-resistance-training-enhances-lean-tissue-mass-and-muscle-strength-and-reduces-circulating-il-6-concentrations-in-elderly
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