The biochemistry of blister fluid from pediatric burn injuries: Proteomics and metabolomics aspects

Journal article


Zang, Tuo, Broszczak, Daniel A., Broadbent, James A., Cuttle, Leila, Lu, Haitao and Parker, Tony J.. (2016) The biochemistry of blister fluid from pediatric burn injuries: Proteomics and metabolomics aspects. Expert Review of Proteomics. 13(1), pp. 35 - 53. https://doi.org/10.1586/14789450.2016.1122528
AuthorsZang, Tuo, Broszczak, Daniel A., Broadbent, James A., Cuttle, Leila, Lu, Haitao and Parker, Tony J.
Abstract

Burn injury is a prevalent and traumatic event for pediatric patients. At present, the diagnosis of burn injury severity is subjective and lacks a clinically relevant quantitative measure. This is due in part to a lack of knowledge surrounding the biochemistry of burn injuries and that of blister fluid. A more complete understanding of the blister fluid biochemistry may open new avenues for diagnostic and prognostic development. Burn insult induces a highly complex network of signaling processes and numerous changes within various biochemical systems, which can ultimately be examined using proteome and metabolome measurements. This review reports on the current understanding of burn wound biochemistry and outlines a technical approach for ‘omics’ profiling of blister fluid from burn wounds of differing severity.

Keywordspediatric burns; proteomics; metabolomics; mass spectrometry; nuclear magnetic resonance; blister fluid
Year2016
JournalExpert Review of Proteomics
Journal citation13 (1), pp. 35 - 53
PublisherTaylor and Francis Ltd
ISSN1478-9450
Digital Object Identifier (DOI)https://doi.org/10.1586/14789450.2016.1122528
Scopus EID2-s2.0-84950162604
Page range35 - 53
Research GroupSchool of Behavioural and Health Sciences
Place of publicationUnited Kingdom
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