A fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: A potential marker of physical activity

Journal article


Parker, Tony J., Sampson, D. L., Broszczak, Daniel, Chng, Yee L., Carter, Shea L., Leavesley, David I., Parker, Anthony and Upton, Z.. (2012) A fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: A potential marker of physical activity. PLoS ONE. 7(3), pp. 1 - 12. https://doi.org/10.1371/journal.pone.0033714
AuthorsParker, Tony J., Sampson, D. L., Broszczak, Daniel, Chng, Yee L., Carter, Shea L., Leavesley, David I., Parker, Anthony and Upton, Z.
Abstract

Biomarker analysis has been implemented in sports research in an attempt to monitor the effects of exertion and fatigue in athletes. This study proposed that while such biomarkers may be useful for monitoring injury risk in workers, proteomic approaches might also be utilised to identify novel exertion or injury markers. We found that urinary urea and cortisol levels were significantly elevated in mining workers following a 12 hour overnight shift. These levels failed to return to baseline over 24 h in the more active maintenance crew compared to truck drivers (operators) suggesting a lack of recovery between shifts. Use of a SELDI-TOF MS approach to detect novel exertion or injury markers revealed a spectral feature which was associated with workers in both work categories who were engaged in higher levels of physical activity. This feature was identified as the LG3 peptide, a C-terminal fragment of the anti-angiogenic/anti-tumourigenic protein endorepellin. This finding suggests that urinary LG3 peptide may be a biomarker of physical activity. It is also possible that the activity mediated release of LG3/endorepellin into the circulation may represent a biological mechanism for the known inverse association between physical activity and cancer risk/survival.

Year2012
JournalPLoS ONE
Journal citation7 (3), pp. 1 - 12
PublisherPublic Library of Science
ISSN1932-6203
Digital Object Identifier (DOI)https://doi.org/10.1371/journal.pone.0033714
Scopus EID2-s2.0-84858771289
Open accessOpen access
Page range1 - 12
Research GroupSchool of Behavioural and Health Sciences
Publisher's version
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Place of publicationUnited States
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