Tobacco smoking in schizophrenia: Investigating the role of incentive salience

Journal article

Freeman, T. P., Stone, J. M., Orgaz, B., Noronha, L. A., Minchin, S. L. and Curran, H. V.. (2014). Tobacco smoking in schizophrenia: Investigating the role of incentive salience. Psychological Medicine. 44(10), pp. 2189 - 2197.
AuthorsFreeman, T. P., Stone, J. M., Orgaz, B., Noronha, L. A., Minchin, S. L. and Curran, H. V.

Background: Smoking is highly prevalent in people diagnosed with schizophrenia, but the reason for this co-morbidity is currently unclear. One possible explanation is that a common abnormality underpins the development of psychosis and independently enhances the incentive motivational properties of drugs and their associated cues. This study aimed to investigate whether incentive salience attribution towards smoking cues, as assessed by attentional bias, is heightened in schizophrenia and associated with delusions and hallucinations. Method: Twenty-two smokers diagnosed with schizophrenia and 23 control smokers were assessed for smoking-related attentional bias using a modified Stroop task. Craving, nicotine dependence, smoking behaviour and positive and negative symptoms of schizophrenia were also recorded. Results: Both groups showed similar craving scores and smoking behaviour according to self-report and expired carbon monoxide (CO), although the patient group had higher nicotine dependence scores. Attentional bias, as evidenced by significant interference from smoking-related words on the modified Stroop task, was similar in both groups and correlated with CO levels. Attentional bias was positively related to severity of delusions but not hallucinations or other symptoms in the schizophrenia group. Conclusions: This study supports the hypothesis that the development of delusions and the incentive motivational aspects of smoking may share a common biological substrate. These findings may offer some explanation for the elevated rates of smoking and other drug use in people with psychotic illness.

Keywordsaberrant salience; addiction; associative learning; attentional bias; delusions; dopamine; drug cue; incentive motivation; psychosis; smoking
JournalPsychological Medicine
Journal citation44 (10), pp. 2189 - 2197
PublisherCambridge University Press
Digital Object Identifier (DOI)
Scopus EID2-s2.0-84902277901
Page range2189 - 2197
Publisher's version
File Access Level
Place of publicationUnited Kingdom
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