High serum SHBG predicts incident vertebral fractures in elderly men

Journal article


Vandenput, Liesbeth, Mellström, Dan, Kindmark, Andreas, Johansson, Helena, Lorentzon, Mattias, Leung, Jason, Redlund-Johnell, Inga, Rosengren, Björn E., Karlsson, Magnus K., Wang, Yi-Xiang, Kwok, Timothy and Ohlsson, Claes. (2016) High serum SHBG predicts incident vertebral fractures in elderly men. Journal of Bone and Mineral Research. 31(3), pp. 683 - 689. https://doi.org/10.1002/jbmr.2718
AuthorsVandenput, Liesbeth, Mellström, Dan, Kindmark, Andreas, Johansson, Helena, Lorentzon, Mattias, Leung, Jason, Redlund-Johnell, Inga, Rosengren, Björn E., Karlsson, Magnus K., Wang, Yi-Xiang, Kwok, Timothy and Ohlsson, Claes
Abstract

Previous prospective cohort studies have shown that serum levels of sex steroids and sex hormone‐binding globulin (SHBG) associate with nonvertebral fracture risk in men. The predictive value of sex hormones and SHBG for vertebral fracture risk specifically is, however, less studied. Elderly men (aged ≥65 years) from Sweden and Hong Kong participating in the Osteoporotic Fractures in Men (MrOS) study had baseline estradiol and testosterone analyzed by gas chromatography–mass spectrometry (GC‐MS) and SHBG by immunoradiometric assay (IRMA). Incident clinical vertebral fractures (n = 242 cases) were evaluated in 4324 men during an average follow‐up of 9.1 years. In a subsample of these men (n = 2256), spine X‐rays were obtained at baseline and after an average follow‐up of 4.3 years to identify incident radiographic vertebral fractures (n = 157 cases). The likelihood of incident clinical and radiographic vertebral fractures was estimated by Cox proportional hazards models and logistic regression models, respectively. Neither serum estradiol (hazard ratio [HR] per SD increase = 0.93, 95% confidence interval [CI] 0.80–1.08) nor testosterone (1.05, 0.91–1.21) predicted incident clinical vertebral fractures in age‐adjusted models in the combined data set. High serum SHBG, however, associated with increased clinical vertebral fracture risk (1.24, 1.12–1.37). This association remained significant after further adjustment for FRAX with or without bone mineral density (BMD). SHBG also associated with increased incident radiographic vertebral fracture risk (combined data set; odds ratio [OR] per SD increase = 1.23, 95% CI 1.05–1.44). This association remained significant after adjustment for FRAX with or without BMD. In conclusion, high SHBG predicts incident clinical and radiographic vertebral fractures in elderly men and adds moderate information beyond FRAX with BMD for vertebral fracture risk prediction. © 2015 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

Keywordssex steroids; osteoporosis; general population studies; fracture risk assessment; men
Year2016
JournalJournal of Bone and Mineral Research
Journal citation31 (3), pp. 683 - 689
PublisherWiley-Blackwell Publishing, Inc.
ISSN0884-0431
Digital Object Identifier (DOI)https://doi.org/10.1002/jbmr.2718
Scopus EID2-s2.0-84955109556
Open accessOpen access
Page range683 - 689
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationUnited States of America
Permalink -

https://acuresearchbank.acu.edu.au/item/89vyz/high-serum-shbg-predicts-incident-vertebral-fractures-in-elderly-men

Download files

  • 0
    total views
  • 1
    total downloads
  • 0
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Strengths and resilience of migrant women in transit: An analysis of the narratives of Central American women in irregular transit through Mexico towards the USA
Lemus-Way, Mayra Carolina and Johansson, Helena. (2020) Strengths and resilience of migrant women in transit: An analysis of the narratives of Central American women in irregular transit through Mexico towards the USA. Journal of International Migration and Integration. 21, pp. 745 - 763. https://doi.org/10.1007/s12134-019-00690-z
Epidemiology of hip fractures in Bulgaria: Development of a country-specific FRAX model
Kirilova, E., Johansson, H., Kirilov, N., Vladeva, S., Petranova, T., Kolarov, Z., Liu, E., Lorentzon, M., Vandenput, L., Harvey, N. C., McCloskey, E. and Kanis, John A.. (2020) Epidemiology of hip fractures in Bulgaria: Development of a country-specific FRAX model. Archives of Osteoporosis. 15(28), pp. 1 - 7. https://doi.org/10.1007/s11657-020-0710-2
Association between recurrent fracture risk and implementation of fracture liaison services in four Swedish hospitals: A cohort study
Axelsson, Kristian F., Johansson, Helena, Lundh, Dan, Moller, Michael and Lorentzon, Mattias. (2020) Association between recurrent fracture risk and implementation of fracture liaison services in four Swedish hospitals: A cohort study. The Lancet Diabetes & Endocrinology. 35(7), pp. 1216 - 1223. https://doi.org/10.1002/jbmr.3990
A decade of FRAX: How has it changed the management of osteoporosis?
Kanis, John A., Harvey, Nicholas C., Johansson, Helena, Liu, Enwu, Vandenput, Liesbeth, Lorentzon, Mattias, Leslie, William D. and McCloskey, Eugene V.. (2020) A decade of FRAX: How has it changed the management of osteoporosis? Aging Clinical and Experimental Research. 32(2), pp. 187 - 196. https://doi.org/10.1007/s40520-019-01432-y
Use of age-dependent FRAX-based intervention thresholds for Singapore
Kanis, John A., Chandran, Manju, Chionh, Siok Bee, Ganeson, Ganga, Harvey, Nicholas C., Koh, Woon-Puay, Kwok, Timothy, Lau, Tang Ching, Liu, Enwu, Lorentzon, Mattias, McCloskey, Eugene V., Tan, Kelvin Bryan, Vandenput, Liesbeth and Johansson, Helena. (2020) Use of age-dependent FRAX-based intervention thresholds for Singapore. Archives of Osteoporosis. 15, pp. 1 - 10. https://doi.org/10.1007/s11657-020-00782-9
Physical function tests predict incident falls: A prospective study of 2969 men in the Swedish Osteoporotic Fractures in Men study
Coster, Marcus E., Karlsson, Magnus, Ohlsson, Claes, Mellstrom, Dan, Lorentzon, Mattias, Ribom, Eva and Rosengren, Bjorn. (2020) Physical function tests predict incident falls: A prospective study of 2969 men in the Swedish Osteoporotic Fractures in Men study. Scandinavian Journal of Public Health. 48(4), pp. 436 - 441. https://doi.org/10.1177/1403494818801628
BMD-related genetic risk scores predict site-specific fractures as well as trabecular and cortical bone microstructure
Nethander, Maria, Pettersson-Kymmer, Ulrika, Vandenput, Liesbeth, Lorentzon, Mattias, Karlsson, Magnus, Mellström, Dan and Ohlsson, Claes. (2020) BMD-related genetic risk scores predict site-specific fractures as well as trabecular and cortical bone microstructure. Journal of Clinical Endocrinology and Metabolism. 105(4), pp. e1344 - e1357. https://doi.org/10.1210/clinem/dgaa082
High plasma erythropoietin predicts incident fractures in elderly men with normal renal function: The MrOS Sweden cohort
Kristjansdottir, Hallgerdur Lind, Lewerin, Catharina, Lerner, Ulf H., Herlitz, Hans, Johansson, Peter, Johansson, Helena, Karlsson, Magnus, Lorentzon, Mattias, Ohlsson, Claes, Ljunggren, Östen and Mellstrom, Dan. (2020) High plasma erythropoietin predicts incident fractures in elderly men with normal renal function: The MrOS Sweden cohort. Journal of Bone and Mineral Research. 35(2), pp. 298 - 305. https://doi.org/10.1002/jbmr.3900
Treating osteoporosis to prevent fractures: Current concepts and future developments
Lorentzon, Mattias. (2019) Treating osteoporosis to prevent fractures: Current concepts and future developments. Journal of Internal Medicine. 285(4), pp. 381 - 394. https://doi.org/10.1111/joim.12873
Mendelian randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures
Zheng, Jie, Maerz, Winfried, Gergei, Ingrid, Kleber, Marcus E., Drechsler, Christiane, Wanner, Christoph, Brandenburg, Vincent, Reppe, Sjur, Gautvik, Kaare M., Medina-Gomez, Carolina, Shevroja, Enisa, Gilly, Arthur, Park, Young-Chan, Dedoussis, George, Zeggini, Eleftheria, Lorentzon, Mattias, Henning, Petra, Lerner, Ulf H., Nilsson, Karin H., ... Tobias, Jonathan H.. (2019) Mendelian randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures. Journal of Bone and Mineral Research. 34(10), pp. 1824 - 1836. https://doi.org/10.1002/jbmr.3803
Evidence of a causal effect of estradiol on fracture risk in men
Nethander, Maria, Vandenput, Liesbeth, Eriksson, Anna L., Windahl, Sara, Funck-Brentano, Thomas and Ohlsson, Claes. (2019) Evidence of a causal effect of estradiol on fracture risk in men. Journal of Clinical Endocrinology and Metabolism. 104(2), pp. 433 - 442. https://doi.org/10.1210/jc.2018-00934
Extensive undertreatment of osteoporosis in older Swedish women
Lorentzon, Mattias, Nilsson, A. G., Johansson, Helena, Kanis, John A., Mellström, Dan and Sundh, D.. (2019) Extensive undertreatment of osteoporosis in older Swedish women. Osteoporosis International. 30(6), pp. 1297 - 1305. https://doi.org/10.1007/s00198-019-04872-4
What is a family? Constructions of family and parenting after a custody transfer from birth parents to foster parents
Wissö, Therése, Johansson, Helena and Höjer, Ingrid. (2019) What is a family? Constructions of family and parenting after a custody transfer from birth parents to foster parents. Child and Family Social Work. 24(1), pp. 9 - 16. https://doi.org/10.1111/cfs.12475
Assessing the risk of osteoporotic fractures: The Ecuadorian FRAX model
Lopez Gavilanez, Enrique, Johansson, Helena, McCloskey, Eugene, Harvey, Nicholas C., Bajana, Angel Segale, Blum, Dennise Marriott, Grijalva, Mario Navarro, Curiel, Manuel Diaz and Kanis, John A.. (2019) Assessing the risk of osteoporotic fractures: The Ecuadorian FRAX model. Archives of Osteoporosis. 14(93), pp. 1 - 8. https://doi.org/10.1007/s11657-019-0644-8
Fracture risk in women with breast cancer initiating aromatase inhibitor therapy: A registry-based cohort study
Leslie, William D., Morin, Suzanne N., Lix, Lisa M., Niraula, Saroj, McCloskey, Eugene V., Johansson, Helena, Harvey, Nicholas C. and Kanis, John A.. (2019) Fracture risk in women with breast cancer initiating aromatase inhibitor therapy: A registry-based cohort study. The Oncologist. 24(11), pp. 1432 - 1438. https://doi.org/10.1634/theoncologist.2019-0149
Fracture prediction from self-reported falls in routine clinical practice: a registry-based cohort study
Leslie, William D., Morin, Suzanne N., Lix, Lisa, Martineau, Patrick, Bryanton, M., McCloskey, Eugene V., Johansson, Helena, Harvey, Nicholas C. and Kanis, John A.. (2019) Fracture prediction from self-reported falls in routine clinical practice: a registry-based cohort study. Osteoporosis International. 30, pp. 2195 - 2203. https://doi.org/10.1007/s00198-019-05106-3
Appendicular lean mass and fracture risk assessment: Implications for FRAX(R) and sarcopenia
Harvey, Nicholas C., Kanis, John A., Liu, Enwu, Johansson, Helena, Lorentzon, Mattias and McCloskey, Eugene. (2019) Appendicular lean mass and fracture risk assessment: Implications for FRAX(R) and sarcopenia. Osteoporosis International. 30(3), pp. 537 - 539. https://doi.org/10.1007/s00198-019-04904-z
Temporal changes in access to FRAX in Thailand between 2010 and 2018
Chotiyarnwong, Pojchong, Harvey, Nicholas C., Johansson, Helena, Liu, Enwu, Lorentzon, Mattias, Kanis, John A. and McCloskey, Eugene V.. (2019) Temporal changes in access to FRAX in Thailand between 2010 and 2018. Archives of Osteoporosis. 14(1), pp. 1 - 7. https://doi.org/10.1007/s11657-019-0613-2
Patients with prostate cancer and androgen deprivation therapy have increased risk of fractures—a study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO)
Wallander, M., Axelsson, K. F., Lundh, D. and Lorentzon, Mattias. (2019) Patients with prostate cancer and androgen deprivation therapy have increased risk of fractures—a study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). Osteoporosis International. 30(1), pp. 115 - 125. https://doi.org/10.1007/s00198-018-4722-3
Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture
Johansson, L., Svensson, H. K., Karlsson, J., Olsson, L. E., Mellström, Dan, Lorentzon, Mattias and Sundh, D.. (2019) Decreased physical health-related quality of life—a persisting state for older women with clinical vertebral fracture. Osteoporosis International. 30, pp. 1961 - 1971. https://doi.org/10.1007/s00198-019-05044-0
Meta-analysis of genomewide association studies reveals genetic variants for hip bone geometry
Hsu, Yi-Hsiang, Estrada, Karol, Evangelou, Evangelos, Ackert-Bicknell, Cheryl, Åkesson, Kristina, Beck, Thomas, Brown, Suzanne J., Capellini, Terence, Carbone, Laura, Cauley, Jane, Cheung, Ching-Lung, Cummings, Steven R., Czerwinski, Stefan, Demissie, Serkalem, Econs, Michael J., Evans, Daniel S., Farber, Charles, Gautvik, Kaare M., Harris, Tamara, ... Karasik, David. (2019) Meta-analysis of genomewide association studies reveals genetic variants for hip bone geometry. Journal of Bone and Mineral Research. 34(7), pp. 1284 - 1296. https://doi.org/10.1002/jbmr.3698
Performance of FRAX in women with breast cancer initiating aromatase inhibitor therapy: A registry-based cohort study
Leslie, William D., Morin, Suzanne N., Lix, Lisa M., Niraula, Saroj, McCloskey, Eugene V., Johansson, Helena, Harvey, Nicholas C. and Kanis, John A.. (2019) Performance of FRAX in women with breast cancer initiating aromatase inhibitor therapy: A registry-based cohort study. Journal of Bone and Mineral Research. 34(8), pp. 1428 - 1435. https://doi.org/10.1002/jbmr.3726
FRAX-based intervention and assessment thresholds for osteoporosis in Iran
Khashayar, P., Keshtkar, A., Ostovar, A., Larijani, B., Johansson, Helena, Harvey, Nicholas C., Lorentzon, Mattias, McCloskey, Eugene and Kanis, John A.. (2019) FRAX-based intervention and assessment thresholds for osteoporosis in Iran. Osteoporosis International. 30, pp. 2225 - 2230. https://doi.org/10.1007/s00198-019-05078-4
The gut microbiota is a major regulator of androgen metabolism in intestinal contents
Colldén, Hannah, Landin, Andreas, Wallenius, Ville, Elebring, Erik, Fändriks, Lars, Nilsson, Maria E., Ryberg, Henrik, Poutanen, Matti, Sjögren, Klara, Vandenput, Liesbeth and Ohlsson, Claes. (2019) The gut microbiota is a major regulator of androgen metabolism in intestinal contents. American Journal of Physiology - Endocrinology and Metabolism. 317(6), pp. E1182 - E1192. https://doi.org/10.1152/ajpendo.00338.2019
Association between cortical bone microstructure and statin use in older women
Larsson, Berit A. M., Sundh, Daniel, Mellström, Dan, Axelsson, Kristian F., Nilsson, Anna G. and Lorentzon, Mattias. (2019) Association between cortical bone microstructure and statin use in older women. Journal of Clinical Endocrinology and Metabolism. 104(2), pp. 250 - 257. https://doi.org/10.1210/jc.2018-02054
Pubertal timing and adult fracture risk in men: A population-based cohort study
Vandenput, Liesbeth, Kindblom, Jenny M., Bygdell, Maria, Nethander, Maria and Ohlsson, Claes. (2019) Pubertal timing and adult fracture risk in men: A population-based cohort study. PLoS Medicine. 16(12), pp. 1 - 14. https://doi.org/10.1371/journal.pmed.1002986
To live a life with COPD: The consequences of symptom burden
Johansson, Helena, Berterö, Carina, Berg, Katarina and Jonasson, Lise-Lotte. (2019) To live a life with COPD: The consequences of symptom burden. The International Journal of Chronic Obstructive Pulmonary Disease. 14, pp. 905 - 909. https://doi.org/10.2147/COPD.S192280
Serum DHEA and Its Sulfate Are Associated With Incident Fall Risk in Older Men: The MrOS Sweden study
Ohlsson, Claes, Nethander, Maria, Karlsson, Magnus K., Rosengren, Björn E., Ribom, Eva, Mellström, Dan and Vandenput, Liesbeth. (2018) Serum DHEA and Its Sulfate Are Associated With Incident Fall Risk in Older Men: The MrOS Sweden study. Journal of Bone and Mineral Research. 33(7), pp. 1227 - 1232. https://doi.org/10.1002/jbmr.3418
High serum serotonin predicts increased risk for hip fracture and nonvertebral osteoporotic fractures: The MrOS Sweden Study
Kristjansdottir, Hallgerdur Lind, Lewerin, C., Lerner, Ulf H., Waern, Ewa, Johansson, Helena, Sundh, Daniel, Karlsson, Magnus, Cummings, Steven R., Zetterberg, Henrik, Lorentzon, Mattias, Ohlsson, Claes and Mellstrom, Dan. (2018) High serum serotonin predicts increased risk for hip fracture and nonvertebral osteoporotic fractures: The MrOS Sweden Study. Journal of Bone and Mineral Research. 33(9), pp. 1560 - 1567. https://doi.org/10.1002/jbmr.3443
High-impact mechanical loading increases bone material strength in postmenopausal women—a 3-month intervention study
Sundh, Daniel, Nilsson, Martin, Zoulakis, Michail, Pasco, Courtney, Yilmaz, Melis, Kazakia, Galateia J., Hellgren, Martin and Lorentzon, Mattias. (2018) High-impact mechanical loading increases bone material strength in postmenopausal women—a 3-month intervention study. Journal of Bone and Mineral Research. 33(7), pp. 1242 - 1251. https://doi.org/10.1002/jbmr.3431
Clinically relevant doses of vitamin a decrease cortical bone mass in mice
Lionikaite, Vikte, Gustafsson, Karin L., Westerlund, Anna, Windahl, Sara H., Koskela, Antti, Tuukkanen, Juha, Johansson, Helena, Ohlsson, Claes, Conaway, H. Herschel, Henning, Petra and Lerner, Ulf H.. (2018) Clinically relevant doses of vitamin a decrease cortical bone mass in mice. Journal of Endocrinology. 239(3), pp. 389 - 402. https://doi.org/10.1530/JOE-18-0316
Comparison of methods for improving fracture risk assessment in diabetes: the Manitoba BMD Registry
Leslie, William D., Johansson, Helena, Mccloskey, Eugene V., Harvey, Nicholas C., Kanis, John and Hans, Didier. (2018) Comparison of methods for improving fracture risk assessment in diabetes: the Manitoba BMD Registry. Journal of Bone and Mineral Research. 33(11), pp. 1923 - 1930. https://doi.org/10.1002/jbmr.3538
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: A randomized, placebo-controlled, double-blind, clinical trial
Nilsson, A. G., Sundh, D., Bäckhed, F. and Lorentzon, Mattias. (2018) Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: A randomized, placebo-controlled, double-blind, clinical trial. Journal of Internal Medicine. 284(3), pp. 307 - 317. https://doi.org/10.1111/joim.12805
Falls predict fractures independently of FRAX probability: A meta-analysis of the Osteoporotic Fractures in Men (MrOS) Study
Harvey, Nicholas C., Oden, Anders, Orwoll, E., Lapidus, Jodi, Kwok, T., Karlsson, Magnus, Rosengren, Björn E., Ljunggren, Östen, Cooper, Cyrus, McCloskey, Eugene, Kanis, John A., Ohlsson, Claes, Mellström, Dan and Johansson, Helena. (2018) Falls predict fractures independently of FRAX probability: A meta-analysis of the Osteoporotic Fractures in Men (MrOS) Study. Journal of Bone and Mineral Research. 33(3), pp. 510 - 516. https://doi.org/10.1002/jbmr.3331
Management of patients with high baseline hip fracture risk by FRAX reduces hip fractures—a post hoc analysis of the scoop study
McCloskey, Eugene, Johansson, Helena, Harvey, Nicholas C., Shepstone, L., Lenaghan, E., Fordham, Ric, Harvey, I., Howe, Amanda, Cooper, Cyrus, Clarke, Shane, Gittoes, Neil, Heawood, A., Holland, R., Marshall, Tarnya, O'Neill, T. W., Peters, T. J., Redmond, Niamh, Torgerson, David and Kanis, John A.. (2018) Management of patients with high baseline hip fracture risk by FRAX reduces hip fractures—a post hoc analysis of the scoop study. Journal of Bone and Mineral Research. 33(6), pp. 1020 - 1026. https://doi.org/10.1002/jbmr.3411
Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects
Medina-Gómez, Carolina, Kemp, John P., Trajanoska, Katerina, Luan, Jian'an, Chesi, Alessandra, Ahluwalia, Tarunveer S., Mook-Kanamori, Dennis O., Ham, Annelies C., Hartwig, Fernando P., Evans, Daniel S., Joro, Raimo, Nedeljkovic, Ivana, Zheng, Hou-Feng, Zhu, Kun, Atalay, Mustafa, Liu, Ching-Ti, Nethander, Maria, Broer, Linda, Porleifsson, Gudmar, ... Rivadeneira, Fernando. (2018) Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects. American Journal of Human Genetics. 102(1), pp. 88 - 102. https://doi.org/10.1016/j.ajhg.2017.12.005
Epidemiology of hip fracture in Belarus: development of a country-specific FRAX model and its comparison to neighboring country models
Ramanau, H., Chernyanin, I., Rudenka, E., Lesnyak, Olga, Zakroyeva, A., Bilezikian, John P., Johansson, Helena, Harvey, Nicholas C., McCloskey, Eugene and Kanis, John A.. (2018) Epidemiology of hip fracture in Belarus: development of a country-specific FRAX model and its comparison to neighboring country models. Archives of Osteoporosis. 13(1), pp. 1 - 5. https://doi.org/10.1007/s11657-018-0454-4
A brief history of FRAX
Kanis, John A., Johansson, Helena, Harvey, Nicholas C. and McCloskey, Eugene V.. (2018) A brief history of FRAX. Archives of Osteoporosis. 13(1), pp. 1 - 16. https://doi.org/10.1007/s11657-018-0510-0
In which patients does lumbar spine trabecular bone score (TBS) have the largest effect?
Martineau, Patrick, Leslie, William D., Johansson, Helena, Harvey, Nicholas C., McCloskey, Eugene, Hans, Didier and Kanis, John A.. (2018) In which patients does lumbar spine trabecular bone score (TBS) have the largest effect? Bone. 113, pp. 161 - 168. https://doi.org/10.1016/j.bone.2018.05.026
Measures of physical performance and muscle strength as predictors of fracture risk independent of FRAX, falls, and aBMD: A meta-analysis of the Osteoporotic Fractures in Men (MrOS) Study
Harvey, Nicholas C., Oden, Anders, Orwoll, E., Lapidus, Jodi, Kwok, T., Karlsson, Magnus, Rosengren, Björn E., Ribom, Eva, Cooper, Cyrus, Cawthon, Peggy M., Kanis, John A., Ohlsson, Claes, Mellström, Dan, Johansson, Helena and McCloskey, Eugene. (2018) Measures of physical performance and muscle strength as predictors of fracture risk independent of FRAX, falls, and aBMD: A meta-analysis of the Osteoporotic Fractures in Men (MrOS) Study. Journal of Bone and Mineral Research. 33(12), pp. 2150 - 2157. https://doi.org/10.1002/jbmr.3556
Transferring custody from birth parents to foster parents - an ambiguous matter
Wisso, Therese and Johansson, Helena. (2018) Transferring custody from birth parents to foster parents - an ambiguous matter. Journal of Social Welfare & Family Law. 40(3), pp. 321 - 339. https://doi.org/10.1080/09649069.2018.1493653
Risk-equivalent T-score adjustment for using lumbar spine trabecular bone score (TBS): The Manitoba BMD registry
Leslie, William D., Shevroja, E., Johansson, Helena, McCloskey, Eugene, Harvey, Nicholas C., Kanis, John A. and Hans, Didier. (2018) Risk-equivalent T-score adjustment for using lumbar spine trabecular bone score (TBS): The Manitoba BMD registry. Osteoporosis International. 29(3), pp. 751 - 758. https://doi.org/10.1007/s00198-018-4405-0
Low risk for hip fracture and high risk for hip arthroplasty due to osteoarthritis among Swedish farmers
Johansson, Helena, Vala, C. H., Oden, Anders, Lorentzon, Mattias, McCloskey, Eugene, Kanis, John, Harvey, Nicholas C., Ohlsson, Claes, Lohmander, L. S., Karrholm, J. and Mellstrom, D.. (2018) Low risk for hip fracture and high risk for hip arthroplasty due to osteoarthritis among Swedish farmers. Osteoporosis International. 29(3), pp. 741 - 749. https://doi.org/10.1007/s00198-017-4355-y
The prevalence of vertebral fractures is associated with reduced hip bone density and inferior peripheral appendicular volumetric bone density and structure in older women
Johansson, Lisa, Sundh, Daniel, Zoulakis, Michael, Rudäng, Robert, Darelid, Anna, Brisby, Helena, Nilsson, Anna G., Mellström, Dan and Lorentzon, Mattias. (2018) The prevalence of vertebral fractures is associated with reduced hip bone density and inferior peripheral appendicular volumetric bone density and structure in older women. Journal of Bone and Mineral Research. 33(2), pp. 250 - 260. https://doi.org/10.1002/jbmr.3297
Application of FRAX to determine the risk of osteoporotic fractures in the Ukrainian population
Povoroznyuk, V. V., Grygorieva, Nataliia V., McCloskey, Eugene, Johansson, Helena and Kanis, John. (2018) Application of FRAX to determine the risk of osteoporotic fractures in the Ukrainian population. International Journal of Osteoporosis and Metabolic Disorders. 11(1), pp. 7 - 13. https://doi.org/10.3923/ijom.2018.7.13
Characteristics of recurrent fractures
Kanis, John A., Johansson, Helena, Odén, Anders, Harvey, Nicholas C., Gudnason, V., Sanders, Kerrie, Sigurdsson, Gunnar, Siggeirsdottir, K., Fitzpatrick, Lorraine A., Borgström, F. and McCloskey, Eugene. (2018) Characteristics of recurrent fractures. Osteoporosis International. 29(8), pp. 1747 - 1757. https://doi.org/10.1007/s00198-018-4502-0
Vertebral fractures and their association with health-related quality of life, back pain and physical function in older women
Johansson, Lisa, Sundh, Daniel, Nilsson, Dan, Mellström, Dan and Lorentzon, Mattias. (2018) Vertebral fractures and their association with health-related quality of life, back pain and physical function in older women. Osteoporosis International. 29(1), pp. 89 - 99. https://doi.org/10.1007/s00198-017-4296-5
Recognition of education and schooling in case files for children and young people placed in out-of-home care
Hojer, Ingrid, Lindberg, Helena, Nielsen, Bo, Gustafsson, Jan Eric and Johansson, Helena. (2018) Recognition of education and schooling in case files for children and young people placed in out-of-home care. Children and Youth Services Review. 93, pp. 135 - 142. https://doi.org/10.1016/j.childyouth.2018.06.042
Fracture risk after gastric bypass surgery: A retrospective cohort study
Axelsson, Kristian F., Werling, Malin, Eliasson, Björn, Szabo, Eva, Näslund, Ingmar, Wedel, Hans, Lundh, Dan and Lorentzon, Mattias. (2018) Fracture risk after gastric bypass surgery: A retrospective cohort study. Journal of Bone and Mineral Research. 33(12), pp. 2122 - 2131. https://doi.org/10.1002/jbmr.3553
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Jiang, Xia, O'Reilly, Paul F., Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J. Brent, Dupuis, Josée, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan, Jianan, Sofianopoulou, Eleni, Streeten, Elizabeth A., Albanes, Demetrius, Lutsey, Pamela L., Yao, Lu, Tang, Weihong, ... Lorentzon, Mattias. (2018) Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nature Communications. 9(1), pp. 1 - 12. https://doi.org/10.1038/s41467-017-02662-2
Genetic determinants of circulating estrogen levels and evidence of a causal effect of estradiol on bone density in men
Eriksson, Anna L., Perry, John R. B., Coviello, Andreas D., Delgado, Graciela E., Ferrucci, Luigi, Hoffman, Andrew R., Huhtaniemi, Ilpo T., Ikram, M. Arfan, Karlsson, Magnus K., Kleber, Marcus E., Laughlin, Gail A., Liu, Yongmei, Lorentzon, Mattias, Lunetta, Kathryn L., Mellström, Dan, Murabito, Joanne M., Murray, Anna, Nethander, Maria, Nielson, Carrie M., ... Ohlsson, Claes. (2018) Genetic determinants of circulating estrogen levels and evidence of a causal effect of estradiol on bone density in men. Journal of Clinical Endocrinology and Metabolism. 103(3), pp. 991 - 1004. https://doi.org/10.1210/jc.2017-02060
Epidemiology of hip fractures in two regions of Ukraine
Povoroznyuk, V. V., Grygorieva, N. V., Kanis, J. A., McCloskey, E. V., Johansson, H., Strafun, S. S., Korzh, M. O., Vaida, V. M., Klymovytsky, F. V., Forosenko, V. S. and Vlasenko, R. O.. (2018) Epidemiology of hip fractures in two regions of Ukraine. Journal of Osteoporosis. 2018, pp. 1 - 6. https://doi.org/10.1155/2018/7182873
Normal bone microstructure and density but worse physical function in older women treated with selective serotonin reuptake inhibitors, a cross-sectional population-based study
Larsson, Berit A. M., Mellström, Dan, Johansson, Lisa, Nilsson, Anna G., Lorentzon, Mattias and Sundh, Daniel. (2018) Normal bone microstructure and density but worse physical function in older women treated with selective serotonin reuptake inhibitors, a cross-sectional population-based study. Calcified Tissue International. 103(3), pp. 278 - 288. https://doi.org/10.1007/s00223-018-0427-z
Performance of FRAX in clinical practice according to sex and osteoporosis definitions: The Manitoba BMD registry
Leslie, William D., Majumdar, S. R., Morin, Suzanne N., Lix, Lisa, Schousboe, J. T., Ensrud, K. E., Johansson, Helena, McCloskey, Eugene and Kanis, John A.. (2018) Performance of FRAX in clinical practice according to sex and osteoporosis definitions: The Manitoba BMD registry. Osteoporosis International. 29(3), pp. 759 - 767. https://doi.org/10.1007/s00198-018-4415-y
Risk factors for low back pain and sciatica in elderly men--the MrOS Sweden study
Kherad, Mehrsa, Rosengren, Björn E., Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Ljunggren, Östen and Karlsson, Magnus K.. (2017) Risk factors for low back pain and sciatica in elderly men--the MrOS Sweden study. Age and Ageing. 46(1), pp. 64 - 71. https://doi.org/10.1093/ageing/afw152
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
Zillikens, M. Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M., Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L., Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Thorleifsson, Gudmar, Vandenput, Liesbeth, Zhao, Jing Hua, Zhang, Weihua, ... Boehnke, Michael. (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nature Communications. 8(1), pp. 1 - 13. https://doi.org/10.1038/s41467-017-00031-7
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, bin Qi, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, ... Lorentzon, Mattias. (2017) Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. PLoS Genetics. 13(4), pp. 1 - 26. https://doi.org/10.1371/journal.pgen.1006528
Cortical bone area predicts incident fractures independently of areal bone mineral density in older men
Ohlsson, Claes, Sundh, Daniel, Wallerek, Andreas, Nilson, Martin, Karlsson, Magnus, Johansson, Helena, Mellstrom, Dan and Lorentzon, Mattias. (2017) Cortical bone area predicts incident fractures independently of areal bone mineral density in older men. Journal of Clinical Endocrinology and Metabolism. 102(2), pp. 516 - 524. https://doi.org/10.1210/jc.2016-3177
Association between alendronate use and hip fracture risk in older patients using oral prednisolone
Axelsson, Kristian F., Nilsson, Anna G., Wedel, Hans, Lundh, Dan and Lorentzon, Mattias. (2017) Association between alendronate use and hip fracture risk in older patients using oral prednisolone. JAMA: Journal of the American Medical Association. 318(2), pp. 146 - 155. https://doi.org/10.1001/jama.2017.8040
Umbilical cord blood androgen levels in girls and boys assessed by gas chromatography-tandem mass spectrometry
Lundell, Anna-Carin, Ryberg, Henrik, Vandenput, Liesbeth, Rudin, Anna, Ohlsson, Claes and Tivesten, Åsa. (2017) Umbilical cord blood androgen levels in girls and boys assessed by gas chromatography-tandem mass spectrometry. The Journal of Steroid Biochemistry and Molecular Biology. 171, pp. 195 - 200. https://doi.org/10.1016/j.jsbmb.2017.03.022
Hip fracture risk and safety with alendronate treatment in the oldest-old
Axelsson, K. F., Wallander, M., Johansson, Helena, Lundh, D. and Lorentzon, Mattias. (2017) Hip fracture risk and safety with alendronate treatment in the oldest-old. Journal of Internal Medicine. 282(6), pp. 546 - 559. https://doi.org/10.1111/joim.12678
Clinical utility of using lumbar spine trabecular bone score to adjust fracture probability: the Manitoba BMD Cohort
Martineau, Patrick, Leslie, William, Johansson, Helena, Oden, Anders, McCloskey, Eugene, Hans, Didier and Kanis, John. (2017) Clinical utility of using lumbar spine trabecular bone score to adjust fracture probability: the Manitoba BMD Cohort. Journal of Bone and Mineral Research. 32(7), pp. 1568 - 1574. https://doi.org/10.1002/jbmr.3124
Type 2 diabetes and risk of hip fractures and non-skeletal fall injuries in the elderly: A study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO)
Wallander, Märit, Axelsson, Kristian F., Nilsson, Anna G., Lundh, Dan and Lorentzon, Mattias. (2017) Type 2 diabetes and risk of hip fractures and non-skeletal fall injuries in the elderly: A study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). Journal of Bone and Mineral Research. 32(3), pp. 449 - 460. https://doi.org/10.1002/jbmr.3002
Access to fracture risk assessment by FRAX and linked National Osteoporosis Guideline Group (NOGG) guidance in the UK: an analysis of anonymous website activity
McCloskey, Eugene, Johansson, Helena, Harvey, Nicholas C., Compston, Juliet E. and Kanis, J.. (2017) Access to fracture risk assessment by FRAX and linked National Osteoporosis Guideline Group (NOGG) guidance in the UK: an analysis of anonymous website activity. Osteoporosis International. 28(1), pp. 71 - 76. https://doi.org/10.1007/s00198-016-3696-2
Increased risk of hip fracture among spouses-evidence of a homogamy effect
Vala, C. H., Oden, Anders, Lorentzon, Mattias, Sundh, V., Johansson, Helena, Karlsson, Magnus, Rosengren, Björn E., Ohlsson, Claes, Johansson, B., Kanis, John and Mellström, Dan. (2017) Increased risk of hip fracture among spouses-evidence of a homogamy effect. Osteoporosis International. 28(1), pp. 95 - 102. https://doi.org/10.1007/s00198-016-3738-9
Total hip bone area affects fracture prediction with FRAX® in Canadian white women
Leslie, William D., Lix, Lisa, Majumdar, S. R., Morin, Suzanne N., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John. (2017) Total hip bone area affects fracture prediction with FRAX® in Canadian white women. Journal of Clinical Endocrinology and Metabolism. 102(11), pp. 4242 - 4249. https://doi.org/10.1210/jc.2017-01327
Epidemiology of fractures in Armenia: development of a country-specific FRAX model and comparison to its surrogate
Lesnyak, Olga, Sahakyan, S., Zakroyeva, A., Bilezikian, John P., Hutchings, N., Babalyan, V., Galstyan, R., Lebedev, A., Johansson, Helena, Harvey, Nicholas C., McCloskey, Eugene and Kanis, John. (2017) Epidemiology of fractures in Armenia: development of a country-specific FRAX model and comparison to its surrogate. Archives of Osteoporosis. 12(98), pp. 1 - 9. https://doi.org/10.1007/s11657-017-0392-6
FRAX for fracture prediction shorter and longer than 10 years: the Manitoba BMD registry
Leslie, William, Majumdar, S. R., Morin, Suzanne N., Lix, Lisa, Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John. (2017) FRAX for fracture prediction shorter and longer than 10 years: the Manitoba BMD registry. Osteoporosis International. 28(9), pp. 2557 - 2564. https://doi.org/10.1007/s00198-017-4091-3
Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice
Ohlsson, Claes, Hammarstedt, Ann, Vandenput, Liesbeth, Saarinen, Niina, Ryberg, Henrik, Windahl, Sara H., Farman, Helen H., Jansson, John-Olov, Movérare-Skrtic, Sofia, Smith, Ulf, Zhang, Fu-Ping, Poutanen, Matti, Hedjazifar, Shahram and Sjögren, Klara. (2017) Increased adipose tissue aromatase activity improves insulin sensitivity and reduces adipose tissue inflammation in male mice. American Journal of Physiology - Endocrinology and Metabolism. 313(4), pp. E450 - E462. https://doi.org/10.1152/ajpendo.00093.2017
Bone traits seem to develop also during the third decade in life—normative cross-sectional data on 1083 men aged 18–28 years
Lindgren, Erik, Karlsson, Magnus K., Lorentzon, Mattias and Rosengren, Björn E.. (2017) Bone traits seem to develop also during the third decade in life—normative cross-sectional data on 1083 men aged 18–28 years. Journal of Clinical Densitometry. 20(1), pp. 32 - 43. https://doi.org/10.1016/j.jocd.2016.07.002
Imminent risk of fracture after fracture
Johansson, Helena, Siggeirsdottir, Kristin, Harvey, Nicholas C., Oden, Anders, Gudnason, Vilmundur, McCloskey, Eugene, Sigurdsson, Gunnar and Kanis, John. (2017) Imminent risk of fracture after fracture. Osteoporosis International. 28(3), pp. 775 - 780. https://doi.org/10.1007/s00198-016-3868-0
Epidemiology of hip fracture and the development of FRAX in Ukraine
Povoroznyuk, V. V., Grygorieva, N. V., Kanis, John, McCloskey, Eugene, Johansson, Helena, Harvey, Nicholas C., Korzh, M. O., Strafun, S. S., Vaida, V. M., Klymovytsky, F. V., Vlasenko, R. R. and Forosenko, V. S.. (2017) Epidemiology of hip fracture and the development of FRAX in Ukraine. Archives of Osteoporosis. 12(1), pp. 1 - 6. https://doi.org/10.1007/s11657-017-0343-2
Low testosterone, but not estradiol, is associated with incident falls in older men: The international MrOS study
Vandenput, Liesbeth, Mellström, Dan, Laughlin, Gail A., Cawthon, Peggy M., Cauley, Jane A., Hoffman, Andrew R., Karlsson, Magnus K., Rosengren, Björn E., Ljunggren, Östen, Nethander, Maria, Eriksson, Anna L., Lorentzon, Mattias, Leung, Jason, Kwok, Timothy, Orwoll, Eric S. and Ohlsson, Claes. (2017) Low testosterone, but not estradiol, is associated with incident falls in older men: The international MrOS study. Journal of Bone and Mineral Research. 32(6), pp. 1174 - 1181. https://doi.org/10.1002/jbmr.3088
Overview of fracture prediction tools
Kanis, Harvey, Nicholas C., Johansson, Helena, Odén, Anders, McCloskey, Eugene V., Leslie, William D. and John.Kanis@acu.edu.au, John A. Kanis. (2017) Overview of fracture prediction tools. Journal of Clinical Densitometry: Assessment & Management of Musculoskeletal Health. 20(3), pp. 444 - 450. https://doi.org/10.1016/j.jocd.2017.06.013
Increased cortical porosity in women with hip fracture
Sundh, Daniel, Nilsson, A. G., Nilsson, Martin, Johansson, L., Mellström, Dan and Lorentzon, Mattias. (2017) Increased cortical porosity in women with hip fracture. Journal of Internal Medicine. 281(5), pp. 496 - 506. https://doi.org/10.1111/joim.12587
FRAX- vs. T-score-based intervention thresholds for osteoporosis
Johansson, Helena, Azizieh, F., al Ali, N., Alessa, T., Harvey, Nicholas C., McCloskey, Eugene and Kanis, John A.. (2017) FRAX- vs. T-score-based intervention thresholds for osteoporosis. Osteoporosis International. 28(11), pp. 3099 - 3105. https://doi.org/10.1007/s00198-017-4160-7
Association of mental disorders and related medication use with risk for major osteoporotic fractures
Bolton, James M., Morin, Suzanne N., Majumdar, S. R., Sareen, Jitender, Lix, Lisa, Johansson, Helena, Oden, Anders, McCloskey, Eugene, Kanis, John and Leslie, William. (2017) Association of mental disorders and related medication use with risk for major osteoporotic fractures. JAMA Psychiatry. 74(6), pp. 641 - 648. https://doi.org/10.1001/jamapsychiatry.2017.0449
The effect of abaloparatide-SC on fracture risk is independent of baseline FRAX fracture probability: a post hoc analysis of the ACTIVE study
McCloskey, Eugene, Johansson, Helena, Oden, Anders, Harvey, Nicholas C., Jiang, Hai, Modin, Sara, Fitzpatrick, Lorraine and Kanis, John. (2017) The effect of abaloparatide-SC on fracture risk is independent of baseline FRAX fracture probability: a post hoc analysis of the ACTIVE study. Journal of Bone and Mineral Research. 32(8), pp. 1625 - 1631. https://doi.org/10.1002/jbmr.3163
Overview of fracture prediction tools
Kanis, Harvey, Nicholas C., Johansson, Helena, Odén, Anders, McCloskey, Eugene V., Leslie, William D. and John.Kanis@acu.edu.au, John A. Kanis. (2017) Overview of fracture prediction tools. Journal of Clinical Densitometry: Assessment & Management of Musculoskeletal Health. 20(3), pp. 444 - 450. https://doi.org/10.1016/j.jocd.2017.06.013
Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study
Lewerin, Catharina, Ljunggren, Östen, Nilsson-Ehle, Herman, Karlsson, Magnus K., Herlitz, Hans, Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2017) Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study. Bone. 98, pp. 1 - 8. https://doi.org/10.1016/j.bone.2017.02.005
Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis
Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Chiang-Ti, Medina-Gómez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Håkan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M. T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., ... Richards, J. Brent. (2017) Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis. American Journal of Human Genetics. 101(2), pp. 227 - 238. https://doi.org/10.1016/j.ajhg.2017.06.014
FRAX update
Kanis, John A., Harvey, Nicholas C., Johansson, Helena, Odén, Anders, Leslie, William D. and McCloskey, Eugene V.. (2017) FRAX update. Journal of Clinical Densitometry: Assessment & Management of Musculoskeletal Health. 20(3), pp. 360 - 367. https://doi.org/10.1016/j.jocd.2017.06.022
Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study
Nilsson, Anna G., Sundh, Daniel, Johansson, Lisa, Nilsson, Martin, Mellström, Dan, Rudäng, Robert, Zoulakis, Michail, Wallander, Märit, Darelid, Anna and Lorentzon, Mattias. (2017) Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study. Journal of Bone and Mineral Research. 32(5), pp. 1062 - 1071. https://doi.org/10.1002/jbmr.3057
Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease
Sigurdsson, Gudmundur Vignir, Schmidt, Susanne, Mellström, Dan, Ohlsson, Claes, Kindblom, Jenny M., Lorentzon, Mattias and Saalman, Robert. (2017) Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease. Inflammatory Bowel Diseases. 23(12), pp. 2215 - 2226. https://doi.org/10.1097/MIB.0000000000001277
Genetic variants associated with circulating parathyroid hormone
Robinson-Cohen, Cassianne, Lutsey, Pamela L., Kleber, Marcus E., Nielson, Carrie M., Mitchell, Braxton D., Bis, Joshua C., Eny, Karen M., Portas, Laura, Eriksson, Joel, Lorentzon, Mattias, Koller, Daniel L., Milaneschi, Yuri, Teumer, Alexander, Pilz, Stefan, Nethander, Maria, Selvin, Elizabeth, Tang, Weihong, Weng, Lu-Chen, Wong, Hoi Suen, ... Kestenbaum, Bryan. (2017) Genetic variants associated with circulating parathyroid hormone. Journal of the American Society of Nephrology. 28(5), pp. 1553 - 1565. https://doi.org/10.1681/ASN.2016010069
Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias, Lorentzon, Mattias, Husemoen, Lise Lotte Nystrup, Völzke, Henry, Karlsson, Magnus, Baumeister, Sebastian E., Linneberg, Allan and Ohlsson, Claes. (2017) Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PLoS ONE. 12(4), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0176277
Romosozumab or alendronate for fracture prevention in women with osteoporosis
Saag, Kenneth G., Petersen, Jeffrey, Brandi, Maria Luisa, Karaplis, Andrew C., Lorentzon, Mattias, Thomas, Thierry A., Maddox, Judy, Fan, Michelle, Meisner, Paul D. and Grauer, Andreas. (2017) Romosozumab or alendronate for fracture prevention in women with osteoporosis. New England Journal of Medicine. 377(15), pp. 1417 - 1427. https://doi.org/10.1056/NEJMoa1708322
FRAX-based intervention and assessment thresholds in seven Latin American countries
Clark, P., Denova-Gutiérrez, E., Zerbini, Cristiano, Sanchez, A., Messina, O. D., Jaller, J. J., Campusano, C., Orces, C. H., Riera, G., Johansson, Helena and Kanis, John. (2017) FRAX-based intervention and assessment thresholds in seven Latin American countries. Osteoporosis International. 29(3), pp. 707 - 715. https://doi.org/10.1007/s00198-017-4341-4
Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study
Ohlsson, Claes, Nethander, Maria, Kindmark, Andreas, Ljunggren, Östen, Lorentzon, Mattias, Rosengren, Björn E., Karlsson, Magnus K., Mellström, Dan and Vandenput, Liesbeth. (2017) Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study. Journal of Bone and Mineral Research. 32(8), pp. 1607 - 1614. https://doi.org/10.1002/jbmr.3123
Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women
Nilsson, Martin, Sundh, Daniel, Mellström, Dan and Lorentzon, Mattias. (2017) Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women. Journal of Bone and Mineral Research. 32(3), pp. 473 - 485. https://doi.org/10.1002/jbmr.3006
Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study
Deminger, Anna, Klingberg, Eva, Lorentzon, Mattias, Geijer, Mats, Göthlin, Jan, Hedberg, Martin, Rehnberg, Eva, Carlsten, Hans, Jacobsson, Lennart T. and Forsblad-d'Elia, Helena. (2017) Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study. Arthritis Research and Therapy. 19(1), pp. 1 - 12. https://doi.org/10.1186/s13075-017-1480-0
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L., Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y., Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zoltán, Xue, Luting, ... Lorentzon, Mattias. (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications. 8(1), pp. 1 - 19. https://doi.org/10.1038/ncomms14977
Characteristics of prevalent vertebral fractures predict new fractures in elderly men
Karlsson, Magnus K., Kherad, Mehrsa, Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Rosengren, Björn E.. (2016) Characteristics of prevalent vertebral fractures predict new fractures in elderly men. Journal of Bone and Joint Surgery: American Volume. 98(5), pp. 379 - 385. https://doi.org/10.2106/JBJS.15.00328
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried, Janina S., Jeff, Janina, Chu, Audrey Y., Bragg-Gresham, Jennifer L., van Dongen, Jenny, Huffman, Jennifer E., Ahluwalia, Tarunveer S., Cadby, Gemma, Eklund, Niina, Eriksson, Joel, Esko, Tõnu, Feitosa, Mary F., Goel, Anuj, Gorski, Mathias, Hayward, Caroline, Heard-Costa, Nancy L., Jackson, Anne U., Jokinen, Eero, Kanoni, Stavroula, ... Loos, Ruth J. F.. (2016) A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications. 7(1), pp. 1 - 11. https://doi.org/10.1038/ncomms13357
Adjusting hip fracture probability in men and women using hip axis length: The Manitoba Bone Density Database
Leslie, William D., Lix, Lisa M., Morin, Suzanne N., Johansson, Helena, Oden, Anders, McCloskey, Eugene V. and Kanis, John Anthony. (2016) Adjusting hip fracture probability in men and women using hip axis length: The Manitoba Bone Density Database. Journal of Clinical Densitometry. 19(3), pp. 326 - 331. https://doi.org/10.1016/j.jocd.2015.07.004
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits
Teumer, Alexander, Qi, bin Qi, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja I., Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen J., Chen, Ming-Huei, Chen, Tai C., Chen, Yii-Der, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, ... Lorentzon, Mattias. (2016) Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 15(5), pp. 811 - 824. https://doi.org/10.1111/acel.12490
Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women
Brembeck, Peter, Winkvist, Anna, Ohlsson, Claes, Lorentzon, Mattias and Augustin, Hanna. (2016) Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women. The British Journal of Nutrition. 116(10), pp. 1736 - 1744. https://doi.org/10.1017/S0007114516003998
A systematic review of intervention thresholds based on FRAX: A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation
Kanis, John A., Harvey, Nicholas C., Cooper, Cyrus, Johansson, Helena, Oden, Anders, McCloskey, Eugene V., The Advisory Board of the National Osteoporosis Guideline Group, and The Advisory Board of the National Osteoporosis Guideline Group. (2016) A systematic review of intervention thresholds based on FRAX: A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation. Archives of Osteoporosis. https://doi.org/10.1007/s11657-016-0278-z
FRAX predicts incident falls in elderly men: findings from MrOs Sweden
Harvey, Nicholas C., Johansson, Helena, Oden, Anders, Karlsson, Magnus, Rosengren, Björn E., Ljunggren, Östen, Cooper, Cyrus, McCloskey, Eugene V., Kanis, John A., Ohlsson, C. and Mellström, Dan. (2016) FRAX predicts incident falls in elderly men: findings from MrOs Sweden. Osteoporosis International. 27(1), pp. 267 - 274. https://doi.org/10.1007/s00198-015-3295-7
Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults
Nilsson, , Eriksson, Joel, Larsson, Berit A. M., Odén, Anders, Johansson, Helena and Lorentzon, Mattias. (2016) Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults. Journal of the American Geriatrics Society. 64(11), pp. 2242 - 2250. https://doi.org/10.1111/jgs.14439
Direct comparison of FRAX(R) and a simplified fracture risk assessment tool in routine clinical practice: A registry-based cohort study
Leslie, William D., Majumdar, S. R., Lix, Lisa M., Josse, R. G., Johansson, Helena, Oden, Anders, McCloskey, Eugene V. and Kanis, John A.. (2016) Direct comparison of FRAX(R) and a simplified fracture risk assessment tool in routine clinical practice: A registry-based cohort study. Osteoporosis International. 27(9), pp. 2689 - 2695. https://doi.org/10.1007/s00198-016-3613-8
Bone material strength is associated with areal BMD but not with prevalent fractures in older women
Rudäng, R., Zoulakis, M., Sundh, D., Brisby, H., Diez-Perez, Aldolfo, Johansson, L., Mellström, Dan, Darelid, A. and Lorentzon, Mattias. (2016) Bone material strength is associated with areal BMD but not with prevalent fractures in older women. Osteoporosis International. 27(4), pp. 1585 - 1592. https://doi.org/10.1007/s00198-015-3419-0
FRAX updates 2016
McCloskey, Eugene V., Harvey, Nicholas C., Johansson, Helena and Kanis, John A.. (2016) FRAX updates 2016. Current Opinion in Rheumatology. 28(4), pp. 433 - 441. https://doi.org/10.1097/BOR.0000000000000304
Effectiveness of a minimal resource fracture liaison service
Axelsson, K. F., Jacobsson, R., Lund, D. and Lorentzon, Mattias. (2016) Effectiveness of a minimal resource fracture liaison service. Osteoporosis International. 27(11), pp. 3165 - 3175. https://doi.org/10.1007/s00198-016-3643-2
High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study
Lewerin, C., Johansson, Helena, Karlsson, Magnus K., Lorentzon, Mattias, Lerner, Ulf H., Kindblom, J. M., Ohlsson, Claes, Smith, Ulf and Mellström, Dan. (2016) High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study. Journal of Internal Medicine. 280(4), pp. 398 - 406. https://doi.org/10.1111/joim.12505
Longer duration of diabetes strongly impacts fracture risk assessment: The Manitoba BMD cohort
Majumdar, Sumit R., Leslie, William D., Lix, Lisa M., Morin, Suzanne N., Johansson, Helena, Oden, Anders, McCloskey, Eugene V. and Kanis, John A.. (2016) Longer duration of diabetes strongly impacts fracture risk assessment: The Manitoba BMD cohort. Journal of Clinical Endocrinology and Metabolism. 101(11), pp. 4489 - 4496. https://doi.org/10.1210/jc.2016-2569
Low serum vitamin D is associated with higher cortical porosity in elderly men
Sundh, D., Mellström, Dan, Ljunggren, Östen, Karlsson, Magnus K., Ohlsson, Claes, Nilsson, M., Nilsson, A. G. and Lorentzon, Mattias. (2016) Low serum vitamin D is associated with higher cortical porosity in elderly men. Journal of Internal Medicine. 280(5), pp. 496 - 508. https://doi.org/10.1111/joim.12514
Novel genetic variants associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SLC1A3 and EPHB2
Nielson, Carrie M., Liu, Ching-Ti, Smith, Albert V., Ackert-Bicknell, Cheryl L., Reppe, Sjur, Jakobsdottir, Johanna, Wassel, Christina, Register, Thomas C., Oei, Ling, Alonso, Nerea, Oei, Edwin H., Parimi, Neeta, Samelson, Elizabeth J., Nalls, Mike A., Zmuda, Joseph, Lang, Thomas, Bouxsein, Mary, Latourelle, Jeanne, Claussnitzer, Melina, ... Hsu, Yi-Hsiang. (2016) Novel genetic variants associated with increased vertebral volumetric BMD, reduced vertebral fracture risk, and increased expression of SLC1A3 and EPHB2. Journal of Bone and Mineral Research. 31(12), pp. 2085 - 2097. https://doi.org/10.1002/jbmr.2913
SIGN Guidelines for Scotland: BMD Versus FRAX Versus QFracture
Kanis, John A., Compston, Juliet, Cooper, Cyrus, Harvey, Nicholas C., Johansson, Helena, Oden, Anders and McCloskey, Eugene V.. (2016) SIGN Guidelines for Scotland: BMD Versus FRAX Versus QFracture. Calcified Tissue International. 98(5), pp. 417 - 425. https://doi.org/10.1007/s00223-015-0092-4
A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX
McCloskey, Eugene, Oden, Anders, Harvey, Nicholas C., Leslie, William, Hans, D., Johansson, Helena, Barkmann, Reinhard, Boutroy, Stephanie, Brown, J. P., Chapurlat, Roland D., Elders, Petra J. M., Fujita, Yuki, Glüer, Claus C., Goltzman, David, Iki, Masayuki, Karlsson, M. K., Kindmark, Andreas, Kotowicz, Mark, Kurumatani, Norio, ... Kanis, John A.. (2016) A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. Journal of Bone and Mineral Research. 31(5), pp. 940 - 948. https://doi.org/10.1002/jbmr.2734
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen, Tuomas O., Martin Carli, Jayne F., Skowronski, Alicja A., Sun, Qi, Kriebel, Jennifer, Feitosa, Mary F., Hedman, Åsa K., Drong, Alexander W., Hayes, James E., Zhao, Jinghua H., Pers, Tune H., Schick, Ursula M., Grarup, Niels, Kutalik, Zoltán, Trompet, Stella, Mangino, Massimo, Kristiansson, Kati, Beekman, Marian, Lyytikäinen, Leo-Pekka, ... Lorentzon, Mattias. (2016) Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nature Communications. 7(1), pp. 1 - 14. https://doi.org/10.1038/ncomms10494
Mathematical reasoning requirements in swedish national physics tests
Johansson, Helena. (2016) Mathematical reasoning requirements in swedish national physics tests. International Journal of Science and Mathematics Education. 14, pp. 1133 - 1152. https://doi.org/10.1007/s10763-015-9636-3
A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women
Sundh, Daniel, Rudäng, Robert, Zoulakis, Michail, Nilsson, Anna G., Darelid, Anna and Lorentzon, Mattias. (2016) A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women. Journal of Bone and Mineral Research. 31(4), pp. 749 - 757. https://doi.org/10.1002/jbmr.2747
Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study
Wallin, Maria, Barregard, Lars, Sallsten, Gerd, Lundh, Thomas, Karlsson, Magnus K., Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2016) Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study. Journal of Bone and Mineral Research. 31(4), pp. 732 - 741. https://doi.org/10.1002/jbmr.2743
Hydroxysteroid (17 beta)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production
Hakkarainen, Janne, Jokela, Heli, Pakarinen, Pirjo, Heikelä, Hanna, Kätkänaho, Laura, Vandenput, Liesbeth, Ohlsson, Claes, Zhang, Fu-Ping and Poutanen, Matti. (2015) Hydroxysteroid (17 beta)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production. The FASEB Journal. 29(9), pp. 3806 - 3816. https://doi.org/10.1096/fj.14-269035
Burden of high fracture probability worldwide: Secular increases 2010--2040
Oden, Anders, McCloskey, Eugene V., Kanis, John A., Harvey, Nicholas C. and Johansson, Helena. (2015) Burden of high fracture probability worldwide: Secular increases 2010--2040. Osteoporosis International. 26(9), pp. 2243 - 2248. https://doi.org/10.1007/s00198-015-3154-6
Osteoporosis: The evolution of a diagnosis
Lorentzon, Mattias and Cummings, Steven R.. (2015) Osteoporosis: The evolution of a diagnosis. Journal of Internal Medicine. 277(6), pp. 650 - 661. https://doi.org/10.1111/joim.12369
Intervention thresholds and the diagnosis of osteoporosis
Kanis, John A., McCloskey, Eugene, Harvey, Nicholas C., Johansson, Helena and Leslie, William D.. (2015) Intervention thresholds and the diagnosis of osteoporosis. Journal of Bone and Mineral Research. 30(10), pp. 1747 - 1753. https://doi.org/10.1002/jbmr.2531
New genetic loci link adipose and insulin biology to body fat distribution
Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., ... Lorentzon, Mattias. (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518, pp. 187 - 196. https://doi.org/10.1038/nature14132
Adjusting fracture probability by trabecular bone score
McCloskey, Eugene V., Oden, Anders, Harvey, Nicholas C., Leslie, William D., Hans, Didier, Johansson, Helena and Kanis, John A.. (2015) Adjusting fracture probability by trabecular bone score. Calcified Tissue International. 96(6), pp. 500 - 509. https://doi.org/10.1007/s00223-015-9980-x
Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement
Haghsheno, Mohammad-Ali, Mellstrom, Dan, Peeker, Ralph, Hammarsten, Jan, Lorentzon, Mattias, Sundh, Valter, Karlsson, Magnus, Ohlsson, Claes and Damber, Jan-Erik. (2015) Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement. Scandinavian Journal of Urology. 49(2), pp. 155 - 161. https://doi.org/10.3109/21681805.2014.936495
Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry
Nilsson, Maria E., Vandenput, Liesbeth, Tivesten, Åsa, Norlén, Anna-Karin, Lagerquist, Marie K., Windahl, Sara H., Börjesson, Anna E., Farman, Helen H., Poutannen, Matti, Benrick, Anna, Maliqueo, Manuel, Stener-Victorin, Elisabet, Ryberg, Henrik and Ohlsson, Claes. (2015) Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry. Endocrinology. 156(7), pp. 2492 - 2502. https://doi.org/10.1210/en.2014-1890
The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis
Kherad, M., Mellström, Dan, Rosengren, Björn E., Hasserius, R., Nilsson, J.-Å., Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias and Karlsson, Magnus K.. (2015) The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis. The Bone and Joint Journal. 97-B(8), pp. 1106 - 1110. https://doi.org/10.1302/0301-620X.97B8.35032
Incidence of hip fracture in Brazil and the development of a FRAX model
Zerbini, C. A. F., Szejnfeld, V. L., Abergaria, B. H., McCloskey, Eugene V., Johansson, Helena and Kanis, John A.. (2015) Incidence of hip fracture in Brazil and the development of a FRAX model. Archives of Osteoporosis. 10(1), pp. 1 - 7. https://doi.org/10.1007/s11657-015-0224-5
Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum
Brembeck, P., Lorentzon, Mattias, Ohlsson, Claes, Winkvist, A. and Augustin, H.. (2015) Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum. Journal of Clinical Endocrinology and Metabolism. 100(2), pp. 535 - 543. https://doi.org/10.1210/jc.2014-2825
Predictive ability of heel quantitative ultrasound for incident fractures: an individual-level meta-analysis
McCloskey, Eugene V., Kanis, John A., Oden, Anders, Harvey, Nicholas C., Bauer, D., Gonzalez-Macias, J., Hans, D., Kaptoge, S., Krieg, Marc Antoine, Kwok, T., Marin, F., Moayyeri, A., Orwoll, E., Gluёr, C. and Johansson, Helena. (2015) Predictive ability of heel quantitative ultrasound for incident fractures: an individual-level meta-analysis. Osteoporosis International. 26(7), pp. 1979 - 1987. https://doi.org/10.1007/s00198-015-3072-7
FRAX-based assessment and intervention thresholds - An exploration of thresholds in women aged 50 years and older in the UK
McCloskey, Eugene V., Kanis, John A., Johansson, Helena, Harvey, Nicholas C., Oden, Anders, Cooper, Alun, Cooper, C., Francis, Roger M., Reid, D. M., Marsh, D., Selby, P., Thompson, F., Hewitt, S. and Compston, Juliet E.. (2015) FRAX-based assessment and intervention thresholds - An exploration of thresholds in women aged 50 years and older in the UK. Osteoporosis International. 26(8), pp. 2091 - 2099. https://doi.org/10.1007/s00198-015-3176-0
FRAX and the effect of teriparatide on vertebral and non-vertebral fracture
Harvey, Nicholas C., Kanis, John A., Oden, Anders, Burge, R., Mitlak, B., Johansson, Helena and McCloskey, Eugene V.. (2015) FRAX and the effect of teriparatide on vertebral and non-vertebral fracture. Osteoporosis International. 26(11), pp. 2677 - 2684. https://doi.org/10.1007/s00198-015-3173-3
Sleep duration and disturbances were associated with testosterone level, muscle mass, and muscle strength - A cross-sectional study in 1274 older men
Auyeung, Tung Wai, Kwok, Tung Wai, Leung, Jason, Shun Wah Lee, Jenny, Ohlsson, Claes, Vandenput, Liesbeth, Wing, Yun Kwok and Woo, Jean. (2015) Sleep duration and disturbances were associated with testosterone level, muscle mass, and muscle strength - A cross-sectional study in 1274 older men. Journal of the American Medical Directors Association (JAMDA). 16(7), pp. 630.e1 - 630.e6. https://doi.org/10.1016/j.jamda.2015.04.006
Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects
Eriksson, Joel, Evans, Daniel S., Nielson, Carrie M., Shen, Jian, Srikanth, Priya, Hochberg, Marc, McWeeney, Shannon, Cawthon, Peggy M., Wilmot, Beth, Zmuda, Joseph, Tranah, Greg, Mirel, Daniel B., Challa, Sashi, Mooney, Michael, Crenshaw, Andrew, Karlsson, Magnus, Mellström, Dan, Vandenput, Liesbeth, Orwoll, Eric and Ohlsson, Claes. (2015) Limited clinical utility of a genetic risk score for the prediction of fracture risk in elderly subjects. Journal of Bone and Mineral Research. 30(1), pp. 184 - 194. https://doi.org/10.1002/jbmr.2314
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Cornelis, Marilyn C., Byrne, Enda M., Esko, Tonu, Nalls, Michael A., Ganna, Andrea, Paynter, Nina, Monda, Keri L., Amin, Najaf, Fischer, Krista, Renstrom, Frida, Ngwa, Julius S., Huikari, Ville, Cavadino, Alana, Nolte, Ilja M., Teumer, Alexander, Yu, Kai, Marques-Vidal, Pedro Manuel, Rawal, Rajesh, Manichaikul, Ani, ... UK Brain Expression Consortium (UKBEC). (2015) Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry. 20(5), pp. 647 - 656. https://doi.org/10.1038/mp.2014.107
Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study
Kherad, Mehrsa, Rosengren, Björn E., Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Karlsson, Magnus K.. (2015) Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study. The Spine Journal. 15(2), pp. 281 - 289. https://doi.org/10.1016/j.spinee.2014.09.016
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Cornelis, Marilyn C., Byrne, Enda M., Esko, Tonu, Nalls, Michael A., Ganna, Andrea, Paynter, Nina, Monda, Keri L., Amin, Najaf, Fischer, Krista, Renstrom, Frida, Ngwa, Julius S., Huikari, Ville, Cavadino, Alana, Nolte, Ilja M., Teumer, Alexander, Yu, Kai, Marques-Vidal, Pedro Manuel, Rawal, Rajesh, Manichaikul, Ani, ... UK Brain Expression Consortium (UKBEC). (2015) Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry. 20(5), pp. 647 - 656. https://doi.org/10.1038/mp.2014.107
Increased cortical porosity in older men with fracture
Sundh, Daniel, Mellström, Dan, Nilsson, Martin, Karlsson, Magnus, Ohlsson, Claes and Lorentzon, Mattias. (2015) Increased cortical porosity in older men with fracture. Journal of Bone and Mineral Research. 30(9), pp. 1692 - 1700. https://doi.org/10.1002/jbmr.2509
Hip axis length is a FRAX-and bone density-independent risk factor for hip fracture in women
Leslie, William D., Lix, Lisa M., Morin, Suzanne N., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2015) Hip axis length is a FRAX-and bone density-independent risk factor for hip fracture in women. Journal of Clinical Endocrinology and Metabolism. 100(5), pp. 2063 - 2070. https://doi.org/10.1210/jc.2014-4390
Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study
Darelid, Anna, Nilsson, Martin, Kindblom, Jenny M., Mellström, Dan, Ohlsson, Claes and Lorentzon, Mattias. (2015) Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study. Journal of Clinical Endocrinology and Metabolism. 100(4), pp. 1460 - 1468. https://doi.org/10.1210/jc.2014-3947
High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study
Lewerin, C., Johansson, Helena, Lerner, Ulf H., Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Smith, Ulf, Ohlsson, Claes and Mellström, Dan. (2015) High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study. Journal of Internal Medicine. 278(1), pp. 68 - 76. https://doi.org/10.1111/joim.12340
Is the Swedish FRAX model appropriate for Swedish immigrants?
Johansson, Helena, Oden, Anders, Lorentzon, Mattias, McCloskey, Eugene V., Kanis, John A., Harvey, Nicholas C., Karlsson, M. K. and Mellström, Dan. (2015) Is the Swedish FRAX model appropriate for Swedish immigrants? Osteoporosis International. 26(11), pp. 2617 - 2622. https://doi.org/10.1007/s00198-015-3180-4
Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX
Harvey, Nicholas C., Kanis, John A., Oden, Anders, Nakamura, T., Shiraki, M., Sugimoto, T., Kuroda, T., Johansson, Helena and McCloskey, Eugene V.. (2015) Efficacy of weekly teriparatide does not vary by baseline fracture probability calculated using FRAX. Osteoporosis International. 26(9), pp. 2347 - 2353. https://doi.org/10.1007/s00198-015-3129-7
FRAX and fracture prediction without bone mineral density
Kanis, John A., Harvey, Nicholas C., Johansson, Helena, Oden, Anders, Leslie, William D. and McCloskey, Eugene. (2015) FRAX and fracture prediction without bone mineral density. Climacteric. 18, pp. 2 - 9. https://doi.org/10.3109/13697137.2015.1092342
Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study
Vimaleswaran, Karani S., Cavadino, Alana, Berry, Diane J., Jorde, Rolf, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J. Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A., Nolte, Ilja M., Houston, Denise K., Ahluwalia, Tarunveer Singh, van der Most, Peter J., Pasko, Dorota, Zgaga, Lina, ... Hyppönen, Elina. (2014) Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study. The Lancet Diabetes & Endocrinology. 2(9), pp. 719 - 729. https://doi.org/10.1016/S2213-8587(14)70113-5
The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX
Siggeirsdottir, K., Aspelund, T., Johansson, Helena, Gudmundsson, E. F., Mogensen, B., Jonsson, B. Y., Gudnason, V., McCloskey, Eugene, Oden, Anders, Sigurdsson, G. and Kanis, John A.. (2014) The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX. Osteoporosis International. 25(10), pp. 2445 - 2451. https://doi.org/10.1007/s00198-014-2777-3
Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus
Oei, Ling, Estrada, Karol, Duncan, Emma L., Christiansen, Claus, Liu, Ching-Ti, Langdahl, Bente L., Obermayer-Pietsch, Barbara, Riancho, José A., Prince, Richard L., van Schoor, Natasja M., McCloskey, Eugene, Hsu, Yi-Hsiang, Evangelou, Evangelos, Ntzani, Evangelia, Evans, David M., Alonso, Nerea, Husted, Lise B., Valero, Carmen, Hernandez, Jose L., ... Rivadeneira, Fernando. (2014) Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus. Bone. 59, pp. 20 - 27. https://doi.org/10.1016/j.bone.2013.10.015
Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men
Nilsson, Martin, Sundh, Daniel, Ohlsson, Claes, Karlsson, Magnus, Mellström, Dan and Lorentzon, Mattias. (2014) Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men. Journal of Bone and Mineral Research. 29(8), pp. 1795 - 1804. https://doi.org/10.1002/jbmr.2212
Mild morphometric vertebral fractures predict vertebral fractures but not non-vertebral fractures
Johansson, Helena, Oden, Anders, McCloskey, Eugene V. and Kanis, John A.. (2014) Mild morphometric vertebral fractures predict vertebral fractures but not non-vertebral fractures. Osteoporosis International. 25(1), pp. 235 - 241. https://doi.org/10.1007/s00198-013-2460-0
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaya, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltán, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., ... Lorentzon, Mattias. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46(11), pp. 1173 - 1186. https://doi.org/10.1038/ng.3097
Lumbar spine texture enhances 10-year fracture probability assessment
Leslie, William D., Johansson, Helena, Kanis, John A., Lamy, Olivier, Oden, Anders, McCloskey, Eugene V. and Hans, D.. (2014) Lumbar spine texture enhances 10-year fracture probability assessment. Osteoporosis International. 25(9), pp. 2271 - 2277. https://doi.org/10.1007/s00198-014-2761-y
A meta-analysis of reference markers of bone turnover for prediction of fracture
Johansson, Helena, Oden, Anders, Kanis, John A., McCloskey, Eugene V., Morris, Howard A., Cooper, Cyrus and Vasikaran, Samuel. (2014) A meta-analysis of reference markers of bone turnover for prediction of fracture. Calcified Tissue International. 94(5), pp. 560 - 567. https://doi.org/10.1007/s00223-014-9842-y
Serum estradiol levels are inversely associated with cortical porosity in older men
Vandenput, Liesbeth, Lorentzon, Mattias, Sundh, Daniel, Nilsson, Maria E., Karlsson, Magnus K., Mellström, Dan and Ohlsson, Claes. (2014) Serum estradiol levels are inversely associated with cortical porosity in older men. Journal of Clinical Endocrinology and Metabolism. 99(7), pp. E1322 - E1326. https://doi.org/10.1210/jc.2014-1319
International and ethnic variability of falls in older men
Karlsson, Magnus L., Ribom, Eva L., Nilsson, J.-Å., Karlsson, Caroline, Cöster, Maria, Vonschewelov, Thord, Mallmin, Hans, Ljunggren, Östen, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Leung, Ping C., Lau, Edith, Cauley, Jane A., Barrett-Connor, Elizabeth, Stefanick, Marcia L., Orwoll, Eric and Rosengren, Björn E.. (2014) International and ethnic variability of falls in older men. Scandinavian Journal of Public Health. 42(2), pp. 194 - 200. https://doi.org/10.1177/1403494813510789
Evaluation of the FRAX model for hip fracture predictions in the population-based Kuopio Osteoporosis Risk Factor and Prevention study (OSTPRE)
Sund, Reijo, Honkanen, Risto, Johansson, Helena, Oden, Anders, McCloskey, Eugene, Kanis, John and Kröger, Heikki. (2014) Evaluation of the FRAX model for hip fracture predictions in the population-based Kuopio Osteoporosis Risk Factor and Prevention study (OSTPRE). Calcified Tissue International. 95(1), pp. 39 - 45. https://doi.org/10.1007/s00223-014-9860-9
Waning predictive value of serum adiponectin for fracture risk in elderly men: MrOS Sweden
Johansson, Helena, Oden, Anders, Karlsson, Magnus, McCloskey, Eugene, Kanis, John A., Ohlsson, Claes and Mellström, Dan. (2014) Waning predictive value of serum adiponectin for fracture risk in elderly men: MrOS Sweden. Osteoporosis International. 25(7), pp. 1831 - 1836. https://doi.org/10.1007/s00198-014-2654-0
Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study
Lewerin, Catharina, Nilsson-Ehle, Herman, Jacobsson, Stefan, Johansson, Helena, Sundh, Valter, Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Vandenput, Liesbeth, Ohlsson, Claes and Mellström, Dan. (2014) Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study. Journal of Clinical Endocrinology and Metabolism. 99(7), pp. 2549 - 2556. https://doi.org/10.1210/jc.2013-4111
Genome-wide association studies on serum sex steroid levels
Vandenput, Liesbeth and Ohlsson, Claes. (2014) Genome-wide association studies on serum sex steroid levels. Molecular and Cellular Endocrinology. 382(1), pp. 758 - 766. https://doi.org/10.1016/j.mce.2013.03.009
Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden
Lewerin, C. Lewerin, Nilsson-Ehle, H., Jacobsson, S., Johansson, Helena, Sundh, V., Karlsson, Magnus, Ljunggren, Östen, Lorentzon, Mattias, Kanis, John A., Lerner, Ulf H., Cummings, Steven R., Ohlsson, Claes and Mellström, Dan. (2014) Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden. Osteoporosis International. 25(1), pp. 131 - 140. https://doi.org/10.1007/s00198-013-2527-y
A meta-analysis of the association of fracture risk and body mass index in women
Johansson, Helena, Kanis, John A., Oden, Anders, McCloskey, Eugene, Chapurlat, Roland D., Christiansen, Claus, Cummings, Steven R., Diez-Perez, A, Eisman, John A., Fujiwara, S., Glüer, C. C., Goltzman, David, Hans, D., Khaw, Kay Tee, Krieg, Marc Antoine, Kröger, Heikki, LaCroix, A. Z., Lau, E., Leslie, William D., ... Zillikens, M. Carola. (2014) A meta-analysis of the association of fracture risk and body mass index in women. Journal of Bone and Mineral Research. 29(1), pp. 223 - 233. https://doi.org/10.1002/jbmr.2017
A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children
Detter, Fredrik, Rosengren, Björn E., Dencker, Magnus, Lorentzon, Mattias, Nilsson, Jan‐Åke and Karlsson, Magnus K.. (2014) A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children. Journal of Bone and Mineral Research. 29(6), pp. 1325 - 1336. https://doi.org/10.1002/jbmr.2168
The effect of latitude on the risk and seasonal variation in hip fracture in Sweden
Oden, Anders, Kanis, John A., McCloskey, Eugene V. and Johansson, Helena. (2014) The effect of latitude on the risk and seasonal variation in hip fracture in Sweden. Journal of Bone and Mineral Research. 29(10), pp. 2217 - 2223. https://doi.org/10.1002/jbmr.2250
Impact of femoral neck and lumbar spine BMD discordances on FRAX probabilities in women: A meta-analysis of international cohorts
Johansson, H., Kanis, J. A., Oden, A., Leslie, W. D., Fujiwara, S., Glüer, C. C., Kröger, H., LaCroix, A. Z., Lau, E., Melton, L. J., Eisman, J. A., O'Neill, T. W., Goltzman, D., Reid, D. M. and McCloskey, E.. (2014) Impact of femoral neck and lumbar spine BMD discordances on FRAX probabilities in women: A meta-analysis of international cohorts. Calcified Tissue International. 95(5), pp. 428 - 435. https://doi.org/10.1007/s00223-014-9911-2
Worldwide uptake of FRAX
Kanis, John A., Johansson, Helena, Oden, Anders, Cooper, Cyrus, McCloskey, Eugene E. V., Epidemiology and Quality of Life Working Group of IOF, and Epidemiology and Quality of Life Working Group of IOF. (2014) Worldwide uptake of FRAX. Archives of Osteoporosis. 9(1), pp. 1 - 10. https://doi.org/10.1007/s11657-013-0166-8
Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT
Kemp, John P., Sayers, Adrian, Paternoster, Lavinia, Evans, David M., Deere, Kevin, St. Pourcain, Beate, Timpson, Nicholas J., Ring, Susan M., Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Smith, George Davey, Fraser, William D., ... Tobias, Jon H.. (2014) Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. Journal of Bone and Mineral Research. 29(4), pp. 1015 - 1024. https://doi.org/10.1002/jbmr.2093
Estimated lean mass and fat mass differentially affect femoral bone density and strength index but are not frax independent risk factors for fracture
Leslie, William D., Orwoll, E., Nielson, Carrie M., Morin, Suzanne N., Majumdar, S. R., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2014) Estimated lean mass and fat mass differentially affect femoral bone density and strength index but are not frax independent risk factors for fracture. Journal of Bone and Mineral Research. 29(S1), pp. 2511 - 2519. https://doi.org/10.1002/jbmr.2280
Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men
Tivesten, Åsa, Vandenput, Liesbeth, Carlzon, Daniel, Nilsson, Maria, Karlsson, Magnus K., Ljunggren, Östen, Barrett-Connor, Elizabeth, Mellström, Dan and Ohlsson, Claes. (2014) Dehydroepiandrosterone and its sulfate predict the 5-year risk of coronary heart disease events in elderly men. Journal of the American College of Cardiology. 64(17), pp. 1801 - 1810. https://doi.org/10.1016/j.jacc.2014.05.076
Genetics of endocrine disorders in the era of genome-wide association studies
Vandenput, Liesbeth and Ohlsson, Claes. (2014) Genetics of endocrine disorders in the era of genome-wide association studies. Molecular and Cellular Endocrinology. 382(1), pp. 725 - 725. https://doi.org/10.1016/j.mce.2013.06.031
Can change in FRAX score be used to "treat to target"? A population-based cohort study
Leslie, William D., Majumdar, S. R., Lix, Lisa, Morin, Suzanne N., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2014) Can change in FRAX score be used to "treat to target"? A population-based cohort study. Journal of Bone and Mineral Research. 29(5), pp. 1074 - 1080. https://doi.org/10.1002/jbmr.2151
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
Kwan, Johnny S. H., Hsu, Yi-Hsiang, Cheung, Ching-Lung, Dupuis, Josée, Saint-Pierre, Aude, Eriksson, Joel, Handelman, Samuel K., Aragaki, Aaron K., Karasik, David, Pramstaller, Peter P., Kooperberg, Charles, Lacroix, Andrea Z., Larson, Martin G., Lau, Kam-Shing, Lorentzon, Mattias, Pichler, Irene, Sham, Pak Chung, Taliun, Daniel, Vandenput, Liesbeth, ... Kung, Annie Wai Chee. (2014) Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. Human Molecular Genetics. 23(24), pp. 6684 - 6693. https://doi.org/10.1093/hmg/ddu386
Incidence of hip fracture in Barranquilla, Colombia, and the development of a Colombian FRAX model
Jaller, J. J., Jaller, J. J., Lechuga, J. A., Navarro, E., Johansson, Helena and Kanis, John. (2013) Incidence of hip fracture in Barranquilla, Colombia, and the development of a Colombian FRAX model. Calcified Tissue International. 93(1), pp. 15 - 22. https://doi.org/10.1007/s00223-013-9717-7
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Paternoster, Lavinia, Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Mellström, Dan, Karlsson, Magnus, Ljunggren, Östen, Grundberg, Elin, Kemp, John P., Sayers, Adrian, Nethander, Maria, Evans, David M., Vandenput, Liesbeth, ... Ohlsson, Claes. (2013) Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genetics. 9(2), pp. 1 - 15. https://doi.org/10.1371/journal.pgen.1003247
Incidence of hip fracture in Romania and the development of a Romanian FRAX model
Grigorie, Daniel, Sucaliuc, Alina, Johansson, Helena, Kanis, John A. and McCloskey, Eugene. (2013) Incidence of hip fracture in Romania and the development of a Romanian FRAX model. Calcified Tissue International. 92(5), pp. 429 - 436. https://doi.org/10.1007/s00223-013-9697-7
Assessing the impact of osteoporosis on the burden of hip fractures
Oden, Anders, McCloskey, Eugene V., Johansson, Helena and Kanis, John A.. (2013) Assessing the impact of osteoporosis on the burden of hip fractures. Calcified Tissue International. 92(1), pp. 42 - 49. https://doi.org/10.1007/s00223-012-9666-6
A FRAX model for the estimation of osteoporotic fracture probability in Portugal.
Marques, Andréa, Mota, António, Canhão, Helena, Romeu, José Carlos, Machado, Pedro, Ruano, Afonso, Barbosa, Ana Paula, Dias, António Aroso, Silva, Daniel, Araújo, Domingos, Simões, Eugénia, Aguas, Fernanda, Rosendo, Inês, Silva, Inês, Crespo, Jorge, Alves, José Delgado, Costa, Lúcia, Mascarenhas, Mário, Lourenço, Óscar, ... Pereira da Silva, José António. (2013) A FRAX model for the estimation of osteoporotic fracture probability in Portugal. Acta reumatológica portuguesa. 38(2), pp. 104 - 112.
FRAX-based intervention and assessment thresholds for osteoporosis in Romania
Grigorie, Daniel, Sucaliuc, Alina, Johansson, Helena, Kanis, John A. and McCloskey, Eugene. (2013) FRAX-based intervention and assessment thresholds for osteoporosis in Romania. Archives of Osteoporosis. 8(2017-02-01), pp. 1 - 5. https://doi.org/10.1007/s11657-013-0164-x
Selection of women aged 50-64yr for bone density measurement
Leslie, William D., Lix, Lisa M., Johansson, Helena, Oden, Anders, McCloskey, Eugene V. and Kanis, John A.. (2013) Selection of women aged 50-64yr for bone density measurement. Journal of Clinical Densitometry. 16(4), pp. 570 - 578. https://doi.org/10.1016/j.jocd.2013.01.004
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Kanis, John A., McCloskey, Eugene V., Johansson, Helena, Cooper, Cyrus, Rizzoli, R. and Reginster, Jean Yves. (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporosis International. 24(1), pp. 23 - 57. https://doi.org/10.1007/s00198-012-2074-y
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt, Sonja I., Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jianan, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., ... Lorentzon, Mattias. (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics. 45, pp. 501 - 512. https://doi.org/10.1038/ng.2606
Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men
Ohlsson, Claes, Nilsson, Maria E., Tivesten, Åsa, Ryberg, Henrik, Mellström, Dan, Karlsson, Magnus K., Ljunggren, Östen, Labrie, Fernand, Orwoll, Eric S., Lee, David M., Pye, Stephen R., O'Neill, Terence W., Finn, Joseph D., Adams, Judith E., Ward, Kate A., Boonen, Steven, Bartfai, Gyorgy, Casanueva, Felipe F., Forti, Gianni, ... EMAS Study Group. (2013) Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men. Journal of Clinical Endocrinology and Metabolism. 98(6), pp. e1097 - e1102. https://doi.org/10.1210/jc.2012-3861
Inflammatory bowel disease and the risk of fracture after controlling for FRAX
Targownik, Laura E., Bernstein, Charles N., Nugent, Zoann, Johansson, Helena, Oden, Anders, McCloskey, Eugene, Kanis, John A. and Leslie, William D.. (2013) Inflammatory bowel disease and the risk of fracture after controlling for FRAX. Journal of Bone and Mineral Research. 28(5), pp. 1007 - 1013. https://doi.org/10.1002/jbmr.1848
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
Hoed, Marcel den, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J.J.M., Peal, David S., Evans, David M., Nolte, Ilja M., Segrè, Ayellet V., Hólm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, ... Lorentzon, Mattias. (2013) Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45(6), pp. 621 - 631. https://doi.org/10.1038/ng.2610
Development and application of FRAX in the management of osteoporosis in Ireland
McGowan, B., Kanis, John A., Johansson, Helena, Silke, C. and Whelan, B.. (2013) Development and application of FRAX in the management of osteoporosis in Ireland. Archives of Osteoporosis. 8(2017-02-01), pp. 1 - 6. https://doi.org/10.1007/s11657-013-0146-z
Hip fracture incidence from 1981 to 2009 in the Czech Republic as a basis of the country-specific FRAX model
Stepan, Jan J., Vaculik, Jan, Pavelka, Karel, Zofka, Jan, Johansson, Helena and Kanis, John A.. (2012) Hip fracture incidence from 1981 to 2009 in the Czech Republic as a basis of the country-specific FRAX model. Calcified Tissue International. 90(5), pp. 365 - 372. https://doi.org/10.1007/s00223-012-9582-9
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
Zheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimäki, Terho, Bergström, Ulrica, Kähönen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lehtimäki, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, ... Lorentzon, Mattias. (2012) WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genetics. 8(7), pp. 1 - 13. https://doi.org/10.1371/journal.pgen.1002745
A systematic review of hip fracture incidence and probability of fracture worldwide
Kanis, John A., Oden, Anders, McCloskey, Eugene V., Johansson, Helena, Wahl, D. A. and Cooper, Cyrus. (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporosis International. 23(9), pp. 2239 - 2256. https://doi.org/10.1007/s00198-012-1964-3
The role of IGF-1 for fracture risk in men
Vandenput, Liesbeth, Sjögren, Klara, Svensson, Johan and Ohlsson, Claes. (2012) The role of IGF-1 for fracture risk in men. Frontiers in Endocrinology. 3, pp. 1 - 3. https://doi.org/10.3389/fendo.2012.00051
Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden
Johansson, Helena Johansson, Oden, Anders, Kanis, John A., McCloskey, Eugene, Lorentzon, Mattias, Ljunggren, Östen, Karlsson, Magnus, Thorsby, P. M., Tivesten, A., Barrett-Connor, Elizabeth, Ohlsson, Claes and Mellström, Dan. (2012) Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden. Osteoporosis International. 23(3), pp. 991 - 999. https://doi.org/10.1007/s00198-011-1809-5
Does osteoporosis therapy invalidate FRAX for fracture prediction?
Leslie, William D., Lix, Lisa M., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2012) Does osteoporosis therapy invalidate FRAX for fracture prediction? Journal of Bone and Mineral Research. 27(6), pp. 1243 - 1251. https://doi.org/10.1002/jbmr.1582
Cost-effective intervention thresholds against osteoporotic fractures based on FRAX® in Switzerland
Lippuner, K., Johansson, Helena, Borgström, F., Kanis, John A. and Rizzoli, R.. (2012) Cost-effective intervention thresholds against osteoporotic fractures based on FRAX® in Switzerland. Osteoporosis International. 23(11), pp. 2579 - 2589. https://doi.org/10.1007/s00198-011-1869-6
A comparative study of using non-hip bone density inputs with FRAX®
Leslie, William D., Lix, Lisa, Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2012) A comparative study of using non-hip bone density inputs with FRAX®. Osteoporosis International. 23(3), pp. 853 - 860. https://doi.org/10.1007/s00198-011-1814-8
Sex steroids and bone health in men
Ohlsson, Claes, Börjesson, Anna E. and Vandenput, Liesbeth. (2012) Sex steroids and bone health in men. BoneKEy Reports. 1(2), pp. 1 - 7. https://doi.org/10.1038/bonekey.2012.3
Incidence of hip fracture and prevalence of osteoporosis in Turkey: The FRACTURK study
Tuzun, Sansin, Eskiyurt, Nurten, Akarirmak, Ulku, Saridogan, Merih, Senocak, M., Johansson, Helena and Kanis, John A.. (2012) Incidence of hip fracture and prevalence of osteoporosis in Turkey: The FRACTURK study. Osteoporosis International. 23(3), pp. 949 - 955. https://doi.org/10.1007/s00198-011-1655-5
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
Johansson, Helena, Oden, Anders, Lerner, Ulf H., Jutberger, Hans, Lorentzon, Mattias, Barrett-Connor, Elizabeth, Karlsson, Magnus, Ljunggren, Östen, Smith, Ulf, McCloskey, Eugene, Kanis, John A., Ohlsson, Claes and Mellstrom, Dan. (2012) High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden. Journal of Bone and Mineral Research. 27(6), pp. 1390 - 1396. https://doi.org/10.1002/jbmr.1591
Fracture risk assessment without bone density measurement in routine clinical practice
Leslie, William D., Morin, Suzanne N., Lix, Lisa M., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2012) Fracture risk assessment without bone density measurement in routine clinical practice. Osteoporosis International. 23(1), pp. 75 - 85. https://doi.org/10.1007/s00198-011-1747-2
FRAX® with and without bone mineral density
Kanis, John A., McCloskey, Eugene, Johansson, Helena, Oden, Anders and Leslie, William D.. (2012) FRAX® with and without bone mineral density. Calcified Tissue International. 90(1), pp. 1 - 13. https://doi.org/10.1007/s00223-011-9544-7
Epidemiology of fracture in the Russian Federation and the development of a FRAX model
Lesnyak, Olga, Ershova, Olga, Belova, Ksenia, Gladkova, Elena, Sinitsina, Olga, Ganert, Olga, Romanova, Marina, Khodirev, Vitalij, Johansson, Helena, McCloskey, Eugene and Kanis, John A.. (2012) Epidemiology of fracture in the Russian Federation and the development of a FRAX model. Archives of Osteoporosis. 7(2017-02-01), pp. 67 - 73. https://doi.org/10.1007/s11657-012-0082-3
Pitfalls in the external validation of FRAX
Kanis, John A., Oden, Anders, Johansson, Helena and McCloskey, Eugene. (2012) Pitfalls in the external validation of FRAX. Osteoporosis International. 23(2), pp. 423 - 431. https://doi.org/10.1007/s00198-011-1846-0
High fracture probability with FRAX® usually indicates densitometric osteoporosis: Implications for clinical practice
Leslie, William D., Majumdar, S. R., Lix, Lisa M., Johansson, Helena, Oden, Anders, McCloskey, Eugene V. and Kanis, John A.. (2012) High fracture probability with FRAX® usually indicates densitometric osteoporosis: Implications for clinical practice. Osteoporosis International. 23(1), pp. 391 - 397. https://doi.org/10.1007/s00198-011-1592-3
Potential extensions of the US FRAX algorithm
Melton, Lisa Joseph, Atkinson, Elizabeth J., Achenbach, Sara J., Kanis, John A., Therneau, Terry M., Johansson, Helena, Khosla, Sundeep and Amin, Shreyasee. (2012) Potential extensions of the US FRAX algorithm. Journal of Osteoporosis. 2012, pp. 1 - 8. https://doi.org/10.1155/2012/528790
FRAX underestimates fracture risk in patients with diabetes
Giangregorio, Lora M., Leslie, William D., Lix, Lisa, Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2012) FRAX underestimates fracture risk in patients with diabetes. Journal of Bone and Mineral Research. 27(2), pp. 301 - 308. https://doi.org/10.1002/jbmr.556
FRAX® probabilities and risk of major osteoporotic fracture in France
Couris, C. M., Chapurlat, Roland D., Kanis, John A., Johansson, Helena, Burlet, N., Delmas, P. D. and Schott, A. M.. (2012) FRAX® probabilities and risk of major osteoporotic fracture in France. Osteoporosis International. 23(9), pp. 2321 - 2327. https://doi.org/10.1007/s00198-011-1883-8
The impact of a FRAX-based intervention threshold in Turkey: The FRAX-TURK study
Tuzun, Sansin, Eskiyurt, Nurten, Akarirmak, Ulku, Saridogan, Merih, Johansson, Helena, McCloskey, Eugene, Kanis, John A., Turkish Osteoporosis Society, and Turkish Osteoporosis Society. (2012) The impact of a FRAX-based intervention threshold in Turkey: The FRAX-TURK study. Archives of Osteoporosis. 7(2017-02-01), pp. 229 - 235. https://doi.org/10.1007/s11657-012-0101-4
Sex steroids and bone health in older Chinese men
Woo, J., Kwok, T., Leung, J. C. S., Ohlsson, C., Vandenput, L. and Leung, P. C.. (2012) Sex steroids and bone health in older Chinese men. Osteoporosis International. 23(5), pp. 1553 - 1562. https://doi.org/10.1007/s00198-011-1552-y
A comparison of case-finding strategies in the UK for the management of hip fractures
Johansson, Helena, Kanis, John A., Oden, Anders, Compston, Juliet E. and McCloskey, Eugene. (2012) A comparison of case-finding strategies in the UK for the management of hip fractures. Osteoporosis International. 23(3), pp. 907 - 915. https://doi.org/10.1007/s00198-011-1864-y
The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: An update in NHANES 2005-2008
Dawson-Hughes, Bess, Looker, A. C., Tosteson, Anna N. A., Johansson, Helena, Kanis, John A. and Melton, Lisa. (2012) The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: An update in NHANES 2005-2008. Osteoporosis International. 23(3), pp. 811 - 820. https://doi.org/10.1007/s00198-011-1694-y
Fracture risk assessment
McCloskey, Eugene, Johansson, Helena, Oden, Anders and Kanis, John A.. (2012) Fracture risk assessment. Clinical Biochemistry. 45(12), pp. 887 - 893. https://doi.org/10.1016/j.clinbiochem.2012.05.001
Denosumab reduces the risk of osteoporotic fractures in postmenopausal women, particularly in those with moderate to high fracture risk as assessed with FRAX
McCloskey, Eugene, Johansson, Helena, Oden, Anders, Austin, Matthew S., Siris, E. S., Wang, Andrea, Lewiecki, E. Michael, Lorenc, R. S., Libanati, Cesar and Kanis, John A.. (2012) Denosumab reduces the risk of osteoporotic fractures in postmenopausal women, particularly in those with moderate to high fracture risk as assessed with FRAX. Journal of Bone and Mineral Research. 27(7), pp. 1480 - 1486. https://doi.org/10.1002/jbmr.1606
The distribution of FRAX®-based probabilities in women from Japan
Kanis, John A., Johansson, Helena, Oden, Anders and McCloskey, Eugene. (2012) The distribution of FRAX®-based probabilities in women from Japan. Journal of Bone and Mineral Metabolism. 30(6), pp. 700 - 705. https://doi.org/10.1007/s00774-012-0371-3
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
Medina-Gomez, Carolina, Kemp, John P., Estrada, Karol, Eriksson, Joel, Liu, Jeff, Reppe, Sjur, Evans, David M., Heppe, Denise H. M., Vandenput, Liesbeth, Herrera, Lizbeth, Ring, Susan M., Kruithof, Claudia J., Timpson, Nicholas J., Zillikens, M. Carola, Olstad, Ole K., Zheng, Hou-Feng, Richards, J. Brent, St. Pourcain, Beate, Hofman, Albert, ... Rivadeneira, Fernando. (2012) Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genetics. 8(7), pp. 1 - 14. https://doi.org/10.1371/journal.pgen.1002718
Calibration of FRAX ® 3.1 to the Dutch population with data on the epidemiology of hip fractures
Lalmohamed, A., Welsing, P. M. J., Lems, Willem F., Jacobs, J. W. G., Kanis, John A., Johansson, Helena, De Boer, A. and De Vries, F.. (2012) Calibration of FRAX ® 3.1 to the Dutch population with data on the epidemiology of hip fractures. Osteoporosis International. 23(3), pp. 861 - 869. https://doi.org/10.1007/s00198-011-1852-2
Fracture prediction and calibration of a Canadian FRAX® tool: A population-based report from CaMos
Fraser, L.-A., Langsetmo, L., Berger, C., Ioannidis, G., Goltzman, David, Adachi, Jonathan D., Papaioannou, A., Josse, R. G., Kovacs, C. S., Olszynski, W. P., Towheed, T., Hanley, David A., Kaiser, S. M., Prior, J., Jamal, S., Kreiger, N., Brown, J. P., Johansson, Helena, Oden, Anders, ... Leslie, William D.. (2011) Fracture prediction and calibration of a Canadian FRAX® tool: A population-based report from CaMos. Osteoporosis International. 22(3), pp. 829 - 837. https://doi.org/10.1007/s00198-010-1465-1
A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX®
Kanis, John A., Johansson, Helena, Oden, Anders and McCloskey, Eugene V.. (2011) A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX®. Osteoporosis International. 22(8), pp. 2347 - 2355. https://doi.org/10.1007/s00198-010-1474-0
Evaluation of FRAX to characterise fracture risk in Poland
Czerwinski, E., Kanis, John A., Osieleniec, J., Kumorek, A., Milert, A., Johansson, Helena, McCloskey, Eugene V. and Gorkiewicz, M.. (2011) Evaluation of FRAX to characterise fracture risk in Poland. Osteoporosis International. 22(9), pp. 2507 - 2512. https://doi.org/10.1007/s00198-010-1502-0
Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment
Leslie, William D., Lix, Lisa M., Langsetmo, L., Berger, C., Goltzman, David, Hanley, David A., Adachi, J. D., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2011) Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment. Osteoporosis International. 22(3), pp. 817 - 827. https://doi.org/10.1007/s00198-010-1464-2
Interpretation and use of FRAX in clinical practice
Kanis, John A., Hans, D., Cooper, Cyrus, Baim, Sanford, Bilezikian, J. P., Binkley, Neil, Cauley, Jane A., Compston, Juliet E., Dawson-Hughes, Bess, Fuleihan, Ghada El-Hajj, Johansson, Helena, Leslie, William D., Lewiecki, E. Michael, Luckey, Marjorie M., Oden, Anders, Papapoulos, S., Poiana, Catalina, Rizzoli, R, Wahl, D. A. and McCloskey, Eugene. (2011) Interpretation and use of FRAX in clinical practice. Osteoporosis International. 22(9), pp. 2395 - 2411. https://doi.org/10.1007/s00198-011-1713-z
FRAX - modell för att beräkna 10-årsrisken för fraktur
Johansson, Helena, Kanis, John, Ljunggren, Östen, Ström, O., Svensson, Olle and Mellström, Dan. (2011) FRAX - modell för att beräkna 10-årsrisken för fraktur. Lakartidningen. 108(7), pp. 336 - 339.
Increasing age- and sex-specific rates of hip fracture in Mexico: A survey of the Mexican institute of social security
Johansson, Helena, Clark, P., Carlos, F., Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2011) Increasing age- and sex-specific rates of hip fracture in Mexico: A survey of the Mexican institute of social security. Osteoporosis International. 22(8), pp. 2359 - 2364. https://doi.org/10.1007/s00198-010-1475-z
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen, Tuomas O., Zillikens, M. Carola, Stančákova, Alena, Finucane, Francis M., Ried, Janina S., Langenberg, Claudia, Zhang, Weihua, Beckmann, Jacques S., Luan, Jian'an, Vandenput, Liesbeth, Styrkarsdottir, Unnur, Zhou, Yanhua, Smith, Albert V., Zhao, Jing-Hua, Amin, Najaf, Vedantam, Sailaja, Shin, So-Youn, Haritunians, Talin, Fu, Mao, ... Loos, Ruth J. F.. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature Genetics. 43(8), pp. 753 - 760. https://doi.org/10.1038/ng.866
Genetic determinants of serum testosterone concentrations in men
Ohlsson, Claes, Wallaschofski, Henri, Lunetta, Kathryn L., Stolk, Lisette, Perry, John R. B., Koster, Annemarie, Petersen, Ann-Kristin, Eriksson, Joel, Lehtima¨ki, Terho, Huhtaniemi, Ilpo T., Hammond, Geoffrey L., Maggio, Marcello, Coviello, Andrea D., Ferrucci, Luigi, Heier, Margit, Hofman, Albert, Holliday, Kate L., Jansson, John-Olov, Kahonen, Mika, ... Melzer, David. (2011) Genetic determinants of serum testosterone concentrations in men. PLoS Genetics. 7(10), pp. 1 - 11. https://doi.org/10.1371/journal.pgen.1002313
The application of FRAX® to determine intervention thresholds in osteoporosis treatment in Poland
Badurski, Janusz E., Kanis, John A., Johansson, Helena, Dobrenko, Andrzej, Nowak, Nonna A., Daniluk, Stefan and Jezienicka, Elzbieta. (2011) The application of FRAX® to determine intervention thresholds in osteoporosis treatment in Poland. Polish Archives of Internal Medicine. 121(5), pp. 148 - 155.
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms
Zhai, Guangju, Teumer, Alexander, Stolk, Lisette, Perry, John R. B., Vandenput, Liesbeth, Coviello, Andrea D., Koster, Annemarie, Bell, Jordana T., Bhasin, Shalender, Eriksson, Joel, Ernst, Florian, Ferrucci, Luigi, Frayling, Timothy M., Glass, Daniel, Grundberg, Elin, Haring, Robin, Hedman, Åsa K., Hofman, Albert, Kiel, Douglas P., ... MuTHER Consortium. (2011) Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genetics. 7(4), pp. 1 - 10. https://doi.org/10.1371/journal.pgen.1002025
Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: results from a large study
Wong, Samuel Y. S., Leung, Jason, Kwok, Timothy, Ohlsson, Claes, Vandenput, Liesbeth, Leung, Ping C. and Woo, Jean. (2011) Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: results from a large study. Asian Journal of Andrology. 13(6), pp. 898 - 902. https://doi.org/10.1038/aja.2011.116
Guidance for the adjustment of FRAX according to the dose of glucocorticoids
Kanis, John A., Johansson, Helena, Oden, Anders and McCloskey, Eugene V.. (2011) Guidance for the adjustment of FRAX according to the dose of glucocorticoids. Osteoporosis International. 22(3), pp. 809 - 816. https://doi.org/10.1007/s00198-010-1524-7
Hip fracture risk in older US adults by treatment eligibility status based on new National Osteoporosis Foundation guidance
Looker, A. C., Dawson-Hughes, B., Tosteson, Anna N. A., Johansson, Helena, Kanis, John A. and Melton, Lisa J.. (2011) Hip fracture risk in older US adults by treatment eligibility status based on new National Osteoporosis Foundation guidance. Osteoporosis International. 22(2), pp. 541 - 549. https://doi.org/10.1007/s00198-010-1288-0
Older men with low serum IGF-1 have an increased risk of incident fractures: The MrOS Sweden study
Ohlsson, Claes, Mellström, Dan, Carlzon, Daniel, Orwoll, Eric, Ljunggren, Östen, Karlsson, Magnus K. and Vandenput, Liesbeth. (2011) Older men with low serum IGF-1 have an increased risk of incident fractures: The MrOS Sweden study. Journal of Bone and Mineral Research. 26(4), pp. 865 - 872. https://doi.org/10.1002/jbmr.281
Spine-hip discordance and fracture risk assessment: A physician-friendly FRAX enhancement
Leslie, William D., Lix, Lisa, Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John A.. (2011) Spine-hip discordance and fracture risk assessment: A physician-friendly FRAX enhancement. Osteoporosis International. 22(3), pp. 839 - 847. https://doi.org/10.1007/s00198-010-1461-5
Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden
Johansson, Helena, Oden, Anders, Kanis, John A., McCloskey, Eugene V., Lorentzon, Mattias, Ljunggren, Östen, Karlsson, Magnus K., Orwoll, E., Tivesten, A., Ohlsson, Claes and Mellström, Dan. (2011) Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden. Osteoporosis International. 22(5), pp. 1411 - 1418. https://doi.org/10.1007/s00198-010-1331-1
Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men
Auyeung, Tung Wai, Shun Wah Lee, Jenny, Kwok, Timothy, Leung, Jason, Ohlsson, Claes, Vandenput, Liesbeth, Leung, Ping Ching and Woo, Jean. (2011) Testosterone but not estradiol level is positively related to muscle strength and physical performance independent of muscle mass: a cross-sectional study in 1489 older men. European Journal of Endocrinology. 164(5), pp. 811 - 817. https://doi.org/10.1530/EJE-10-0952
High serum testosterone is associated with reduced risk of cardiovascular events in elderly men - The MrOS (Osteoporotic Fractures in Men) study in Sweden
Ohlsson, Claes, Barrett-Connor, Elizabeth, Bhasin, Shalender, Orwoll, Eric, Labrie, Fernand, Karlsson, Magnus K., Ljunggren, Östen, Vandenput, Liesbeth, Mellström, Dan and Tivesten, Åsa. (2011) High serum testosterone is associated with reduced risk of cardiovascular events in elderly men - The MrOS (Osteoporotic Fractures in Men) study in Sweden. Journal of the American College of Cardiology. 58(16), pp. 1674 - 1681. https://doi.org/10.1016/j.jacc.2011.07.019
A FRAX® model for the assessment of fracture probability in Belgium
Johansson, Helena, Kanis, John, McCloskey, Eugene, Oden, Anders, Devogelaer, J. P., Kaufman, J-M, Neuprez, A., Hiligsmann, Mickaël, Bruyère, O. and Reginster, Jean Yves. (2011) A FRAX® model for the assessment of fracture probability in Belgium. Osteoporosis International. 22(2), pp. 453 - 461. https://doi.org/10.1007/s00198-010-1218-1
Cost-effectiveness of bazedoxifene incorporating the FRAX® algorithm in a European perspective
Borgström, F., Ström, O., Kleman, M., McCloskey, Eugene, Johansson, Helena, Oden, Anders and Kanis, John A.. (2011) Cost-effectiveness of bazedoxifene incorporating the FRAX® algorithm in a European perspective. Osteoporosis International. 22(3), pp. 955 - 965. https://doi.org/10.1007/s00198-010-1291-5
The cost-effectiveness of strontium ranelate in the UK for the management of osteoporosis
Borgström, F., Ström, O., Coelho, J., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John. (2010) The cost-effectiveness of strontium ranelate in the UK for the management of osteoporosis. Osteoporosis International. 21(2), pp. 339 - 349. https://doi.org/10.1007/s00198-009-0971-5
Independent clinical validation of a Canadian FRAX tool: Fracture prediction and model calibration
Leslie, William D., Lix, Lisa, Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John. (2010) Independent clinical validation of a Canadian FRAX tool: Fracture prediction and model calibration. Journal of Bone and Mineral Research. 25(11), pp. 2350 - 2358. https://doi.org/10.1002/jbmr.123
FRAX® and its applications in health economics-Cost-effectiveness and intervention thresholds using bazedoxifene in a Swedish setting as an example
Ström, O., Borgström, F., Kleman, M., McCloskey, Eugene, Oden, Anders, Johansson, Helena and Kanis, John. (2010) FRAX® and its applications in health economics-Cost-effectiveness and intervention thresholds using bazedoxifene in a Swedish setting as an example. Bone. 47(2), pp. 430 - 437. https://doi.org/10.1016/j.bone.2010.05.020
Smoking predicts incident fractures in elderly men: Mr OS Sweden
Jutberger, Hans, Lorentzon, Mattias, Barrett-Connor, Elizabeth, Johansson, Helena, Kanis, John, Ljunggren, Östen, Karlsson, Magnus, Rosengren, Björn E., Redlund-Johnell, Inga, Orwoll, E, Ohlsson, Claes and Mellström, Dan. (2010) Smoking predicts incident fractures in elderly men: Mr OS Sweden. Journal of Bone and Mineral Research. 25(5), pp. 1010 - 1016. https://doi.org/10.1359/jbmr.091112
Application of the national osteoporosis foundation guidelines to postmenopausal women and men: The Framingham osteoporosis study
Berry, S. D., Kiel, Douglas P., Donaldson, Meghan G., Cummings, Steven R., Kanis, John, Johansson, Helena and Samelson, E. J.. (2010) Application of the national osteoporosis foundation guidelines to postmenopausal women and men: The Framingham osteoporosis study. Osteoporosis International. 21(1), pp. 53 - 60. https://doi.org/10.1007/s00198-009-1127-3
Development and use of FRAX® in osteoporosis
Kanis, J. A., McCloskey, E. V., Johansson, H., Oden, Anders, Ström, O. and Borgström, F.. (2010) Development and use of FRAX® in osteoporosis. Osteoporosis International. 21(Supplement 2), pp. S407 - S413. https://doi.org/10.1007/s00198-010-1253-y
The cost-effectiveness of risedronate in the UK for the management of osteoporosis using the FRAX®
Borgström, F., Ström, O., Coelho, J., Johansson, Helena, Oden, Anders, McCloskey, Eugene and Kanis, John. (2010) The cost-effectiveness of risedronate in the UK for the management of osteoporosis using the FRAX®. Osteoporosis International. 21(3), pp. 495 - 505. https://doi.org/10.1007/s00198-009-0989-8
The effects of a FRAX® revision for the USA
Kanis, John, Johansson, Helena, Oden, Anders, Dawson-Hughes, Bess, Melton, Lisa and McCloskey, Eugene. (2010) The effects of a FRAX® revision for the USA. Osteoporosis International. 21(1), pp. 35 - 40. https://doi.org/10.1007/s00198-009-1033-8
FRAX assessment of osteoporotic fracture probability in Switzerland
Lippuner, K., Johansson, Helena, Kanis, John and Rizzoli, Rene. (2010) FRAX assessment of osteoporotic fracture probability in Switzerland. Osteoporosis International. 21(3), pp. 381 - 389. https://doi.org/10.1007/s00198-009-0975-1
The potential impact of new National Osteoporosis Foundation guidance on treatment patterns
Dawson-Hughes, Bess, Looker, A. C., Tosteson, Anna N. A., Johansson, Helena, Kanis, John and Melton, Lisa. (2010) The potential impact of new National Osteoporosis Foundation guidance on treatment patterns. Osteoporosis International. 21(1), pp. 41 - 52. https://doi.org/10.1007/s00198-009-1034-7
A meta-analysis of the efficacy of raloxifene on all clinical and vertebral fractures and its dependency on FRAX®
Kanis, John, Johansson, Helena, Oden, Anders and McCloskey, Eugene. (2010) A meta-analysis of the efficacy of raloxifene on all clinical and vertebral fractures and its dependency on FRAX®. Bone. 47(4), pp. 729 - 735. https://doi.org/10.1016/j.bone.2010.06.009
The incidence and risk of hip fracture in Poland
Czerwinski, E., Kanis, John, Trybulec, B., Johansson, Helena, Borowy, P. and Osieleniec, J.. (2009) The incidence and risk of hip fracture in Poland. Osteoporosis International. 20(8), pp. 1363 - 1367. https://doi.org/10.1007/s00198-008-0787-8
BMD, clinical risk factors and their combination for hip fracture prevention
Johansson, Helena, Kanis, John, Oden, Anders, Johnell, O. and McCloskey, Eugene. (2009) BMD, clinical risk factors and their combination for hip fracture prevention. Osteoporosis International. 20(10), pp. 1675 - 1682. https://doi.org/10.1007/s00198-009-0845-x
How to decide who to treat
Kanis, John, McCloskey, Eugene, Johansson, Helena, Ström, O., Borgström, F. and Oden, Anders. (2009) How to decide who to treat. Best Practice and Research: Clinical Rheumatology. 23(6), pp. 711 - 726. https://doi.org/10.1016/j.berh.2009.09.002
FRAX® and its applications to clinical practice
Kanis, John, Oden, Anders, Johansson, Helena, Borgström, F., Ström, O. and McCloskey, Eugene. (2009) FRAX® and its applications to clinical practice. Bone. 44(5), pp. 734 - 743. https://doi.org/10.1016/j.bone.2009.01.373
Can fall risk be incorporated into fracture risk assessment algorithms: A pilot study of responsiveness to clodronate
Kayan, K., Johansson, Helena, Oden, Anders, Vasireddy, S., Pande, K., Orgee, J., Kanis, John and McCloskey, Eugene. (2009) Can fall risk be incorporated into fracture risk assessment algorithms: A pilot study of responsiveness to clodronate. Osteoporosis International. 20(12), pp. 2055 - 2061. https://doi.org/10.1007/s00198-009-0942-x
Approaches to the targeting of treatment for osteoporosis.
Kanis, John, McCloskey, Eugene, Johansson, Helena and Oden, Anders. (2009) Approaches to the targeting of treatment for osteoporosis. Nature Reviews Rheumatology. 5(8), pp. 425 - 431. https://doi.org/10.1038/nrrheum.2009.139
Assessment of fracture risk
Kanis, John, Johansson, Helena, Oden, Anders and McCloskey, Eugene. (2009) Assessment of fracture risk. European Journal of Radiology. 71(3), pp. 392 - 397. https://doi.org/10.1007/s11914-011-0093-9
Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women
Lippuner, K., Johansson, Helena, Kanis, John and Rizzoli, Rene. (2009) Remaining lifetime and absolute 10-year probabilities of osteoporotic fracture in Swiss men and women. Osteoporosis International. 20(7), pp. 1131 - 1140. https://doi.org/10.1007/s00198-008-0779-8
Ten-year fracture probability identifies women who will benefit from clodronate therapy-additional results from a double-blind, placebo-controlled randomised study
McCloskey, Eugene, Johansson, Helena, Oden, Anders, Vasireddy, S., Kayan, K., Pande, K., Jalava, T. and Kanis, John. (2009) Ten-year fracture probability identifies women who will benefit from clodronate therapy-additional results from a double-blind, placebo-controlled randomised study. Osteoporosis International. 20(5), pp. 811 - 817. https://doi.org/10.1007/s00198-008-0786-9
Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX®
Kanis, John, Johansson, Helena, Oden, Anders and McCloskey, Eugene. (2009) Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX®. Bone. 44(6), pp. 1049 - 1054. https://doi.org/10.1016/j.bone.2009.02.014
From relative risk to absolute fracture risk calculation: The FRAX algorithm
McCloskey, Eugene, Johansson, Helena, Oden, Anders and Kanis, John. (2009) From relative risk to absolute fracture risk calculation: The FRAX algorithm. Current Osteoporosis Reports. 7(3), pp. 77 - 83. https://doi.org/10.1007/s11914-009-0013-4
Ten-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores
Tsang, S. W. Y., Kung, Annie Wai Chee, Kanis, John, Johansson, Helena and Oden, Anders. (2009) Ten-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores. Osteoporosis International. 20(11), pp. 1939 - 1945. https://doi.org/10.1007/s00198-009-0906-1
Assessment of the 10-year probability of osteoporotic hip fracture combining clinical risk factors and heel bone ultrasound: The EPISEM prospective cohort of 12,958 elderly women
Hans, Didier, Durosier, Claire, Kanis, John, Johansson, Helena, Schott-Pethelaz, Anne Marie and Krieg, Marc Antoine. (2008) Assessment of the 10-year probability of osteoporotic hip fracture combining clinical risk factors and heel bone ultrasound: The EPISEM prospective cohort of 12,958 elderly women. Journal of Bone and Mineral Research. 23(7), pp. 1045 - 1051. https://doi.org/10.1359/jbmr.080229
Development and application of a Japanese model of the WHO fracture risk assessment tool (FRAX)
Fujiwara, S., Nakamura, T., Orimo, H., Hosoi, T., Gorai, I., Oden, Anders, Johansson, Helena and Kanis, John. (2008) Development and application of a Japanese model of the WHO fracture risk assessment tool (FRAX). Osteoporosis International. 19(4), pp. 429 - 435. https://doi.org/10.1007/s00198-007-0544-4
A reference standard for the description of osteoporosis
Kanis, John, McCloskey, Eugene, Johansson, Helena, Oden, Anders, Melton, Lisa and Khaltaev, Nikolai. (2008) A reference standard for the description of osteoporosis. Bone. 42(3), pp. 467 - 475. https://doi.org/10.1016/j.bone.2007.11.001
FRAX' and the assessment of fracture probability in men and women from the UK
Kanis, John, Johnell, O., Oden, Anders, Johansson, Helena and McCloskey, Eugene. (2008) FRAX' and the assessment of fracture probability in men and women from the UK. Osteoporosis International. 19(4), pp. 385 - 397. https://doi.org/10.1007/s00198-007-0543-5
Case finding for the management of osteoporosis with FRAX® - Assessment and intervention thresholds for the UK
Kanis, John, McCloskey, Eugene, Johansson, Helena, Ström, O., Borgström, F., Oden, Anders, Compston, Juliet E., Cooper, Alun, Cooper, Cyrus, Francis, Roger M., Marsh, D., Reid, David M., Selby, P. and Wilkins, M.. (2008) Case finding for the management of osteoporosis with FRAX® - Assessment and intervention thresholds for the UK. Osteoporosis International. 19(10), pp. 1395 - 1408. https://doi.org/10.1007/s00198-008-0712-1
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
Kanis, John, Oden, Anders, Johnell, O., Johansson, Helena, Laet, C. De, Brown, Jacques P., Burckhardt, Peter, Cooper, Cyrus, Christiansen, Claus, Cummings, Steven R., Eisman, John A., Fujiwara, S., Glüer, C. C., Goltzman, David, Hans, Didier, Krieg, Marc Antoine, Lacroix, Andrea Z., McCloskey, Eugene, Mellström, Dan, ... Yoshimura, N.. (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International. 18(8), pp. 1033 - 1046. https://doi.org/10.1007/s00198-007-0343-y
The use of multiple sites for the diagnosis of osteoporosis
Kanis, John, Johnell, O., Oden, Anders, Johansson, Helena, Eisman, John A., Fujiwara, S., Kröger, Heikki, Honkanen, Risto, Melton, Lisa, O'Neill, T. W., Reeve, Jonathan, Silman, A. and Tenenhouse, A.. (2006) The use of multiple sites for the diagnosis of osteoporosis. Osteoporosis International. 17(4), pp. 527 - 534. https://doi.org/10.1007/s00198-005-0014-9