Skeletal muscle fiber characteristics in patients with chronic heart failure: Impact of disease severity and relation with muscle oxygenation during exercise
Journal article
Niemeijer, Victor M., Snijders, Tim, Verdijk, Lex B., Van Kranenburg, Janneau, Groen, Bart B.L., Holwerda, Andrew M., Spee, Ruud F., Wijn, Pieter F. F., van Loon, Luc and Kemps, Hareld M.C.. (2018). Skeletal muscle fiber characteristics in patients with chronic heart failure: Impact of disease severity and relation with muscle oxygenation during exercise. Journal of Applied Physiology. 125(4), pp. 1266 - 1276. https://doi.org/10.1152/japplphysiol.00057.2018
Authors | Niemeijer, Victor M., Snijders, Tim, Verdijk, Lex B., Van Kranenburg, Janneau, Groen, Bart B.L., Holwerda, Andrew M., Spee, Ruud F., Wijn, Pieter F. F., van Loon, Luc and Kemps, Hareld M.C. |
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Abstract | Skeletal muscle function in patients with heart failure and reduced ejection fraction (HFrEF) greatly determines exercise capacity. However, reports on skeletal muscle fiber dimensions, fiber capillarization, and their physiological importance are inconsistent. Twenty-five moderately impaired patients with HFrEF and 25 healthy control (HC) subjects underwent muscle biopsy sampling. Type I and type II muscle fiber characteristics were determined by immunohistochemistry. In patients with HFrEF, enzymatic oxidative capacity was assessed, and pulmonary oxygen uptake (V̇o2) and skeletal muscle oxygenation during maximal and moderate-intensity exercise were measured using near-infrared spectroscopy. While muscle fiber cross-sectional area (CSA) was not different between patients with HFrEF and HC, the percentage of type I fibers was higher in HC (46 ± 15 vs. 37 ± 12%, respectively, P = 0.041). Fiber type distribution and CSA were not different between patients in New York Heart Association (NYHA) class II and III. Type I muscle fiber capillarization was higher in HFrEF compared with HC[capillary-to-fiber perimeter exchange (CFPE) index: 5.70 ± 0.92 vs. 5.05 ± 0.82, respectively, P = 0.027]. Patients in NYHA class III had slower V̇o2 and muscle deoxygenation kinetics during onset of exercise and lower muscle oxidative capacity than those in class II (P < 0.05). Also, fiber capillarization was lower but not compared with HC. Higher CFPE index was related to faster deoxygenation (rspearman = −0.682, P = 0.001), however, not to muscle oxidative capacity (r = −0.282, P = 0.216). Type I muscle fiber capillarization is higher in HFrEF compared with HC but not in patients with greater exercise impairment. Greater capillarization may positively affect V̇o2 kinetics by enhancing muscle oxygen diffusion. |
Keywords | exercise capacity; fiber type; microvascular; myopathy; oxidative capacity; oxygen diffusion |
Year | 2018 |
Journal | Journal of Applied Physiology |
Journal citation | 125 (4), pp. 1266 - 1276 |
Publisher | American Physiological Society |
ISSN | 8750-7587 |
Digital Object Identifier (DOI) | https://doi.org/10.1152/japplphysiol.00057.2018 |
Scopus EID | 2-s2.0-85056095695 |
Page range | 1266 - 1276 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/89wq4/skeletal-muscle-fiber-characteristics-in-patients-with-chronic-heart-failure-impact-of-disease-severity-and-relation-with-muscle-oxygenation-during-exercise
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