Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States

Journal article


Arnold, Melina, Freisling, Heinz, Stolzenberg-Solomon, Rachael, Kee, Frank, O'Doherty, Mark George, Ordóñez-Mena, José Manuel, Wilsgaard, Tom, May, Anne Maria, Bueno-de-Mesquita, Hendrik Bas, Tjønneland, Anne, Orfanos, Philippos, Trichopoulou, Antonia, Boffetta, Paolo, Bray, Freddie, Jenab, Mazda, Soerjomataram, Isabelle, Baceviciene, Migle, Boer, Jolanda M. A., Drygas, Wojciech, ... Wennberg, Patrik. (2016). Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States. European Journal of Epidemiology. 31(9), pp. 893 - 904. https://doi.org/10.1007/s10654-016-0169-z
AuthorsArnold, Melina, Freisling, Heinz, Stolzenberg-Solomon, Rachael, Kee, Frank, O'Doherty, Mark George, Ordóñez-Mena, José Manuel, Wilsgaard, Tom, May, Anne Maria, Bueno-de-Mesquita, Hendrik Bas, Tjønneland, Anne, Orfanos, Philippos, Trichopoulou, Antonia, Boffetta, Paolo, Bray, Freddie, Jenab, Mazda, Soerjomataram, Isabelle, Baceviciene, Migle, Boer, Jolanda M. A., Drygas, Wojciech, Eriksson, Sture, Feskens, Edith, Gafarov, Valeriy, Gardiner, Julian, Hakansson, Niclas, Jansson, Jan-Hakkan, Jousilahti, Pekka, Kampman, Ellen, Kontto, Jukka, Kubinova, Ruzena, Leenders, Max, Linneberg, Allan, Loechen, Maja-Lisa, Lorbeer, Roberto, Malyutina, Sofia, Mathiesen, Ellisiv Bøgeberg, Melhus, Hakan, Michaëlsson, Karl, Njølstad, Inger, Orsini, Nicola, Pajak, Andrzej, Pikhart, Hynek, Pisinger, Charlotta, Salomaa, Veikko, Sanchez, Maria-Jose, Sans, Susana, Schaan, Barbara, Schneider, Andrea, Siganos, Galatios, Soderberg, Stefan, Streppel, Martinette, Tamosiunas, Abdonas, Veronesi, Giovanni, Waterham, Eveline and Wennberg, Patrik
Abstract

Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n = 329,576). Trajectories of body mass index (BMI) across ages were estimated using a quadratic growth model; overweight duration (BMI ≥ 25) and cumulative weighted overweight years were calculated. In multivariate Cox models and random effects analyses, a longer duration of overweight was significantly associated with the incidence of obesity-related cancer [overall hazard ratio (HR) per 10-year increment: 1.36; 95 % CI 1.12–1.60], but also increased the risk of postmenopausal breast and colorectal cancer. Additionally accounting for the degree of overweight further increased the risk of obesity-related cancer. Risks associated with a longer overweight duration were higher in men than in women and were attenuated by smoking. For postmenopausal breast cancer, increased risks were confined to women who never used hormone therapy. Overall, 8.4 % of all obesity-related cancers could be attributed to overweight at any age. These findings provide further insights into the role of overweight duration in the etiology of cancer and indicate that weight control is relevant at all ages. This knowledge is vital for the development of effective and targeted cancer prevention strategies.

KeywordsCHANCES; ageing; cohort; obesity; cancer; prevention
Year2016
JournalEuropean Journal of Epidemiology
Journal citation31 (9), pp. 893 - 904
PublisherSpringer Netherlands
ISSN0393-2990
Digital Object Identifier (DOI)https://doi.org/10.1007/s10654-016-0169-z
Scopus EID2-s2.0-84974818404
Page range893 - 904
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationNetherlands
Permalink -

https://acuresearchbank.acu.edu.au/item/89zw6/overweight-duration-in-older-adults-and-cancer-risk-a-study-of-cohorts-in-europe-and-the-united-states

Restricted files

Publisher's version

  • 98
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as