A meta-analysis of reference markers of bone turnover for prediction of fracture
Journal article
Johansson, Helena, Oden, Anders, Kanis, John A., McCloskey, Eugene V., Morris, Howard A., Cooper, Cyrus and Vasikaran, Samuel. (2014). A meta-analysis of reference markers of bone turnover for prediction of fracture. Calcified Tissue International. 94(5), pp. 560 - 567. https://doi.org/10.1007/s00223-014-9842-y
Authors | Johansson, Helena, Oden, Anders, Kanis, John A., McCloskey, Eugene V., Morris, Howard A., Cooper, Cyrus and Vasikaran, Samuel |
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Abstract | Abstract The aim of this report was to summarize the clinical performance of two reference bone turnover markers (BTMs) in the prediction of fracture risk. We used an updated systematic review to examine the performance characteristics of serum procollagen type I N propeptide (s-PINP) and serum C-terminal cross-linking telopeptide of type I collagen (s-CTX) in fracture risk prediction in untreated individuals in prospective cohort studies. We excluded cross-sectional studies. Ten potentially eligible publications were identified and six included in the metaanalysis. There was a significant association between s-PINP and the risk of fracture. The hazard ratio per SD increase in s-PINP (gradient of risk [GR]) was 1.23 (95 % CI 1.09–1.39) for men and women combined unadjusted for bone mineral density. There was also a significant association between s-CTX and risk of fracture, GR = 1.18 (95 % CI 1.05–1.34) unadjusted for bone mineral density. For the outcome of hip fracture, the association between s-CTX and risk of fracture was slightly higher, 1.23 (95 % CI 1.04–1.47). Thus, there is a modest but significant association between BTMs and risk of future fractures. |
Keywords | Marker of bone turnover; Fracture; Serum procollagen type I N propeptide; Serum carboxy-terminal cross-linking telopeptide of type I collagen; Meta-analysis |
Year | 2014 |
Journal | Calcified Tissue International |
Journal citation | 94 (5), pp. 560 - 567 |
Publisher | Springer New York LLC |
ISSN | 0171-967X |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00223-014-9842-y |
Scopus EID | 2-s2.0-84898895943 |
Page range | 560 - 567 |
Research Group | Institute for Health and Ageing |
Publisher's version | File Access Level Controlled |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/8q1q0/a-meta-analysis-of-reference-markers-of-bone-turnover-for-prediction-of-fracture
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