Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction
Journal article
de Boer, Rudolf, Lok, Dirk, Jaarsma, Tiny, van der Meer, Peter, Voors, Adriaan, Hillege, Hans and van Veldhuisen, Dirk. (2011). Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction. Annals of Medicine. 43(1), pp. 60 - 68. https://doi.org/10.3109/07853890.2010.538080
Authors | de Boer, Rudolf, Lok, Dirk, Jaarsma, Tiny, van der Meer, Peter, Voors, Adriaan, Hillege, Hans and van Veldhuisen, Dirk |
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Abstract | Aims: Galectin-3 is an emerging biomarker which has been studied in relatively small heart failure (HF) cohorts with predominantly systolic HF. We studied the prognostic value of base-line galectin-3 in a large HF cohort, with preserved and reduced left ventricular ejection fraction (LVEF), and compared this to other biomarkers. Methods: We studied 592 HF patients who had been hospitalized for HF and were followed for 18 months. The primary end-point was a composite of all-cause mortality and HF hospitalization. Results: A doubling of galectin-3 levels was associated with a hazard ratio (HR) of 1.97 (1.62–2.42) for the primary outcome (P < 0.001). After correction for age, gender, BNP, eGFR, and diabetes the HR was 1.38 (1.07–1.78; P = 0.015). Galectin-3 levels were correlated with higher IL-6 and CRP levels (P < 0.002). Changes of galectin-3 levels after 6 months did not add prognostic information to the base-line value (n = 291); however, combining plasma galectin-3 and BNP levels increased prognostic value over either biomarker alone (ROC analysis, P < 0.05). The predictive value of galectin-3 was stronger in patients with preserved LVEF (n = 114) compared to patients with reduced LVEF (P < 0.001). Conclusions: Galectin-3 is an independent marker for outcome in HF and appears to be particularly useful in HF patients with preserved LVEF. |
Year | 2011 |
Journal | Annals of Medicine |
Journal citation | 43 (1), pp. 60 - 68 |
ISSN | 0785-3890 |
Digital Object Identifier (DOI) | https://doi.org/10.3109/07853890.2010.538080 |
Page range | 60 - 68 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
https://acuresearchbank.acu.edu.au/item/8q22q/predictive-value-of-plasma-galectin-3-levels-in-heart-failure-with-reduced-and-preserved-ejection-fraction
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