Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population

Journal article


Eriksen, B. O., Løchen, Maja-Lisa, Arntzen, Kjell A., Bertelsen, Geir, Eilertsen, Britt-Ann W., von Hanno, Therese, Herder, Marit, Jenssen, Trond G., Mathisen, Ulla D., Melsom, Toralf, Njølstad, Inger, Solbu, Marit D., Toft, Ingrid and Mathiesen, Ellisiv B.. (2014). Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population. Kidney International. 86(1), pp. 146 - 153. https://doi.org/10.1038/ki.2013.470
AuthorsEriksen, B. O., Løchen, Maja-Lisa, Arntzen, Kjell A., Bertelsen, Geir, Eilertsen, Britt-Ann W., von Hanno, Therese, Herder, Marit, Jenssen, Trond G., Mathisen, Ulla D., Melsom, Toralf, Njølstad, Inger, Solbu, Marit D., Toft, Ingrid and Mathiesen, Ellisiv B.
Abstract

A reduced glomerular filtration rate (GFR) in chronic kidney disease is a risk factor for cardiovascular disease. However, evidence indicates that a high GFR may also be a cardiovascular risk factor. This issue remains unresolved due to a lack of longitudinal studies of manifest cardiovascular disease with precise GFR measurements. Here, we performed a cross-sectional study of the relationship between high GFR measured as iohexol clearance and subclinical cardiovascular disease in the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6), a representative sample of the middle-aged general population. A total of 1521 persons without cardiovascular disease, chronic kidney disease, diabetes, or micro- or macroalbuminuria were examined with carotid ultrasonography and electrocardiography. The GFR in the highest quartile was associated with an increased odds ratio of having total carotid plaque area greater than the median of non-zero values (odds ratio 1.56, 95% confidence interval 1.02–2.39) or electrocardiographic signs of left ventricular hypertrophy (odds ratio 1.62, 95% confidence interval 1.10–2.38) compared to the lowest quartile. The analyses were adjusted for cardiovascular risk factors, urinary albumin excretion, and fasting serum glucose. Thus, high GFR is associated with carotid atherosclerosis and left ventricular hypertrophy and should be investigated as a possible risk factor for manifest cardiovascular disease in longitudinal studies.

Keywordsarteriosclerosis; cardiovascular disease; glomerular filtration rate; hyperfiltration; left ventricular hypertrophy; risk factors
Year2014
JournalKidney International
Journal citation86 (1), pp. 146 - 153
PublisherElsevier Inc.
ISSN0085-2538
Digital Object Identifier (DOI)https://doi.org/10.1038/ki.2013.470
Scopus EID2-s2.0-84903691500
Page range146 - 153
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States of America
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