Musculoskeletal decline and mortality: prospective data from the Geelong Osteoporosis Study

Journal article


Pasco, Julie, Mohebbi, Mohammadreza, Holloway, Kara, Brennan-Olsen, Sharon, Hyde, Natalie and Kotowicz, Mark. (2017) Musculoskeletal decline and mortality: prospective data from the Geelong Osteoporosis Study. Journal of Cachexia, Sarcopenia and Muscle. 8(3), pp. 482 - 489. https://doi.org/10.1002/jcsm.12177
AuthorsPasco, Julie, Mohebbi, Mohammadreza, Holloway, Kara, Brennan-Olsen, Sharon, Hyde, Natalie and Kotowicz, Mark
Abstract

Background We aimed to examine the relationship between musculoskeletal deterioration and all-cause mortality in a cohort of women studied prospectively over a decade. Methods A cohort of 750 women aged 50–94 years was followed for a decade after femoral neck bone mineral density (BMD) and appendicular lean mass (ALM) were measured using dual energy X-ray absorptiometry, in conjunction with comorbidities, health behaviour data, and other clinical measures. The outcome was all-cause mortality identified from the Australian National Deaths Index. Using Cox proportional hazards models and age as the time variable, mortality risks were estimated according to BMD groups (ideal-BMD, osteopenia, and osteoporosis) and ALM groups (T-scores > 1.0 high, 2.0 to 1.0 medium, < 2.0 low). Results During 6712 person years of follow-up, there were 190 deaths, the proportions increasing with diminishing BMD: 10.7% (23/215) ideal-BMD, 23.5% (89/378) osteopenia, 49.7% (78/157) osteoporosis; and with diminishing ALM: 17.0% (59/345) high, 26.2% (79/301) medium, 50.0% (52/104) low. In multivariable models adjusted for smoking, polypharmacy, and mobility, compared with those with ideal BMD, mortality risk was greater for those with osteopenia [hazard ratio (HR) 1.77, 95% confidence interval (CI) 1.11–2.81] and osteoporosis (HR 2.61, 95%CI 1.60–4.24). Similarly, compared with those with high ALM, adjusted mortality risk was greater for medium ALM (HR 1.36, 95%CI 0.97–1.91) and low ALM (HR 1.65, 95%CI 1.11–2.45). When BMD and ALM groups were tested together in the model, BMD remained a predictor of mortality (HR 1.74, 95%CI 1.09–2.78; HR 2.82, 95%CI 1.70–4.70; respectively), and low ALM had borderline significance (HR 1.52, 95%CI 1.00–2.31), which was further attenuated after adjusting for smoking, polypharmacy, and mobility. Conclusions Poor musculoskeletal health increased the risk for mortality independent of age. This appears to be driven mainly by a decline in bone mass. Low lean mass independently exacerbated mortality risk, and this appeared to operate through poor health exposures.

Year2017
JournalJournal of Cachexia, Sarcopenia and Muscle
Journal citation8 (3), pp. 482 - 489
PublisherB M J Group
ISSN2190-5991
Digital Object Identifier (DOI)https://doi.org/10.1002/jcsm.12177
Scopus EID2-s2.0-85007373732
Open accessOpen access
Page range482 - 489
Research GroupInstitute for Health and Ageing
Publisher's version
License
Place of publicationGermany
EditorsS. D. Anker and S. von Haehling
Permalink -

https://acuresearchbank.acu.edu.au/item/8q3qw/musculoskeletal-decline-and-mortality-prospective-data-from-the-geelong-osteoporosis-study

Download files

  • 1
    total views
  • 1
    total downloads
  • 0
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Effect of clinical care pathways on quality of life and physical function after fragility fracture: A meta-analysis
Talevski, Jason, Sanders, Kerrie M., Duque, Gustavo, Connaughton, Catherine, Beauchamp, Alison, Green, Darci, Millar, Lynne and Brennan-Olsen, Sharon L.. (2019) Effect of clinical care pathways on quality of life and physical function after fragility fracture: A meta-analysis. Journal of the American Medical Directors Association. 20(7), pp. 926.e1 - 926.e11. https://doi.org/10.1016/j.jamda.2019.02.022
Prediction of major osteoporotic and hip fractures in Australian men using FRAX scores adjusted with trabecular bone score
Holloway, Kara, Mohebbi, Mohammadreza, Betson, A. G., Hans, Didier, Hyde, Natalie, Brennan-Olsen, Sharon, Kotowicz, Mark and Pasco, Julie. (2018) Prediction of major osteoporotic and hip fractures in Australian men using FRAX scores adjusted with trabecular bone score. Osteoporosis International. 29(1), pp. 101 - 108. https://doi.org/10.1007/s00198-017-4226-6
The epidemiology of hip fractures across Western Victoria, Australia
Holloway, Kara, Sajjad, Muhammad A., Mohebbi, Mohammadreza, Kotowicz, Mark, Livingston, Patricia M., Khasraw, Mustafa, Hakkennes, Sharon, Dunning, Trisha, Brumby, Susan, Page, Richard S., Pedler, Daryl, Sutherland, Alasdair, Venkatesh, Svetha, Brennan-Olsen, Sharon, Williams, Lana J. and Pasco, Julie. (2018) The epidemiology of hip fractures across Western Victoria, Australia. Bone. 108, pp. 1 - 9. https://doi.org/10.1016/j.bone.2017.12.007
Health literacy in a population-based sample of Australian women: A cross-sectional profile of the Geelong Osteoporosis Study
Hosking, Sarah, Brennan-Olsen, Sharon, Beauchamp, Allison, Buchbinder, Rachelle, Williams, Lana J. and Pasco, Julie. (2018) Health literacy in a population-based sample of Australian women: A cross-sectional profile of the Geelong Osteoporosis Study. BMC Public Health. 18(1), pp. 1 - 14. https://doi.org/10.1186/s12889-018-5751-8
Health literacy and uptake of anti-fracture medications in a population-based sample of Australian women
Hosking, Sarah, Brennan-Olsen, Sharon, Beauchamp, Allison, Buchbinder, Rachelle, Williams, Lana J. and Pasco, Julie. (2018) Health literacy and uptake of anti-fracture medications in a population-based sample of Australian women. Research in Social and Administrative Pharmacy. 14(9), pp. 846 - 850. https://doi.org/10.1016/j.sapharm.2018.05.002
The subjective wellbeing profile of the ‘pretiree’ demographic: a cross-sectional study
Pasco, Julie, Holloway, Kara, Stuart, Amanda L., Williams, Lana J., Brennan-Olsen, Sharon and Berk, Michael. (2018) The subjective wellbeing profile of the ‘pretiree’ demographic: a cross-sectional study. Maturitas. 110, pp. 111 - 117. https://doi.org/10.1016/j.maturitas.2018.02.006
Vitamin D during pregnancy and offspring body composition: A prospective cohort study
Hyde, Natalie, Brennan-Olsen, Sharon, Wark, John, Hosking, Sarah, Holloway-Kew, K. L. and Pasco, Julie. (2018) Vitamin D during pregnancy and offspring body composition: A prospective cohort study. Pediatric Obesity. 13(8), pp. 514 - 521. https://doi.org/10.1111/ijpo.12286
Is there a social gradient of sarcopenia? A meta-analysis and systematic review protocol
Green, Darci, Duque, Gustavo, Fredman, Nick, Rizvi, Aoun and Brennan-Olsen, Sharon. (2018) Is there a social gradient of sarcopenia? A meta-analysis and systematic review protocol. BMJ Open. 8(1), pp. 1 - 4. https://doi.org/10.1136/bmjopen-2017-019088
Maternal dietary nutrient intake during pregnancy and offspring linear growth and bone: the vitamin d in pregnancy cohort study
Hyde, Natalie, Brennan-Olsen, Sharon, Wark, John, Hosking, Sarah and Pasco, Julie. (2017) Maternal dietary nutrient intake during pregnancy and offspring linear growth and bone: the vitamin d in pregnancy cohort study. Calcified Tissue International. 100(1), pp. 47 - 54. https://doi.org/10.1007/s00223-016-0199-2
Personality disorder is an excess risk factor for physical multimorbidity among women with mental state disorders
Quirk, Shae E., Stuart, Amanda L., Berk, Michael, Pasco, Julie A., Brennan-Olsen, Sharon L., Koivumaa-Honkanen, Heli, Honkanen, Risto, Lukkala, Pyry S., Chanen, Andrew M., Kotowicz, Mark and Williams, Lana J.. (2017) Personality disorder is an excess risk factor for physical multimorbidity among women with mental state disorders. Psychiatry Research. 257, pp. 546 - 549. https://doi.org/10.1016/j.psychres.2017.08.010
The prevalence, age distribution and comorbidity of personality disorders in Australian women
Quirk, Shae E., Berk, Michael, Pasco, Julie A., Brennan-Olsen, Sharon L., Chanen, Andrew M., Koivumaa-Honkanen, Heli, Burke, Lisa M., Jackson, Henry J., Hulbert, Carol, Olsson, Craig A., Moran, Paul, Stuart, Amanda L. and Williams, Lana J.. (2017) The prevalence, age distribution and comorbidity of personality disorders in Australian women. Australian and New Zealand Journal of Psychiatry. 51(2), pp. 141 - 150. https://doi.org/10.1177/0004867416649032
Maternal nutrition during pregnancy: intake of nutrients important for bone health
Hyde, Natalie, Brennan-Olsen, Sharon, Bennett, Kathy E., Moloney, David J. and Pasco, Julie. (2017) Maternal nutrition during pregnancy: intake of nutrients important for bone health. Maternal and Child Health Journal. 21(4), pp. 845 - 851. https://doi.org/10.1007/s10995-016-2178-7
Maternal vitamin D and offspring trabecular bone score
Hyde, Natalie, Brennan-Olsen, Sharon, Wark, John, Hosking, Sarah, Holloway, Kara and Pasco, Julie. (2017) Maternal vitamin D and offspring trabecular bone score. Osteoporosis International. 28(12), pp. 3407 - 3414. https://doi.org/10.1007/s00198-017-4208-8
Geographic region, socioeconomic position and the utilisation of primary total joint replacement for hip or knee osteoarthritis across western Victoria: a cross-sectional multilevel study of the Australian orthopaedic association national joint replacement registry
Brennan-Olsen, Sharon, Vogrin, Sara, Holloway, Kara, Page, Richard S., Sajjad, Muhammad A., Kotowicz, Mark, Livingston, Patricia M., Khasraw, Mustafa, Hakkennes, Sharon, Dunning, Trish L., Brumby, Susan, Pedler, Daryl, Sutherland, Alasdair, Venkatesh, Svetha, Williams, Lana J., Duque, Gustavo and Pasco, Julie. (2017) Geographic region, socioeconomic position and the utilisation of primary total joint replacement for hip or knee osteoarthritis across western Victoria: a cross-sectional multilevel study of the Australian orthopaedic association national joint replacement registry. Archives of Osteoporosis. 12(97), pp. 1 - 7. https://doi.org/10.1007/s11657-017-0396-2
Fractures in indigenous compared to non-indigenous populations: a systematic review of rates and aetiology
Brennan-Olsen, Sharon, Vogrin, Sara, Leslie, William D., Kinsella, Rita, Toombs, Maree, Duque, Gustavo, Hosking, Sarah, Holloway, Kara, Doolan, Brianna J., Williams, Lana J., Page, Richard S., Pasco, Julie and Quirk, Shae. (2017) Fractures in indigenous compared to non-indigenous populations: a systematic review of rates and aetiology. Bone Reports. 6, pp. 145 - 158. https://doi.org/10.1016/j.bonr.2017.04.003
Association between bipolar spectrum disorder and bone health: a meta-analysis and systematic review protocol
Chandrasekaran, Vinoomika, Brennan-Olsen, Sharon, Stuart, Amanda L., Pasco, Julie, Berk, Michael, Hodge, Jason M. and Williams, Lana J.. (2017) Association between bipolar spectrum disorder and bone health: a meta-analysis and systematic review protocol. BMJ Open. 7(2), pp. 1 - 4. https://doi.org/10.1136/bmjopen-2016-013981
Pattern of psychotropic medication use over two decades in Australian women
Stuart, Amanda L., Mohebbi, Mohammadreza, Pasco, Julie, Quirk, Shae, Brennan-Olsen, Sharon, Berk, Michael and Williams, Lana J.. (2017) Pattern of psychotropic medication use over two decades in Australian women. Australian and New Zealand Journal of Psychiatry. 51(12), pp. 1212 - 1219. https://doi.org/10.1177/0004867417704056
The association of time and medications with changes in bone mineral density in the 2 years after critical illness
Orford, Neil R., Bailey, Michael, Bellomo, Rinaldo, Pasco, Julie A., Cattigan, Claire, Elderkin, Tania, Brennan-Olsen, Sharon L., Cooper, David J. and Kotowicz, Mark A.. (2017) The association of time and medications with changes in bone mineral density in the 2 years after critical illness. Critical Care. 21(1), pp. 1 - 10. https://doi.org/10.1186/s13054-017-1657-6
Physical health comorbidities in women with personality disorder: Data from the Geelong Osteoporosis Study
Quirk, Shae, Stuart, Amanda L., Brennan-Olsen, Sharon, Pasco, Julie, Berk, Michael, Chanen, Andrew, Koivumaa-Honkanen, Heli, Kotowicz, Mark, Lukkala, P. S. and Williams, Lana J.. (2016) Physical health comorbidities in women with personality disorder: Data from the Geelong Osteoporosis Study. European Psychiatry. 34, pp. 29 - 35. https://doi.org/10.1016/j.eurpsy.2015.12.007
Ageing, chronic disease and injury: A study in Western Victoria (Australia)
Sajjad, M. Amber, Holloway, Kara L., Kotowicz, Mark A., Livingston, Patricia M., Khasraw, Mustafa, Hakkennes, Sharon, Dunning, Trisha, Brumby, Susan, Page, Richard S., Pedler, Daryl, Sutherland, Alasdair, Venkatesh, Svetha, Brennan-Olsen, Sharon L., Williams, Lana J. and Pasco, Julie A.. (2016) Ageing, chronic disease and injury: A study in Western Victoria (Australia). Journal of Public Health Research. 5(2), pp. 81 - 86. https://doi.org/10.4081/jphr.2016.678
Non-hip and non-vertebral fractures: the neglected fracture sites
Holloway, Kara, Henry, Margaret, Brennan-Olsen, Sharon, Bucki-Smith, Gosia, Nicholson, Geoffrey Charles, Korn, S., Sanders, Kerrie, Pasco, Julie and Kotowicz, Mark. (2016) Non-hip and non-vertebral fractures: the neglected fracture sites. Osteoporosis International. 27(3), pp. 905 - 913. https://doi.org/10.1007/s00198-015-3322-8
Fracture prediction from repeat BMD measurements in clinical practice
Leslie, William D., Brennan-Olsen, Sharon L., Morin, Suzanne N. and Lix, Lisa M.. (2016) Fracture prediction from repeat BMD measurements in clinical practice. Osteoporosis International. 27(1), pp. 203 - 210. https://doi.org/10.1007/s00198-015-3259-y
DNA methylation and the social gradient of osteoporotic fracture: A conceptual model
Brennan-Olsen, Sharon L., Page, Richard S., Berk, Michael, Riancho, Jose A., Leslie, William D., Wilson, Scott G., Saban, Karen L., Janusek, Linda, Pasco, Julie A., Hodge, Jason M., Quirk, Shae E., Hyde, Natalie K., Hosking, Sarah M. and Williams, Lana J.. (2016) DNA methylation and the social gradient of osteoporotic fracture: A conceptual model. Bone. 84, pp. 204 - 212. https://doi.org/10.1016/j.bone.2015.12.015
Anxiety Disorders and falls among older adults
Holloway, Kara L., Williams, L. J., Brennan-Olsen, Sharon L., Morse, Amelia G., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A.. (2016) Anxiety Disorders and falls among older adults. Journal of Affective Disorders. 205, pp. 20 - 27. https://doi.org/10.1016/j.jad.2016.06.052
Changes in bone mineral density in the year after critical illness
Orford, Neil R., Lane, Steven E., Bailey, Michael, Pasco, Julie A., Cattigan, Claire, Elderkin, Tania, Brennan-Olsen, Sharon L., Bellomo, Rinaldo, Cooper, David J. and Kotowicz, Mark A.. (2016) Changes in bone mineral density in the year after critical illness. American Journal of Respiratory and Critical Care Medicine. 193(7), pp. 736 - 744. https://doi.org/10.1164/rccm.201508-1514OC
Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data
Brennan-Olsen, Sharon L., Page, Richard S., Lane, Steven E., Lorimer, Michelle, Buchbinder, Rachelle, Osborne, Richard H., Pasco, Julie A., Wluka, Anita E., Sanders, Kerrie M., Ebeling, Peter R. and Graves, Stephen E.. (2016) Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data. BMC Musculoskeletal Disorders. 17(291), pp. 1 - 9. https://doi.org/10.1186/s12891-016-1134-4
Population prevalence of personality disorder and associations with physical health comorbidities and health care service utlization: A Review
Quirk, Shae E., Berk, Michael, Chanen, Andrew M., Koivumaa-Honkanen, Heli, Brennan-Olsen, Sharon L., Pasco, Julie A. and Williams, Lana J.. (2016) Population prevalence of personality disorder and associations with physical health comorbidities and health care service utlization: A Review. Personality Disorders: Theory, Research, and Treatment (print). 7(2), pp. 136 - 146. https://doi.org/10.1037/per0000148
The epidemiology of incident fracture from cradle to senescence
Pasco, Julie, Lane, Stephen, Brennan-Olsen, Sharon, Holloway, Kara, Timney, Elizabeth, Bucki-Smith, Gosia, Morse, Amelia, Dobbins, Amelia, Williams, Lana, Hyde, Natalie and Kotowicz, Mark. (2015) The epidemiology of incident fracture from cradle to senescence. Calcified Tissue International. 97(6), pp. 568 - 576. https://doi.org/10.1007/s00223-015-0053-y
Humeral fractures in south-eastern Australia: Epidemiology and risk factors
Holloway, Kara, Bucki-Smith, Gosia, Morse, Amelia, Brennan-Olsen, Sharon, Kotowicz, Mark, Moloney, David, Sanders, Kerrie, Korn, S, Timney, Elizabeth, Dobbins, Amelia and Pasco, Julie. (2015) Humeral fractures in south-eastern Australia: Epidemiology and risk factors. Calcified Tissue International. 97(5), pp. 453 - 465. https://doi.org/10.1007/s00223-015-0039-9
Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines
Coulson, Carolyn E., Williams, Lana J., Henry, Margaret, Berk, Michael, Lubman, Dan, Brennan-Olsen, Sharon, Nicholson, Geoff, Kotowicz, Mark, Korn, S and Pasco, Julie. (2010) Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines. Australian and New Zealand Journal of Psychiatry. 44(10), pp. 946 - 951. https://doi.org/10.3109/00048674.2010.495051
Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study
Brennan-Olsen, Sharon, Henry, Margaret, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie. (2010) Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study. Journal of Men's Health. 7(1), pp. 31 - 41. https://doi.org/10.1016/j.jomh.2009.10.004
Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?
Brennan-Olsen, Sharon, Cicuttini, Flavia, Pasco, Julie, Henry, Margaret, Wang, Yuanyuan, Kotowicz, Mark, Nicholson, Geoff and Wluka, Anita. (2010) Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women? Arthritis Research and Therapy. 12(4), pp. 1 - 7. https://doi.org/10.1186/ar3078
Socioeconomic status and bone mineral density in a population-based sample of men
Brennan-Olsen, Sharon, Henry, Margaret, Wluka, Anita, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie. (2010) Socioeconomic status and bone mineral density in a population-based sample of men. Bone. 46(4), pp. 993 - 999. https://doi.org/10.1016/j.bone.2009.12.029