Inflammation and anaemia in a broad spectrum of patients with heart failure
Journal article
Kleijn, Lennaert, Belonje, Anne, Voors, Adriaan, de Boer, Rudolf, Jaarsma, Tiny, Ghosh, Sudip, Kim, Joseph, Hillege, Hans, van Gilst, Wiek, van Veldhuisen, Dirk and van der Meer, Peter. (2012). Inflammation and anaemia in a broad spectrum of patients with heart failure. Heart. 98(16), pp. 1237 - 1241. https://doi.org/10.1136/heartjnl-2012-301954
Authors | Kleijn, Lennaert, Belonje, Anne, Voors, Adriaan, de Boer, Rudolf, Jaarsma, Tiny, Ghosh, Sudip, Kim, Joseph, Hillege, Hans, van Gilst, Wiek, van Veldhuisen, Dirk and van der Meer, Peter |
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Abstract | Aims: Anaemia in heart failure (HF) is associated with a poor prognosis. Although inflammation is assumed to be an important cause of anaemia, the association between anaemia and inflammatory markers in patients with HF has not been well established. Methods: Data from a multicentre randomised clinical trial, in which patients were eligible if they were > 18 years of age and admitted for HF (New York Heart Association II–IV), were used. In a subset of 326 patients, haemoglobin (Hb), haematocrit, high sensitivity C-reactive protein (hsCRP), interleukin-(IL) 6, soluble tumour necrosis factor receptor (sTNFR)-1 and erythropoietin (Epo) were measured at discharge and the primary endpoint was all-cause mortality. Follow-up was 18 months. Results: Anaemia (Hb < 13 g/dl (men) and < 12 g/dl (women)) was present in 40% (130/326) of the study population. Median levels of IL-6, hsCRP and sTNFR-1 were significantly higher in anaemic patients than in non-anaemic patients. Logistic regression demonstrated that each increase in hsCRP values (OR 1.58 per SD log hsCRP; 95% CI 1.09 to 2.29; p=0.016) and each increase in sTNFR-1 values (OR 1.62 per SD log sTNFR-1; 95% CI 1.24 to 2.11; p < 0.001) were independently associated with anaemia. Epo (HR 1.31 per log Epo; 95% CI 1.01 to 1.69; p=0.041) and sTNFR-1 (HR 1.47 per log sTNFR-1; 95% CI 1.16 to 1.86; p=0.001) levels were independently associated with outcome. Conclusion: Anaemia is present in 40% of patients hospitalised for HF and is independently associated with inflammation. |
Year | 2012 |
Journal | Heart |
Journal citation | 98 (16), pp. 1237 - 1241 |
ISSN | 1355-6037 |
Digital Object Identifier (DOI) | https://doi.org/10.1136/heartjnl-2012-301954 |
Page range | 1237 - 1241 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
https://acuresearchbank.acu.edu.au/item/8q491/inflammation-and-anaemia-in-a-broad-spectrum-of-patients-with-heart-failure
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