Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease
Journal article
Small, David, Beetham, Kassia, Howden, Erin, Briskey, David, Johnson, David, Isbel, Nicole, Gobe, Glenda and Coombes, Jeff S.. (2017). Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease. Redox Report. 22(3), pp. 127 - 136. https://doi.org/10.1080/13510002.2016.1276314
Authors | Small, David, Beetham, Kassia, Howden, Erin, Briskey, David, Johnson, David, Isbel, Nicole, Gobe, Glenda and Coombes, Jeff S. |
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Abstract | Objectives: Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients. Methods: A total of 136 stage 3–4 CKD patients were randomized to receive standard nephrological care with (N = 72) or without (N = 64) a lifestyle and exercise intervention for 12 months. Plasma total F2-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months. Results: There were no significant differences between groups at baseline. There were no significant differences in changes for standard care and lifestyle intervention, respectively, in IsoP (p = 0.88), GPX (p = 0.87), or TAC (p = 0.56). Patients identified as having high IsoP at baseline ( > 250 pg/mL) had a greater decrease in IsoP with lifestyle intervention compared to standard care; however, the difference was not statistically significant (p = 0.06). There was no difference in the change in kidney function (eGFR) between standard care and lifestyle intervention (p = 0.33). Discussion: Exercise and lifestyle modification in stage 3–4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-month period, but patients with high IsoP may benefit most from the addition of intervention to standard care. |
Year | 2017 |
Journal | Redox Report |
Journal citation | 22 (3), pp. 127 - 136 |
Publisher | Taylor and Francis Ltd |
ISSN | 1351-0002 |
Digital Object Identifier (DOI) | https://doi.org/10.1080/13510002.2016.1276314 |
Scopus EID | 2-s2.0-85009266932 |
Page range | 127 - 136 |
Research Group | Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre |
Publisher's version | File Access Level Controlled |
https://acuresearchbank.acu.edu.au/item/8q4y8/effects-of-exercise-and-lifestyle-intervention-on-oxidative-stress-in-chronic-kidney-disease
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