Remarkable enhancement in boron uptake within glioblastoma cells with carboranyl–indole carboxamides
Journal article
Narlawar, Rajeshwar, Austin, Christopher J. D., Kahlert, Jan, Selleri, Silvia, Da Pozzo, Eleonora, Martini, Claudia, Werry, Eryn L., Rendina, Louis M. and Kassiou, Michael. (2018). Remarkable enhancement in boron uptake within glioblastoma cells with carboranyl–indole carboxamides. Chemistry: An Asian Journal. 13(21), pp. 3321 - 3327. https://doi.org/10.1002/asia.201801175
Authors | Narlawar, Rajeshwar, Austin, Christopher J. D., Kahlert, Jan, Selleri, Silvia, Da Pozzo, Eleonora, Martini, Claudia, Werry, Eryn L., Rendina, Louis M. and Kassiou, Michael |
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Abstract | Novel boron‐rich, carboranyl–indole carboxamide ligands were prepared and found to effectively target the 18 kDa translocator protein (TSPO), an upregulated mitochondrial membrane‐bound protein which has been observed in variety of tumor cell lines and its expression appears to be proportional to the degree of tumorigenicity, emphasizing a key role in cancer cell proliferation. Both boronated compounds displayed remarkably high affinities for the TSPO. In addition, the in vitro uptake of these compounds into T98G human glioma cells was found to be 25‐ to 100‐fold greater than that of clinical boron neutron capture therapy (BNCT) agents. |
Year | 2018 |
Journal | Chemistry: An Asian Journal |
Journal citation | 13 (21), pp. 3321 - 3327 |
Publisher | Wiley-Blackwell |
ISSN | 1861-4728 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/asia.201801175 |
Scopus EID | 2-s2.0-85055726005 |
Page range | 3321 - 3327 |
Research Group | School of Behavioural and Health Sciences |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8q669/remarkable-enhancement-in-boron-uptake-within-glioblastoma-cells-with-carboranyl-indole-carboxamides
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