Remarkable enhancement in boron uptake within glioblastoma cells with carboranyl–indole carboxamides

Journal article

Narlawar, Rajeshwar, Austin, Christopher J. D., Kahlert, Jan, Selleri, Silvia, Da Pozzo, Eleonora, Martini, Claudia, Werry, Eryn L., Rendina, Louis M. and Kassiou, Michael. (2018). Remarkable enhancement in boron uptake within glioblastoma cells with carboranyl–indole carboxamides. Chemistry: An Asian Journal. 13(21), pp. 3321 - 3327. https://doi.org/10.1002/asia.201801175
AuthorsNarlawar, Rajeshwar, Austin, Christopher J. D., Kahlert, Jan, Selleri, Silvia, Da Pozzo, Eleonora, Martini, Claudia, Werry, Eryn L., Rendina, Louis M. and Kassiou, Michael
Abstract

Novel boron‐rich, carboranyl–indole carboxamide ligands were prepared and found to effectively target the 18 kDa translocator protein (TSPO), an upregulated mitochondrial membrane‐bound protein which has been observed in variety of tumor cell lines and its expression appears to be proportional to the degree of tumorigenicity, emphasizing a key role in cancer cell proliferation. Both boronated compounds displayed remarkably high affinities for the TSPO. In addition, the in vitro uptake of these compounds into T98G human glioma cells was found to be 25‐ to 100‐fold greater than that of clinical boron neutron capture therapy (BNCT) agents.

Year2018
JournalChemistry: An Asian Journal
Journal citation13 (21), pp. 3321 - 3327
PublisherWiley-Blackwell
ISSN1861-4728
Digital Object Identifier (DOI)https://doi.org/10.1002/asia.201801175
Scopus EID2-s2.0-85055726005
Page range3321 - 3327
Research GroupSchool of Behavioural and Health Sciences
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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https://acuresearchbank.acu.edu.au/item/8q669/remarkable-enhancement-in-boron-uptake-within-glioblastoma-cells-with-carboranyl-indole-carboxamides

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