Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies

Journal article

Santesteban-Echarri, Olga, Paino, Mercedes, Rice, Simon, González-Blanch, César, McGorry, Patrick, Gleeson, John and Alvarez-Jimenez, Mario. (2017). Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies. Clinical Psychology Review. 58, pp. 59 - 75. https://doi.org/10.1016/j.cpr.2017.09.007
AuthorsSantesteban-Echarri, Olga, Paino, Mercedes, Rice, Simon, González-Blanch, César, McGorry, Patrick, Gleeson, John and Alvarez-Jimenez, Mario
Abstract

Background: Three out of four first-episode psychosis (FEP) patients achieve clinical remission following treatment. Unfortunately, functional recovery lags behind symptomatic remission, and many individuals with FEP remain socially isolated with poor functional outcomes. Aims: To systematically compile and analyse predictors of functional recovery in FEP. Method: Systematic review and meta-analysis of peer-reviewed, longitudinal studies reporting predictors of functioning, with a minimum 12-month follow-up and at least 80% of participants diagnosed with FEP. Results: Out of 2205 citations, 274 articles were retrieved for detailed evaluation resulting in 50 eligible studies (N = 6669). Sociodemographic, clinical, physical and neuroimaging variables had little impact on long-term functioning. Conversely duration of untreated psychosis (DUP), most cognitive variables, and concurrent remission of positive and negative symptoms were independently related to functional recovery. Conclusions: These findings strongly support the rationale for early intervention in FEP. Novel treatments targeting cognitive deficits may improve functional outcomes in FEP.

Keywordsfirst-episode psychosis; functioning
Year2017
JournalClinical Psychology Review
Journal citation58, pp. 59 - 75
PublisherElsevier
ISSN0272-7358
Digital Object Identifier (DOI)https://doi.org/10.1016/j.cpr.2017.09.007
Scopus EID2-s2.0-85031321817
Page range59 - 75
Research GroupSchool of Philosophy
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
EditorsG. J. G. Asmundson
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Rossell, Susan, Chong, Derina, O'Connor, David and Gleeson, John F.. (2014). An investigation of gender differences in semantic processing in individuals with high schizotypy. Psychiatry Research. 215(2), pp. 491 - 493. https://doi.org/10.1016/j.psychres.2013.11.015
Online, social media and mobile technologies for psychosis treatment : A systematic review on novel user-led interventions
Alvarez-Jimenez, Mario, Alcazar-Corcoles, M. A., Gonzalez-Blanch, Cesar, Bendall, Sarah, McGorry, Patrick and Gleeson, John. (2014). Online, social media and mobile technologies for psychosis treatment : A systematic review on novel user-led interventions. Schizophrenia Research. 156(1), pp. 96 - 106. https://doi.org/10.1016/j.schres.2014.03.021
Social relationships and quality of life moderate distress associated with delusional ideation
Lim, Michelle, Gleeson, John, Jackson, Henry and Fernandez, Katya. (2014). Social relationships and quality of life moderate distress associated with delusional ideation. Social Psychiatry and Psychiatric Epidemiology. 49(1), pp. 97 - 107. https://doi.org/10.1007/s00127-013-0738-3
Cyberbullying in social networking sites: An adolescent victim's perspective
Dredge, Rebecca, Gleeson, John and de la Piedad Garcia, Xochitl. (2014). Cyberbullying in social networking sites: An adolescent victim's perspective. Computers in Human Behavior. 36, pp. 13 - 20. https://doi.org/10.1016/j.chb.2014.03.026
Online and social networking interventions for the treatment of depression in young people : A systematic review
Rice, Simon, Goodall, Joanne, Hetrick, Sarah, Parker, Alexandra, Gilbertson, Tamsyn, Amminger, G, Davey, Christopher, McGorry, Patrick, Gleeson, John and Alvarez-Jimenez, Mario. (2014). Online and social networking interventions for the treatment of depression in young people : A systematic review. Journal of Medical Internet Research. 16(9), pp. 1 - 22. https://doi.org/10.2196/jmir.3304
Risk factors associated with impact severity of cyberbullying victimization : A qualitative study of adolescent online social networking
Dredge, Rebecca, Gleeson, John and De la Piedad Garcia, Xochitl. (2014). Risk factors associated with impact severity of cyberbullying victimization : A qualitative study of adolescent online social networking. CyberPsychology, Behavior and Social Networking. 17(5), pp. 287 - 291. https://doi.org/10.1089/cyber.2013.0541
Presentation on Facebook and risk of cyberbullying victimisation
Dredge, Rebecca, Gleeson, John and de la Piedad Garcia, Xochitl. (2014). Presentation on Facebook and risk of cyberbullying victimisation. Computers in Human Behavior. 40, pp. 16 - 22. https://doi.org/10.1016/j.chb.2014.07.035
Safety and privacy outcomes from a moderated online social therapy for young people with first-episode psychosis
Gleeson, John, Lederman, Reeva, Wadley, Greg, Bendall, Sarah, McGorry, Patrick and Alvarez-Jimenez, Mario. (2014). Safety and privacy outcomes from a moderated online social therapy for young people with first-episode psychosis. Psychiatric Services. 65(4), pp. 546 - 550. https://doi.org/10.1176/appi.ps.201300078
On the HORYZON : Moderated online social therapy for long-term recovery in first episode psychosis
Alvarez-Jimenez, Mario, Bendall, Sarah, Lederman, Reeva, Wadley, Greg, Chinnery, G, Vargas, S, Larkin, M, Killackey, Eoin, McGorry, Patrick and Gleeson, John. (2013). On the HORYZON : Moderated online social therapy for long-term recovery in first episode psychosis. Schizophrenia Research. https://doi.org/10.1016/j.schres.2012.10.009
A Randomized Controlled Trial of Bibliotherapy for Carers of Young People With First-Episode Psychosis
McCann, Terence, Lubmann, Dan, Cotton, Sue, Murphy, Brendan, Crisp, Kingsley, Catania, Lisa, Marck, Claudia and Gleeson, John. (2013). A Randomized Controlled Trial of Bibliotherapy for Carers of Young People With First-Episode Psychosis. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbs121
Coping strategies in carers of young people with a first episode of psychosis : Outcome at 30-Month Follow-Up
Cotton, Sue, McCann, Terence, Gleeson, John, Crisp, Kingsley, Murphy, Brendan and Lubman, Dan. (2013). Coping strategies in carers of young people with a first episode of psychosis : Outcome at 30-Month Follow-Up. Schizophrenia Research. https://doi.org/10.1016/j.schres.2013.02.008
A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients : Outcome at 30-month follow-up
Gleeson, John, Cotton, Sue, Alvarez-Jimenez, Mario, Wade, Darryl, Gee, Donna, Crisp, Kingsley, Pearce, Tracey, Spiliotacopoulos, Daniela, Newman, Belinda and McGorry, Patrick. (2013). A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients : Outcome at 30-month follow-up. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/sbr165
Differences between first episode schizophrenia and schizoaffective disorder
Cotton, Sue, Lambert, M, Schimmelmann, B, Mackinnon, Andrew, Gleeson, John, Berk, Michael, Hides, L, Chanen, Andrew, Scott, J and Schottle, D. (2013). Differences between first episode schizophrenia and schizoaffective disorder. Schizophrenia Research. https://doi.org/10.1016/j.schres.2013.02.036
Progress and limitations in the measurement of cyber bullying
Dredge, Rebecca Katherine, Gleeson, John Francis Martin and de la Piedad Garcia, Xochitl. (2013). Progress and limitations in the measurement of cyber bullying. In In R. Hanewald (Ed.). From cyber bullying to cyber safety: Issues and approaches in educational contexts pp. 271 - 288 Nova Science Publishers.
Participatory design of an online therapy for youth mental health
Wadley, Greg, Lederman, Reeva, Gleeson, John and Alvarez-Jimenez, Mario. (2013). Participatory design of an online therapy for youth mental health. 25th Australian Computer-Human Interaction Conference on Augmentation, Application, Innovation, Collaboration. United States: The Association for Computing Machinery. pp. 517 - 526 https://doi.org/10.1145/2541016.2541030
The jumping-to-conclusions bias in new religious movements
Lim, Michelle, Gleeson, John Francis Martin and Jackson, Henry. (2012). The jumping-to-conclusions bias in new religious movements. Journal of Nervous and Mental Disease. 200(10), pp. 868 - 875. https://doi.org/10.1097/NMD.0b013e31826b6eb4
Depressive symptoms in first episode schizophrenia spectrum disorder
Cotton, Sue, Lambert, M, Schimmelmann, B, Mackinnon, Andrew, Gleeson, John Francis Martin, Berk, Michael, Hides, L, Chanen, Andrew, McGorry, Patrick and Conus, P. (2012). Depressive symptoms in first episode schizophrenia spectrum disorder. Schizophrenia Research. 134(1), pp. 20 - 26. https://doi.org/10.1016/j.schres.2011.08.018
Internet-Based Interventions for Psychosis : A Sneak-Peek into the Future
Alvarez-Jimenez, Mario, Gleeson, John, Bendall, Sarah, Lederman, Reeva, Wadley, Greg, Killackey, Eoin and McGorry, Patrick. (2012). Internet-Based Interventions for Psychosis : A Sneak-Peek into the Future. Psychiatric Clinics of North America. 35(3), pp. 735 - 747. https://doi.org/10.1016/j.psc.2012.06.011
Road to full recovery: Longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years
Alvarez-Jimenez, Mario, Gleeson, John, Henry, L., Harrigan, Susan, Harris, M., Killackey, Eoin, Bendall, Sarah, Amminger, G., Yung, Alison and Herrman, H.. (2012). Road to full recovery: Longitudinal relationship between symptomatic remission and psychosocial recovery in first-episode psychosis over 7.5 years. Psychological Medicine. 42(3), pp. 595 - 606. https://doi.org/10.1017/S0033291711001504
Treating co-occurring first-episode psychosis and borderline personality : a pilot randomized controlled trial
Gleeson, John Francis Martin, Chanen, Andrew, Cotton, Sue, Pearce, Tracey, Newman, Belinda and McCutcheon, Louise. (2012). Treating co-occurring first-episode psychosis and borderline personality : a pilot randomized controlled trial. Early Intervention in Psychiatry. 6(1), pp. 21 - 29. https://doi.org/10.1111/j.1751-7893.2011.00306.x
Risk factors for relapse following treatment for first episode psychosis : A systematic review and meta-analysis of longitudinal studies
Alvarez-Jimenez, Mario, Priede, A., Hetrick, Sarah, Bendall, Sarah, Killackey, Eoin, Parker, Alexandra, McGorry, Patrick and Gleeson, John. (2012). Risk factors for relapse following treatment for first episode psychosis : A systematic review and meta-analysis of longitudinal studies. Schizophrenia Research. 139(1-3), pp. 116 - 128. https://doi.org/10.1016/j.schres.2012.05.007
The Jumping-to-Conclusions Bias in New Religious Movements
Lim, Michelle, Gleeson, John and Jackson, Henry J.. (2012). The Jumping-to-Conclusions Bias in New Religious Movements. The Journal of Nervous and Mental Disease. 200(10), pp. 868 - 875. https://doi.org/10.1097/NMD.0b013e31826b6eb4
The relationship between impulsivity and vocational outcome in outpatient youth with borderline personality features
Sio, I. T., Chanen, A., Killackey, E. and Gleeson, John. (2011). The relationship between impulsivity and vocational outcome in outpatient youth with borderline personality features. Early Intervention in Psychiatry (print version). 5(3), pp. 249 - 253. https://doi.org/10.1111/j.1751-7893.2011.00271.x
Prediction of a single psychotic episode :A 7.5-year, prospective study in first-episode psychosis
Alvarez-Jimenez, Mario, Gleeson, John, Henry, Lisa, Harrigan, Susan, Harris, Meredith, Amminger, G, Killackey, Eoin, Yung, Alison, Herrman, Helen, Jackson, Henry and McGorry, Patrick. (2011). Prediction of a single psychotic episode :A 7.5-year, prospective study in first-episode psychosis. Schizophrenia Research. 125(2/3), pp. 236 - 246. https://doi.org/10.1016/j.schres.2010.10.020
Selective attention to treat bias in delusion-prone individuals
Lim, Michelle H., Gleeson, John and Jackson, Henry J.. (2011). Selective attention to treat bias in delusion-prone individuals. Journal of Nervous and Mental Disease (print version). 199(10), pp. 765 - 772. https://doi.org/10.1097/NMD.0b013e31822fc9e9
Supporting young people with psychosis in the community :An ICT enabled repalse prevention tool
Lederman, Reeva, Wadley, Greg, Gleeson, John, Alvarez-Jimenez, Mario and Spiteri-Staines, Anneliese. (2011). Supporting young people with psychosis in the community :An ICT enabled repalse prevention tool. Pacific Asia Conference on Information Systems 2011. Australia: AIS Electronic Library. pp. 1 - 11
Supporting young people with psychosis in the community: An ICT enabled repalse prevention tool
Lederman, Reeva, Wadley, Greg, Gleeson, John, Alvarez-Jimenez, Mario and Spiteri-Staines, Anneliese. (2011). Supporting young people with psychosis in the community: An ICT enabled repalse prevention tool. Pacific Asia Conference on Information Systems 2011. Australia: AIS Electronic Library. pp. 1 - 11
Preventing the second episode :A systematic review and Meta-analysis of Psychosocial and Pharmacological Trials in First-Episode psychosis
Alvarez-Jimenez, Mario, Parker, Alexandra, Hetrick, Sarah, McGorry, Patrick and Gleeson, John Francis Martin. (2011). Preventing the second episode :A systematic review and Meta-analysis of Psychosocial and Pharmacological Trials in First-Episode psychosis. Schizophrenia Bulletin. 37(3), pp. 619 - 630. https://doi.org/10.1093/schbul/sbp129
Selective Attention to Threat Bias in Delusion-Prone Individuals
Lim, Michelle H., Gleeson, John and Jackson, Henry J.. (2011). Selective Attention to Threat Bias in Delusion-Prone Individuals. The Journal of Nervous and Mental Disease. 199(10), pp. 765 - 772. https://doi.org/10.1097/NMD.0b013e31822fc9e9
Group programmes in early intervention services
Cotton, Sue, Luxmoore, Marni, Woodhead, Gina, Albiston, Dianne, Gleeson, John and McGorry, Patrick. (2011). Group programmes in early intervention services. Early Intervention in Psychiatry. 5(3), pp. 259 - 266. https://doi.org/10.1111/j.1751-7893.2011.00277.x
Differential predictors of critical comments and emotional over-involvement in first-episode psychosis
Alvarez-Jimenez, Mario, Gleeson, John Francis Martin, Cotton, Sue, Wade, Darryl, Crisp, Kingsley, Yap, M and McGorry, Patrick. (2010). Differential predictors of critical comments and emotional over-involvement in first-episode psychosis. Psychological Medicine. 40(1), pp. 63 - 72. https://doi.org/10.1017/S0033291708004765
Family Outcomes From a Randomized Control Trial of Relapse Prevention Therapy in First-Episode Psychosis
Gleeson, John Francis Martin, Cotton, Sue, Alvarez-Jimenez, Mario, Wade, Darryl, Crisp, Kingsley, Newman, Belinda, Spiliotacopoulos, Daniela and McGorry, Patrick. (2010). Family Outcomes From a Randomized Control Trial of Relapse Prevention Therapy in First-Episode Psychosis. Journal of Clinical Psychiatry. 71(4), pp. 475 - 783. https://doi.org/10.4088/JCP.08m04672yel
Quality of life in patients who have remitted from their first episode of psychosis
Cotton, Sue, Gleeson, John Francis Martin, Alvarez-Jimenez, Mario and McGorry, Patrick. (2010). Quality of life in patients who have remitted from their first episode of psychosis. Schizophrenia Research. 121, pp. 259 - 265. https://doi.org/10.1016/j.schres.2010.05.027
A systematic review of relapse measurement in randomized controlled trials of relapse prevention in first-episode psychosis
Gleeson, John Francis Martin, Alvarez-Jimenez, Mario, Cotton, Sue, Parker, Alexandra and Hetrick, Sarah. (2010). A systematic review of relapse measurement in randomized controlled trials of relapse prevention in first-episode psychosis. Schizophrenia Research. 119(1-3), pp. 79 - 88. https://doi.org/10.1016/j.schres.2010.02.1073
A systematic review of relapse measurement in randomized controlled trials of relapse prevention in first-episode psychosis
Gleeson, John Francis Martin, Alvarez-Jimenez, Mario, Cotton, Sue, Parker, Alexandra and Hetrick, Sarah. (2010). A systematic review of relapse measurement in randomized controlled trials of relapse prevention in first-episode psychosis. Schizophrenia Research. 119(1-3), pp. 79 - 88. https://doi.org/10.1016/j.schres.2010.02.1073
The reliability and validity of the alcohol, smoking and substance involvement screening test (assist)
Hides, L., Cotton, Sue, Berger, G., Gleeson, John, O'Donnell, C., Proffitt, T., McGorry, Patrick and Lubman, Dan. (2009). The reliability and validity of the alcohol, smoking and substance involvement screening test (assist). Addictive Behaviors. 34(10), pp. 821 - 825. https://doi.org/10.1016/j.addbeh.2009.03.040
Predictors of adherence to cognitive-behavioural therapy in first-episode psychosis
Álvarez-Jiménez, Mario, Gleeson, John, Cotton, Sue, Wade, Darryl, Gee, Donna, Pearce, Tracey, Crisp, Kingsley, Spiliotacopoulos, Daniela, Newman, Belinda and McGorry, Patrick. (2009). Predictors of adherence to cognitive-behavioural therapy in first-episode psychosis. Journal of Clinical Psychiatry. 54(10), pp. 710 - 718. https://doi.org/10.1177/070674370905401008
One Ace and three faults don't win the set
Álvarez-Jiménez, Mario, Hetrick, Sarah, Gonzalez-Blanch, Cesar, Gleeson, John and McGorry, Patrick. (2009). One Ace and three faults don't win the set. British Journal of Psychiatry. 194(1), pp. 89 - 89. https://doi.org/10.1192/bjp.194.1.89
A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients
Gleeson, John, Cotton, Sue, Álvarez-Jiménez, Mario, Wade, Darryl, Gee, Donna, Crisp, Kingsley, Pearce, Tracey, Newman, Belinda, Spiliotacopoulos, Daniela, Castle, David J. and McGorry, Patrick. (2009). A randomized controlled trial of relapse prevention therapy for first-episode psychosis patients. Journal of Clinical Psychiatry. 70(4), pp. 477 - 486. https://doi.org/10.4088/JCP.08m04407
The episode ii trial of cognitive and family therapy for relapse prevention in early psychosis: Rationale and sample characteristics
Gleeson, John, Wade, Darryl, Castle, David J., Gee, Donna, Crisp, Kingsley, Pearce, Tracey, Newman, Belinda, Cotton, Sue, Álvarez-Jiménez, Mario, Gilbert, Monica and McGorry, Patrick. (2008). The episode ii trial of cognitive and family therapy for relapse prevention in early psychosis: Rationale and sample characteristics. Journal of Mental Health. 17(1), pp. 19 - 32. https://doi.org/10.1080/09638230701504999
Small shifts in diurnal rhythms are associated with an increase in suicide: The effect of daylight saving
Berk, Michael, Dodd, Seetal, Hallam, Karen, Berk, Lesley, Gleeson, John and Henry, Margaret. (2008). Small shifts in diurnal rhythms are associated with an increase in suicide: The effect of daylight saving. Sleep and Biological Rhythm. 6(1), pp. 22 - 25. https://doi.org/10.1111/j.1479-8425.2007.00331.x
Non-pharmacological management of antipsychotic-induced weight gain: systematic review and meta-analysis of randomised controlled trials
Álvarez-Jiménez, Mario, Hetrick, Sarah, Gonzalez-Blanch, Cesar, Gleeson, John and McGorry, Patrick. (2008). Non-pharmacological management of antipsychotic-induced weight gain: systematic review and meta-analysis of randomised controlled trials. British Journal of Psychiatry. 193(2), pp. 101 - 107. https://doi.org/10.1192/bjp.bp.107.042853
Evidence of semantic processing abnormalities in schizotypy using an indirect semantic priming task
Johnston, Alana, Rossell, Susan and Gleeson, John. (2008). Evidence of semantic processing abnormalities in schizotypy using an indirect semantic priming task. Journal of Nervous and Mental Disease. 196(9), pp. 694 - 701. https://doi.org/10.1097/NMD.0b013e318183f882
Acute-phase and 1-year follow-up results of a randomized controlled trial of cbt versus befriending for first-episode psychosis: The ace project
Jackson, Henry, McGorry, Patrick, Killackey, Eoin, Bendall, Sarah, Allott, Kelly, Dudgeon, P., Gleeson, John, Johnson, Tracy and Harrigan, Susan. (2008). Acute-phase and 1-year follow-up results of a randomized controlled trial of cbt versus befriending for first-episode psychosis: The ace project. Psychological Medicine. 38(5), pp. 725 - 735. https://doi.org/10.1017/S0033291707002061
The Credibility and Acceptability of Befriending as a Control Therapy in a Randomized Controlled Trial of Cognitive Behaviour Therapy for Acute First Episode Psychosis
Bendall, Sarah, Jackson, Henry, Killackey, Eoin, Allott, Kelly, Johnson, Tracy, Harrigan, Susan, Gleeson, John and McGorry, Patrick. (2006). The Credibility and Acceptability of Befriending as a Control Therapy in a Randomized Controlled Trial of Cognitive Behaviour Therapy for Acute First Episode Psychosis. Behavioural and Cognitive Psychotherapy. 34(3), pp. 277 - 291. https://doi.org/10.1017/S1352465806002815
The need for the development and evaluation of preventive psychosocial forensic interventions in mainstream adult community mental health services
Gleeson, John, Nathan, Pamela and Bradley, Gail. (2006). The need for the development and evaluation of preventive psychosocial forensic interventions in mainstream adult community mental health services. Australasian Psychiatry. 14(2), pp. 180 - 185. https://doi.org/10.1111/j.1440-1665.2006.02278.x
Exciting career opportunity beckons! Early intervention and vocational rehabilitation in first-episode psychosis: Employing cautious optimism
Killackey, Eoin, Jackson, Henry, Gleeson, John, Hickie, Ian and McGorry, Patrick. (2006). Exciting career opportunity beckons! Early intervention and vocational rehabilitation in first-episode psychosis: Employing cautious optimism. Australian and New Zealand Journal of Psychiatry. 40(44176), pp. 951 - 962. https://doi.org/10.1111/j.1440-1614.2006.01918.x
Agreeableness and neuroticism as predictors of relapse after first-episode psychosis
Gleeson, John, Rawlings, David, Jackson, Henry and McGorry, Patrick. (2005). Agreeableness and neuroticism as predictors of relapse after first-episode psychosis. Journal of Nervous and Mental Disease. 193(3), pp. 160 - 169. https://doi.org/10.1097/01.nmd.0000154841.99550.d3
Implementing cognitive-behavioural therapy for first-episode psychosis
Addington, Jean and Gleeson, John. (2005). Implementing cognitive-behavioural therapy for first-episode psychosis. British Journal of Psychiatry. 13(4), pp. 384 - 387. https://doi.org/10.1192/bjp.187.48.s72
Early warning signs of relapse following a first episode of psychosis.
Gleeson, John, Rawlings, David, Jackson, Henry and McGorry, Patrick. (2005). Early warning signs of relapse following a first episode of psychosis. Schizophrenia Research. 80(1), pp. 107 - 111. https://doi.org/10.1016/j.schres.2005.07.019