Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies

Journal article

Santesteban-Echarri, Olga, Paino, Mercedes, Rice, Simon, González-Blanch, César, McGorry, Patrick, Gleeson, John and Alvarez-Jimenez, Mario. (2017) Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies. Clinical Psychology Review. 58, pp. 59 - 75. https://doi.org/10.1016/j.cpr.2017.09.007
AuthorsSantesteban-Echarri, Olga, Paino, Mercedes, Rice, Simon, González-Blanch, César, McGorry, Patrick, Gleeson, John and Alvarez-Jimenez, Mario
Abstract

Background: Three out of four first-episode psychosis (FEP) patients achieve clinical remission following treatment. Unfortunately, functional recovery lags behind symptomatic remission, and many individuals with FEP remain socially isolated with poor functional outcomes. Aims: To systematically compile and analyse predictors of functional recovery in FEP. Method: Systematic review and meta-analysis of peer-reviewed, longitudinal studies reporting predictors of functioning, with a minimum 12-month follow-up and at least 80% of participants diagnosed with FEP. Results: Out of 2205 citations, 274 articles were retrieved for detailed evaluation resulting in 50 eligible studies (N = 6669). Sociodemographic, clinical, physical and neuroimaging variables had little impact on long-term functioning. Conversely duration of untreated psychosis (DUP), most cognitive variables, and concurrent remission of positive and negative symptoms were independently related to functional recovery. Conclusions: These findings strongly support the rationale for early intervention in FEP. Novel treatments targeting cognitive deficits may improve functional outcomes in FEP.

Keywordsfirst-episode psychosis; functioning
Year2017
JournalClinical Psychology Review
Journal citation58, pp. 59 - 75
PublisherElsevier
ISSN0272-7358
Digital Object Identifier (DOI)https://doi.org/10.1016/j.cpr.2017.09.007
Scopus EID2-s2.0-85031321817
Page range59 - 75
Research GroupSchool of Philosophy
Place of publicationUnited Kingdom
EditorsG. J. G. Asmundson
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Johnston, Alana, Rossell, Susan and Gleeson, John. (2008) Evidence of semantic processing abnormalities in schizotypy using an indirect semantic priming task. Journal of Nervous and Mental Disease. 196(9), pp. 694 - 701. https://doi.org/10.1097/NMD.0b013e318183f882
Acute-phase and 1-year follow-up results of a randomized controlled trial of cbt versus befriending for first-episode psychosis: The ace project
Jackson, Henry, McGorry, Patrick, Killackey, Eoin, Bendall, Sarah, Allott, Kelly, Dudgeon, P., Gleeson, John, Johnson, Tracy and Harrigan, Susan. (2008) Acute-phase and 1-year follow-up results of a randomized controlled trial of cbt versus befriending for first-episode psychosis: The ace project. Psychological Medicine. 38(5), pp. 725 - 735. https://doi.org/10.1017/S0033291707002061
The Credibility and Acceptability of Befriending as a Control Therapy in a Randomized Controlled Trial of Cognitive Behaviour Therapy for Acute First Episode Psychosis
Bendall, Sarah, Jackson, Henry, Killackey, Eoin, Allott, Kelly, Johnson, Tracy, Harrigan, Susan, Gleeson, John and McGorry, Patrick. (2006) The Credibility and Acceptability of Befriending as a Control Therapy in a Randomized Controlled Trial of Cognitive Behaviour Therapy for Acute First Episode Psychosis. Behavioural and Cognitive Psychotherapy. 34(3), pp. 277 - 291. https://doi.org/10.1017/S1352465806002815
The need for the development and evaluation of preventive psychosocial forensic interventions in mainstream adult community mental health services
Gleeson, John, Nathan, Pamela and Bradley, Gail. (2006) The need for the development and evaluation of preventive psychosocial forensic interventions in mainstream adult community mental health services. Australasian Psychiatry. 14(2), pp. 180 - 185. https://doi.org/10.1111/j.1440-1665.2006.02278.x
Exciting career opportunity beckons! Early intervention and vocational rehabilitation in first-episode psychosis: Employing cautious optimism
Killackey, Eoin, Jackson, Henry, Gleeson, John, Hickie, Ian and McGorry, Patrick. (2006) Exciting career opportunity beckons! Early intervention and vocational rehabilitation in first-episode psychosis: Employing cautious optimism. Australian and New Zealand Journal of Psychiatry. 40(44176), pp. 951 - 962. https://doi.org/10.1111/j.1440-1614.2006.01918.x
Agreeableness and neuroticism as predictors of relapse after first-episode psychosis
Gleeson, John, Rawlings, David, Jackson, Henry and McGorry, Patrick. (2005) Agreeableness and neuroticism as predictors of relapse after first-episode psychosis. Journal of Nervous and Mental Disease. 193(3), pp. 160 - 169. https://doi.org/10.1097/01.nmd.0000154841.99550.d3
Implementing cognitive-behavioural therapy for first-episode psychosis
Addington, Jean and Gleeson, John. (2005) Implementing cognitive-behavioural therapy for first-episode psychosis. British Journal of Psychiatry. 13(4), pp. 384 - 387. https://doi.org/10.1192/bjp.187.48.s72
Early warning signs of relapse following a first episode of psychosis.
Gleeson, John, Rawlings, David, Jackson, Henry and McGorry, Patrick. (2005) Early warning signs of relapse following a first episode of psychosis. Schizophrenia Research. 80(1), pp. 107 - 111. https://doi.org/10.1016/j.schres.2005.07.019