Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies
Journal article
Santesteban-Echarri, Olga, Paino, Mercedes, Rice, Simon, González-Blanch, César, McGorry, Patrick, Gleeson, John and Alvarez-Jimenez, Mario. (2017). Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies. Clinical Psychology Review. 58, pp. 59 - 75. https://doi.org/10.1016/j.cpr.2017.09.007
Authors | Santesteban-Echarri, Olga, Paino, Mercedes, Rice, Simon, González-Blanch, César, McGorry, Patrick, Gleeson, John and Alvarez-Jimenez, Mario |
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Abstract | Background: Three out of four first-episode psychosis (FEP) patients achieve clinical remission following treatment. Unfortunately, functional recovery lags behind symptomatic remission, and many individuals with FEP remain socially isolated with poor functional outcomes. Aims: To systematically compile and analyse predictors of functional recovery in FEP. Method: Systematic review and meta-analysis of peer-reviewed, longitudinal studies reporting predictors of functioning, with a minimum 12-month follow-up and at least 80% of participants diagnosed with FEP. Results: Out of 2205 citations, 274 articles were retrieved for detailed evaluation resulting in 50 eligible studies (N = 6669). Sociodemographic, clinical, physical and neuroimaging variables had little impact on long-term functioning. Conversely duration of untreated psychosis (DUP), most cognitive variables, and concurrent remission of positive and negative symptoms were independently related to functional recovery. Conclusions: These findings strongly support the rationale for early intervention in FEP. Novel treatments targeting cognitive deficits may improve functional outcomes in FEP. |
Keywords | first-episode psychosis; functioning |
Year | 2017 |
Journal | Clinical Psychology Review |
Journal citation | 58, pp. 59 - 75 |
Publisher | Elsevier |
ISSN | 0272-7358 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.cpr.2017.09.007 |
Scopus EID | 2-s2.0-85031321817 |
Page range | 59 - 75 |
Research Group | School of Philosophy |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
Editors | G. J. G. Asmundson |
https://acuresearchbank.acu.edu.au/item/8q691/predictors-of-functional-recovery-in-first-episode-psychosis-a-systematic-review-and-meta-analysis-of-longitudinal-studies
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