Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis

Journal article


Tournadre, Anne, Pereira, Bruno, Dutheil, Fréderic, Giraud, Charlotte, Courteix, Daniel, Sapin, Vincent, Frayssac, Thomas, Mathieu, Sylvain, Malochet-Guinamand, Sandrine and Soubrier, Martin. (2017). Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis. Journal of Cachexia, Sarcopenia and Muscle. 8(4), pp. 639 - 646. https://doi.org/10.1002/jcsm.12189
AuthorsTournadre, Anne, Pereira, Bruno, Dutheil, Fréderic, Giraud, Charlotte, Courteix, Daniel, Sapin, Vincent, Frayssac, Thomas, Mathieu, Sylvain, Malochet-Guinamand, Sandrine and Soubrier, Martin
Abstract

Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by increased mortality associated with cardiometabolic disorders including dyslipidaemia, insulin resistance, and cachectic obesity. Tumour necrosis factor inhibitors and interleukin 6 receptor blocker licensed for the treatment of RA decrease inflammation and could thus improve cardiovascular risk, but their effects on body composition and metabolic profile need to be clarified. We investigated the effects of tocilizumab (TCZ), a humanized anti‐interleukin 6 receptor antibody, on body composition and metabolic profile in patients treated for RA. Methods Twenty‐one active RA patients treated with TCZ were included in a 1 year open follow‐up study. Waist circumference, body mass index, blood pressure, lipid profile, fasting glucose, insulin, serum levels of adipokines and pancreatic/gastrointestinal hormones, and body composition (dual‐energy X‐ray absorptiometry) were measured at baseline and 6 and 12 months of treatment. At baseline, RA patients were compared with 21 non‐RA controls matched for age, sex, body mass index, and metabolic syndrome. Results Compared with controls, body composition was altered in RA with a decrease in total and appendicular lean mass, whereas fat composition was not modified. Among RA patients, 28.6% had a skeletal muscle mass index below the cut‐off point for sarcopaenia (4.8% of controls). After 1 year of treatment with TCZ, there was a significant weight gain without changes for fat mass. In contrast, an increase in lean mass was observed with a significant gain in appendicular lean mass and skeletal muscle mass index between 6 and 12 months. Distribution of the fat was modified with a decrease in trunk/peripheral fat ratio and an increase in subcutaneous adipose tissue. No changes for waist circumference, blood pressure, fasting glucose, and atherogenic index were observed. Conclusions Despite weight gain during treatment with TCZ, no increase in fat but a modification in fat distribution was observed. In contrast, muscle gain suggests that blocking IL‐6 might be efficient in treating sarcopaenia associated with RA.

Keywordssarcopaenia; cachexia; rheumatoid arthritis; tocilizumab; metabolic change
Year2017
JournalJournal of Cachexia, Sarcopenia and Muscle
Journal citation8 (4), pp. 639 - 646
PublisherWiley - V C H Verlag GmbH & Co. KGaA
ISSN2190-5991
Digital Object Identifier (DOI)https://doi.org/10.1002/jcsm.12189
Scopus EID2-s2.0-85017140186
Open accessOpen access
Page range639 - 646
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
License
Place of publicationGermany
Permalink -

https://acuresearchbank.acu.edu.au/item/8q69x/changes-in-body-composition-and-metabolic-profile-during-interleukin-6-inhibition-in-rheumatoid-arthritis

Download files

  • 110
    total views
  • 171
    total downloads
  • 0
    views this month
  • 1
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Muscle function and architecture in children with juvenile idiopathic arthritis
Bourdier, Pierre, Birat, Anthony, Rochette, Emmanuelle, Doré, Éric, Courteix, Daniel, Dutheil, Frédéric, Pereira, Bruno, Ratel, Sébastien, Merlin, Etienne and Duché, Pascale. (2021). Muscle function and architecture in children with juvenile idiopathic arthritis. Acta Paediatrica. 110(1), pp. 280-287. https://doi.org/10.1111/apa.15335
Heart rate variability as a possible predictor of sport performance in junior rhythmic gymnastics
Urzeala, Constanta, Bota, Aura, Serbanoiu, Sorin, Mezei, Mariana, Dutheil, Frederic and Courteix, Daniel. (2020). Heart rate variability as a possible predictor of sport performance in junior rhythmic gymnastics. Isokinetics and Exercise Science. 28(2), pp. 171-179. https://doi.org/10.3233/IES-192222
Cognitive restriction accentuates the increased energy intake response to a 10-month multidisciplinary weight loss program in adolescents with obesity
Miguet, M., Masurier, J., Chaput, J. P., Pereira, B., Lambert, C., Dâmaso, A. R., Courteix, D., Duclos, M., Boirie, Y. and Thivel, D.. (2019). Cognitive restriction accentuates the increased energy intake response to a 10-month multidisciplinary weight loss program in adolescents with obesity. Appetite. 134, pp. 125-134. https://doi.org/10.1016/j.appet.2018.12.015
Effects of a short residential thermal spa program to prevent work-related stress/burnout on stress biomarkers: The thermstress proof of concept study
Dutheil, Frederic, Chaplais, Elodie, Vilmant, Audrey, Lanoir, Denise, Courteix, Daniel, Duche, Pascale, Abergel, Armand, Pfabigan, Daniela M., Han, Shihui, Mondillon, Laurie, Vallet, Guillaume, Mermillod, Martial, Boudet, Gil, Obert, Phillippe, Izem, Omar, Boirie, Yves, Pereira, Bruno and Lesage, Francois-Xavier. (2019). Effects of a short residential thermal spa program to prevent work-related stress/burnout on stress biomarkers: The thermstress proof of concept study. Journal of International Medical Research. 47(10), pp. 5130 - 5145. https://doi.org/10.1177/0300060519859119
Long-term effects of high-intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals: The RESOLVE Study
Tremblay, Angelo, Dutheil, Frédéric, Drapeau, Vicky, Metz, Lore, Lesour, Bruno, Chapier, Robert, Pereira, Bruno, Verney, Julien, Baker, Julien S., Vinet, Agnes, Walther, Guillaume, Obert, Phillippe, Courteix, Daniel and Thivel, David. (2019). Long-term effects of high-intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals: The RESOLVE Study. Applied Physiology, Nutrition and Metabolism. 44(11), pp. 1172 - 1179. https://doi.org/10.1139/apnm-2019-0019
Different modalities of exercise improve macrovascular function but not microvascular function in metabolic syndrome: The RESOLVE randomized trial
Agnes Vinet, Phillippe Obert, Daniel Courteix, Robert Chapier, Bruno Lesourd, Julien Verney, Frederic Dutheil and Guillaume Walther. (2018). Different modalities of exercise improve macrovascular function but not microvascular function in metabolic syndrome: The RESOLVE randomized trial. International Journal of Cardiology. 267, pp. 165-170. https://doi.org/10.1016/j.ijcard.2018.05.073
Cardiovascular risk of adipokines: A review
Frederic Dutheil, Brett Ashley Gordon, Geraldine Naughton, Edward Crendal, Daniel Courteix, Elodie Chaplais, David Thivel, Gerard Lac and Amanda Benson. (2018). Cardiovascular risk of adipokines: A review. Journal of International Medical Research. 46(6), pp. 2082-2095. https://doi.org/10.1177/0300060517706578
Effects of interventions with a physical activity component on bone health in obese children and adolescents: a systematic review and meta-analysis
Elodie, Chaplais, Naughton, Geraldine, Greene, David, Dutheil, Frederic, Pereira, Bruno, Thivel, David and Courteix, Daniel. (2018). Effects of interventions with a physical activity component on bone health in obese children and adolescents: a systematic review and meta-analysis. Journal of Bone and Mineral Metabolism. 36(1), pp. 12 - 30. https://doi.org/10.1007/s00774-017-0858-z
Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX Study
Chaplais, Elodie, Naughton, Geraldine, Dutheil, Frederic, Masurier, Julie, Greene, David, Pereira, Bruno, Duclos, Martine, Thivel, David and Courteix, Daniel. (2018). Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX Study. Journal of Clinical Densitometry. 23(2), pp. 254 - 263. https://doi.org/10.1016/j.jocd.2018.06.002
Longitudinal determinants of 12-month changes on bone health in adolescent male athletes
Ubago-Guisado, Esther, Vlachopoulos, Dimitris, Fatouros, Ioannis G., Deli, Chariklia K., Leontsini, Diamanda, Moreno, Luis A., Courteix, Daniel and Gracia-Marco, Luis. (2018). Longitudinal determinants of 12-month changes on bone health in adolescent male athletes. Archives of Osteoporosis. 13(1), pp. 1 - 9. https://doi.org/10.1007/s11657-018-0519-4
Total and regional bone mineral and tissue composition in female adolescent athletes: Comparison between volleyball players and swimmers
Valente-dos-Santos, João, Tavares, Óscar M., Duarte, João P., Sousa-e-Silva, Paulo M., Rama, Luís M., Casanova, José M., Fontes-Ribeiro, Carlos A., Marques, Elisa A., Courteix, Daniel, Ronque, Enio R. V., Cyrino, Edilson S., Conde, Jorge and Coelho-e-Silva, Manuel J.. (2018). Total and regional bone mineral and tissue composition in female adolescent athletes: Comparison between volleyball players and swimmers. BMC Pediatrics. 18(1), pp. 1 - 11. https://doi.org/10.1186/s12887-018-1182-z
Paradoxical dissociation between heart rate and heart rate variability following different modalities of exercise in individuals with metabolic syndrome: The RESOLVE study
Boudet, Gil, Walther, Guillaume, Courteix, Daniel, Obert, Phillippe, Lesourd, Bruno, Pereira, Bruno, Chapier, Robert, Vinet, Agnès, Chamoux, Alain, Naughton, Geraldine, Poirier, Paul and Dutheil, Frédéric. (2017). Paradoxical dissociation between heart rate and heart rate variability following different modalities of exercise in individuals with metabolic syndrome: The RESOLVE study. European Journal of Preventative Cardiology. 24(3), pp. 281 - 296. https://doi.org/10.1177/2047487316679523
Long-term cost reduction of routine medications following a residential programme combining physical activity and nutrition in the treatment of type 2 diabetes: a prospective cohort study
Lanhers, Charlotte, Walther, Guillaume, Chapier, Robert, Lesourd, Bruno, Naughton, Geraldine, Pereira, Bruno, Duclos, Martine, Vinet, Agnes, Obert, Phillippe, Courteix, Daniel and Dutheil, Frederic. (2017). Long-term cost reduction of routine medications following a residential programme combining physical activity and nutrition in the treatment of type 2 diabetes: a prospective cohort study. BMJ Open. 7(4), pp. 1 - 10. https://doi.org/10.1136/bmjopen-2016-013763
Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial
Serrano-Ferrer, Juan, Crendal, Edward, Walther, Guillaume, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine Ann, Lesourd, Bruno, Chapier, Robert, Courteix, Daniel and Obert, Philippe. (2016). Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial. Metabolism. 65(9), pp. 1350 - 1360. https://doi.org/10.1016/j.metabol.2016.05.006
Concurrent agreement between an anthropometric model to predict thigh volume and dual-energy X-Ray absorptiometry assessment in female volleyball players aged 14-18 years
Tavares, Óscar M., Valente-dos-Santos, João, Duarte, João P., Póvoas, Susana C., Gobbo, Luís A., Fernandes, Rômulo A., Marinho, Daniel Almeida, Casanova, José M., Sherar, Lauren B., Courteix, Daniel and Coelho-e-Silva, Manuel J.. (2016). Concurrent agreement between an anthropometric model to predict thigh volume and dual-energy X-Ray absorptiometry assessment in female volleyball players aged 14-18 years. BMC Pediatrics. 16(190), pp. 1 - 10. https://doi.org/10.1186/s12887-016-0730-7
Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: Effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project
Chaplais, Elodie, Dutheil, Frederic, Naughton, Geraldine Ann, Greene, David Anthony, Pereira, Bruno, Thivel, David and Courteix, Daniel. (2016). Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: Effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project. BMJ Open. 6, pp. 1 - 9. https://doi.org/10.1136/bmjopen-2016-011407
Multilevel approach of a 1-year program of dietary and exercise interventions on bone mineral content and density in metabolic syndrome - the RESOLVE randomized controlled trial
Courteix, Daniel, Valente-dos-Santos, Joao, Ferry, Beatrice, Lac, Gerard, Lesourd, Bruno, Chapier, Robert, Naughton, Geraldine, Marceau, Geoffroy, Coelho-E-Silva, Manuel, Vinet, Agnes, Walther, Guillaume, Obert, Philippe and Dutheil, Frederic. (2015). Multilevel approach of a 1-year program of dietary and exercise interventions on bone mineral content and density in metabolic syndrome - the RESOLVE randomized controlled trial. PLoS One (online). 10(9), pp. 1 - 20. https://doi.org/10.1371/journal.pone.0136491
Bone-adiposity cross-talk: implications for pediatric obesity
Chaplais, Elodie, Thivel, David, Greene, David, Dutheil, Frederic, Duche, Pascale, Naughton, Geraldine and Courteix, Daniel. (2015). Bone-adiposity cross-talk: implications for pediatric obesity. Journal of Bone and Mineral Metabolism. 33(6), pp. 592 - 602. https://doi.org/10.1007/s00774-015-0654-6
Smartphone interventions for weight treatment and behavioral change in pediatric obesity : A systematic review
Chaplais, Elodie, Naughton, Geraldine, Thivel, David, Courteix, Daniel and Greene, David. (2015). Smartphone interventions for weight treatment and behavioral change in pediatric obesity : A systematic review. Telemedicine and e-Health (print). 21(10), pp. 822 - 830. https://doi.org/10.1089/tmj.2014.0197
Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction : Cross-sectional study
Walther, Guillaume, Obert, Philippe, Dutheil, Frederic, Chapier, Robert, Lesourd, Bruno, Naughton, Geraldine, Courteix, Daniel and Vinet, Agnes. (2015). Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction : Cross-sectional study. Arteriosclerosis Thrombosis and Vascular Biology. 35(4), pp. 1022 - 1029. https://doi.org/10.1161/ATVBAHA.114.304591
Left ventricular myocardial dyssynchrony is already present in nondiabetic patients with metabolic syndrome
Crendal, Edward, Walther, Guillaume, Dutheil, Frederic, Courteix, Daniel, Lesourd, Bruno, Chapier, Robert, Naughton, Geraldine A., Vinet, Agnes and Obert, Phillippe. (2014). Left ventricular myocardial dyssynchrony is already present in nondiabetic patients with metabolic syndrome. Canadian Journal of Cardiology. 30(3), pp. 320 - 324. https://doi.org/10.1016/j.cjca.2013.10.019
Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial
Dutheil, Frederic, Walther, Guillame, Chapier, Robert, Mnatzaganian, George, Lesourd, Bruno, Naughton, Geraldine, Verney, Julien, Fogli, Anne, Sapin, Vincent, Duclos, Martine, Vinet, Agnes, Obert, Philippe, Courteix, Daniel and Lac, Gerard. (2014). Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial. Lipids in Health and Disease. 13(1). https://doi.org/10.1186/1476-511X-13-112
Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: Effects of a 3-month lifestyle intervention program
Serrano-Ferrer, Juan, Walther, Guillaume, Crendal, Edward, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine A., Lesourd, Bruno, Chapier, Robert, Courteix, Daniel and Obert, Philippe. (2014). Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: Effects of a 3-month lifestyle intervention program. Cardiovascular Diabetology. 13(1), pp. 1 - 11. https://doi.org/10.1186/s12933-014-0116-9
Myocardial deformation and twist mechanics in adults with metabolic syndrome : Impact of cumulative metabolic burden
Crendal, Edward, Walther, Guillaume, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine, Lesourd, Bruno, Chapier, Robert, Rupp, Thomas, Courteix, Daniel and Obert, Philippe. (2013). Myocardial deformation and twist mechanics in adults with metabolic syndrome : Impact of cumulative metabolic burden. Obesity: a resourch journal. https://doi.org/10.1002/oby.20537
Gymnastics participation is associated with skeletal benefits in the distal forearm : a 6-month study using peripheral Quantitative Computed Tomography
Burt, Lauren, Ducher, Gaele, Naughton, Geraldine, Courteix, Daniel and Greene, David. (2013). Gymnastics participation is associated with skeletal benefits in the distal forearm : a 6-month study using peripheral Quantitative Computed Tomography. The Journal of Musculoskeletal and Neuronal Interactions.
Non-elite gymnastics participation is associated with greater bone strength, muscle size, and function in pre- and early pubertal girls
Burt, Lauren, Naughton, Geraldine, Greene, David and Courteix, Daniel. (2012). Non-elite gymnastics participation is associated with greater bone strength, muscle size, and function in pre- and early pubertal girls. Osteoporosis International. 23(4), pp. 1277 - 1286. https://doi.org/10.1007/s00198-011-1677-z
Treatment of Metabolic syndrome by combination of physical activity and diet needs an optimal protein intake: a randomized controlled trial
Dutheil, Frederic, Lac, Gerard, Courteix, Daniel, Dore, Eric, Chapier, Robert, Roszyk, Laurence, Sapin, Vincent and Lesourd, Bruno. (2012). Treatment of Metabolic syndrome by combination of physical activity and diet needs an optimal protein intake: a randomized controlled trial. Nutrition Journal. 11(1). https://doi.org/10.1186/1475-2891-11-72
Bone geometry and strength adaptations to physical constraints inherent in different sports: Comparison between elite female soccer players and swimmers
Ferry, B., Duclos, M., Burt, Lauren A., Therre, P., Le Gall, F., Jaffré, C. and Courteix, D.. (2011). Bone geometry and strength adaptations to physical constraints inherent in different sports: Comparison between elite female soccer players and swimmers. Journal of Bone and Mineral Metabolism (print version). 29(3), pp. 342 - 351. https://doi.org/10.1007/s00774-010-0226-8
Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers
Ferry, Beatrice, Duclos, Martine, Burt, Lauren, Therre, Perrine, Le Gall, Franck, Jaffre, Christelle and Courteix, Daniel. (2011). Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers. Journal of Bone and Mineral Metabolism. 29(3). https://doi.org/10.1007/s00774-010-0226-8
Effect of a six-month training programme on the physical capacities of Romanian schoolchildren
Greene, David, Serbescu, Carmen, Flora, D., Hantiu, Iacob, Benhamou, Claude Laurent and Courteix, Daniel. (2006). Effect of a six-month training programme on the physical capacities of Romanian schoolchildren. Acta Paediatrica. 10(10), pp. 1258 - 1265. https://doi.org/10.1080/08035250600599719