Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study

Journal article


Simpson, Richard W., Nicholson, Geoffrey C., Proietto, Joseph, Sarah, Alana, Sanders, Kerrie M., Phillips, Gabrielle, Chambers, Jo, MacGinley, Rob, Orford, Neil, Walder, Ken, Krippner, Guy, Skoff, Kathy and Wacher, Vincent J. 2014. Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study. Diabetes Care. 37 (11), pp. 3121 - 3123. https://doi.org/10.2337/dc14-1038
AuthorsSimpson, Richard W., Nicholson, Geoffrey C., Proietto, Joseph, Sarah, Alana, Sanders, Kerrie M., Phillips, Gabrielle, Chambers, Jo, MacGinley, Rob, Orford, Neil, Walder, Ken, Krippner, Guy, Skoff, Kathy and Wacher, Vincent J.
Abstract

OBJECTIVE To evaluate the safety and efficacy of methazolamide as a potential therapy for type 2 diabetes. RESEARCH DESIGN AND METHODS This double-blind, placebo-controlled study randomized 76 patients to oral methazolamide (40 mg b.i.d.) or placebo for 24 weeks. The primary efficacy end point for methazolamide treatment was a placebo-corrected reduction in HbA1c from baseline after 24 weeks (ΔHbA1c). RESULTS Mean ± SD baseline HbA1c was 7.1 ± 0.7% (54 ± 5 mmol/mol; n = 37) and 7.4 ± 0.6% (57 ± 5 mmol/mol; n = 39) in the methazolamide and placebo groups, respectively. Methazolamide treatment was associated with a ΔHbA1c of –0.39% (95% CI –0.82, 0.04; P < 0.05) (–4.3 mmol/mol [–9.0, 0.4]), an increase in the proportion of patients achieving HbA1c ≤6.5% (48 mmol/mol) from 8 to 33%, a rapid reduction in alanine aminotransferase (∼10 units/L), and weight loss (2%) in metformin-cotreated patients. CONCLUSIONS Methazolamide is the archetype for a new intervention in type 2 diabetes with clinical benefits beyond glucose control.

Year2014
JournalDiabetes Care
Journal citation37 (11), pp. 3121 - 3123
ISSN0149-5992
Digital Object Identifier (DOI)https://doi.org/10.2337/dc14-1038
Open accessOpen access
Page range3121 - 3123
Research GroupInstitute for Health and Ageing
Publisher's version
Permalink -

https://acuresearchbank.acu.edu.au/item/8q943/efficacy-and-safety-of-oral-methazolamide-in-patients-with-type-2-diabetes-a-24-week-placebo-controlled-double-blind-study

  • 0
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Resident perceptions of opportunity for communication and contribution
Bennett, Michelle, Treuer, Kathryn von, McCabe, Marita P., Beattie, Elizabeth, Karantzas, Gery, Mellor, David, Sanders, Kerrie, Busija, Ljoudmila, Goodenough, Belinda and Byers, Jessica 2020. Resident perceptions of opportunity for communication and contribution. International Journal of Older People Nursing. 15 (1), pp. 1 - 11. https://doi.org/10.1111/opn.12276
The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017
Tatangelo, Gemma, Watts, Jennifer J., Lim, Karen, Connaughton, Catherine, Abimanyi-Ochom, Julie, Borgström, Fredrik, Nicholson, Geoff C., Shore-Lorenti, Catherine, Stuart, Amanda L., Iuliano-Burns, Sandra, Seeman, Ego, Prince, Richard L., March, Lyn, Cross, Marita, Winzenberg, Tania, Laslett, Laura L., Duque, Gustavo, Ebeling, Peter R. and Sanders, Kerrie M. 2019. The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017. Journal of Bone and Mineral Research. 34 (4), pp. 616 - 625. https://doi.org/10.1002/jbmr.3640
Effect of clinical care pathways on quality of life and physical function after fragility fracture: A meta-analysis
Talevski, Jason, Sanders, Kerrie M., Duque, Gustavo, Connaughton, Catherine, Beauchamp, Alison, Green, Darci, Millar, Lynne and Brennan-Olsen, Sharon L. 2019. Effect of clinical care pathways on quality of life and physical function after fragility fracture: A meta-analysis. Journal of the American Medical Directors Association. 20 (7), pp. 926.e1 - 926.e11. https://doi.org/10.1016/j.jamda.2019.02.022
Do replicable profiles of multimorbidity exist? Systematic review and synthesis
Busija, Ljoudmila, Lim, Karen, Szoeke, Cassandra, Sanders, Kerrie M. and McCabe, Marita P. 2019. Do replicable profiles of multimorbidity exist? Systematic review and synthesis. European Journal of Epidemiology. 34, pp. 1025 - 1053. https://doi.org/10.1007/s10654-019-00568-5
Stepping strategy used to recover balance during an induced fall is associated with impaired function and strength in people with knee osteoarthritis
Levinger, P., Downie, Calum, Nagano, Hanatsu, Petersen, Aaron, Hayes, A., Sanders, Kerrie, Cicuttini, Flavia and Begg, Rezaul 2018. Stepping strategy used to recover balance during an induced fall is associated with impaired function and strength in people with knee osteoarthritis. International Journal of Rheumatic Diseases. 21 (10), pp. 1763 - 1771. https://doi.org/10.1111/1756-185X.12891
Calf muscle density in independently associated with physical function in overweight and obese older adults
Scott, David, Shore-Lorenti, Catherine, McMillan, L. B., Mesinovic, J., Clark, Ross, Hayes, A., Sanders, Kerrie, Duque, Gustavo and Ebeling, Peter 2018. Calf muscle density in independently associated with physical function in overweight and obese older adults. The Journal of Musculoskeletal and Neuronal Interactions. 18 (1), pp. 9 - 17.
Associations of components of sarcopenic obesity with bone health and balance in older adults
Scott, David, Shore-Lorenti, Catherine, McMillan, Lachlan, Mesinovic, Jakub, Clark, Ross, Hayes, A., Sanders, Kerrie, Duque, Gustavo and Ebeling, Peter 2018. Associations of components of sarcopenic obesity with bone health and balance in older adults. Archives of Gerontology and Geriatrics. 75, pp. 125 - 131. https://doi.org/10.1016/j.archger.2017.12.006
Characteristics of recurrent fractures
Kanis, John A., Johansson, Helena, Odén, Anders, Harvey, Nicholas C., Gudnason, V., Sanders, Kerrie, Sigurdsson, Gunnar, Siggeirsdottir, K., Fitzpatrick, Lorraine A., Borgström, F. and McCloskey, Eugene 2018. Characteristics of recurrent fractures. Osteoporosis International. 29 (8), pp. 1747 - 1757. https://doi.org/10.1007/s00198-018-4502-0
Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults
Shang, Xianwen, Scott, David, Hodge, Allison, English, Dallas, Giles, Graham G., Ebeling, Peter and Sanders, Kerrie 2017. Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults. Clinical Nutrition. 36 (6), pp. 1540 - 1548. https://doi.org/10.1016/j.clnu.2016.09.024
Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury
Sanders, Kerrie, Lim, Karen, Stuart, Amanda L., Macleod, Ashley, Scott, David, Nicholson, Geoff and Busija, Lucy 2017. Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury. Osteoporosis International. 28 (10), pp. 3005 - 3015. https://doi.org/10.1007/s00198-017-4145-6
Osteoporosis costing Victoria: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam 2017. Osteoporosis costing Victoria: A burden of disease analysis - 2012 to 2022. Australia: Osteoporosis Australia.
Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS
Svedbom, A., Borgström, Fredrik, Hernlund, E., Ström, O., Alekna, V., Bianchi, Maria L., Clark, P., Curiel, M. D., Dimai, Hans P., Jürisson, M., Uusküla, A., Lember, M., Kallikorm, R., Lesnyak, Olga, McCloskey, Eugene, Ershova, Olga, Sanders, Kerrie, Silverman, S., Tamulaitiene, M., ... Kanis, John 2017. Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS. Quality of Life Research. 27 (3), pp. 707 - 716. https://doi.org/10.1007/s11136-017-1748-5
Osteoporosis costing NSW and ACT: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam 2017. Osteoporosis costing NSW and ACT: A burden of disease analysis - 2012 to 2022. Australia: Osteoporosis Australia.
Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS
Svedbom, A., Borgstöm, F., Hernlund, E., Ström, O., Alekna, V., Bianchi, M. L., Clark, P., Curiel, M. D., Dimai, Hans P., Jürisson, M., Kallikorm, R., Lember, M., Lesnyak, Olga, McCloskey, Eugene, Sanders, Kerrie, Silverman, S., Solodovnikov, A., Tamulaitiene, M., Thomas, T., ... John, Handelshogskolan i Stockholm 2017. Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS. Osteoporosis International. 29 (3), pp. 557 - 566. https://doi.org/10.1007/s00198-017-4317-4
Vitamin D, bones and muscle: myth versus reality
Duque, Gustavo, Daly, Rob, Sanders, Kerrie and Kiel, Douglas P. 2017. Vitamin D, bones and muscle: myth versus reality. Australasian Journal on Ageing. 36 (1), pp. 8 - 13. https://doi.org/10.1111/ajag.12408
Associations between illness duration and health-related quality of life in specified mental and physical chronic health conditions: results from a population-based survey
Busija, Lucy, Tan, Jeretine and Sanders, Kerrie 2017. Associations between illness duration and health-related quality of life in specified mental and physical chronic health conditions: results from a population-based survey. Quality of Life Research. 26 (10), pp. 2671 - 2681. https://doi.org/10.1007/s11136-017-1592-7
The effect of vitamin D status on pain, lower limb strength and knee function during balance recovery in people with knee osteoarthritis: an exploratory study
Levinger, P., Begg, Rezaul, Sanders, Kerrie, Nagano, Hanatsu, Downie, Calum, Petersen, Aaron, Hayes, A. and Cicuttini, Flavia 2017. The effect of vitamin D status on pain, lower limb strength and knee function during balance recovery in people with knee osteoarthritis: an exploratory study. Archives of Osteoporosis. 12 (83), pp. 1 - 6. https://doi.org/10.1007/s11657-017-0378-4
Osteoporosis costing Tasmania: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam 2017. Osteoporosis costing Tasmania: A burden of disease analysis - 2012 to 2022. Australia: Osteoporosis Australia.
Osteoporosis costing Northern Territory: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam 2017. Osteoporosis costing Northern Territory: A burden of disease analysis - 2012 to 2022. Australia: Osteoporosis Australia.
Dietary quality is associated with abdominal aortic calcification: a mean of 18-year longitudinal study in community-dwelling older adults
Shang, Xianwen, Scott, David, Hodge, Allison, Khan, Belal, Khan, Nayab, English, Dallas, Giles, Graham G., Ebeling, Peter and Sanders, Kerrie 2017. Dietary quality is associated with abdominal aortic calcification: a mean of 18-year longitudinal study in community-dwelling older adults. Journal of Nutrition, Health and Aging. 21 (2), pp. 147 - 151. https://doi.org/10.1007/s12603-016-0738-6
Osteoporosis costing Western Australia: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam 2017. Osteoporosis costing Western Australia: A burden of disease analysis - 2012 to 2022. Australia: Osteoporosis Australia.
Osteoporosis costing South Australia: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam 2017. Osteoporosis costing South Australia: A burden of disease analysis - 2012 to 2022. Australia: Osteoporosis Australia.
Osteoporosis costing Queensland: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam 2017. Osteoporosis costing Queensland: A burden of disease analysis - 2012 to 2022. Australia: Osteoporosis Australia.
A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy
Barker, Anna L., McNeil, John, Seeman, Ego, Ward, Stephanie A., Sanders, Kerrie M., Khosla, Sundeep, Cumming, Robert G., Pasco, Julie A., Bohensky, Megan A., Ebeling, Peter E., Woods, Robyn L., Lockery, Jessica E., Wolfe, Rory and Talevski, Jason 2016. A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy. Injury Prevention. 22 (4), pp. 297 - 301. https://doi.org/10.1136/injuryprev-2015-041655
Non-hip and non-vertebral fractures: the neglected fracture sites
Holloway, Kara, Henry, Margaret, Brennan-Olsen, Sharon, Bucki-Smith, Gosia, Nicholson, Geoffrey Charles, Korn, S., Sanders, Kerrie, Pasco, Julie and Kotowicz, Mark 2016. Non-hip and non-vertebral fractures: the neglected fracture sites. Osteoporosis International. 27 (3), pp. 905 - 913. https://doi.org/10.1007/s00198-015-3322-8
The association between anxiety and falls: A meta-analysis
Hallford, David John, Nicholson, Geoffrey Charles, Sanders, Kerrie and McCabe, Marita Patricia 2016. The association between anxiety and falls: A meta-analysis. Journal of Gerontology: Psychological Sciences. 00 (00), pp. 1 - 13. https://doi.org/10.1093/geronb/gbv160
Therapy: New findings on vitamin D3 supplementation and falls-when more is perhaps not better
Sanders, Kerrie and Seibel, Markus J. 2016. Therapy: New findings on vitamin D3 supplementation and falls-when more is perhaps not better. Nature Reviews Endocrinology. 12 (4), pp. 190 - 191. https://doi.org/10.1038/nrendo.2016.29
Anxiety Disorders and falls among older adults
Holloway, Kara L., Williams, L. J., Brennan-Olsen, Sharon L., Morse, Amelia G., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A. 2016. Anxiety Disorders and falls among older adults. Journal of Affective Disorders. 205, pp. 20 - 27. https://doi.org/10.1016/j.jad.2016.06.052
Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data
Brennan-Olsen, Sharon L., Page, Richard S., Lane, Steven E., Lorimer, Michelle, Buchbinder, Rachelle, Osborne, Richard H., Pasco, Julie A., Wluka, Anita E., Sanders, Kerrie M., Ebeling, Peter R. and Graves, Stephen E. 2016. Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data. BMC Musculoskeletal Disorders. 17 (291), pp. 1 - 9. https://doi.org/10.1186/s12891-016-1134-4
Dietary protein intake and risk of type 2 diabetes: Results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies
Shang, Xianwen, Scott, David, Hodge, Allison M., English, Dallas R., Giles, Graham G., Ebeling, Peter R. and Sanders, Kerrie M. 2016. Dietary protein intake and risk of type 2 diabetes: Results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies. American Journal of Clinical Nutrition. 104 (5), pp. 1352 - 1365. https://doi.org/10.3945/ajcn.116.140954
Vitamin D and physical activity status : Associations with five-year changes in body composition and muscle function in community-dwelling older adults
Scott, David, Ebeling, Peter, Sanders, Kerrie, Aitken, Dawn, Winzenberg, Tania and Jones, Graeme 2015. Vitamin D and physical activity status : Associations with five-year changes in body composition and muscle function in community-dwelling older adults. Journal of Clinical Endocrinology and Metabolism. 100 (2), pp. 670 - 678. https://doi.org/10.1210/jc.2014-3519
Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies
Niu, Tianhua, Liu, Ning, Zhao, Ming, Xie, Guie, Zhang, Lei, Li, Jian, Pei, Yu-Fang, Shen, Hui, Fu, Xiaoying, He, Hao, Lu, Shan, Chen, Xiang-Ding, Tan, Li-Jun, Yang, Tie-Lin, Guo, Yan, Leo, Paul, Duncan, Emma, Shen, Jie, Guo, Yan-Fang, ... Deng, Hong-Wen 2015. Identification of a novel FGFRL1 MicroRNA target site polymorphism for bone mineral density in meta-analyses of genome-wide association studies. Human Molecular Genetics. https://doi.org/10.1093/hmg/ddv144
Determinants of rural practice : Positive interaction between rural background and rural undergraduate training
Kondalsamy-Chennakes, Srinivas, Eley, Diann, Ranmuthugala, Geetha, Chater, Alan, Toombs, Maree, Darshan, Deepak and Nicholson, Geoff 2015. Determinants of rural practice : Positive interaction between rural background and rural undergraduate training. Medical Journal of Australia. https://doi.org/10.5694/mja14.00236
Validity of 12-month falls recall in community-dwelling older women participating in a clinical trial
Sanders, Kerrie M., Stuart, Amanda L., Scott, David, Kotowicz, Mark A. and Nicholson, Geoff C. 2015. Validity of 12-month falls recall in community-dwelling older women participating in a clinical trial. International Journal of Endocrinology. https://doi.org/10.1155/2015/210527
Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)
Abimanyi-Ochom, J., Watts, Jennifer, Borgstrom, F., Nicholson, Geoffrey, Shore-Lorenti, Catherine, Stuart, Amanda, Zhang, Y., Luliano, S., Seeman, Ego, Prince, Richard, March, Lyn, Winzenberg, T., Laslett, Laura, Duque, Gustavo, Ebeling, P. and Sanders, K. M. 2015. Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 26 (6), pp. 1781 - 1790. https://doi.org/10.1007/s00198-015-3088-z
Effectiveness of dual-task functional power training for preventing falls in older people : Study protocol for a cluster randomised controlled trial
Daly, Robin, Duckham, Rachel, Tait, Jamie, Rantalainen, Timo, Nowson, Caryl, Taaffe, Dennis, Sanders, Kerrie, Hill, Keith, Kidgell, Dawson and Busija, Ljoudmila 2015. Effectiveness of dual-task functional power training for preventing falls in older people : Study protocol for a cluster randomised controlled trial. Trials (online). 16 (120), pp. 1 - 15. https://doi.org/10.1186/s13063-015-0652-y
Humeral fractures in south-eastern Australia: Epidemiology and risk factors
Holloway, Kara, Bucki-Smith, Gosia, Morse, Amelia, Brennan-Olsen, Sharon, Kotowicz, Mark, Moloney, David, Sanders, Kerrie, Korn, S, Timney, Elizabeth, Dobbins, Amelia and Pasco, Julie 2015. Humeral fractures in south-eastern Australia: Epidemiology and risk factors. Calcified Tissue International. 97 (5), pp. 453 - 465. https://doi.org/10.1007/s00223-015-0039-9
Dietary a-linolenic acid and total omega-3 fatty acids are inversely associated with abdominal aortic calcification in older women, but not in older men
Shang, Xianwen, Sanders, Kerrie, Scott, David, Khan, Belal, Hodge, Allison, Khan, Nayab, English, Dallas, Giles, Graham and Ebeling, Peter 2015. Dietary a-linolenic acid and total omega-3 fatty acids are inversely associated with abdominal aortic calcification in older women, but not in older men. The Journal of Nutrition. 145 (8), pp. 1778 - 1786. https://doi.org/10.3945/jn.115.211789
Changes in gait performance over several years are associated with recurrent falls status in community-dwelling older women at high risk of fracture
Scott, David, McLaughlin, Patrick, Nicholson, Geoff C., Ebeling, Peter, Stuart, Amanda, Kay, Deborah and Sanders, Kerrie 2015. Changes in gait performance over several years are associated with recurrent falls status in community-dwelling older women at high risk of fracture. Age and Ageing. 44 (2), pp. 287 - 293. https://doi.org/10.1093/ageing/afu169
Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: A community-based randomized controlled trial
Gianoudis, Jenny, Bailey, Christine A., Ebeling, Peter R., Nowson, Caryl A., Sanders, Kerrie M., Hill, Keith and Daly, Robin M. 2014. Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: A community-based randomized controlled trial. Journal of Bone and Mineral Research. 29 (1), pp. 182 - 191. https://doi.org/10.1002/jbmr.2014
Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003-10: data from the Australian Orthopaedic Association National Joint Replacement Registry
Brennan, Sharon L., Lane, Stephen E., Lorimer, Michelle, Buchbinder, Rachelle, Wluka, Anita E., Page, Richard S., Osborne, Richard H., Pasco, Julie A., Sanders, Kerrie M., Cashman, Kara, Ebeling, Peter R. and Graves, Stephen E. 2014. Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003-10: data from the Australian Orthopaedic Association National Joint Replacement Registry. BMC Musculoskeletal Disorders. 15 (356), pp. 1 - 9. https://doi.org/10.1186/1471-2474-15-356
Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults
Scott, David, Sanders, Kerrie M., Aitken, Dawn, Hayes, Alan, Ebeling, Peter R. and Jones, Graeme 2014. Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults. Obesity. 22 (6), pp. 1568 - 1574. https://doi.org/10.1002/oby.20734
Fracture risk among older men: Osteopenia and osteoporosis defined using cut-points derived from female versus male reference data
Pasco, Julie A., Lane, Steven E., Brennan, Sharon L., Timney, Elizabeth N., Bucki-Smith, Gosia, Dobbins, Amelia Grace, Nicholson, Geoffrey Charles and Kotowicz, Mark A. 2014. Fracture risk among older men: Osteopenia and osteoporosis defined using cut-points derived from female versus male reference data. Osteoporosis International. 25 (3), pp. 857 - 862. https://doi.org/10.1007/s00198-013-2561-9
Musculoskeletal deterioration in men accompanies increases in body fat
Pasco, Julie A., Gould, Haslinda, Brennan, Sharon L., Nicholson, Geoffrey Charles and Kotowicz, Mark A. 2014. Musculoskeletal deterioration in men accompanies increases in body fat. Obesity. 22 (3), pp. 863 - 867. https://doi.org/10.1002/oby.20496
Shining the Light on Sunshine: A systematic review of the influence of sun exposure on type 2 diabetes mellitus-related outcomes
Shore-Lorenti, Catherine, Brennan, Sharon L., Sanders, Kerrie M., Neale, Rachel E., Lucas, Robyn M. and Ebeling, Peter R. 2014. Shining the Light on Sunshine: A systematic review of the influence of sun exposure on type 2 diabetes mellitus-related outcomes. Clinical Endocrinology. 81 (6), pp. 799 - 811. https://doi.org/10.1111/cen.12567
Total and appendicular lean mass reference ranges for Australian men and women: The Geelong Osteoporosis Study
Gould, Haslinda, Brennan, Sharon L., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A. 2014. Total and appendicular lean mass reference ranges for Australian men and women: The Geelong Osteoporosis Study. Calcified Tissue International. 94 (4), pp. 363 - 372. https://doi.org/10.1007/s00223-013-9830-7
Serum selenium status in Graves' disease with and without orbitopathy: A case-control study
Khong, Jwu Jin, Goldstein, Rebecca F., Sanders, Kerrie M., Schneider, Hans, Pope, Jeffrey, Burdon, Kathryn P., Craigh, Jamie E., Ebeling, Peter R. and Peter, 2014. Serum selenium status in Graves' disease with and without orbitopathy: A case-control study. Clinical Endocrinology. 80 (6), pp. 905 - 910. https://doi.org/10.1111/cen.12392
Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture
Scott, David, Stuart, Amanda, Kay, Deborah, Ebeling, Peter, Nicholson, Geoffrey and Sanders, Kerrie 2014. Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture. Archives of Gerontology and Geriatrics. 58 (3), pp. 308 - 313. https://doi.org/10.1016/j.archger.2013.11.004
The prevalence of vitamin B12 deficiency in a random sample from the Australian population
Moore, Eileen, Pasco, Julie, Mander, Alastair, Sanders, Kerrie, Carne, Ross, Jenkins, Nicole, Black, Marion, Schneider, Hans, Ames, David and Watters, David 2014. The prevalence of vitamin B12 deficiency in a random sample from the Australian population. Journal of Investigational Biochemistry. 3 (3), pp. 95 - 100. https://doi.org/10.5455/jib.20140716041521
Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women
Levinger, Itamar, Scott, David, Nicholson, Geoffrey, Stuart, Amanda, Duque, Gustavo, McCorquodale, Thomas, Herrmann, Markus, Ebeling, Peter and Sanders, Kerrie 2014. Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. Bone. 64, pp. 8 - 12. https://doi.org/10.1016/j.bone.2014.03.008
Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Moayyeri, Alireza, Hsu, Yi-Hsiang, Karasik, David, Estrada, Karol, Xiao, Su-Mei, Nielson, Carrie, Srikanth, Priya, Giroux, Sylvie, Wilson, Scott G., Zheng, Hou-Feng, Smith, Albert V., Pye, Stephen R., Leo, Paul J., Teumer, Alexander, Hwang, Joo-Yeon, Ohlsson, Claes, McGuigan, Fiona, Minster, Ryan L., Hayward, Caroline, ... Kaptoge, Stephen K. 2014. Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Human Molecular Genetics. 23 (11), pp. 3054 - 3068. https://doi.org/10.1093/hmg/ddt675
A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia''s Indigenous populations
Black, Emma B., Ranmuthugala, Geetha, Kondalsamy-Chennakesavan, Srinivas, Toombs, Maree R., Nicholson, Geoffrey C. and Kisely, Steve 2014. A systematic review: Identifying the prevalence rates of psychiatric disorder in Australia''s Indigenous populations. Australian and New Zealand Journal of Psychiatry. 115 (5), pp. 518 - 524. https://doi.org/10.1177/0004867415569802
Is high dose Vitamin D harmful?
Sanders, Kerrie, Nicholson, Geoffrey and Ebeling, Peter 2013. Is high dose Vitamin D harmful? Calcified Tissue International. 92 (2), pp. 191 - 206. https://doi.org/10.1007/s00223-012-9679-1
Impact of denosumab on the peripheral skeleton of postmenopausal women with osteoporosis: Bone density, mass, and strength of the radius, and wrist fracture
Simon, James A., Recknor, Christopher, Moffett, Alfred H., Adachi, Jonathan D., Franek, Edward, Lewiecki, E. Michael, McClung, Michael R., Mautalen, Carlos A., Ragi-Eis, Sergio, Nicholson, Geoffrey Charles, Muschitz, Christian, Nuti, Ranuccio, Torring, Ove, Wang, Andrea and Libanati, Cesar 2013. Impact of denosumab on the peripheral skeleton of postmenopausal women with osteoporosis: Bone density, mass, and strength of the radius, and wrist fracture. Menopause. 20 (2), pp. 130 - 137. https://doi.org/10.1097/gme.0b013e318267f909
Calcaneal ultrasound reference ranges for Australian men and women: The Geelong Osteoporosis Study
Gould, Haslinda, Brennan, Sharon L., Nicholson, Geoffrey Charles, Kotowicz, Mark A., Henry, Margaret J. and Pasco, Julie A. 2013. Calcaneal ultrasound reference ranges for Australian men and women: The Geelong Osteoporosis Study. Osteoporosis International. 24 (4), pp. 1369 - 1377. https://doi.org/10.1007/s00198-012-2082-y
Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women
Gunardi, A. J., Brennan, Sharon L., Wang, Yuanyuan, Cicuttini, Flavia M., Pasco, Julie A., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Wluka, Anita E. 2013. Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women. International Journal of Obesity. 37 (12), pp. 1586 - 1589. https://doi.org/10.1038/ijo.2013.42
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
Zheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimäki, Terho, Bergström, Ulrica, Kähönen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lehtimäki, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, ... Lorentzon, Mattias 2012. WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genetics. 8 (7), pp. 1 - 13. https://doi.org/10.1371/journal.pgen.1002745
Cross-sectional analysis of association between socioeconomic status and utilization of primary total hip joint replacements 2006-7: Australian Orthopaedic Association National Joint Replacement Registry
Brennan, Sharon L., Stanford, Tyman, Wluka, Anita E., Henry, Margaret J., Page, Richard S., Graves, Stephen E., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A. 2012. Cross-sectional analysis of association between socioeconomic status and utilization of primary total hip joint replacements 2006-7: Australian Orthopaedic Association National Joint Replacement Registry. BMC Musculoskeletal Disorders. 13 (63), pp. 63 - 69. https://doi.org/10.1186/1471-2474-13-63
Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women
Brennan, Sharon L., Cicuttini, Flavia M., Nicholson, Geoffrey Charles, Pasco, Julie A., Kotowicz, Mark A. and Wluka, Anita E. 2012. Endogenous parathyroid hormone is associated with reduced cartilage volume in vivo in a population-based sample of adult women. Annals of the Rheumatic Diseases. 71 (6), pp. 1000 - 1003. https://doi.org/10.1136/annrheumdis-2011-200957
Dietary selenium and major depression: A nested case-control study
Pasco, Julie A., Jacka, Felice N., Willia, Lana J., Evans-Cleverdon, Melinda, Brennan, Sharon L., Kotowicz, Mark A., Nicholson, Geoffrey Charles, Ball, Madeleine J. and Berk, Michael 2012. Dietary selenium and major depression: A nested case-control study. Complementary Therapies in Medicine. 20 (3), pp. 119 - 123. https://doi.org/10.1016/j.ctim.2011.12.008
Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: A systematic review
Brennan, Sharon, Wluka, Anita, Gould, Haslinda, Nicholson, Geoffrey, Leslie, William, Ebeling, Peter, Oldenburg, Brian, Kotowicz, Mark and Pasco, Julie 2012. Social determinants of bone densitometry uptake for osteoporosis risk in patients aged 50yr and older: A systematic review. Journal of Clinical Densitometry. 15 (2), pp. 165 - 175. https://doi.org/10.1016/j.jocd.2011.12.005
Osteo-cise: Strong Bones for Life: Protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fractures
Gianoudis, Jenny, Bailey, Christine A., Sanders, Kerrie M., Nowson, Caryl A., Hill, Keith, Ebeling, Peter R. and Daly, Robin M. 2012. Osteo-cise: Strong Bones for Life: Protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fractures. BMC Musculoskeletal Disorders. 13 (78), pp. 1 - 16. https://doi.org/10.1186/1471-2474-13-78
Utilisation of primary total knee joint replacements across socioeconomic status in the Barwon Statistical Division, Australia, 2006-2007: A cross-sectional study
Brennan, Sharon L., Stanford, Tyman, Wluka, Anita, Page, Richard S., Graves, Stephen E., Kotowicz, Mark A., Nicholson, Geoffrey Charles and Pasco, Julie A. 2012. Utilisation of primary total knee joint replacements across socioeconomic status in the Barwon Statistical Division, Australia, 2006-2007: A cross-sectional study. BMJ Open. 2 (5), pp. 1 - 6. https://doi.org/10.1136/bmjopen-2012-001310
Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials
Rejnmark, Lars, Avenell, Alison, Masud, Tahir, Anderson, Frazer, Meyer, Haakon E., Sanders, Kerrie M., Salovaara, Kari, Cooper, Cyrus, Smith, Helen E., Jacobs, Elizabeth T., Torgerson, David, Jackson, Rebecca D., Manson, JoAnn E., Brixon, Kim, Mosekilde, Leif, Robbins, John A., Francis, Roger M. and Abrahamsen, Bo 2012. Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials. Journal of Clinical Endocrinology and Metabolism. 97 (8), pp. 2670 - 2681. https://doi.org/10.1210/jc.2011-3328
The epidemiology of the first wave of H1N1 influenza pandemic in Australia: A population-based study
Pasco, Julie A., Nicholson, Geoffrey Charles, Brennan, Sharon L., Bennett, Kathy E., Dobbins, Amelia Grace and Athan, Eugene 2012. The epidemiology of the first wave of H1N1 influenza pandemic in Australia: A population-based study. The Open Public Health Journal. 5, pp. 80 - 85. https://doi.org/10.2174/1874944501205010080
Prevalence of obesity and the relationship between the body mass index and body fat: Cross-sectional, population-based data
Pasco, Julie A., Nicholson, Geoffrey C., Brennan, Sharon L. and Kotowicz, Mark A. 2012. Prevalence of obesity and the relationship between the body mass index and body fat: Cross-sectional, population-based data. PLoS ONE. 7 (1), pp. 1 - 7. https://doi.org/10.1371/journal.pone.0029580
Incident hip fracture and social disadvantage in an Australian population aged 50 years or greater
Brennan, Sharon, Henry, Margaret, Kotowicz, Mark, Nicholson, Geoffrey, Zhang, Yu and Pasco, Julie 2011. Incident hip fracture and social disadvantage in an Australian population aged 50 years or greater. Bone. 48 (3), pp. 607 - 610. https://doi.org/10.1016/j.bone.2010.10.175
Fracture risk score and absolute risk of fracture
Henry, Margaret, Pasco, Julie, Merriman, Elizabeth, Zhang, Yu, Sanders, Kerrie, Kotowicz, Mark and Nicholson, Geoffrey 2011. Fracture risk score and absolute risk of fracture. Radiology. 259 (2), pp. 495 - 501. https://doi.org/10.1148/radiol.10101406
Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007
Pasco, Julie, Brennan, Sharon, Henry, Margaret, Nicholson, Geoffrey, Sanders, Kerrie, Zhang, Yu and Kotowicz, Mark 2011. Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007. Journal of Bone and Mineral Research. 26 (7), pp. 1648 - 1654. https://doi.org/10.1002/jbmr.393
Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial
Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie, Nicholson, Geoffrey, Seibel, Markus, Salmon, Jo and Daly, Robin 2011. Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial. Journal of Clinical Endocrinology and Metabolism. 96 (4), pp. 955 - 963. https://doi.org/10.1210/jc.2010-2284
Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial
Peake, Jonathan, Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie and Daly, Robin 2011. Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial. European Journal of Applied Physiology. 111 (12), pp. 3079 - 3088. https://doi.org/10.1007/s00421-011-1942-z
Paracetamol (acetaminophen) use, fracture and bone mineral density
Williams, Lana, Pasco, Julie, Henry, Margaret, Sanders, Kerrie, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael 2011. Paracetamol (acetaminophen) use, fracture and bone mineral density. Bone. 48 (6), pp. 1277 - 1281. https://doi.org/10.1016/j.bone.2011.03.435
Area-based socioeconomic status and mood disorders: Cross-sectional evidence from a cohort of randomly selected adult women
Williams, Lana, Brennan, Sharon, Henry, Margaret, Berk, Michael, Jacka, Felice, Nicholson, Geoffrey, Kotowicz, Mark and Pasco, Julie 2011. Area-based socioeconomic status and mood disorders: Cross-sectional evidence from a cohort of randomly selected adult women. Maturitas. 69 (2), pp. 173 - 178. https://doi.org/10.1016/j.maturitas.2011.03.015
Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial
Sanders, Kerrie, Stuart, Amanda, Williamson, Elizabeth, Jacka, Felice, Dodd, Seetal, Nicholson, Geoff and Berk, Michael 2011. Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial. British Journal of Psychiatry. 198 (5), pp. 357 - 364. https://doi.org/10.1192/bjp.bp.110.087544
Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study
Brennan, Sharon, Pasco, Julie, Cicuttini, Flavia, Henry, Margaret, Kotowicz, Mark, Nicholson, Geoffrey and Wluka, Anita 2011. Bone mineral density is cross sectionally associated with cartilage volume in healthy, asymptomatic adult females: Geelong Osteoporosis Study. Bone. 49 (4), pp. 839 - 844. https://doi.org/10.1016/j.bone.2011.06.015
Habitual physical activity and the risk for depressive and anxiety disorders among older men and women
Pasco, Julie, Williams, Lana, Jacka, Felice, Henry, Margaret, Coulson, Carolyn, Brennan, Sharon, Leslie, Eva, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael 2011. Habitual physical activity and the risk for depressive and anxiety disorders among older men and women. International Psychogeriatrics. 23 (2), pp. 292 - 298. https://doi.org/10.1017/S1041610210001833
Annual feedback is an effective tool for a sustained increase in calcium intake among older women
Sanders, Kerrie, Stuart, Amanda L., Kotowicz, Mark and Nicholson, Geoff 2010. Annual feedback is an effective tool for a sustained increase in calcium intake among older women. Nutrients. 2 (9), pp. 1018 - 1025. https://doi.org/10.3390/nu2091018
Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines
Coulson, Carolyn E., Williams, Lana J., Henry, Margaret, Berk, Michael, Lubman, Dan, Brennan-Olsen, Sharon, Nicholson, Geoff, Kotowicz, Mark, Korn, S and Pasco, Julie 2010. Patterns of alcohol use and associated physical and lifestyle characteristics according to new Australian guidelines. Australian and New Zealand Journal of Psychiatry. 44 (10), pp. 946 - 951. https://doi.org/10.3109/00048674.2010.495051
Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study
Brennan-Olsen, Sharon, Henry, Margaret, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie 2010. Socioeconomic status, obesity and lifestyle in men: The Geelong Osteoporosis Study. Journal of Men's Health. 7 (1), pp. 31 - 41. https://doi.org/10.1016/j.jomh.2009.10.004
Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?
Brennan-Olsen, Sharon, Cicuttini, Flavia, Pasco, Julie, Henry, Margaret, Wang, Yuanyuan, Kotowicz, Mark, Nicholson, Geoff and Wluka, Anita 2010. Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women? Arthritis Research and Therapy. 12 (4), pp. 1 - 7. https://doi.org/10.1186/ar3078
Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial
Sanders, Kerrie, Stuart, Amanda L., Williamson, Elizabeth J., Simpson, Julie A., Kotowicz, Mark, Young, Doris and Nicholson, Geoff 2010. Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA: Journal of the American Medical Association. 303 (18), pp. 1815 - 1822. https://doi.org/10.1001/jama.2010.594
Socioeconomic status and bone mineral density in a population-based sample of men
Brennan-Olsen, Sharon, Henry, Margaret, Wluka, Anita, Nicholson, Geoff, Kotowicz, Mark and Pasco, Julie 2010. Socioeconomic status and bone mineral density in a population-based sample of men. Bone. 46 (4), pp. 993 - 999. https://doi.org/10.1016/j.bone.2009.12.029
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
Kanis, John, Oden, Anders, Johnell, O., Johansson, Helena, Laet, C. De, Brown, Jacques P., Burckhardt, Peter, Cooper, Cyrus, Christiansen, Claus, Cummings, Steven R., Eisman, John A., Fujiwara, S., Glüer, C. C., Goltzman, David, Hans, Didier, Krieg, Marc Antoine, Lacroix, Andrea Z., McCloskey, Eugene, Mellström, Dan, ... Yoshimura, N. 2007. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International. 18 (8), pp. 1033 - 1046. https://doi.org/10.1007/s00198-007-0343-y