Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD)

Journal article


Williams, Katrina, Brignell, Amanda, Randall, Melinda Joy, Silove, Natalie and Hazell, Philip. (2013) Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). The Cochrane Database of Systematic Reviews. 8, pp. 1 - 51. https://doi.org/10.1002/14651858.CD004677.pub3
AuthorsWilliams, Katrina, Brignell, Amanda, Randall, Melinda Joy, Silove, Natalie and Hazell, Philip
Abstract

Background: Autism spectrum disorders ( ASD ) are characterised by abnormalities in social interaction and communication skills, as well as stereotypic behaviours and restricted activities and interests. Selective serotonin reuptake inhibitors ( SSRIs ) are prescribed for the treatment of conditions often comorbid with ASD such as depression, anxiety and obsessive-compulsive behaviours. Objectives: To determine if treatment with an SSRI: 1. improves the core features of autism ( social interaction, communication and behavioural problems ); 2. improves other non-core aspects of behaviour or function such as self-injurious behaviour; 3. improves the quality of life of adults or children and their carers; 4. has short- and long-term effects on outcome; 5. causes harm. Search methods: We searched the following databases up until March 2013: CENTRAL, Ovid MEDLINE, Embase, CINAHL, PsycINFO, ERIC and Sociological Abstracts. We also searched ClinicalTrials.gov and the International Clinical Trials Registry Platform ( ICTRP ). This was supplemented by searching reference lists and contacting known experts in the field. Selection criteria: Randomised controlled trials ( RCTs ) of any dose of oral SSRI compared with placebo, in people with ASD. Data collection and analysis: Two authors independently selected studies for inclusion, extracted data and appraised each study's risk of bias. Main results: Nine RCTs with a total of 320 participants were included. Four SSRIs were evaluated: fluoxetine ( three studies ), fluvoxamine ( two studies ), fenfluramine ( two studies ) and citalopram ( two studies ). Five studies included only children and four studies included only adults. Varying inclusion criteria were used with regard to diagnostic criteria and intelligence quotient of participants. Eighteen different outcome measures were reported. Although more than one study reported data for Clinical Global Impression ( CGI ) and obsessive-compulsive behaviour ( OCB ), different tool types or components of these outcomes were used in each study. As such, data were unsuitable for meta-analysis, except for one outcome ( proportion improvement ). One large, high-quality study in children showed no evidence of positive effect of citalopram. Three small studies in adults showed positive outcomes for CGI and OCB; one study showed improvements in aggression, and another in anxiety. Authors' conclusions: There is no evidence of effect of SSRIs in children and emerging evidence of harm. There is limited evidence of the effectiveness of SSRIs in adults from small studies in which risk of bias is unclear.

Year2013
JournalThe Cochrane Database of Systematic Reviews
Journal citation8, pp. 1 - 51
PublisherJohn Wiley & Sons, Inc.
ISSN1469-493X
Digital Object Identifier (DOI)https://doi.org/10.1002/14651858.CD004677.pub3
Scopus EID2-s2.0-84893391547
Page range1 - 51
Research GroupSchool of Allied Health
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/8q973/selective-serotonin-reuptake-inhibitors-ssris-for-autism-spectrum-disorders-asd

Restricted files

Publisher's version

  • 5
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Rationale for prescription, and effectiveness of, upper limb orthotic intervention for children with cerebral palsy: A systematic review
Garbellini, Simon, Robert, Yvette, Randall, Melinda, Elliott, Catherine M. and Imms, Christine. (2018) Rationale for prescription, and effectiveness of, upper limb orthotic intervention for children with cerebral palsy: A systematic review. Disability and Rehabilitation. 40(12), pp. 1361 - 1371. https://doi.org/10.1080/09638288.2017.1297498
Congenital methemoglobinemia type II: Clinical improvement with short-term methylene blue treatment
Cooper, Monica S., Randall, Melinda, Rowell, Margaret, Charlton, Margaret, Greenway, Anthea and Barnes, Chris D.. (2016) Congenital methemoglobinemia type II: Clinical improvement with short-term methylene blue treatment. Pediatric Blood and Cancer. 63(3), pp. 558 - 560. https://doi.org/10.1002/pbc.25791
Minimising impariment: Protocol for a multicentre randomised controlled trial of upper limb orthoses for children with cerebral palsy
Imms, Christine, Wallen, Margaret, Elliott, Catherine, Hoare, Brian, Randall, Melinda Joy, Greaves, Susan, Adair, Brooke, Bradshaw, Elizabeth, Carter, Rob, Orsini, Francesca, Shih, Sophy T. F. and Reddihough, Dinah S.. (2016) Minimising impariment: Protocol for a multicentre randomised controlled trial of upper limb orthoses for children with cerebral palsy. BMC Pediatrics. 16(70), pp. 1 - 15. https://doi.org/10.1186/s12887-016-0608-8
Minimising impairment: Protocol for a multicentre randomised controlled trial of upper limb orthoses for children with cerebral palsy
Imms, Christine, Wallen, Margaret, Elliott, Catherine M., Hoare, Brian, Randall, Melinda Joy, Greaves, Susan, Adair, Brooke, Bradshaw, Elizabeth Jane, Carter, Robert, Orsini, Francesca, Shih, Sophy T. F. and Reddihough, Dinah S.. (2016) Minimising impairment: Protocol for a multicentre randomised controlled trial of upper limb orthoses for children with cerebral palsy. BMC Pediatrics. 16(1), pp. 70 - 85. https://doi.org/10.1186/s12887-016-0608-8
Rasch analysis of The Melbourne Assessment of Unilateral Upper Limb Function
Randall, Melinda, Imms, Christine, Carey, Leeanne and Pallant, Julie. (2014) Rasch analysis of The Melbourne Assessment of Unilateral Upper Limb Function. Developmental Medicine and Child Neurology. 56(7), pp. 665 - 672. https://doi.org/10.1111/dmcn.12391
Children with cerebral palsy and periventricular white matter injury : Does gestational age affect functional outcome?
Harvey, Adrienne, Randall, Melinda, Reid, Susan M., Lee, Katherine, Imms, Christine, Rodda, Jillian, Eldridge, Beverley, Orsini, Francesca and Reddihough, Dinah. (2013) Children with cerebral palsy and periventricular white matter injury : Does gestational age affect functional outcome? Research in Developmental Disabilities. https://doi.org/10.1016/j.ridd.2013.05.030
Reliable classification of functional profiles and movement disorders of children with cerebral palsy
Randall, Melinda, Harvey, Adrienne, Imms, Christine, Reid, Sue, Lee, Katherine J. and Reddihough, Dinah. (2013) Reliable classification of functional profiles and movement disorders of children with cerebral palsy. Physical & Occupational Therapy in Pediatrics. https://doi.org/10.3109/01942638.2012.747584
Reliable classification of functional profiles and movement disorders of children with cerebral palsy
Randall, Melinda, Harvey, Adrienne, Imms, Christine, Reid, Sue, Lee, Katherine and Reddihough, Dinah. (2013) Reliable classification of functional profiles and movement disorders of children with cerebral palsy. Physical & Occupational Therapy in Pediatrics. 33(3), pp. 342 - 352. https://doi.org/10.3109/01942638.2012.747584
Further evidence of validity of the Modified Melbourne Assessment for the neurologically impaired children aged 2 to 4 years
Randall, Melinda, Imms, Christine and Carey, Leeanne. (2012) Further evidence of validity of the Modified Melbourne Assessment for the neurologically impaired children aged 2 to 4 years. Developmental Medicine and Child Neurology. 54(5), pp. 424 - 428. https://doi.org/10.1111/j.1469-8749.2012.04252.x
Linking cerebral palsy upper limb measurements to the international classification of functioning disability and health
Hoare, Brian, Imms, Christine, Randall, Melinda and Carey, Leeanne. (2011) Linking cerebral palsy upper limb measurements to the international classification of functioning disability and health. Scandinavian Journal of Rehabilitation Medicine. 43(11), pp. 987 - 996. https://doi.org/10.2340/16501977-0886
Psychometric Properties of the 'Extended' Melbourne Assessment of Unilateral Upper Limb Function Based on Rasch Analysis
Randall, Melinda, Pallant, Julie, Imms, Christine and Carey, Leeanne. (2010) Psychometric Properties of the 'Extended' Melbourne Assessment of Unilateral Upper Limb Function Based on Rasch Analysis. Developmental Medicine and Child Neurology.
Family centred outcome measurement following paediatric stroke
Galvin, Jane, Randall, Melinda, Hewish, Sara, Rice, James and MacKay, Mark T.. (2010) Family centred outcome measurement following paediatric stroke. Australian Occupational Therapy Journal. 57(3), pp. 152 - 158. https://doi.org/10.1111/j.1440-1630.2010.00853.x
Establishing validity of a modified Melbourne assessment for children ages 2 to 4 years
Randall, Melinda, Imms, Christine and Carey, Leeanne. (2008) Establishing validity of a modified Melbourne assessment for children ages 2 to 4 years. American Journal of Occupational Therapy. 62(4), pp. 373 - 383. https://doi.org/10.5014/ajot.62.4.373
Group-Based Task-Related Training for Children with Cerebral Palsy: A Pilot Study
Crompton, Jodi, Imms, Christine, McCoy, Anne, Randall, Melinda, Eldridge, Beverly, Scoullar, Barbara and Galea, Mary. (2007) Group-Based Task-Related Training for Children with Cerebral Palsy: A Pilot Study. Physical & Occupational Therapy in Pediatrics. 27(4), pp. 43 - 65. https://doi.org/10.1300/J006v27n04_04