Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy : Analysis of the EMPHASIS-HF study
Journal article
Krum, Henry, Shi, Harry, Pitt, Bertram, McMurray, John, Swedberg, Karl, van Veldhuisen, Dirk J., Vincent, John, Pocock, Stuart J. and Zannad, Faiez. (2013). Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy : Analysis of the EMPHASIS-HF study. Circulation: Heart Failure. 6(4), pp. 711 - 718. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000173
Authors | Krum, Henry, Shi, Harry, Pitt, Bertram, McMurray, John, Swedberg, Karl, van Veldhuisen, Dirk J., Vincent, John, Pocock, Stuart J. and Zannad, Faiez |
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Abstract | In EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure), eplerenone significantly reduced major cardiovascular events versus placebo in 2737 patients with mild symptoms of heart failure and an ejection fraction of <35%, in addition to recommended therapy. However, it is not known whether such benefits were preserved in patients receiving optimal background drug therapy, that is, high doses of angiotensin-converting enzyme inhibitor (ACEi, or angiotensin receptor blocker), β-blocker, or both drug classes. |
Keywords | ACE inhibitor; aldosterone; angiotensin receptor blocker; β-blocker; eplerenone; heart failure |
Year | 2013 |
Journal | Circulation: Heart Failure |
Journal citation | 6 (4), pp. 711 - 718 |
Publisher | Lippincott Williams & Wilkins |
ISSN | 1941-3289 |
Digital Object Identifier (DOI) | https://doi.org/10.1161/CIRCHEARTFAILURE.112.000173 |
Scopus EID | 2-s2.0-84884644195 |
Open access | Open access |
Page range | 711 - 718 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | |
Place of publication | United States |
https://acuresearchbank.acu.edu.au/item/8qq68/clinical-benefit-of-eplerenone-in-patients-with-mild-symptoms-of-systolic-heart-failure-already-receiving-optimal-best-practice-background-drug-therapy-analysis-of-the-emphasis-hf-study
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