The translocator protein (TSPO): A novel target for cancer chemotherapy

Journal article

Austin, Christopher J. D., Kahlert, Jan, Kassiou, Michael and Rendina, Louis M.. (2013). The translocator protein (TSPO): A novel target for cancer chemotherapy. The International Journal of Biochemistry and Cell Biology. 45(7), pp. 1212 - 1216. https://doi.org/10.1016/j.biocel.2013.03.004
AuthorsAustin, Christopher J. D., Kahlert, Jan, Kassiou, Michael and Rendina, Louis M.
Abstract

The translocator protein (TSPO) is an 18 kDa transmembrane protein primarily found in the outer mitochondrial membrane where it forms a key part of the mitochondrial permeability transition pore (MPTP). Omnipresent in almost all tissues, TSPO up-regulation has been connected to neuronal damage and inflammation, making the protein an important bio-imaging marker for disease progression. More recently, TSPO has attracted attention as a possible molecular target for tumour imaging and chemotherapy. In this review we summarize TSPO's molecular characteristics and highlight research progress in recent years in the field of TSPO-targeted cancer diagnostics and treatments.

Keywordstranslocator protein; TSPO; cancer; apoptosis; cell homoeostasis
Year2013
JournalThe International Journal of Biochemistry and Cell Biology
Journal citation45 (7), pp. 1212 - 1216
PublisherPergamon Press
ISSN1357-2725
Digital Object Identifier (DOI)https://doi.org/10.1016/j.biocel.2013.03.004
Scopus EID2-s2.0-84877057572
Page range1212 - 1216
Research GroupSchool of Behavioural and Health Sciences
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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