Descriptive characteristics and in-hospital mortality of critically bleeding patients requiring massive transfusion: Results from the Australian and New Zealand Massive Transfusion Registry
Journal article
Ruseckaite, Rasa, McQuilten, Z. K., Oldroyd, John C., Richter, T. H., Cameron, Peter A., Isbister, J. P. and Wood, E. M.. (2017). Descriptive characteristics and in-hospital mortality of critically bleeding patients requiring massive transfusion: Results from the Australian and New Zealand Massive Transfusion Registry. Vox Sanguinis. 112(3), pp. 240 - 248. https://doi.org/10.1111/vox.12487
Authors | Ruseckaite, Rasa, McQuilten, Z. K., Oldroyd, John C., Richter, T. H., Cameron, Peter A., Isbister, J. P. and Wood, E. M. |
---|---|
Abstract | Background and Objectives Critically bleeding patients requiring massive transfusion (MT) are clinically challenging, and limited data exist to support management decisions. This study describes patient characteristics, transfusion support and clinical outcomes from the Australian and New Zealand (NZ) Massive Transfusion Registry (ANZ‐MTR). Materials and Methods Retrospective, cohort study of all adult patients receiving MT (≥5 units red blood cells [RBC] in 4 h) at participating ANZ‐MTR hospitals, 2011–2015. Mortality information was collected from the Australian National Death Index and NZ Ministry of Health. Associations between patient characteristics and outcomes were modelled using logistic regression. Results A total of 3560 MT cases were identified. For in‐hospital deaths, cardiothoracic surgery was the most frequent bleeding context (24·5%) followed by trauma (18·3%). Age (OR = 1·03; 95% CI: 1·02–1·04), more comorbidities (OR = 1·14; 95% CI: 1·09–1·21), larger volume of RBC in first 24 h from MT onset (OR = 1·04; 95% CI: 1·02–1·06), higher platelet to RBC ratio at 4 h (OR = 2·76; 95% CI: 1·14–6·65) and higher activated partial thromboplastin time (OR = 1·02; 95% CI: 1·01–1·03) were associated with in‐hospital mortality. Conclusion Patients with more comorbidities, older age, traumatic or surgical bleeding or requiring more blood components had higher in‐hospital mortality. These findings provide a basis to evaluate and monitor practice relating to optimal use of blood products, variation in transfusion practices and patient outcomes, and also enable benchmarking of hospital performance for management of MT in specific patient groups. |
Keywords | critical bleeding; massive transfusion; mortality; registry |
Year | 2017 |
Journal | Vox Sanguinis |
Journal citation | 112 (3), pp. 240 - 248 |
Publisher | Wiley-Blackwell Publishing Ltd. |
ISSN | 0042-9007 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/vox.12487 |
Scopus EID | 2-s2.0-85013130646 |
Page range | 240 - 248 |
Publisher's version | File Access Level Controlled |
Grant ID | NHMRC/1074654 |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8qv42/descriptive-characteristics-and-in-hospital-mortality-of-critically-bleeding-patients-requiring-massive-transfusion-results-from-the-australian-and-new-zealand-massive-transfusion-registry
Restricted files
Publisher's version
78
total views0
total downloads1
views this month0
downloads this month