Angiotensin receptor-neprilysin inhibitors: A new paradigm in heart failure with reduced ejection fraction
Journal article
Docherty, Kieran F. and McMurray, John J. V.. (2019). Angiotensin receptor-neprilysin inhibitors: A new paradigm in heart failure with reduced ejection fraction. International Journal of Cardiology. 281, pp. 179 - 185. https://doi.org/10.1016/j.ijcard.2018.05.124
Authors | Docherty, Kieran F. and McMurray, John J. V. |
---|---|
Abstract | Despite significant advances in the last 30 years in reducing morbidity and mortality from heart failure with reduced ejection fraction (HFrEF) with pharmacological and device-based therapies, patients remain at a high risk of adverse cardiovascular outcomes. Sacubitril/valsartan, a first-in-class angiotensin receptor-neprilysin inhibitors (ARNI), has been shown to reduce the risk of cardiovascular death or heart failure hospitalisation and improve symptoms in patients with chronic, ambulatory, symptomatic HFrEF in a large, phase 3, multicentre, international, randomised controlled trial, PARADIGM-HF, when compared to the gold-standard angiotensin converting enzyme inhibitor, enalapril. This article will review the development of sacubitril/valsartan, the evidence for its use and its current and future role in the management of HFrEF. |
Keywords | heart failure; heart failure with reduced ejection fraction; renin-angiotensin aldosterone system; natriuretic peptides; neprilysin; angiotensin receptor-neprilysin inhibitor |
Year | 2019 |
Journal | International Journal of Cardiology |
Journal citation | 281, pp. 179 - 185 |
Publisher | Elsevier Ireland Ltd. |
ISSN | 0167-5273 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.ijcard.2018.05.124 |
Scopus EID | 2-s2.0-85048190059 |
Page range | 179 - 185 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | Ireland |
https://acuresearchbank.acu.edu.au/item/8qv47/angiotensin-receptor-neprilysin-inhibitors-a-new-paradigm-in-heart-failure-with-reduced-ejection-fraction
Restricted files
Publisher's version
103
total views0
total downloads0
views this month0
downloads this month