Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls

Journal article


Kouw, Imre W. K., Gorissen, Stefan H. M., Burd, Nicholas A., Cermak, Naomi M., Gijsen, Annemie P., van Kranenburg, Janneau and van Loon, Luc J. C.. (2015) Postprandial protein handling is not impaired in type 2 diabetes patients when compared with normoglycemic controls. Journal of Clinical Endocrinology and Metabolism. 100(8), pp. 3103 - 3111. https://doi.org/10.1210/jc.2015-1234
AuthorsKouw, Imre W. K., Gorissen, Stefan H. M., Burd, Nicholas A., Cermak, Naomi M., Gijsen, Annemie P., van Kranenburg, Janneau and van Loon, Luc J. C.
Abstract

Context: The progressive loss of muscle mass with aging is accelerated in type 2 diabetes patients. It has been suggested that this is attributed to a blunted muscle protein synthetic response to food intake. Objective: The objective of the study was to test the hypothesis that the muscle protein synthetic response to protein ingestion is impaired in older type 2 diabetes patients when compared with healthy, normoglycemic controls. Design: A clinical intervention study with two parallel groups was conducted between August 2011 and July 2012. Setting: The study was conducted at the research unit of Maastricht University, The Netherlands. Intervention, Participants, and Main Outcome Measures: Eleven older type 2 diabetes males [diabetes; age 71 ± 1 y, body mass index ( BMI ) 26.2 ± 0.5 kg/m2] and 12 age- and BMI-matched normoglycemic controls ( control; age 74 ± 1 y, BMI 24.8 ± 1.1 kg/m2 ) participated in an experiment in which they ingested 20 g intrinsically L-[1-13C]phenylalanine-labeled protein. Continuous iv L-[ring-2H5]phenylalanine infusion was applied, and blood and muscle samples were obtained to assess amino acid kinetics and muscle protein synthesis rates in the postabsorptive and postprandial state. Results: Plasma insulin concentrations increased after protein ingestion in both groups, with a greater rise in the diabetes group. Postabsorptive and postprandial muscle protein synthesis rates did not differ between groups and averaged 0.029 ± 0.003 vs 0.029 ± 0.003%/h1 and 0.031 ± 0.002 vs 0.033 ± 0.002%/h1 in the diabetes versus control group, respectively. Postprandial L-[1-13C]phenylalanine incorporation into muscle protein did not differ between groups ( 0.018 ± 0.001 vs 0.019 ± 0.002 mole percent excess, respectively ). Conclusions: Postabsorptive muscle protein synthesis and postprandial protein handling is not impaired in older individuals with type 2 diabetes when compared with age-matched, normoglycemic controls.

Year2015
JournalJournal of Clinical Endocrinology and Metabolism
Journal citation100 (8), pp. 3103 - 3111
PublisherOxford University Press
ISSN0021-972X
Digital Object Identifier (DOI)https://doi.org/10.1210/jc.2015-1234
Scopus EID2-s2.0-84939191637
Page range3103 - 3111
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationUnited States
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