Changes in cue reactivity and attentional bias following experimental cue exposure and response prevention: A laboratory study of the effects of D-cycloserine in heavy drinkers

Journal article


Kamboj, Sunjeev K., Massey-Chase, Rachel, Rodney, Lydia, Das, Ravi, Almahdi, Basil, Curran, H. Valerie and Morgan, Celia J. A.. (2011) Changes in cue reactivity and attentional bias following experimental cue exposure and response prevention: A laboratory study of the effects of D-cycloserine in heavy drinkers. Psychopharmacology. 217(1), pp. 25 - 37. https://doi.org/10.1007/s00213-011-2254-z
AuthorsKamboj, Sunjeev K., Massey-Chase, Rachel, Rodney, Lydia, Das, Ravi, Almahdi, Basil, Curran, H. Valerie and Morgan, Celia J. A.
Abstract

Rationale: The effects of D-cycloserine (DCS) in animal models of anxiety disorders and addiction indicate a role for N-methyl D-aspartate (NMDA) receptors in extinction learning. Exposure/response prevention treatments for anxiety disorders in humans are enhanced by DCS, suggesting a promising co-therapy regime, mediated by NMDA receptors. Exposure/response prevention may also be effective in problematic drinkers, and DCS might enhance habituation to cues in these individuals. Since heavy drinkers show ostensible conditioned responses to alcohol cues, habituation following exposure/response prevention should be evident in these drinkers, with DCS enhancing this effect. Objectives: The objective of this study is to investigate the effect of DCS on exposure/response prevention in heavy drinkers. Methods: In a randomised, double-blind, placebo-controlled study, heavy social drinkers recruited from the community received either DCS (125 mg; n = 19) or placebo (n = 17) 1 h prior to each of two sessions of exposure/response prevention. Cue reactivity and attentional bias were assessed during these two sessions and at a third follow-up session. Between-session drinking behaviour was recorded. Results: Robust cue reactivity and attentional bias to alcohol cues was evident, as expected of heavy drinkers. Within- and between-session habituation of cue reactivity, as well as a reduction in attentional bias to alcohol cues over time was found. However, there was no evidence of greater habituation in the DCS group. Subtle stimulant effects (increased subjective contentedness and euphoria) which were unrelated to exposure/response prevention were found following DCS. Conclusions: DCS does not appear to enhance habituation of alcohol cue reactivity in heavy non-dependent drinkers. Its utility in enhancing treatments based on exposure/response prevention in dependent drinkers or drug users remains open.

Keywordscue exposure; response prevention; d-Cycloserine; cue reactivity; attentional bias; alcohol; dependence; hazardous drinking; habituation extinction
Year2011
JournalPsychopharmacology
Journal citation217 (1), pp. 25 - 37
PublisherSpringer Verlag
ISSN0033-3158
Digital Object Identifier (DOI)https://doi.org/10.1007/s00213-011-2254-z
Scopus EID2-s2.0-82955236101
Page range25 - 37
Research GroupSchool of Philosophy
Place of publicationGermany
Permalink -

https://acuresearchbank.acu.edu.au/item/8qzv0/changes-in-cue-reactivity-and-attentional-bias-following-experimental-cue-exposure-and-response-prevention-a-laboratory-study-of-the-effects-of-d-cycloserine-in-heavy-drinkers

Restricted files

Publisher's version

  • 1
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as