Congenital methemoglobinemia type II: Clinical improvement with short-term methylene blue treatment

Journal article

Cooper, Monica S., Randall, Melinda, Rowell, Margaret, Charlton, Margaret, Greenway, Anthea and Barnes, Chris D.. (2016). Congenital methemoglobinemia type II: Clinical improvement with short-term methylene blue treatment. Pediatric Blood and Cancer. 63(3), pp. 558 - 560. https://doi.org/10.1002/pbc.25791
AuthorsCooper, Monica S., Randall, Melinda, Rowell, Margaret, Charlton, Margaret, Greenway, Anthea and Barnes, Chris D.
Abstract

We report a case of prophylactic management with methylene blue (MB) in an almost 4‐year‐old male with congenital methemoglobinemia type II. He has a CYB5R3 compound heterozygote mutation, causing a cytochrome‐b(5) reductase deficiency. Since the MB treatment regimen has commenced, his methemoglobin level has been significantly lower. He has shown modest behavioral improvements (as assessed on the Achenbach behavior report scales). There have been no iatrogenic side effects. These findings are encouraging for symptomatic improvement with regular prophylactic MB treatment but represent a single case report, which must be interpreted with caution.

Keywordsmethemoglobinemia; methemoglobin; cytochrome-b(5)reductase; methylene blue; cyanosis
Year2016
JournalPediatric Blood and Cancer
Journal citation63 (3), pp. 558 - 560
PublisherJohn Wiley & Sons
ISSN1545-5009
Digital Object Identifier (DOI)https://doi.org/10.1002/pbc.25791
Scopus EID2-s2.0-84955379808
Page range558 - 560
Research GroupSchool of Allied Health
Publisher's version
File Access Level
Controlled
Place of publicationUnited States of America
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