Congenital methemoglobinemia type II: Clinical improvement with short-term methylene blue treatment
Journal article
Cooper, Monica S., Randall, Melinda, Rowell, Margaret, Charlton, Margaret, Greenway, Anthea and Barnes, Chris D.. (2016). Congenital methemoglobinemia type II: Clinical improvement with short-term methylene blue treatment. Pediatric Blood and Cancer. 63(3), pp. 558 - 560. https://doi.org/10.1002/pbc.25791
Authors | Cooper, Monica S., Randall, Melinda, Rowell, Margaret, Charlton, Margaret, Greenway, Anthea and Barnes, Chris D. |
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Abstract | We report a case of prophylactic management with methylene blue (MB) in an almost 4‐year‐old male with congenital methemoglobinemia type II. He has a CYB5R3 compound heterozygote mutation, causing a cytochrome‐b(5) reductase deficiency. Since the MB treatment regimen has commenced, his methemoglobin level has been significantly lower. He has shown modest behavioral improvements (as assessed on the Achenbach behavior report scales). There have been no iatrogenic side effects. These findings are encouraging for symptomatic improvement with regular prophylactic MB treatment but represent a single case report, which must be interpreted with caution. |
Keywords | methemoglobinemia; methemoglobin; cytochrome-b(5)reductase; methylene blue; cyanosis |
Year | 2016 |
Journal | Pediatric Blood and Cancer |
Journal citation | 63 (3), pp. 558 - 560 |
Publisher | John Wiley & Sons |
ISSN | 1545-5009 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/pbc.25791 |
Scopus EID | 2-s2.0-84955379808 |
Page range | 558 - 560 |
Research Group | School of Allied Health |
Publisher's version | File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/8v05x/congenital-methemoglobinemia-type-ii-clinical-improvement-with-short-term-methylene-blue-treatment
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