Reproducibility of multiphase pseudo-continuous arterial spin labeling and the effect of post-processing analysis methods

Journal article


Fazlollahi, Amir, Bourgeat, Pierrick, Liang, Xiaoyun, Meriaudeau, Fabrice, Connelly, Alan, Salvado, Olivier and Calamante, Fernando. (2015) Reproducibility of multiphase pseudo-continuous arterial spin labeling and the effect of post-processing analysis methods. NeuroImage. 117, pp. 191 - 201. https://doi.org/10.1016/j.neuroimage.2015.05.048
AuthorsFazlollahi, Amir, Bourgeat, Pierrick, Liang, Xiaoyun, Meriaudeau, Fabrice, Connelly, Alan, Salvado, Olivier and Calamante, Fernando
Abstract

Arterial spin labeling (ASL) is an emerging MRI technique for non-invasive measurement of cerebral blood flow (CBF). Compared to invasive perfusion imaging modalities, ASL suffers from low sensitivity due to poor signal-to-noise ratio (SNR), susceptibility to motion artifacts and low spatial resolution, all of which limit its reliability. In this work, the effects of various state of the art image processing techniques for addressing these ASL limitations are investigated. A processing pipeline consisting of motion correction, ASL motion correction imprecision removal, temporal and spatial filtering, partial volume effect correction, and CBF quantification was developed and assessed. To further improve the SNR for pseudo-continuous ASL (PCASL) by accounting for errors in tagging efficiency, the data from multiphase (MP) acquisitions were analyzed using a novel weighted-averaging scheme. The performances of each step in terms of SNR and reproducibility were evaluated using test–retest ASL data acquired from 12 young healthy subjects. The proposed processing pipeline was shown to improve the within-subject coefficient of variation and regional reproducibility by 17% and 16%, respectively, compared to CBF maps computed following motion correction but without the other processing steps. The CBF measurements of MP-PCASL compared to PCASL had on average 23% and 10% higher SNR and reproducibility, respectively.

Keywordsarterial spin labeling; multiphase pseudo-continuous arterial; spin labeling; perfusion MRI; cerebral blood flow; test–retest; reproducibility
Year2015
JournalNeuroImage
Journal citation117, pp. 191 - 201
PublisherElsevier BV
ISSN1053-8119
Digital Object Identifier (DOI)https://doi.org/10.1016/j.neuroimage.2015.05.048
Scopus EID2-s2.0-84936741410
Page range191 - 201
Research GroupMary MacKillop Institute for Health Research
Place of publicationUnited States of America
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