Semantic feature disturbance in Alzheimer disease: evidence from an object decision task

Journal article


Flanagan, Kieran, Copland, David, Chenery, Helen, Byrne, Gerard J.A. and Angwin, Anthony. (2017). Semantic feature disturbance in Alzheimer disease: evidence from an object decision task. Cognitive and Behavioral Neurology. 30(4), pp. 159 - 171. https://doi.org/10.1097/WNN.0000000000000140
AuthorsFlanagan, Kieran, Copland, David, Chenery, Helen, Byrne, Gerard J.A. and Angwin, Anthony
Abstract

Background and Objective: It is widely held that semantic disturbance in Alzheimer disease (AD) involves the loss of distinctive features but the relative sparing of nondistinctive features. Many previous studies of semantic feature disturbance have used cognitively challenging tasks with verbal stimuli that allow for potential cognitive confounds. Our objective was to use a task with lower memory demands to investigate distinctive feature disturbance in AD. Methods: We used an object decision task to compare the processing of distinctive and nondistinctive semantic features in people with AD and age-matched controls. The task included six conditions based on the relationship between each prime and target object. We tested the processing of distinctive and nondistinctive features by selectively altering distinctive and nondistinctive semantic features between prime and target pairs. Results: Performance accuracy was significantly lower for participants with AD than for age-matched controls when distinctive features were manipulated, but no difference was found when nondistinctive features were manipulated. Conclusions: Our results provide evidence of semantic content disturbance in AD in the context of a task with low cognitive demands.

Year2017
JournalCognitive and Behavioral Neurology
Journal citation30 (4), pp. 159 - 171
PublisherLippincott Williams and Wilkins
ISSN1543-3633
Digital Object Identifier (DOI)https://doi.org/10.1097/WNN.0000000000000140
Scopus EID2-s2.0-85038640795
Page range159 - 171
Research GroupSchool of Allied Health
Publisher's version
File Access Level
Controlled
Place of publicationUnited States
EditorsB. Gordon
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