Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: A feasibility study

Objective: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients ( DM2 ). Methods: Eleven DM2 patients ( 7 men and 4 women ) were included in the study. The patients cycled ( 30 min at 20 % Wmax ) whilst breathing three different supplemental oxygen flows ( SOF, 5, 10, 15 L min−1 ). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. Results: Arterial pO2 levels increased significantly ( ANOVA, p < 0.05 ) with SOF: 13.9 ± 1.2 ( 0 L min−1 ); 18.5 ± 1.5 ( 5 L min−1 ); 21.7 ± 1.7 ( 10 L min−1 ); 24.0 ± 2.3 ( 15 L min−1 ). Heart rate ( HR ) and pH increased significantly after terminating administration of hyperoxic air. Conclusions: An SOF of 15 L min−1 appears to be more effective than 5 or 10 L min−1. Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.

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