Cognitive decline following psychosis onset: Data from the PACE clinic

Journal article


Wood, Stephen J., Brewer, Warrick J., Koutsouradis, Penny, Phillips, Lisa J., Francey, Shona M., Proffitt, Tina Marie, Yung, Alison R., Jackson, Henry J., McGorry, Patrick D. and Pantelis, Christos. (2007) Cognitive decline following psychosis onset: Data from the PACE clinic. British Journal of Psychiatry. 191(Suppl 51), pp. s52 - s57. https://doi.org/10.1192/bjp.191.51.s52
AuthorsWood, Stephen J., Brewer, Warrick J., Koutsouradis, Penny, Phillips, Lisa J., Francey, Shona M., Proffitt, Tina Marie, Yung, Alison R., Jackson, Henry J., McGorry, Patrick D. and Pantelis, Christos
Abstract

Background: The origin of cognitive impairments in psychotic disorders is still unclear. Although some deficits are apparent prior to the onset of frank illness, it is unknown if they progress. Aims: To investigate whether cognitive function declined over the transition to psychosis in a group of ultra-high risk individuals. Method: Participants consisted of two groups: controls ( n=17 ) and individuals at ultra-high risk for development of psychosis ( n=16 ). Seven of the latter group later developed psychosis. Neuropsychological testing was conducted at baseline and again after at least a 12-month interval. Results: Both the Visual Reproduction sub-test of the Wechsler Memory Scale-Revised and Trail-Making Test B showed a decline over the follow-up period that was specific to the group who became psychotic. In addition, both high-risk groups showed a decline in digit span performance. No other task showed significant change over time. Conclusions: These preliminary data suggest that as psychosis develops there may be a specific decline in visual memory and attentional set-shifting, reflecting impairments in efficient organisation of visual stimuli. This may be caused by either the illness itself or treatment with antipsychotic medication.

Year2007
JournalBritish Journal of Psychiatry
Journal citation191 (Suppl 51), pp. s52 - s57
PublisherRoyal College of Psychiatrists
ISSN0007-1250
Digital Object Identifier (DOI)https://doi.org/10.1192/bjp.191.51.s52
Scopus EID2-s2.0-37249035910
Page ranges52 - s57
Research GroupSchool of Philosophy
Place of publicationUnited Kingdom
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