Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study

Journal article


Storhaug, Hilde M., Toft, Ingrid, Norvik, Jon V., Jenssen, Trond, Eriksen, Bjørn O., Melsom, Toralf, Løchen, Maja-Lisa and Solbu, Marit Dahl. (2015) Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of followup: The Tromsø Study. BMC Nephrology. 16(210), pp. 1 - 10. https://doi.org/10.1186/S12882-015-0207-1
AuthorsStorhaug, Hilde M., Toft, Ingrid, Norvik, Jon V., Jenssen, Trond, Eriksen, Bjørn O., Melsom, Toralf, Løchen, Maja-Lisa and Solbu, Marit Dahl
Abstract

Background: The role of uric acid in development of renal dysfunction (RD) remains controversial. Earlier studies have reported inconsistent results, possibly because of their varying ability to adjust for confounding. The impact of longitudinal change in uric acid on renal outcome has not been assessed previously. We aimed to study the impact of change in serum uric acid (SUA) as well as baseline SUA on the development of RD. Methods: In a prospective cohort study, we assessed the associations between change in SUA during follow-up, baseline SUA and RD (defined as albumin-creatinine-ratio (ACR) ≥1.13 mg albumin/mmol creatinine and/or eGFR < 60 ml/min/1.73 m2) in a large cohort from a general population participating in the Tromsø Study (n = 2637). Participants were stratified according to tertiles of change in SUA between baseline (1994/95) and follow-up 13 years later. (upper tertile: SUA increasing group, two lower tertiles: SUA non-increasing group). Logistic regression analysis was applied with RD and each component of RD after 7 and 13 years as the dependent variables. Adjustments were made for baseline eGFR, cardiovascular risk factors, and the use of antihypertensive drugs including diuretics. Results: After excluding participants with RD at baseline, SUA increasers, compared to SUA non-increasers, had a doubled risk of RD after 7 years (odds ratio 2.00, (95 % CI 1.45, 2.75)). Odds ratio for RD in SUA increasers after 13 years was 2.18 (95 % CI 1.71, 2.79). The risk of developing ACR ≥1.13 mg/mmol alone was not significantly increased after 7 years (odds ratio 1.30 (95 % CI 0.90, 1.89), but after 13 years (odds ratio 1.43 (95 % CI 1.09, 1.86)). An increase in baseline SUA of 59 μmol/L (1 mg/dL) gave an odds ratio for RD after 13 years of 1.16 (95 % CI 1.04, 1.29). Conclusion: An increase in SUA during follow-up was associated with an increased risk of developing RD after 7 and 13 years.

Keywordsserum uric acid; renal dysfunction; epidemiology; albumin-creatinine ratio
Year2015
JournalBMC Nephrology
Journal citation16 (210), pp. 1 - 10
PublisherBiomed Central Ltd
ISSN1471-2369
Digital Object Identifier (DOI)https://doi.org/10.1186/S12882-015-0207-1
Open accessOpen access
Page range1 - 10
Research GroupMary MacKillop Institute for Health Research
Publisher's version
Additional information

© 2015 Storhaug et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/8v4xx/uric-acid-is-associated-with-microalbuminuria-and-decreased-glomerular-filtration-rate-in-the-general-population-during-7-and-13-years-of-followup-the-troms-study

  • 4
    total views
  • 11
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Left atrial diameter, left ventricle indices, and association with all-cause mortality: Results from the population-based Tromso Study
Stylidis, Michael, Sharashova, Ekaterina, Wilsgaard, Tom, Leon, David A., Heggelund, Geir, Rösner, Assami, Njølstad, Inger, Løchen, Maja-Lisa and Schirmer, Henrik. (2019) Left atrial diameter, left ventricle indices, and association with all-cause mortality: Results from the population-based Tromso Study. Echocardiography. 36(3), pp. 439 - 450. https://doi.org/10.1111/echo.14270
Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study
Rinde, Ludvig B., Morelli, Vania M., Småbrekke, Birgit, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Smith, Erin F., Rosendaal, Frits R., Frazer, Kelly A., Brækkan, Sigrid Kufaas and Hansen, John-Bjarne. (2019) Effect of prothrombotic genotypes on the risk of venous thromboembolism in patients with and without ischemic stroke: The Tromso Study. Journal of Thrombosis and Haemostasis. 17(5), pp. 749 - 758. https://doi.org/10.1111/jth.14410
Gender differences in the association of syndecan-4 with myocardial infarction: The population-based Tromso Study
Solbu, Marit D., Kolset, Svein O., Jenssen, Trond G., Wilsgaard, Tom, Løchen, Maja-Lisa, Mathiesen, Ellisiv B., Melsom, Toralf, Eriksen, Bjørn O. and Reine, Trine M.. (2018) Gender differences in the association of syndecan-4 with myocardial infarction: The population-based Tromso Study. Atherosclerosis. 278, pp. 166 - 173. https://doi.org/10.1016/j.atherosclerosis.2018.08.005
Data on gender contrasts in the risk of incident myocardial infarction by age: The Tromsø Study 1979-2012
Albrektsen, Grethe, Heuch, Ivar, Løchen, Maja-Lisa, Thelle, Dag Steinar, Wilsgaard, Tom, Njølstad, Inger and Bønaa, Kaare Harald. (2017) Data on gender contrasts in the risk of incident myocardial infarction by age: The Tromsø Study 1979-2012. Data in Brief. 13, pp. 779 - 784. https://doi.org/10.1016/j.dib.2017.07.001
Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium
Gaksch, Martin, Jorde, Rolf, Grimnes, Guri, Joakimsen, Ragnar Martin, Schirmer, Henrik, Wilsgaard, Tom, Mathiesen, Ellisiv B., Njølstad, Inger, Løchen, Maja-Lisa, März, Winfried, Kleber, Marcus E., Tomaschitz, Andreas, Grübler, Martin, Eiriksdottir, Gudny, Gudmundsson, Elias F., Harris, Tamara B., Cotch, Mary F., Aspelund, Thor, Gudnason, Vilmundur, ... Pilz, Stefan. (2017) Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS ONE. 12(2), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0170791
Declining incidence of ischemic stroke: What is the impact of changing risk factors? The Tromsø Study 1995 to 2012
Vangen-Lønne, Anne M., Wilsgaard, Tom, Johnsen, Stein Harald, Løchen, Maja-Lisa, Njølstad, Inger and Mathiesen, Ellisiv B.. (2017) Declining incidence of ischemic stroke: What is the impact of changing risk factors? The Tromsø Study 1995 to 2012. Stroke. 48(3), pp. 544 - 550. https://doi.org/10.1161/STROKEAHA.116.014377
Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979-2012
Albrektsen, Grethe, Heuch, Ivar, Løchen, Maja-Lisa, Thelle, Dag Steinar, Wilsgaard, Tom, Njølstad, Inger and Bønaa, Kaare Harald. (2017) Risk of incident myocardial infarction by gender: Interactions with serum lipids, blood pressure and smoking. The Tromsø Study 1979-2012. Atherosclerosis. 261, pp. 52 - 59. https://doi.org/10.1016/j.atherosclerosis.2017.04.009
A new diagnosis of asthma or COPD is linked to smoking cessation - The Tromsø study
Danielsen, Signe Elise, Løchen, Maja-Lisa, Medbø, Astri, Vold, Monica Linea and Melbye, Hasse. (2016) A new diagnosis of asthma or COPD is linked to smoking cessation - The Tromsø study. The International Journal of Chronic Obstructive Pulmonary Disease. 11, pp. 1453 - 1458. https://doi.org/10.2147/Copd.S108046
Guía ESC 2016 sobre prevención de la enfermedad cardiovascular en la práctica clínica
Piepoli, Massimo F., Hoes, Arno W., Agewall, Stefan, Albus, Christian, Brotons, Carlos, Catapano, Alberico L., Cooney, Marie Therese, Corra, Ugo, Cosyns, Bernard, Deaton, Christi, Graham, Ian, Hall, Michael Stephen, Hobbs, F. D. Richard, Løchen, Maja-Lisa, Löllgen, Herbert, Marques-Vidal, Pedro, Perk, Joep, Prescott, Eva, Redon, Josep, ... Zamorano, José Luis. (2016) Guía ESC 2016 sobre prevención de la enfermedad cardiovascular en la práctica clínica. Revista Espanola de Cardiologia. 69(10), pp. 939.e1 - 939.e87. https://doi.org/10.1016/j.recesp.2016.09.004
Impact of incident myocardial infarction on the risk of venous thromboembolism: The Tromsø Study
Rinde, L. B., Lind, C., Smabrekke, B., Njølstad, I., Mathiesen, E. B., Wilsgaard, T., Løchen, Maja-Lisa, Hald, E. M., Vik, A., Braekkan, Sigrid K. and Hansen, J.-B.. (2016) Impact of incident myocardial infarction on the risk of venous thromboembolism: The Tromsø Study. Journal of Thrombosis and Haemostasis. 14(6), pp. 1183 - 1191. https://doi.org/10.1111/jth.13329
Ischemic stroke and risk of venous thromboembolism in the general population: The Tromsø Study
Rinde, Ludvig B., Småbrekke, Birgit, Mathiesen, Ellisiv B., Løchen, Maja-Lisa, Njølstad, Inger, Hald, Erin M., Wilsgaard, Tom, Braekkan, Sigrid K. and Hansen, John-Bjarne. (2016) Ischemic stroke and risk of venous thromboembolism in the general population: The Tromsø Study. Journal of the American Heart Association. 5(11), pp. 1 - 9. https://doi.org/10.1161/JAHA.116.004311
Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population
Mannsverk, Jan, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Rasmussen, Knut, Thelle, Dag S., Njølstad, Inger, Hopstock, Laila Arnesdatter and Bønaa, Kaare Harald. (2016) Trends in modifiable risk factors are associated with declining incidence of hospitalized and nonhospitalized acute coronary heart disease in a population. Circulation. 133(1), pp. 74 - 81. https://doi.org/10.1161/CIRCULATIONAHA.115.016960
Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromsø Study
Sharashova, Ekaterina, Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Løchen, Maja-Lisa, Njølstad, Inger and Brenn, Tormod. (2016) Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population: The Tromsø Study. Journal of Epidemiology and Community Health. 70(9), pp. 902 - 909. https://doi.org/10.1136/jech-2015-206663
Temporal trends in incidence and case fatality of intracerebral hemorrhage: The Tromsø Study 1995-2012
Carlsson, Maria, Wilsgaard, Tom, Johnsen, Stein Harald, Vangen-Lønne, Anne Merete, Løchen, Maja-Lisa, Njølstad, Inger and Mathiesen, Ellisiv Bøgeberg. (2016) Temporal trends in incidence and case fatality of intracerebral hemorrhage: The Tromsø Study 1995-2012. Cerebrovascular Diseases Extra. 6(2), pp. 40 - 49. https://doi.org/10.1159/000447719
Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study
Enga, Kristin F., Rye-Holmboe, I., Hald, Erin M., Løchen, Maja-Lisa, Mathiesen, E. B., Njølstad, I., Wilsgaard, Tom, Braekkan, S. K. and Hansen, John-Bjarne. (2015) Atrial fibrillation and future risk of venous thromboembolism: The Tromsø study. Journal of Thrombosis and Haemostasis. 13(1), pp. 10 - 16. https://doi.org/10.1111/jth.12762
Kvinnehjerter: En medisinsk fagbok om vanlige hjertesykdommer
Løchen, Maja-Lisa and Gerdts, Eva. (2015) Kvinnehjerter: En medisinsk fagbok om vanlige hjertesykdommer Gyldendal Norwegian Publishing.
Clinically significant novel biomarkers for prediction of first ever myocardial infarction: The Tromsø Study
Wilsgaard, Tom, Mathiesen, Ellisiv Bøgeberg, Patwardhan, Anil, Rowe, Michael W., Schirmer, Henrik, Løchen, Maja-Lisa, Sudduth-Klinger, Julie, Hamren, Sarah, Bønaa, Kaare Harald and Njølstad, Inger. (2015) Clinically significant novel biomarkers for prediction of first ever myocardial infarction: The Tromsø Study. Circulation: Cardiovascular Genetics. 8(2), pp. 363 - 371. https://doi.org/10.1161/CIRCGENETICS.113.000630
Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population
Eriksen, B. O., Løchen, Maja-Lisa, Arntzen, Kjell A., Bertelsen, Geir, Eilertsen, Britt-Ann W., von Hanno, Therese, Herder, Marit, Jenssen, Trond G., Mathisen, Ulla D., Melsom, Toralf, Njølstad, Inger, Solbu, Marit D., Toft, Ingrid and Mathiesen, Ellisiv B.. (2014) Subclinical cardiovascular disease is associated with a high glomerular filtration rate in the nondiabetic general population. Kidney International. 86(1), pp. 146 - 153. https://doi.org/10.1038/ki.2013.470
Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study
Hald, Erin M., Enga, Kristin F., Løchen, Maja-Lisa, Mathiesen, Ellisiv B., Njølstad, Inger, Wilsgaard, Tom, Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014) Venous thromboembolism increases the risk of atrial fibrillation: The Tromsø Study. Journal of the American Heart Association. 3(1), pp. 1 - 7. https://doi.org/10.1161/JAHA.113.000483
Red cell distribution width is associated with incident myocardial infarction in a general population: The Tromsø Study
Skjelbakken, Tove, Lappegard, Jostein, Ellingsen, Trygve S., Barret-Connor, Elizabeth, Brox, Jan, Løchen, Maja-Lisa, Njølstad, Inger, Wilsgaard, Tom, Mathiesen, Ellisiv B., Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014) Red cell distribution width is associated with incident myocardial infarction in a general population: The Tromsø Study. Journal of the American Heart Association. 3(4), pp. 1 - 10. https://doi.org/10.1161/JAHA.114.001109
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
Holmen, Oddgeir L., Zhang, He, Fan, Yanbo, Hovelson, Daniel H., Schmidt, Ellen, Zhou, Wei, Guo, Yanhong, Zhang, Ji, Langhammer, Arnulf, Løchen, Maja-Lisa, Ganesh, Santhi K., Vatten, Lars, Skorpen, Frank, Dalen, Havard, Zhang, Jifeng, Pennathur, Subramaniam, Chen, Jin, Platou, Carl, Mathiesen, Ellisiv B., ... Willer, Cristen J.. (2014) Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nature Genetics. 46(4), pp. 345 - 351. https://doi.org/10.1038/ng.2926
Long-term cardiovascular consequences of Rose angina at age 20-54 years: 29-years' follow-up of the Tromso Study
Graff-Iversen, Sidsel, Wilsgaard, Tom, Mathiesen, Ellisiv B., Njølstad, Inger and Løchen, Maja-Lisa. (2014) Long-term cardiovascular consequences of Rose angina at age 20-54 years: 29-years' follow-up of the Tromso Study. Journal of Epidemiology and Community Health. 68(8), pp. 754 - 759. https://doi.org/10.1136/jech-2013-203642
Carotid atherosclerosis predicts future myocardial infarction but not venous thromboembolism: The Tromsø Study
Hald, Erin M., Lijfering, Willem M., Mathiesen, Ellisiv B., Johnsen, Stein Harald, Løchen, Maja-Lisa, Njølstad, I., Wilsgaard, Tom, Rosendaal, Frits R., Braekkan, Sigrid K. and Hansen, John-Bjarne. (2014) Carotid atherosclerosis predicts future myocardial infarction but not venous thromboembolism: The Tromsø Study. Arteriosclerosis Thrombosis and Vascular Biology. 34(1), pp. 226 - 230. https://doi.org/10.1161/Atvbaha.113.302162
QT interval and the risk of myocardial infarction and all-cause death: A cohort study
Lindekleiv, Haakon, Wilsgaard, Tom, Macfarlane, Peter W. and Løchen, Maja-Lisa. (2012) QT interval and the risk of myocardial infarction and all-cause death: A cohort study. Journal of Cardiovascular Electrophysiology. 23(8), pp. 846 - 852. https://doi.org/10.1111/j.1540-8167.2012.02308.x
Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study
Toft, Ingrid, Solbu, Marit, Kronborg, Jens, Mathisen, Ulla D., Eriksen, Bjørn O., Storhaug, Hilde, Melsom, Toralf, Løchen, Maja-Lisa, Mathiesen, E. B., Njølstad, Inger, Wilsgaard, Tom and Brox, Jan. (2012) Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study. Nephrology Dialysis Transplantation. 27(7), pp. 2780 - 2787. https://doi.org/10.1093/ndt/gfr751
Total and cause-specific mortality rates in a prospective study of community-acquired hepatitis C virus infection in northern Norway
Kristiansen, M. G., Løchen, Maja-Lisa, Guttenberg, T. J., Mortensen, L., Eriksen, B. O. and Florholmen, J.. (2011) Total and cause-specific mortality rates in a prospective study of community-acquired hepatitis C virus infection in northern Norway. Journal of Viral Hepatitis. 18(4), pp. 237 - 244. https://doi.org/10.1111/j.1365-2893.2010.01290.x
Incidence and mortality of aneurysmal subarachnoid hemorrhage in two Norwegian cohorts, 1984-2007
Sandvei, M. S., Mathiesen, E. B., Vatten, L. J., Müller, T. B., Lindekleiv, H., Ingebrigtsen, T., Njølstad, I., Wilsgaard, Tom, Løchen, Maja-Lisa, Vik, A. and Romundstad, P. R.. (2011) Incidence and mortality of aneurysmal subarachnoid hemorrhage in two Norwegian cohorts, 1984-2007. Neurology. 77(20), pp. 1833 - 1839. https://doi.org/10.1212/WNL.0b013e3182377de3
Sex differences in risk factors for aneurysmal subarachnoid hemorrhage: A cohort study
Lindekleiv, H., Sandvei, M. S., Njølstad, I., Løchen, Maja-Lisa, Romundstad, P. R., Vatten, L., Ingebrigtsen, T., Vik, A. and Mathiesen, E. B.. (2011) Sex differences in risk factors for aneurysmal subarachnoid hemorrhage: A cohort study. Neurology. 76(7), pp. 637 - 643. https://doi.org/10.1212/WNL.0b013e31820c30d3