Cue exposure and response prevention with heavy smokers: A laboratory-based randomised placebo-controlled trial examining the effects of D-cycloserine on cue reactivity and attentional bias

Journal article


Kamboj, Sunjeev K., Joye, Alyssa, Das, Ravi K., Gibson, Andrew J. W., Morgan, Celia J. A. and Curran, H. Valerie. (2012). Cue exposure and response prevention with heavy smokers: A laboratory-based randomised placebo-controlled trial examining the effects of D-cycloserine on cue reactivity and attentional bias. Psychopharmacology. 221(2), pp. 273 - 284. https://doi.org/10.1007/s00213-011-2571-2
AuthorsKamboj, Sunjeev K., Joye, Alyssa, Das, Ravi K., Gibson, Andrew J. W., Morgan, Celia J. A. and Curran, H. Valerie
Abstract

Rationale: Treatments based on exposure/response prevention (Exp/RP) produce only modest benefits in substance dependence disorders. However, a new strategy, which has shown promise in animal models of addiction involves combining Exp/RP with extinction-enhancing pharmacological treatments. A prototype of the latter is D-cycloserine (DCS), a partial agonist at the glycine site of the NMDA receptor. Methods: In a laboratory-based randomised, double-blind, placebo-controlled trial with non-treatment-seeking heavy smokers (nā€‰=ā€‰32), we examined the efficacy of Exp/RP combined with DCS (125 mg). Two sessions of Exp/RP were carried out during which cue reactivity was monitored. Effects on attentional bias and/or subjective craving and smoking behaviour were also evaluated after at least 48 h and 2 weeks following session 2 of Exp/RP. Results: Within- and between-session reductions in cue reactivity were observed in both treatment groups, although the DCS group did not show an enhanced reduction by the end of session 2. However, a subtle effect of DCS on the emotionality subscale of the Tobacco Craving Questionnaire was observed, with a trend towards a sustained reduction in this aspect of craving at 2-week follow-up. Conclusion: Our findings suggest that two sessions of Exp/RP combined with DCS does not enhance the reduction in episodic cue reactivity in non-treatment seeking smokers. A trend towards a greater sustained reduction in the emotionality scale of the TCQ in the DCS group suggests that further detailed study of the effects of combined Exp/RP-DCS on different aspects of craving is warranted, especially in smokers with a current intention to quit.

Keywordsnicotine; substance dependence; cue exposure; response prevention; d-cycloserine; cue reactivity; attentional bias; habituation; extinction
Year2012
JournalPsychopharmacology
Journal citation221 (2), pp. 273 - 284
PublisherSpringer-Verlag
ISSN0033-3158
Digital Object Identifier (DOI)https://doi.org/10.1007/s00213-011-2571-2
Scopus EID2-s2.0-84862680157
Page range273 - 284
Publisher's version
File Access Level
Controlled
Place of publicationGermany
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