Obesity is associated with retinopathy and macrovascular disease in type 1 diabetes
Journal article
Price, Sarah A., Gorelik, Alexandra, Fourlanos, Spiros, Colman, Peter G. and Wentworth, John M.. (2014). Obesity is associated with retinopathy and macrovascular disease in type 1 diabetes. Obesity Research and Clinical Practice. 8(2), pp. e178 - e182. https://doi.org/10.1016/j.orcp.2013.03.007
Authors | Price, Sarah A., Gorelik, Alexandra, Fourlanos, Spiros, Colman, Peter G. and Wentworth, John M. |
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Abstract | Excessive body weight is increasingly seen in type 1 diabetes but its impact is debated. To address this uncertainty, we aimed to determine the association between excess body weight and the macro- and microvascular complications of type 1 diabetes. We identified 501 adults with type 1 diabetes attending an Australian hospital clinic and extracted their clinical and biochemical data from our patient management database. In both men and women, obesity (BMI > 30 kg/m2) was the predominant risk factor for retinopathy and cardiovascular disease despite similar HbA1c and increased use of cardioprotective drugs compared to non-obese patients. Obesity was associated with albuminuria in women, but not renal impairment or neuropathy in either sex. We conclude that obesity in type 1 diabetes may promote retinopathy and macrovascular disease. Future trials to determine the effect of weight loss on type 1 diabetes in obese people are needed. |
Keywords | type 1 diabetes; obesity; body mass index; macrovascular; complications; microvascular |
Year | 2014 |
Journal | Obesity Research and Clinical Practice |
Journal citation | 8 (2), pp. e178 - e182 |
Publisher | Elsevier |
ISSN | 1871-403X |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.orcp.2013.03.007 |
Scopus EID | 2-s2.0-84898827667 |
Page range | e178 - e182 |
Publisher's version | File Access Level Controlled |
Place of publication | United Kingdom |
https://acuresearchbank.acu.edu.au/item/8v59y/obesity-is-associated-with-retinopathy-and-macrovascular-disease-in-type-1-diabetes
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