Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study

Journal article


Vimaleswaran, Karani S., Cavadino, Alana, Berry, Diane J., Jorde, Rolf, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J. Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A., Nolte, Ilja M., Houston, Denise K., Ahluwalia, Tarunveer Singh, van der Most, Peter J., Pasko, Dorota, Zgaga, Lina, ... Hyppönen, Elina. (2014) Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study. The Lancet Diabetes & Endocrinology. 2(9), pp. 719 - 729. https://doi.org/10.1016/S2213-8587(14)70113-5
AuthorsVimaleswaran, Karani S., Cavadino, Alana, Berry, Diane J., Jorde, Rolf, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J. Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A., Nolte, Ilja M., Houston, Denise K., Ahluwalia, Tarunveer Singh, van der Most, Peter J., Pasko, Dorota, Zgaga, Lina, Thiering, Elisabeth, Vitart, Veronique, Fraser, Ross M., Huffman, Jennifer E., de Boer, Rudolf A., Schöttker, Ben, Saum, Kai-Uwe, McCarthy, Mark I., Dupuis, Josée, Herzig, Karl-Heinz, Sebert, Sylvain, Pouta, Anneli, Laitinen, Jaana, Kleber, Marcus E., Navis, Gerjan, Lorentzon, Mattias, Jameson, Karen, Arden, Nigel, Cooper, Jackie A., Acharya, Jayshree, Hardy, Rebecca, Raitakari, Olli, Ripatti, Samuli, Billings, Liana K., Lahti, Jari, Osmond, Clive, Penninx, Brenda W., Rejnmark, Lars, Lohman, Kurt K., Paternoster, Lavinia, Stolk, Ronald P., Hernandez, Dena G., Byberg, Liisa, Hagström, Emil, Melhus, Håkan, Ingelsson, Erik, Mellström, Dan, Ljunggren, Östen, Tzoulaki, Ioanna, McLachlan, Stela, Theodoratou, Evropi, Tiesler, Carla M. T., Jula, Antti, Navarro, Pau, Wright, Alan F., Polasek, Ozren, Wilson, James F., Rudan, Igor, Salomaa, Veikko, Heinrich, Joachim, Campbell, Harry, Price, Jacqueline F., Karlsson, Magnus, Lind, Lars, Michaëlsson, Karl, Bandinelli, Stefania, Frayling, Timothy M., Hartman, Catharina A., Sørensen, Thorkild I. A., Kritchevsky, Stephen B., Langdahl, Bente Lomholt, Eriksson, Johan G., Florez, Jose C., Spector, Tim D., Lehtimäki, Terho, Kuh, Diana, Humphries, Steve E., Cooper, Cyrus, Ohlsson, Claes, März, Winfried, de Borst, Martin H., Kumari, Meena, Kivimaki, Mika, Wang, Thomas J., Power, Chris, Brenner, Hermann, Grimnes, Guri, van der Harst, Pim, Snieder, Harold, Hingorani, Aroon D., Pilz, Stefan, Whittaker, John C., Järvelin, Marjo-Riitta and Hyppönen, Elina
Abstract

Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. Methods In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. Findings In phenotypic analyses (up to n=49 363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, −0·12 mm Hg, 95% CI −0·20 to −0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97–0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, −0·02 mm Hg, −0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146 581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of −0·10 mm Hg in systolic blood pressure (−0·21 to −0·0001; p=0·0498) and a change of −0·08 mm Hg in diastolic blood pressure (−0·15 to −0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142 255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96–0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of −0·29 mm Hg in diastolic blood pressure (−0·52 to −0·07; p=0·01), a change of −0·37 mm Hg in systolic blood pressure (−0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87–0·97; p=0·002). Interpretation Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This finding warrants further investigation in an independent, similarly powered study. Funding British Heart Foundation, UK Medical Research Council, and Academy of Finland.

Year2014
JournalThe Lancet Diabetes & Endocrinology
Journal citation2 (9), pp. 719 - 729
PublisherThe Lancet Publishing Group
ISSN2213-8587
Digital Object Identifier (DOI)https://doi.org/10.1016/S2213-8587(14)70113-5
Scopus EID2-s2.0-84908324133
Open accessOpen access
Page range719 - 729
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationUnited Kingdom
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Kanis, J. A., Cooper, C., Rizzoli, R. and Reginster, J.-Y.. (2018) Review of the guideline of the American College of Physicians on the treatment of osteoporosis. Osteoporosis International. 29(7), pp. 1505 - 1510. https://doi.org/10.1007/s00198-018-4504-y
Does nutrition play a role in the prevention and management of sarcopenia?
Robinson, S. M., Reginster, J. Y., Rizzoli, R., Shaw, S. C., Kanis, J. A., Bautmans, I., Bischoff-Ferrari, H., Bruyère, O., Cesari, M., Dawson-Hughes, B., Fielding, R. A., Kaufman, J. M., Landi, F., Malafarina, Vincenzo, Rolland, Y., van Loon, L. J., Vellas, B., Visser, M. and Cooper, C.. (2018) Does nutrition play a role in the prevention and management of sarcopenia? Clinical Nutrition. 37(4), pp. 1121 - 1132. https://doi.org/10.1016/j.clnu.2017.08.016
Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial
Shepstone, L., Lenaghan, E., Cooper, C., Clarke, Shane, Fong-Soe-Khioe, Rebekah, Fordham, R., Gittoes, Neil, Harvey, Ian, Harvey, Nicholas C., Heawood, A., Holland, R., Howe, A., Kanis, John, Marshall, Tarnya, O'Neill, T. W., Peters, T. J., Redmond, Niamh, Torgerson, David, Turner, David and McCloskey, Eugene. (2018) Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial. The Lancet. 391(10122), pp. 741 - 747. https://doi.org/10.1016/S0140-6736(17)32640-5
Risk factors for low back pain and sciatica in elderly men--the MrOS Sweden study
Kherad, Mehrsa, Rosengren, Björn E., Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Ljunggren, Östen and Karlsson, Magnus K.. (2017) Risk factors for low back pain and sciatica in elderly men--the MrOS Sweden study. Age and Ageing. 46(1), pp. 64 - 71. https://doi.org/10.1093/ageing/afw152
Mind the (treatment) gap: A global perspective on current and future strategies for prevention of fragility fractures
Harvey, N. C., McCloskey, E. V., Mitchell, P. J., Dawson-Hughes, B., Pierroz, D. D., Reginster, J.-Y. Yves, Rizzoli, R., Cooper, C. and Kanis, J. A.. (2017) Mind the (treatment) gap: A global perspective on current and future strategies for prevention of fragility fractures. Osteoporosis International. 28(5), pp. 1507 - 1529. https://doi.org/10.1007/s00198-016-3894-y
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff, Mariaelisa, Scott, Robert A., Justice, Anne E., Young, Kristin L., Feitosa, Mary F., Barata, Llilda, Winkler, Thomas W., Chu, Audrey Y., Mahajan, Anubha, Hadley, David, Xue, Luting, Workalemahu, Tsegaselassie, Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, bin Qi, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, ... Lorentzon, Mattias. (2017) Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. PLoS Genetics. 13(4), pp. 1 - 26. https://doi.org/10.1371/journal.pgen.1006528
Cortical bone area predicts incident fractures independently of areal bone mineral density in older men
Ohlsson, Claes, Sundh, Daniel, Wallerek, Andreas, Nilson, Martin, Karlsson, Magnus, Johansson, Helena, Mellstrom, Dan and Lorentzon, Mattias. (2017) Cortical bone area predicts incident fractures independently of areal bone mineral density in older men. Journal of Clinical Endocrinology and Metabolism. 102(2), pp. 516 - 524. https://doi.org/10.1210/jc.2016-3177
Association between alendronate use and hip fracture risk in older patients using oral prednisolone
Axelsson, Kristian F., Nilsson, Anna G., Wedel, Hans, Lundh, Dan and Lorentzon, Mattias. (2017) Association between alendronate use and hip fracture risk in older patients using oral prednisolone. JAMA: Journal of the American Medical Association. 318(2), pp. 146 - 155. https://doi.org/10.1001/jama.2017.8040
Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: Research for evidence and a scientific statement from the European society for clinical and economic aspects of osteopo
Cianferotti, Luisella, Bertoldo, Francesco, Bischoff-Ferrari, Heike A., Bruyere, O., Cooper, Cyrus, Cutolo, Maurizio, Kanis, John A., Kaufman, Jean-Marc, Reginster, Jean-Yves, Rizzoli, Rene and Brandi, Maria Luisa. (2017) Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: Research for evidence and a scientific statement from the European society for clinical and economic aspects of osteopo. Endocrine. 56(2), pp. 245 - 261. https://doi.org/10.1007/s12020-017-1290-9
Hip fracture risk and safety with alendronate treatment in the oldest-old
Axelsson, K. F., Wallander, M., Johansson, Helena, Lundh, D. and Lorentzon, Mattias. (2017) Hip fracture risk and safety with alendronate treatment in the oldest-old. Journal of Internal Medicine. 282(6), pp. 546 - 559. https://doi.org/10.1111/joim.12678
Erratum to: diacerein: benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO
Pavelka, Karel, Bruyère, O., Cooper, Cyrus, Kanis, John, Leeb, Burkhard F., Maheu, E., Martel-Pelletier, Johanne, Monfort, Jordi, Pelletier, Jean P., Rizzoli, Rene and Reginster, Jean Yves. (2017) Erratum to: diacerein: benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO. Drugs and Aging. 34(5), pp. 413 - 413. https://doi.org/10.1007/s40266-017-0457-7
Type 2 diabetes and risk of hip fractures and non-skeletal fall injuries in the elderly: A study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO)
Wallander, Märit, Axelsson, Kristian F., Nilsson, Anna G., Lundh, Dan and Lorentzon, Mattias. (2017) Type 2 diabetes and risk of hip fractures and non-skeletal fall injuries in the elderly: A study from the Fractures and Fall Injuries in the Elderly Cohort (FRAILCO). Journal of Bone and Mineral Research. 32(3), pp. 449 - 460. https://doi.org/10.1002/jbmr.3002
Erratum to: can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis
Bruyère, O., Cooper, Cyrus, Arden, Nigel, Branco, J., Brandi, Maria L., Herrero-Beaumont, G., Berenbaum, F., Dennison, Elaine M., Devogelaer, J. P., Hochberg, Marc, Kanis, John, Laslop, A., McAlindon, T., Reiter, Susanne, Richette, P., Rizzoli, Rene and Reginster, Jean Y.. (2017) Erratum to: can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis. Drugs and Aging. 34(5), pp. 411 - 411. https://doi.org/10.1007/s40266-017-0456-8
Increased risk of hip fracture among spouses-evidence of a homogamy effect
Vala, C. H., Oden, Anders, Lorentzon, Mattias, Sundh, V., Johansson, Helena, Karlsson, Magnus, Rosengren, Björn E., Ohlsson, Claes, Johansson, B., Kanis, John and Mellström, Dan. (2017) Increased risk of hip fracture among spouses-evidence of a homogamy effect. Osteoporosis International. 28(1), pp. 95 - 102. https://doi.org/10.1007/s00198-016-3738-9
International osteoporosis foundation and European calcified tissue society working group. Recommendations for the screening of adherence to oral bisphosphonates
Diez-Perez, Aldolfo, Naylor, K. E., Abrahamsen, Bo, Agnusdei, D., Brandi, Maria L., Cooper, Cyrus, Dennison, Elaine M., Eriksen, E. F., Gold, D. T., Guañabens, N., Hadji, P., Hiligsmann, Mickaël, Horne, R., Josse, R. G., Kanis, John, Obermayer-Pietsch, Barbara, Prieto-Alhambra, D., Reginster, Jean Y., Rizzoli, Rene, ... Eastell, Richard. (2017) International osteoporosis foundation and European calcified tissue society working group. Recommendations for the screening of adherence to oral bisphosphonates. Osteoporosis International. 28(3), pp. 767 - 774. https://doi.org/10.1007/s00198-017-3906-6
Identification and management of patients at increased risk of osteoporotic fracture: Outcomes of an ESCEO expert consensus meeting
Kanis, J. A., Cooper, C., Rizzoli, R., Abrahamsen, B., Al-Daghri, N. M., Brandi, M. L., Cannata-Andia, J., Cortet, B., Dimai, H. P., Ferrari, S., Hadji, P., Harvey, N. C., Kraenzlin, M., Kurth, A., McCloskey, E., Minisola, S., Thomas, T. and Reginster, J.-Y.. (2017) Identification and management of patients at increased risk of osteoporotic fracture: Outcomes of an ESCEO expert consensus meeting. Osteoporosis International. 28(7), pp. 2023 - 2034. https://doi.org/10.1007/s00198-017-4009-0
Management of aromatase inhibitor-associated bone loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG
Hadji, P., Aapro, Matti S., Body, Jean J., Gnant, Michael, Brandi, Maria L., Reginster, Jean Y., Zillikens, M. C., Glüer, C. C., de Villiers, T., Baber, Rod, Roodman, G. David, Cooper, Cyrus, Langdahl, Bente Lomholt, Palacios, Santiago, Kanis, John, Al-Daghri, Nasser M., Nogues, Xavier, Eriksen, Erik F., Kurth, Andreas, ... Coleman, Robert E.. (2017) Management of aromatase inhibitor-associated bone loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG. Journal of Bone Oncology. 7, pp. 1 - 12. https://doi.org/10.1016/j.jbo.2017.03.001
Bone traits seem to develop also during the third decade in life—normative cross-sectional data on 1083 men aged 18–28 years
Lindgren, Erik, Karlsson, Magnus K., Lorentzon, Mattias and Rosengren, Björn E.. (2017) Bone traits seem to develop also during the third decade in life—normative cross-sectional data on 1083 men aged 18–28 years. Journal of Clinical Densitometry. 20(1), pp. 32 - 43. https://doi.org/10.1016/j.jocd.2016.07.002
Clinical settings in knee osteoarthritis: Pathophysiology guides treatment
Herrero-Beaumont, Gabriel, Roman-Blas, Jorge A., Bruyère, Olivier, Cooper, Cyrus, Kanis, John, Maggi, S., Rizzoli, René and Reginster, Jean-Yves. (2017) Clinical settings in knee osteoarthritis: Pathophysiology guides treatment. Maturitas. 96, pp. 54 - 57. https://doi.org/10.1016/j.maturitas.2016.11.013
Clinical usefulness of bone turnover marker concentrations in osteoporosis
Morris, H. A., Eastell, R., Jorgesen, N. R., Cavalier, E., Vasikaran, S., Chubb, S. A. P., Kanis, J. A., Cooper, C. and Makris, K.. (2017) Clinical usefulness of bone turnover marker concentrations in osteoporosis. Clinica Chimica Acta. 467, pp. 34 - 41. https://doi.org/10.1016/j.cca.2016.06.036
Low testosterone, but not estradiol, is associated with incident falls in older men: The international MrOS study
Vandenput, Liesbeth, Mellström, Dan, Laughlin, Gail A., Cawthon, Peggy M., Cauley, Jane A., Hoffman, Andrew R., Karlsson, Magnus K., Rosengren, Björn E., Ljunggren, Östen, Nethander, Maria, Eriksson, Anna L., Lorentzon, Mattias, Leung, Jason, Kwok, Timothy, Orwoll, Eric S. and Ohlsson, Claes. (2017) Low testosterone, but not estradiol, is associated with incident falls in older men: The international MrOS study. Journal of Bone and Mineral Research. 32(6), pp. 1174 - 1181. https://doi.org/10.1002/jbmr.3088
Increased cortical porosity in women with hip fracture
Sundh, Daniel, Nilsson, A. G., Nilsson, Martin, Johansson, L., Mellström, Dan and Lorentzon, Mattias. (2017) Increased cortical porosity in women with hip fracture. Journal of Internal Medicine. 281(5), pp. 496 - 506. https://doi.org/10.1111/joim.12587
Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study
Lewerin, Catharina, Ljunggren, Östen, Nilsson-Ehle, Herman, Karlsson, Magnus K., Herlitz, Hans, Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2017) Low serum iron is associated with high serum intact FGF23 in elderly men: The Swedish MrOS study. Bone. 98, pp. 1 - 8. https://doi.org/10.1016/j.bone.2017.02.005
Erratum to: identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting
Kanis, John, Cooper, Cyrus, Rizzoli, Rene, Abrahamsen, Bo, Al-Daghri, N. M., Brandi, Maria L., Cannata, J. B., Cortet, B., Dimai, Hans P., Ferrari, S., Hadji, P., Harvey, Nicholas C., Kraenzlin, M., Kurth, Andreas, McCloskey, Eugene, Minisola, Salvatore, Thomas, T. and Reginster, Jean Y.. (2017) Erratum to: identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting. Osteoporosis International. 28(11), pp. 3285 - 3286. https://doi.org/10.1007/s00198-017-4161-6
Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review
Beaudart, Charlotte, Dawson, A., Shaw, S. C., Harvey, Nicholas C., Kanis, John, Binkley, Neil, Reginster, Jean Yves, Chapurlat, R., Chan, D. C., Bruyère, O., Rizzoli, Rene, Cooper, Cyrus and Dennison, Elaine M.. (2017) Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review. Osteoporosis International. 28(6), pp. 1817 - 1833. https://doi.org/10.1007/s00198-017-3980-9
Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis
Manousaki, Despoina, Dudding, Tom, Haworth, Simon, Hsu, Yi-Hsiang, Liu, Chiang-Ti, Medina-Gómez, Carolina, Voortman, Trudy, van der Velde, Nathalie, Melhus, Håkan, Robinson-Cohen, Cassianne, Cousminer, Diana L., Nethander, Maria, Vandenput, Liesbeth, Noordam, Raymond, Forgetta, Vincenzo, Greenwood, Celia M. T., Biggs, Mary L., Psaty, Bruce M., Rotter, Jerome I., ... Richards, J. Brent. (2017) Low-frequency synonymous coding variation in CYP2R1 has large effects on vitamin d levels and risk of multiple sclerosis. American Journal of Human Genetics. 101(2), pp. 227 - 238. https://doi.org/10.1016/j.ajhg.2017.06.014
Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study
Nilsson, Anna G., Sundh, Daniel, Johansson, Lisa, Nilsson, Martin, Mellström, Dan, Rudäng, Robert, Zoulakis, Michail, Wallander, Märit, Darelid, Anna and Lorentzon, Mattias. (2017) Type 2 diabetes mellitus is associated with better bone microarchitecture but lower bone material strength and poorer physical function in elderly women: A population-based study. Journal of Bone and Mineral Research. 32(5), pp. 1062 - 1071. https://doi.org/10.1002/jbmr.3057
Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease
Sigurdsson, Gudmundur Vignir, Schmidt, Susanne, Mellström, Dan, Ohlsson, Claes, Kindblom, Jenny M., Lorentzon, Mattias and Saalman, Robert. (2017) Bone mass development from childhood into young adulthood in patients with childhood-onset inflammatory bowel disease. Inflammatory Bowel Diseases. 23(12), pp. 2215 - 2226. https://doi.org/10.1097/MIB.0000000000001277
Genetic variants associated with circulating parathyroid hormone
Robinson-Cohen, Cassianne, Lutsey, Pamela L., Kleber, Marcus E., Nielson, Carrie M., Mitchell, Braxton D., Bis, Joshua C., Eny, Karen M., Portas, Laura, Eriksson, Joel, Lorentzon, Mattias, Koller, Daniel L., Milaneschi, Yuri, Teumer, Alexander, Pilz, Stefan, Nethander, Maria, Selvin, Elizabeth, Tang, Weihong, Weng, Lu-Chen, Wong, Hoi Suen, ... Kestenbaum, Bryan. (2017) Genetic variants associated with circulating parathyroid hormone. Journal of the American Society of Nephrology. 28(5), pp. 1553 - 1565. https://doi.org/10.1681/ASN.2016010069
The role of calcium supplementation in healthy musculoskeletal ageing: An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF)
Harvey, Nicholas C., Biver, Emmanuel, Kaufman, J,, Bauer, Jürgen M., Branco, J., Brandi, Maria Luisa, Bruyère, O., Coxam, V., Cruz-Jentoft, Alfonso J., Czerwinski, E., Dimai, Hans P., Fardellone, P., Landi, Francesco, Reginster, Jean Yves, Dawson-Hughes, Bess, Kanis, John, Rizzoli, Rene and Cooper, Cyrus. (2017) The role of calcium supplementation in healthy musculoskeletal ageing: An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF). Osteoporosis International. 28(2), pp. 447 - 462. https://doi.org/10.1007/s00198-016-3773-6
Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias, Lorentzon, Mattias, Husemoen, Lise Lotte Nystrup, Völzke, Henry, Karlsson, Magnus, Baumeister, Sebastian E., Linneberg, Allan and Ohlsson, Claes. (2017) Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PLoS ONE. 12(4), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0176277
UK clinical guideline for the prevention and treatment of osteoporosis
Compston, Juliet E., Cooper, Alun, Cooper, Cyrus, Gittoes, Neil, Gregson, C., Harvey, Nicholas C., Hope, S., Kanis, John, McCloskey, Eugene, Poole, Kenneth E.S., Reid, David M., Selby, P., Thompson, F., Thurston, A. and Vine, N.. (2017) UK clinical guideline for the prevention and treatment of osteoporosis. Archives of Osteoporosis. 12(43), pp. 1 - 24. https://doi.org/10.1007/s11657-017-0324-5
Romosozumab or alendronate for fracture prevention in women with osteoporosis
Saag, Kenneth G., Petersen, Jeffrey, Brandi, Maria Luisa, Karaplis, Andrew C., Lorentzon, Mattias, Thomas, Thierry A., Maddox, Judy, Fan, Michelle, Meisner, Paul D. and Grauer, Andreas. (2017) Romosozumab or alendronate for fracture prevention in women with osteoporosis. New England Journal of Medicine. 377(15), pp. 1417 - 1427. https://doi.org/10.1056/NEJMoa1708322
Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study
Ohlsson, Claes, Nethander, Maria, Kindmark, Andreas, Ljunggren, Östen, Lorentzon, Mattias, Rosengren, Björn E., Karlsson, Magnus K., Mellström, Dan and Vandenput, Liesbeth. (2017) Low serum DHEAS predicts increased fracture risk in older men: The MrOS Sweden study. Journal of Bone and Mineral Research. 32(8), pp. 1607 - 1614. https://doi.org/10.1002/jbmr.3123
Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women
Nilsson, Martin, Sundh, Daniel, Mellström, Dan and Lorentzon, Mattias. (2017) Current physical activity is independently associated with cortical bone size and bone strength in elderly Swedish women. Journal of Bone and Mineral Research. 32(3), pp. 473 - 485. https://doi.org/10.1002/jbmr.3006
Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study
Deminger, Anna, Klingberg, Eva, Lorentzon, Mattias, Geijer, Mats, Göthlin, Jan, Hedberg, Martin, Rehnberg, Eva, Carlsten, Hans, Jacobsson, Lennart T. and Forsblad-d'Elia, Helena. (2017) Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study. Arthritis Research and Therapy. 19(1), pp. 1 - 12. https://doi.org/10.1186/s13075-017-1480-0
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice, Anne E., Winkler, Thomas W., Feitosa, Mary F., Graff, Misa, Fisher, Virginia A., Young, Kristin L., Barata, Llilda, Deng, Xuan, Czajkowski, Jacek, Hadley, David, Ngwa, Julius S., Ahluwalia, Tarunveer S., Chu, Audrey Y., Heard-Costa, Nancy L., Lim, Elise, Perez, Jeremiah, Eicher, John D., Kutalik, Zoltán, Xue, Luting, ... Lorentzon, Mattias. (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications. 8(1), pp. 1 - 19. https://doi.org/10.1038/ncomms14977
Characteristics of prevalent vertebral fractures predict new fractures in elderly men
Karlsson, Magnus K., Kherad, Mehrsa, Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Rosengren, Björn E.. (2016) Characteristics of prevalent vertebral fractures predict new fractures in elderly men. Journal of Bone and Joint Surgery: American Volume. 98(5), pp. 379 - 385. https://doi.org/10.2106/JBJS.15.00328
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried, Janina S., Jeff, Janina, Chu, Audrey Y., Bragg-Gresham, Jennifer L., van Dongen, Jenny, Huffman, Jennifer E., Ahluwalia, Tarunveer S., Cadby, Gemma, Eklund, Niina, Eriksson, Joel, Esko, Tõnu, Feitosa, Mary F., Goel, Anuj, Gorski, Mathias, Hayward, Caroline, Heard-Costa, Nancy L., Jackson, Anne U., Jokinen, Eero, Kanoni, Stavroula, ... Loos, Ruth J. F.. (2016) A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications. 7(1), pp. 1 - 11. https://doi.org/10.1038/ncomms13357
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits
Teumer, Alexander, Qi, bin Qi, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja I., Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen J., Chen, Ming-Huei, Chen, Tai C., Chen, Yii-Der, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, ... Lorentzon, Mattias. (2016) Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 15(5), pp. 811 - 824. https://doi.org/10.1111/acel.12490
Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women
Brembeck, Peter, Winkvist, Anna, Ohlsson, Claes, Lorentzon, Mattias and Augustin, Hanna. (2016) Determinants of microstructural, dimensional and bone mineral changes postpartum in Swedish women. The British Journal of Nutrition. 116(10), pp. 1736 - 1744. https://doi.org/10.1017/S0007114516003998
A systematic review of intervention thresholds based on FRAX: A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation
Kanis, John A., Harvey, Nicholas C., Cooper, Cyrus, Johansson, Helena, Oden, Anders, McCloskey, Eugene V., The Advisory Board of the National Osteoporosis Guideline Group, and The Advisory Board of the National Osteoporosis Guideline Group. (2016) A systematic review of intervention thresholds based on FRAX: A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation. Archives of Osteoporosis. https://doi.org/10.1007/s11657-016-0278-z
FRAX predicts incident falls in elderly men: findings from MrOs Sweden
Harvey, Nicholas C., Johansson, Helena, Oden, Anders, Karlsson, Magnus, Rosengren, Björn E., Ljunggren, Östen, Cooper, Cyrus, McCloskey, Eugene V., Kanis, John A., Ohlsson, C. and Mellström, Dan. (2016) FRAX predicts incident falls in elderly men: findings from MrOs Sweden. Osteoporosis International. 27(1), pp. 267 - 274. https://doi.org/10.1007/s00198-015-3295-7
Assessment of muscle mass, muscle strength and physical performance in clinical practice: An international survey
Bruyère, O., Beaudart, Charlotte, Reginster, Jean Yves, Buckinx, F., Schoene, D., Hirani, V., Cooper, Cyrus, Kanis, John, Rizzoli, Rene, McCloskey, Eugene, Cederholm, T., Cruz-Jentoft, Alfonso J. and Freiberger, E.. (2016) Assessment of muscle mass, muscle strength and physical performance in clinical practice: An international survey. European Geriatric Medicine. 7(3), pp. 243 - 246. https://doi.org/10.1016/j.eurger.2015.12.009
A comprehensive fracture prevention strategy in older adults: The European Union Geriatric Medicine Society (EUGMS) statement
Blain, H., Masud, Tahir, Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, Nathalie, Bousquet, J., Benetos, A., Cooper, Cyrus, Kanis, John A., Reginster, Jean Yves, Rizzoli, Rene, Cortet, Bernard, Barbagallo, M., Dreinhöfer, K., Vellas, B., Maggi, S., Strandberg, Timo, Alvarez, M. N., ... Treml, J.. (2016) A comprehensive fracture prevention strategy in older adults: The European Union Geriatric Medicine Society (EUGMS) statement. European Geriatric Medicine. 7(6), pp. 519 - 525. https://doi.org/10.1016/j.eurger.2016.04.012
Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults
Nilsson, , Eriksson, Joel, Larsson, Berit A. M., Odén, Anders, Johansson, Helena and Lorentzon, Mattias. (2016) Fall risk assessment predicts fall-related injury, hip fracture, and head injury in older adults. Journal of the American Geriatrics Society. 64(11), pp. 2242 - 2250. https://doi.org/10.1111/jgs.14439
Bone material strength is associated with areal BMD but not with prevalent fractures in older women
Rudäng, R., Zoulakis, M., Sundh, D., Brisby, H., Diez-Perez, Aldolfo, Johansson, L., Mellström, Dan, Darelid, A. and Lorentzon, Mattias. (2016) Bone material strength is associated with areal BMD but not with prevalent fractures in older women. Osteoporosis International. 27(4), pp. 1585 - 1592. https://doi.org/10.1007/s00198-015-3419-0
A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement
Blain, H., Masud, Tahir, Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, Nathalie, Bousquet, J., Benetos, A., Cooper, Cyrus, Kanis, John, Reginster, Jean Y., Rizzoli, Rene, Cortet, B., Barbagallo, M., Dreinhöfer, K., Vellas, B., Maggi, S., Strandberg, Timo E., Alvarez, M. N., ... Macijauskien, J. (2016) A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement. Aging Clinical and Experimental Research. 28(4), pp. 797 - 803. https://doi.org/10.1007/s40520-016-0588-4
Diacerein: Benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO
Pavelka, Karel, Bruyère, Olivier, Cooper, Cyrus, Kanis, John A., Leeb, Burkhard F., Maheu, Emmanuel, Martel-Pelletier, Johanne, Monfort, Jordi, Pelletier, Jean-Pierre, Rizzoli, Rene and Reginster, Jean-Yves. (2016) Diacerein: Benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO. Drugs and Aging. 33(2), pp. 75 - 85. https://doi.org/10.1007/s40266-016-0347-4
High serum SHBG predicts incident vertebral fractures in elderly men
Vandenput, Liesbeth, Mellström, Dan, Kindmark, Andreas, Johansson, Helena, Lorentzon, Mattias, Leung, Jason, Redlund-Johnell, Inga, Rosengren, Björn E., Karlsson, Magnus K., Wang, Yi-Xiang, Kwok, Timothy and Ohlsson, Claes. (2016) High serum SHBG predicts incident vertebral fractures in elderly men. Journal of Bone and Mineral Research. 31(3), pp. 683 - 689. https://doi.org/10.1002/jbmr.2718
Effectiveness of a minimal resource fracture liaison service
Axelsson, K. F., Jacobsson, R., Lund, D. and Lorentzon, Mattias. (2016) Effectiveness of a minimal resource fracture liaison service. Osteoporosis International. 27(11), pp. 3165 - 3175. https://doi.org/10.1007/s00198-016-3643-2
High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study
Lewerin, C., Johansson, Helena, Karlsson, Magnus K., Lorentzon, Mattias, Lerner, Ulf H., Kindblom, J. M., Ohlsson, Claes, Smith, Ulf and Mellström, Dan. (2016) High plasma osteocalcin is associated with low blood haemoglobin in elderly men: The MrOS Sweden Study. Journal of Internal Medicine. 280(4), pp. 398 - 406. https://doi.org/10.1111/joim.12505
A comprehensive fracture prevention strategy in older adults: The European Union Geriatric Medicine Society (EUGMS) statement
Blain, H., Masud, Tahir, Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, N., Bousquet, J., Benetos, A., Cooper, Cyrus, Kanis, John A., Reginster, Jean Yves, Rizzoli, R., Cortet, B., Barbagallo, M., Dreinhöfer, K. E., Vellas, B., Maggi, S. and Strandberg, T.. (2016) A comprehensive fracture prevention strategy in older adults: The European Union Geriatric Medicine Society (EUGMS) statement. Aging Clinical and Experimental Research. 28(4), pp. 797 - 803. https://doi.org/10.1007/s40520-016-0588-4
A comprehensive fracture prevention strategy in older adults: The European Union Geriatric Medicine Society (EUGMS) statement
Blain, H., Masud, Tahir, Dargent-Molina, P., Martin, F. C., Rosendahl, E., van der Velde, N., Bousquet, J., Benetos, A., Cooper, Cyrus, Kanis, John A., Reginster, Jean Yves, Rizzoli, R., Cortet, B., Barbagallo, M., Dreinhöfer, K. E., Vellas, B., Maggi, S. and Strandberg, T.. (2016) A comprehensive fracture prevention strategy in older adults: The European Union Geriatric Medicine Society (EUGMS) statement. Journal of Nutrition, Health and Aging. 20(6), pp. 647 - 652. https://doi.org/10.1007/s12603-016-0741-y
Low serum vitamin D is associated with higher cortical porosity in elderly men
Sundh, D., Mellström, Dan, Ljunggren, Östen, Karlsson, Magnus K., Ohlsson, Claes, Nilsson, M., Nilsson, A. G. and Lorentzon, Mattias. (2016) Low serum vitamin D is associated with higher cortical porosity in elderly men. Journal of Internal Medicine. 280(5), pp. 496 - 508. https://doi.org/10.1111/joim.12514
Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and O
Cooper, Cyrus, Bardin, Thomas, Brandi, M. L., Cacoub, Patrice, Caminis, John, Civitelli, Roberto, Cutolo, Maurizio, Dere, Willard, Devogelaer, Jean-Pierre, Diez-Perez, Adolfo, Einhorn, Thomas A., Emonts, Patrick, Ethgen, Olivier, Kanis, John A., Kaufman, Jean-Marc, Kvien, Tore K., Lems, Willem F., McCloskey, Eugene, Miossec, Pierre, ... Reginster, Jean-Yves. (2016) Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and O. Aging Clinical and Experimental Research. 28(1), pp. 1 - 16. https://doi.org/10.1007/s40520-015-0522-1
SIGN Guidelines for Scotland: BMD Versus FRAX Versus QFracture
Kanis, John A., Compston, Juliet, Cooper, Cyrus, Harvey, Nicholas C., Johansson, Helena, Oden, Anders and McCloskey, Eugene V.. (2016) SIGN Guidelines for Scotland: BMD Versus FRAX Versus QFracture. Calcified Tissue International. 98(5), pp. 417 - 425. https://doi.org/10.1007/s00223-015-0092-4
A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis-From evidence-based medicine to the real-life setting
Bruyère, Olivier, Cooper, Cyrus, Pelletier, Jean-Pierre, Maheu, Emmanuel, Rannou, François, Branco, Jaime, Brandi, Maria Luisa, Kanis, John A., Altman, Roy D., Hochberg, Marc C., Martel-Pelletier, Johanne and Reginster, Jean-Yves. (2016) A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis-From evidence-based medicine to the real-life setting. Seminars in Arthritis and Rheumatism. 45(4), pp. S3 - S11. https://doi.org/10.1016/j.semarthrit.2015.11.010
A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX
McCloskey, Eugene, Oden, Anders, Harvey, Nicholas C., Leslie, William, Hans, D., Johansson, Helena, Barkmann, Reinhard, Boutroy, Stephanie, Brown, J. P., Chapurlat, Roland D., Elders, Petra J. M., Fujita, Yuki, Glüer, Claus C., Goltzman, David, Iki, Masayuki, Karlsson, M. K., Kindmark, Andreas, Kotowicz, Mark, Kurumatani, Norio, ... Kanis, John A.. (2016) A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. Journal of Bone and Mineral Research. 31(5), pp. 940 - 948. https://doi.org/10.1002/jbmr.2734
Sarcopenia in daily practice: Assessment and management
Beaudart, Charlotte, McCloskey, Eugene, Bruyère, Olivier, Cesari, Matteo, Rolland, Yves, Rizzoli, Rene, de Carvalho, Islène Araujo, Thiyagarajan, Jotheeswaran Amuthavalli, Bautmans, Ivan, Bertière, Marie-Claude, Brandi, Maria Luisa, Al-Daghri, Nasser M., Burlet, Nansa, Cavalier, Etienne, Cerreta, Francesca, Cherubini, Antonio, Fielding, Roger, Gielen, Evelien, Landi, Francesco, ... Cooper, Cyrus. (2016) Sarcopenia in daily practice: Assessment and management. BMC Geriatrics. 16(170), pp. 1 - 10. https://doi.org/10.1186/s12877-016-0349-4
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen, Tuomas O., Martin Carli, Jayne F., Skowronski, Alicja A., Sun, Qi, Kriebel, Jennifer, Feitosa, Mary F., Hedman, Åsa K., Drong, Alexander W., Hayes, James E., Zhao, Jinghua H., Pers, Tune H., Schick, Ursula M., Grarup, Niels, Kutalik, Zoltán, Trompet, Stella, Mangino, Massimo, Kristiansson, Kati, Beekman, Marian, Lyytikäinen, Leo-Pekka, ... Lorentzon, Mattias. (2016) Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nature Communications. 7(1), pp. 1 - 14. https://doi.org/10.1038/ncomms10494
Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, Jean Yves, Cooper, Cyrus, Rizzoli, Rene, Kanis, John A., Appelboom, Geoff, Bautmans, Ivan, Bischoff-Ferrari, Heike A., Boers, Maarten, Brandi, Maria Luisa, Bruyère, Olivier, Cherubini, Antonio, Flamion, Bruno, Fielding, Roger A., Gasparik, Andrea Ildiko, Van Loon, Lucas, McCloskey, Eugene, Mitlak, Bruce, Pilotto, Alberto, Reiter-Niesert, Suzanne, ... Cruz-Jentoft, Alfonso J.. (2016) Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia. Aging Clinical and Experimental Research. https://doi.org/10.1007/s40520-015-0517-y
A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women
Sundh, Daniel, Rudäng, Robert, Zoulakis, Michail, Nilsson, Anna G., Darelid, Anna and Lorentzon, Mattias. (2016) A high amount of local adipose tissue Is associated with high cortical porosity and low bone material strength in older women. Journal of Bone and Mineral Research. 31(4), pp. 749 - 757. https://doi.org/10.1002/jbmr.2747
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015
Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Alexandria, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Z., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Dilegge, Tina, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Tom, ... Murray, Christopher J. L.. (2016) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1545 - 1602. https://doi.org/10.1016/S0140-6736(16)31678-6
Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study
Wallin, Maria, Barregard, Lars, Sallsten, Gerd, Lundh, Thomas, Karlsson, Magnus K., Lorentzon, Mattias, Ohlsson, Claes and Mellström, Dan. (2016) Low-level cadmium exposure is associated with decreased bone mineral density and increased risk of incident fractures in elderly men: The MrOS Sweden study. Journal of Bone and Mineral Research. 31(4), pp. 732 - 741. https://doi.org/10.1002/jbmr.2743
Osteoporosis: The evolution of a diagnosis
Lorentzon, Mattias and Cummings, Steven R.. (2015) Osteoporosis: The evolution of a diagnosis. Journal of Internal Medicine. 277(6), pp. 650 - 661. https://doi.org/10.1111/joim.12369
Comments on the discordant recommendations for the use of symptomatic slow-acting drugs in knee osteoarthritis
Reginster, Jean Yves, Cooper, Cyrus, Hochberg, Marc, Pelletier, Jean Pierre, Rizzoli, R, Kanis, John A., Abadie, Eric, Maheu, E., Brandi, Maria Luisa, Devogelaer, J. P., Branco, J., Herrero-Beaumont, G., D'Hooghe, Pieter and Bruyère, O.. (2015) Comments on the discordant recommendations for the use of symptomatic slow-acting drugs in knee osteoarthritis. Current Medical Research and Opinion. 31(5), pp. 1041 - 1045. https://doi.org/10.1185/03007995.2015.1027183
Effective secondary fracture prevention: implementation of a global benchmarking of clinical quality using the IOF Capture the Fracture® Best Practice Framework tool
Javaid, M. K., Kyer, C., Mitchell, P. J., Chana, J., Moss, C., Edwards, M. H., McLellan, A. R., Stenmark, J., Pierroz, D. D., Schneider, M. C., Kanis, John A., Akesson, K. and Cooper, Cyrus. (2015) Effective secondary fracture prevention: implementation of a global benchmarking of clinical quality using the IOF Capture the Fracture® Best Practice Framework tool. Osteoporosis International. 26(11), pp. 2573 - 2578. https://doi.org/10.1007/s00198-015-3192-0
New genetic loci link adipose and insulin biology to body fat distribution
Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., ... Lorentzon, Mattias. (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518, pp. 187 - 196. https://doi.org/10.1038/nature14132
Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice
Harvey, N. C., Glüer, C. C., Binkley, N., McCloskey, E. V., Brandi, M. L., Cooper, C., Kendler, D., Lamy, O., Laslop, A., Camargos, B. M., Reginster, J-Y, Rizzoli, R. and Kanis, J. A.. (2015) Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice. Bone. 78, pp. 216 - 224. https://doi.org/10.1016/j.bone.2015.05.016
Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement
Haghsheno, Mohammad-Ali, Mellstrom, Dan, Peeker, Ralph, Hammarsten, Jan, Lorentzon, Mattias, Sundh, Valter, Karlsson, Magnus, Ohlsson, Claes and Damber, Jan-Erik. (2015) Lower urinary symptoms are associated with low levels of serum serotonin, high levels of adinopectin and fasting glucose, and benign prostatic enlargement. Scandinavian Journal of Urology. 49(2), pp. 155 - 161. https://doi.org/10.3109/21681805.2014.936495
Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on biomarkers and frailty
Arden, Nigel, Richette, Pascal, Cooper, Cyrus, Bruyère, Olivier, Abadie, Eric, Branco, Jaime, Brandi, Maria Luisa, Berenbaum, Francis, Clerc, Cécile, Dennison, Elaine M., Devogelaer, Jean-Pierre, Hochberg, Marc, D'Hooghe, Pieter, Herrero-Beaumont, Gabriel, Kanis, John A., Laslop, Andrea, Leblanc, Véronique, Maggi, Stefania, Mautone, Giuseppe, ... Reginster, Jean-Yves. (2015) Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on biomarkers and frailty. Drugs and Aging. 32(7), pp. 525 - 535. https://doi.org/10.1007/s40266-015-0276-7
The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis
Kherad, M., Mellström, Dan, Rosengren, Björn E., Hasserius, R., Nilsson, J.-Å., Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias and Karlsson, Magnus K.. (2015) The number and characteristics of prevalent vertebral fractures in elderly men are associated with low bone mass and osteoporosis. The Bone and Joint Journal. 97-B(8), pp. 1106 - 1110. https://doi.org/10.1302/0301-620X.97B8.35032
Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum
Brembeck, P., Lorentzon, Mattias, Ohlsson, Claes, Winkvist, A. and Augustin, H.. (2015) Changes in cortical volumetric bone mineral density and thickness, and trabecular thickness in lactating women postpartum. Journal of Clinical Endocrinology and Metabolism. 100(2), pp. 535 - 543. https://doi.org/10.1210/jc.2014-2825
Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: Expert consensus statement
Reginster, Jean Yves, Reiter-Niesert, S., Bruyère, O., Berenbaum, F., Brandi, Maria-Luisa, Branco, J., Devogelaer, J.-P., Herrero-Beaumont, G., Kanis, John A., Maggi, S., Maheu, E., Richette, P., Rizzoli, R. and Cooper, C.. (2015) Recommendations for an update of the 2010 European regulatory guideline on clinical investigation of medicinal products used in the treatment of osteoarthritis and reflections about related clinically relevant outcomes: Expert consensus statement. Osteoarthritis and Cartilage. 23(12), pp. 2086 - 2093. https://doi.org/10.1016/j.joca.2015.07.001
FRAX-based assessment and intervention thresholds - An exploration of thresholds in women aged 50 years and older in the UK
McCloskey, Eugene V., Kanis, John A., Johansson, Helena, Harvey, Nicholas C., Oden, Anders, Cooper, Alun, Cooper, C., Francis, Roger M., Reid, D. M., Marsh, D., Selby, P., Thompson, F., Hewitt, S. and Compston, Juliet E.. (2015) FRAX-based assessment and intervention thresholds - An exploration of thresholds in women aged 50 years and older in the UK. Osteoporosis International. 26(8), pp. 2091 - 2099. https://doi.org/10.1007/s00198-015-3176-0
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Cornelis, Marilyn C., Byrne, Enda M., Esko, Tonu, Nalls, Michael A., Ganna, Andrea, Paynter, Nina, Monda, Keri L., Amin, Najaf, Fischer, Krista, Renstrom, Frida, Ngwa, Julius S., Huikari, Ville, Cavadino, Alana, Nolte, Ilja M., Teumer, Alexander, Yu, Kai, Marques-Vidal, Pedro Manuel, Rawal, Rajesh, Manichaikul, Ani, ... UK Brain Expression Consortium (UKBEC). (2015) Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry. 20(5), pp. 647 - 656. https://doi.org/10.1038/mp.2014.107
Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study
Kherad, Mehrsa, Rosengren, Björn E., Hasserius, Ralph, Nilsson, Jan-Åke, Redlund-Johnell, Inga, Ohlsson, Claes, Lorentzon, Mattias, Mellström, Dan and Karlsson, Magnus K.. (2015) Low clinical relevance of a prevalent vertebral fracture in elderly men - the MrOs Sweden study. The Spine Journal. 15(2), pp. 281 - 289. https://doi.org/10.1016/j.spinee.2014.09.016
Increased cortical porosity in older men with fracture
Sundh, Daniel, Mellström, Dan, Nilsson, Martin, Karlsson, Magnus, Ohlsson, Claes and Lorentzon, Mattias. (2015) Increased cortical porosity in older men with fracture. Journal of Bone and Mineral Research. 30(9), pp. 1692 - 1700. https://doi.org/10.1002/jbmr.2509
Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study
Darelid, Anna, Nilsson, Martin, Kindblom, Jenny M., Mellström, Dan, Ohlsson, Claes and Lorentzon, Mattias. (2015) Bone turnover markers predict bone mass development in young adult men: A five-year longitudinal study. Journal of Clinical Endocrinology and Metabolism. 100(4), pp. 1460 - 1468. https://doi.org/10.1210/jc.2014-3947
High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study
Lewerin, C., Johansson, Helena, Lerner, Ulf H., Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Smith, Ulf, Ohlsson, Claes and Mellström, Dan. (2015) High serum adiponectin is associated with low blood haemoglobin in elderly men: The Swedish MrOS study. Journal of Internal Medicine. 278(1), pp. 68 - 76. https://doi.org/10.1111/joim.12340
Is the Swedish FRAX model appropriate for Swedish immigrants?
Johansson, Helena, Oden, Anders, Lorentzon, Mattias, McCloskey, Eugene V., Kanis, John A., Harvey, Nicholas C., Karlsson, M. K. and Mellström, Dan. (2015) Is the Swedish FRAX model appropriate for Swedish immigrants? Osteoporosis International. 26(11), pp. 2617 - 2622. https://doi.org/10.1007/s00198-015-3180-4
Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis
Bruyère, Olivier, Cooper, Cyrus, Arden, Nigel, Branco, Jaime, Brandi, Maria Luisa, Herrero-Beaumont, Gabriel, Berenbaum, Francis, Dennison, Elaine M., Devogelaer, Jean-Pierre, Hochberg, Marc, Kanis, John A., Laslop, Andrea, McAlindon, Tim, Reiter, Susanne, Richette, Pascal, Rizzoli, Rene and Reginster, Jean-Yves. (2015) Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis. Drugs and Aging. 32(3), pp. 179 - 187. https://doi.org/10.1007/s40266-015-0243-3
Serum 25-hydroxyvitamin D levels: Variability, knowledge gaps, and the concept of a desirable range
El-Hajj Fuleihan, Ghada, Bouillon, Roger, Clarke, Bart, Chakhtoura, Marlene, Cooper, Cyrus, McClung, Michael R. and Singh, Ravinder J.. (2015) Serum 25-hydroxyvitamin D levels: Variability, knowledge gaps, and the concept of a desirable range. Journal of Bone and Mineral Research. 30(7), pp. 1119 - 1133. https://doi.org/10.1002/jbmr.2536
Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men
Nilsson, Martin, Sundh, Daniel, Ohlsson, Claes, Karlsson, Magnus, Mellström, Dan and Lorentzon, Mattias. (2014) Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men. Journal of Bone and Mineral Research. 29(8), pp. 1795 - 1804. https://doi.org/10.1002/jbmr.2212
Management of osteoporosis of the oldest old
Rizzoli, R, Branco, J., Brandi, Maria Luisa, Boonen, S., Bruyère, O., Cacoub, P., Cooper, Cyrus, Diez-Perez, A, Duder, J., Fielding, R. A., Harvey, Nicholas C., Hiligsmann, Mickaël, Kanis, John A., Petermans, J., Ringe, J. D., Tsouderos, Y., Weinman, J. and Reginster, Jean Yves. (2014) Management of osteoporosis of the oldest old. Osteoporosis International. 25(11), pp. 2507 - 2529. https://doi.org/10.1007/s00198-014-2755-9
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaya, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltán, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., ... Lorentzon, Mattias. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46(11), pp. 1173 - 1186. https://doi.org/10.1038/ng.3097
Value of biomarkers in osteoarthritis: Current status and perspectives
Lotz, M., Martel-Pelletier, Johanne, Christiansen, Claus, Brandi, Maria Luisa, Bruyère, O., Chapurlat, Roland D., Collette, J., Cooper, Cyrus, Giacovelli, G., Kanis, John A., Karsdal, M. A., Kraus, V., Lems, Willem F., Meulenbelt, I., Pelletier, Jean Pierre, Raynauld, J. P., Reiter-Niesert, S., Rizzoli, R., Sandell, L. J., ... Reginster, Jean Yves. (2014) Value of biomarkers in osteoarthritis: Current status and perspectives. Postgraduate Medical Journal. 90(1061), pp. 171 - 178. https://doi.org/10.1136/postgradmedj-2013-203726rep
A meta-analysis of reference markers of bone turnover for prediction of fracture
Johansson, Helena, Oden, Anders, Kanis, John A., McCloskey, Eugene V., Morris, Howard A., Cooper, Cyrus and Vasikaran, Samuel. (2014) A meta-analysis of reference markers of bone turnover for prediction of fracture. Calcified Tissue International. 94(5), pp. 560 - 567. https://doi.org/10.1007/s00223-014-9842-y
Serum estradiol levels are inversely associated with cortical porosity in older men
Vandenput, Liesbeth, Lorentzon, Mattias, Sundh, Daniel, Nilsson, Maria E., Karlsson, Magnus K., Mellström, Dan and Ohlsson, Claes. (2014) Serum estradiol levels are inversely associated with cortical porosity in older men. Journal of Clinical Endocrinology and Metabolism. 99(7), pp. E1322 - E1326. https://doi.org/10.1210/jc.2014-1319
International and ethnic variability of falls in older men
Karlsson, Magnus L., Ribom, Eva L., Nilsson, J.-Å., Karlsson, Caroline, Cöster, Maria, Vonschewelov, Thord, Mallmin, Hans, Ljunggren, Östen, Ohlsson, Claes, Mellström, Dan, Lorentzon, Mattias, Leung, Ping C., Lau, Edith, Cauley, Jane A., Barrett-Connor, Elizabeth, Stefanick, Marcia L., Orwoll, Eric and Rosengren, Björn E.. (2014) International and ethnic variability of falls in older men. Scandinavian Journal of Public Health. 42(2), pp. 194 - 200. https://doi.org/10.1177/1403494813510789
The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Rizzoli, Rene, Stevenson, John C., Bauer, Jürgen M., Van Loon, Lucas J.C., Walrand, Stéphane, Kanis, John A., Cooper, Cyrus, Brandi, Maria Luisa, Diez-Perez, Adolfo and Reginster, Jean Yves. (2014) The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: A consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Maturitas. 79(1), pp. 122 - 132. https://doi.org/10.1016/j.maturitas.2014.07.005
Epidemiological burden of postmenopausal osteoporosis in Italy from 2010 to 2020: Estimations from a disease model
Piscitelli, P., Brandi, M., Cawston, H., Gauthier, A., Kanis, J. A., Compston, J., Borgstrom, F., Cooper, C. and McCloskey, E.. (2014) Epidemiological burden of postmenopausal osteoporosis in Italy from 2010 to 2020: Estimations from a disease model. Calcified Tissue International. 95(5), pp. 419 - 427. https://doi.org/10.1007/s00223-014-9910-3
An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Bruyère, Olivier, Cooper, Cyrus, Pelletier, Jean-Pierre, Branco, Jaime, Brandi, Maria Luisa, Guillemin, Francis, Hochberg, Marc C., Kanis, John A., Kvien, Tore K., Martel-Pelletier, Johanne, Rizzoli, Rene, Silverman, Stuart and Reginster, Jean-Yves. (2014) An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Seminars in Arthritis and Rheumatism. 44(3), pp. 253 - 263. https://doi.org/10.1016/j.semarthrit.2014.05.014
Challenges for the development of bone-forming agents in Europe
Kanis, John A., Rizzoli, Rene, Cooper, Cyrus and Reginster, Jean-Yves. (2014) Challenges for the development of bone-forming agents in Europe. Calcified Tissue International. 94(5), pp. 469 - 473. https://doi.org/10.1007/s00223-014-9844-9
Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study
Lewerin, Catharina, Nilsson-Ehle, Herman, Jacobsson, Stefan, Johansson, Helena, Sundh, Valter, Karlsson, Magnus K., Lorentzon, Mattias, Barrett-Connor, Elizabeth, Vandenput, Liesbeth, Ohlsson, Claes and Mellström, Dan. (2014) Serum estradiol associates with blood hemoglobin in elderly men: The MrOS Sweden study. Journal of Clinical Endocrinology and Metabolism. 99(7), pp. 2549 - 2556. https://doi.org/10.1210/jc.2013-4111
Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden
Lewerin, C. Lewerin, Nilsson-Ehle, H., Jacobsson, S., Johansson, Helena, Sundh, V., Karlsson, Magnus, Ljunggren, Östen, Lorentzon, Mattias, Kanis, John A., Lerner, Ulf H., Cummings, Steven R., Ohlsson, Claes and Mellström, Dan. (2014) Low holotranscobalamin and cobalamins predict incident fractures in elderly men: The MrOS Sweden. Osteoporosis International. 25(1), pp. 131 - 140. https://doi.org/10.1007/s00198-013-2527-y
A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children
Detter, Fredrik, Rosengren, Björn E., Dencker, Magnus, Lorentzon, Mattias, Nilsson, Jan‐Åke and Karlsson, Magnus K.. (2014) A 6-year exercise program improves skeletal traits without affecting fracture risk: A prospective controlled study in 2621 children. Journal of Bone and Mineral Research. 29(6), pp. 1325 - 1336. https://doi.org/10.1002/jbmr.2168
A reference case for economic evaluations in osteoarthritis: An expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Hiligsmann, Mickaël, Cooper, Cyrus, Guillemin, Francis, Hochberg, Marc C., Tugwell, Peter, Arden, Nigel, Berenbaum, Francis, Boers, Maarten, Boonen, Annelies, Branco, Jaime C., Maria-Luisa, Brandi, Bruyère, Olivier, Gasparik, Andrea Ildiko, Kanis, John A., Kvien, Tore K., Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Pinedo-Villanueva, Rafael, Pinto, Daniel, ... Reginster, Jean-Yves. (2014) A reference case for economic evaluations in osteoarthritis: An expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Seminars in Arthritis and Rheumatism. 44(3), pp. 271 - 282. https://doi.org/10.1016/j.semarthrit.2014.06.005
Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Moayyeri, Alireza, Hsu, Yi-Hsiang, Karasik, David, Estrada, Karol, Xiao, Su-Mei, Nielson, Carrie, Srikanth, Priya, Giroux, Sylvie, Wilson, Scott G., Zheng, Hou-Feng, Smith, Albert V., Pye, Stephen R., Leo, Paul J., Teumer, Alexander, Hwang, Joo-Yeon, Ohlsson, Claes, McGuigan, Fiona, Minster, Ryan L., Hayward, Caroline, ... Kaptoge, Stephen K.. (2014) Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium. Human Molecular Genetics. 23(11), pp. 3054 - 3068. https://doi.org/10.1093/hmg/ddt675
Worldwide uptake of FRAX
Kanis, John A., Johansson, Helena, Oden, Anders, Cooper, Cyrus, McCloskey, Eugene E. V., Epidemiology and Quality of Life Working Group of IOF, and Epidemiology and Quality of Life Working Group of IOF. (2014) Worldwide uptake of FRAX. Archives of Osteoporosis. 9(1), pp. 1 - 10. https://doi.org/10.1007/s11657-013-0166-8
Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT
Kemp, John P., Sayers, Adrian, Paternoster, Lavinia, Evans, David M., Deere, Kevin, St. Pourcain, Beate, Timpson, Nicholas J., Ring, Susan M., Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Smith, George Davey, Fraser, William D., ... Tobias, Jon H.. (2014) Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type i collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT. Journal of Bone and Mineral Research. 29(4), pp. 1015 - 1024. https://doi.org/10.1002/jbmr.2093
Gaucher disease and bone manifestations
Marcucci, Gemma, Zimran, Ari, Bembi, Bruno, Kanis, John, Reginster, Jean-Yves, Rizzoli, Rene, Cooper, Cyrus and Brandi, Maria Luisa. (2014) Gaucher disease and bone manifestations. Calcified Tissue International. 95(6), pp. 477 - 494. https://doi.org/10.1007/s00223-014-9923-y
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels
Kwan, Johnny S. H., Hsu, Yi-Hsiang, Cheung, Ching-Lung, Dupuis, Josée, Saint-Pierre, Aude, Eriksson, Joel, Handelman, Samuel K., Aragaki, Aaron K., Karasik, David, Pramstaller, Peter P., Kooperberg, Charles, Lacroix, Andrea Z., Larson, Martin G., Lau, Kam-Shing, Lorentzon, Mattias, Pichler, Irene, Sham, Pak Chung, Taliun, Daniel, Vandenput, Liesbeth, ... Kung, Annie Wai Chee. (2014) Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. Human Molecular Genetics. 23(24), pp. 6684 - 6693. https://doi.org/10.1093/hmg/ddu386
Treatment of osteoporosis in men
Kaufman, J-M, Reginster, J-Y, Boonen, S., Brandi, M. L., Cooper, Cyrus, Dere, W., Devogelaer, J. P., Diez-Perez, A, Kanis, John A., McCloskey, Eugene, Mitlak, B., Orwoll, E, Ringe, J. D., Weryha, G. and Rizzoli, R. (2013) Treatment of osteoporosis in men. Bone. 53(1), pp. 134 - 144. https://doi.org/10.1016/j.bone.2012.11.018
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure
Paternoster, Lavinia, Lorentzon, Mattias, Lehtimäki, Terho, Eriksson, Joel, Kähönen, Mika, Raitakari, Olli, Laaksonen, Marika, Sievänen, Harri, Viikari, Jorma, Lyytikäinen, Leo-Pekka, Mellström, Dan, Karlsson, Magnus, Ljunggren, Östen, Grundberg, Elin, Kemp, John P., Sayers, Adrian, Nethander, Maria, Evans, David M., Vandenput, Liesbeth, ... Ohlsson, Claes. (2013) Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genetics. 9(2), pp. 1 - 15. https://doi.org/10.1371/journal.pgen.1003247
Value of biomarkers in osteoarthritis: Current status and perspectives
Lotz, M., Martel-Pelletier, Johanne, Christiansen, Claus, Brandi, Maria-Luisa, Bruyère, O., Chapurlat, Roland D., Collette, J., Cooper, Cyrus, Giacovelli, G., Kanis, John A., Karsdal, M. A., Kraus, V., Lems, Willem F., Meulenbelt, I., Pelletier, Jean-Pierre, Raynauld, J.-P., Reiter-Niesert, S., Rizzoli, R., Sandell, L. J., ... Reginster, Jean-Yves. (2013) Value of biomarkers in osteoarthritis: Current status and perspectives. Annals of the Rheumatic Diseases. 72(11), pp. 1756 - 1763. https://doi.org/10.1136/annrheumdis-2013-203726
Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013
Compston, J., Bowring, C., Cooper, A., Cooper, C., Davies, C., Francis, R., Kanis, J. A., Marsh, D., McCloskey, E. V., Reid, D. M. and Selby, P.. (2013) Diagnosis and management of osteoporosis in postmenopausal women and older men in the UK: National Osteoporosis Guideline Group (NOGG) update 2013. Maturitas. 75(4), pp. 392 - 396. https://doi.org/10.1016/j.maturitas.2013.05.013
Quality of life in sarcopenia and frailty
Rizzoli, Rene, Reginster, Jean-Yves, Arnal, Jean-Francois, Bautmans, Ivan, Beaudart, Charlotte, Bischoff-Ferrari, Heike, Biver, Emmanuel, Boonen, Steven, Brandi, Maria-Luisa, Chines, Arkadi, Cooper, Cyrus, Epstein, Sol, Fielding, Roger A., Goodpaster, Bret, Kanis, John A., Kaufman, J., Laslop, A., Malafarina, Vincenzo, Mañas, Leocadio Rodriguez, ... Bruyère, O.. (2013) Quality of life in sarcopenia and frailty. Calcified Tissue International. 93(2), pp. 101 - 120. https://doi.org/10.1007/s00223-013-9758-y
Vitamin D supplementation in elderly or postmenopausal women: A 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Rizzoli, R., Boonen, S., Brandi, Maria-Luisa, Bruyère, O., Cooper, Cyrus, Kanis, John A., Kaufman, J.-M., Ringe, J. D., Weryha, G. and Reginster, Jean Yves. (2013) Vitamin D supplementation in elderly or postmenopausal women: A 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Current Medical Research and Opinion. 29(4), pp. 305 - 313. https://doi.org/10.1185/03007995.2013.766162
Health technology assessment in osteoporosis
Hiligsmann, Mickaël, Kanis, John A., Compston, Juliet, Cooper, Cyrus, Flamion, Bruno, Bergmann, Pierre, Body, Jean-Jaques, Boonen, Steven, Bruyère, Olivier, Devogelaer, Jean-Pierre, Goemaere, Stefan, Kaufman, Jean-Marc, Rozenberg, Serge and Reginster, Jean-Yves. (2013) Health technology assessment in osteoporosis. Calcified Tissue International. 93(1), pp. 1 - 14. https://doi.org/10.1007/s00223-013-9724-8
Health economics in the field of osteoarthritis: An expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
Hiligsmann, Mickaël, Cooper, Cyrus, Arden, Nigel, Boers, Maarten, Branco, Jaime C., Brandi, Maria Luisa, Bruyère, Olivier, Guillemin, Francis, Hochberg, Marc C., Hunter, David J., Kanis, John A., Kvien, Tore K., Laslop, Andrea, Pelletier, Jean-Pierre, Pinto, Daniel, Reiter-Niesert, Susanne, Rizzoli, Rene, Rovati, Lucio C., Severens, Johan L., ... Reginster, Jean-Yves. (2013) Health economics in the field of osteoarthritis: An expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Seminars in Arthritis and Rheumatism. 43(3), pp. 303 - 313. https://doi.org/10.1016/j.semarthrit.2013.07.003
Osteoporosis in the European Union: A compendium of country-specific reports
Svedbom, A., Hernlund, E., Ivergård, M., Compston, Juliet E., Cooper, Cyrus, Stenmark, J., McCloskey, Eugene V., Jönsson, Bengt, Kanis, John A., The EU review panel of the IOF, and The EU review panel of the IOF. (2013) Osteoporosis in the European Union: A compendium of country-specific reports. Archives of Osteoporosis. 8(1-2), pp. 1 - 218. https://doi.org/10.1007/s11657-013-0137-0
How to define responders in osteoarthritis
Cooper, Cyrus, Adachi, Jonathan D., Bardin, Thomas, Berenbaum, Francis, Flamion, Bruno, Jonsson, Helgi, Kanis, John A., Pelousse, Franz, Lems, Willem F., Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Reiter, Susanne, Reginster, Jean-Yves, Rizzoli, Rene and Bruyère, Olivier. (2013) How to define responders in osteoarthritis. Current Medical Research and Opinion. 29(6), pp. 719 - 729. https://doi.org/10.1185/03007995.2013.792793
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Kanis, John A., McCloskey, Eugene V., Johansson, Helena, Cooper, Cyrus, Rizzoli, R. and Reginster, Jean Yves. (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporosis International. 24(1), pp. 23 - 57. https://doi.org/10.1007/s00198-012-2074-y
Tools in the assessment of sarcopenia
Cooper, C., Fielding, R., Visser, M., Van Loon, L. J., Rolland, Y., Orwoll, E., Reid, K., Boonen, S., Dere, W., Epstein, S., Mitlak, B., Tsouderos, Y., Sayer, A. A., Rizzoli, R., Reginster, J. Y. and Kanis, J. A.. (2013) Tools in the assessment of sarcopenia. Calcified Tissue International. 93(3), pp. 201 - 210. https://doi.org/10.1007/s00223-013-9757-z
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt, Sonja I., Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jianan, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., ... Lorentzon, Mattias. (2013) Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics. 45, pp. 501 - 512. https://doi.org/10.1038/ng.2606
Osteoporosis in the European Union: Medical management, epidemiology and economic burden: A report prepared in collaboration with the International Osteoporosis Foundation IOF and the European Federation of Pharmaceutical Industry Associations EFPIA
Hernlund, E., Svedbom, A., Ivergård, M., Compston, Juliet E., Cooper, Cyrus, Stenmark, J., McCloskey, Eugene V., Jönsson, Bengt and Kanis, John A.. (2013) Osteoporosis in the European Union: Medical management, epidemiology and economic burden: A report prepared in collaboration with the International Osteoporosis Foundation IOF and the European Federation of Pharmaceutical Industry Associations EFPIA. Archives of Osteoporosis. 8(1-2), pp. 1 - 115. https://doi.org/10.1007/s11657-013-0136-1
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders
Hoed, Marcel den, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J.J.M., Peal, David S., Evans, David M., Nolte, Ilja M., Segrè, Ayellet V., Hólm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, ... Lorentzon, Mattias. (2013) Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45(6), pp. 621 - 631. https://doi.org/10.1038/ng.2610
Standardising the descriptive epidemiology of osteoporosis: Recommendations from the Epidemiology and Quality of Life Working Group of IOF
Kanis, John A., Adachi, Jonathan D., Cooper, Cyrus, Clark, P., Cummings, Steven R., Diaz-Curiel, M., Harvey, Nicholas C., Hiligsmann, Mickaël, Papaioannou, A., Pierroz, D. D., Silverman, S. L. and Szulc, P.. (2013) Standardising the descriptive epidemiology of osteoporosis: Recommendations from the Epidemiology and Quality of Life Working Group of IOF. Osteoporosis International. 24(11), pp. 2763 - 2764. https://doi.org/10.1007/s00198-013-2413-7
What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?
Pelletier, Jean Pierre, Cooper, Cyrus, Peterfy, C., Reginster, Jean Yves, Brandi, Maria Luisa, Bruyère, O., Chapurlat, Roland D., Cicuttini, Flavia, Conaghan, P. G., Doherty, M., Genant, H., Giacovelli, G., Hochberg, Marc, Hunter, David J., Kanis, John A., Kloppenburg, M., Laredo, J. D., McAlindon, T., Nevitt, M., ... Guermazi, A.. (2013) What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis? Annals of the Rheumatic Diseases. 72(10), pp. 1594 - 1604. https://doi.org/10.1136/annrheumdis-2013-203631
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk
Zheng, Hou-Feng, Tobias, Jon H., Duncan, Emma, Evans, David M., Eriksson, Joel, Paternoster, Lavinia, Yerges-Armstrong, Laura M., Lehtimäki, Terho, Bergström, Ulrica, Kähönen, Mika, Leo, Paul J., Raitakari, Olli, Laaksonen, Marika, Nicholson, Geoffrey C., Viikari, Jorma, Ladouceur, Martin, Lehtimäki, Leo-Pekka, Medina-Gomez, Carolina, Rivadeneira, Fernando, ... Lorentzon, Mattias. (2012) WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. PLoS Genetics. 8(7), pp. 1 - 13. https://doi.org/10.1371/journal.pgen.1002745
A systematic review of hip fracture incidence and probability of fracture worldwide
Kanis, John A., Oden, Anders, McCloskey, Eugene V., Johansson, Helena, Wahl, D. A. and Cooper, Cyrus. (2012) A systematic review of hip fracture incidence and probability of fracture worldwide. Osteoporosis International. 23(9), pp. 2239 - 2256. https://doi.org/10.1007/s00198-012-1964-3
Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden
Johansson, Helena Johansson, Oden, Anders, Kanis, John A., McCloskey, Eugene, Lorentzon, Mattias, Ljunggren, Östen, Karlsson, Magnus, Thorsby, P. M., Tivesten, A., Barrett-Connor, Elizabeth, Ohlsson, Claes and Mellström, Dan. (2012) Low serum vitamin D is associated with increased mortality in elderly men: MrOS Sweden. Osteoporosis International. 23(3), pp. 991 - 999. https://doi.org/10.1007/s00198-011-1809-5
Long-term treatment of osteoporosis in postmenopausal women: A review from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF)
Cooper, Cyrus, Reginster, Jean-Yves, Cortet, B., Diaz-Curiel, M., Lorenc, R. S., Kanis, John A. and Rizzoli, R.. (2012) Long-term treatment of osteoporosis in postmenopausal women: A review from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF). Current Medical Research and Opinion. 28(3), pp. 475 - 491. https://doi.org/10.1185/03007995.2012.663750
Antidepressant medications and osteoporosis
Rizzoli, R., Cooper, C., Reginster, Jean Yves, Abrahamsen, Bo, Adachi, Jonathan, Brandi, Maria Luisa, Bruyère, O., Compston, Juliet E., Ducy, P., Ferrari, S., Harvey, Nicholas C., Kanis, John A., Karsenty, G., Laslop, A., Rabenda, V. and Vestergaard, P.. (2012) Antidepressant medications and osteoporosis. Bone. 51(3), pp. 606 - 613. https://doi.org/10.1016/j.bone.2012.05.018
Epidemiological burden of postmenopausal osteoporosis in France from 2010 to 2020: Estimations from a disease model
Cawston, H., Maravic, M., Fardellone, P., Gauthier, A., Kanis, John A., Compston, Juliet E., Borgström, F., Cooper, Cyrus and McCloskey, Eugene. (2012) Epidemiological burden of postmenopausal osteoporosis in France from 2010 to 2020: Estimations from a disease model. Archives of Osteoporosis. 7(2017-02-01), pp. 237 - 246. https://doi.org/10.1007/s11657-012-0102-3
High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden
Johansson, Helena, Oden, Anders, Lerner, Ulf H., Jutberger, Hans, Lorentzon, Mattias, Barrett-Connor, Elizabeth, Karlsson, Magnus, Ljunggren, Östen, Smith, Ulf, McCloskey, Eugene, Kanis, John A., Ohlsson, Claes and Mellstrom, Dan. (2012) High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden. Journal of Bone and Mineral Research. 27(6), pp. 1390 - 1396. https://doi.org/10.1002/jbmr.1591
A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis
Lekamwasam, S., Adachi, Jonathan D., Agnusdei, D., Bilezikian, J. P., Boonen, S., Borgström, F., Cooper, Cyrus, Diez-Perez, A., Eastell, Richard, Hofbauer, L. C., Kanis, John A., Langdahl, B. L., Lesnyak, Olga, Lorenc, R. S., McCloskey, Eugene, Messina, O. D., Napoli, N., Obermayer-Pietsch, B., Ralston, Stuart H., ... Compston, Juliet E.. (2012) A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis. Osteoporosis International. 23(9), pp. 2257 - 2276. https://doi.org/10.1007/s00198-012-1958-1
Burden of postmenopausal osteoporosis in Germany: Estimations from a disease model
Gauthier, A., Kanis, John A., Jiang, Yling, Dreinhöfer, K., Martin, M., Compston, Juliet E., Borgström, F., Cooper, Cyrus and McCloskey, Eugene. (2012) Burden of postmenopausal osteoporosis in Germany: Estimations from a disease model. Archives of Osteoporosis. 7(2017-02-01), pp. 209 - 218. https://doi.org/10.1007/s11657-012-0099-7
A reappraisal of generic bisphosphonates in osteoporosis
Kanis, John A., Reginster, Jean Yves, Kaufman, J.-M., Ringe, J.-D., Adachi, Jonathan D., Hiligsmann, Mickaël, Rizzoli, R. and Cooper, Cyrus. (2012) A reappraisal of generic bisphosphonates in osteoporosis. Osteoporosis International. 23(1), pp. 213 - 221. https://doi.org/10.1007/s00198-011-1796-6
Management of glucocorticoid-induced osteoporosis
Rizzoli, R., Adachi, J. D., Cooper, C., Dere, W., Devogelaer, J. P., Diez-Perez, A., Kanis, J. A., Laslop, A., Mitlak, B., Papapoulos, S., Ralston, S., Reiter, S., Werhya, G. and Reginster, J. Y.. (2012) Management of glucocorticoid-induced osteoporosis. Calcified Tissue International. 91(4), pp. 225 - 243. https://doi.org/10.1007/s00223-012-9630-5
Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials
Rejnmark, Lars, Avenell, Alison, Masud, Tahir, Anderson, Frazer, Meyer, Haakon E., Sanders, Kerrie M., Salovaara, Kari, Cooper, Cyrus, Smith, Helen E., Jacobs, Elizabeth T., Torgerson, David, Jackson, Rebecca D., Manson, JoAnn E., Brixon, Kim, Mosekilde, Leif, Robbins, John A., Francis, Roger M. and Abrahamsen, Bo. (2012) Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials. Journal of Clinical Endocrinology and Metabolism. 97(8), pp. 2670 - 2681. https://doi.org/10.1210/jc.2011-3328
An appendix to the 2012 IOF-ECTS guidelines for the management of glucocorticoid-induced osteoporosis
Lekamwasam, S., Adachi, Jonathan D., Agnusdei, D., Bilezikian, J P., Boonen, S., Borgström, F., Cooper, Cyrus, Perez, A. Diez, Eastell, Richard, Hofbauer, L. C., Kanis, John A., Langdahl, B. L., Lesnyak, Olga, Lorenc, R. S., McCloskey, Eugene, Messina, O. D., Napoli, N., Obermayer-Pietsch, B., Ralston, Stuart H., ... Compston, Juliet E.. (2012) An appendix to the 2012 IOF-ECTS guidelines for the management of glucocorticoid-induced osteoporosis. Archives of Osteoporosis. 7(2017-02-01), pp. 25 - 30. https://doi.org/10.1007/s11657-012-0070-7
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus
Medina-Gomez, Carolina, Kemp, John P., Estrada, Karol, Eriksson, Joel, Liu, Jeff, Reppe, Sjur, Evans, David M., Heppe, Denise H. M., Vandenput, Liesbeth, Herrera, Lizbeth, Ring, Susan M., Kruithof, Claudia J., Timpson, Nicholas J., Zillikens, M. Carola, Olstad, Ole K., Zheng, Hou-Feng, Richards, J. Brent, St. Pourcain, Beate, Hofman, Albert, ... Rivadeneira, Fernando. (2012) Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. PLoS Genetics. 8(7), pp. 1 - 14. https://doi.org/10.1371/journal.pgen.1002718
A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of screening older women for the prevention of fractures: Rationale, design and methods for the SCOOP study
Shepstone, L., Fordham, R., Lenaghan, E., Harvey, I., Cooper, Cyrus, Gittoes, Neil, Heawood, A., Peters, T. J., O¿Neill, T. W., Torgerson, David, Holland, R., Howe, A., Marshall, T., Kanis, John A. and McCloskey, Eugene. (2012) A pragmatic randomised controlled trial of the effectiveness and cost-effectiveness of screening older women for the prevention of fractures: Rationale, design and methods for the SCOOP study. Osteoporosis International. 23(10), pp. 2507 - 2515. https://doi.org/10.1007/s00198-011-1876-7
Frailty and sarcopenia: Definitions and outcome parameters
Cooper, Cyrus, Dere, W., Evans, William J., Kanis, John A., Rizzoli, R, Sayer, A. A., Sieber, C. C., Kaufman, J, Van Kan, G. Abellan, Boonen, S., Adachi, Jonathan, Mitlak, B., Tsouderos, Y., Rolland, Y. and Reginster, Jean Yves. (2012) Frailty and sarcopenia: Definitions and outcome parameters. Osteoporosis International. 23(7), pp. 1839 - 1848. https://doi.org/10.1007/s00198-012-1913-1
Subtrochanteric fractures after long-term treatment with bisphosphonates: A European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report
Rizzoli, R, Åkesson, K., Bouxsein, M. L., Kanis, John A., Napoli, N., Papapoulos, S., Reginster, Jean Yves and Cooper, Cyrus. (2011) Subtrochanteric fractures after long-term treatment with bisphosphonates: A European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report. Osteoporosis International. 22(2), pp. 373 - 390. https://doi.org/10.1007/s00198-010-1453-5
Interpretation and use of FRAX in clinical practice
Kanis, John A., Hans, D., Cooper, Cyrus, Baim, Sanford, Bilezikian, J. P., Binkley, Neil, Cauley, Jane A., Compston, Juliet E., Dawson-Hughes, Bess, Fuleihan, Ghada El-Hajj, Johansson, Helena, Leslie, William D., Lewiecki, E. Michael, Luckey, Marjorie M., Oden, Anders, Papapoulos, S., Poiana, Catalina, Rizzoli, R, Wahl, D. A. and McCloskey, Eugene. (2011) Interpretation and use of FRAX in clinical practice. Osteoporosis International. 22(9), pp. 2395 - 2411. https://doi.org/10.1007/s00198-011-1713-z
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen, Tuomas O., Zillikens, M. Carola, Stančákova, Alena, Finucane, Francis M., Ried, Janina S., Langenberg, Claudia, Zhang, Weihua, Beckmann, Jacques S., Luan, Jian'an, Vandenput, Liesbeth, Styrkarsdottir, Unnur, Zhou, Yanhua, Smith, Albert V., Zhao, Jing-Hua, Amin, Najaf, Vedantam, Sailaja, Shin, So-Youn, Haritunians, Talin, Fu, Mao, ... Loos, Ruth J. F.. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature Genetics. 43(8), pp. 753 - 760. https://doi.org/10.1038/ng.866
Epidemiological burden of postmenopausal osteoporosis in the UK from 2010 to 2021: Estimations from a disease model
Gauthier, A., Kanis, John A., Jiang, Yling, Martin, M., Compston, Juliet E., Borgström, F., Cooper, Cyrus and McCloskey, Eugene. (2011) Epidemiological burden of postmenopausal osteoporosis in the UK from 2010 to 2021: Estimations from a disease model. Archives of Osteoporosis. 6(2017-02-01), pp. 179 - 188. https://doi.org/10.1007/s11657-011-0063-y
Joint official positions of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®. Executive Summary of the 2010 Position Development Conference on Interpretation and Use of FRAX® in Clinical Practice
Hans, Dieder B. L., Kanis, John A., Baim, Sanford, Bilezikian, John P., Binkley, Neil, Cauley, Jane A., Compston, Juliet E., Cooper, Cyrus, Dawson-Hughes, Bess, El-Hajj Fuleihan, Ghada, Leslie, William D., Lewiecki, E. Michael, Luckey, Marjorie M., McCloskey, Eugene V., Papapoulos, Socrates E., Poiana, Catalina and Rizzoli, Rene. (2011) Joint official positions of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®. Executive Summary of the 2010 Position Development Conference on Interpretation and Use of FRAX® in Clinical Practice. Journal of Clinical Densitometry. 14(3), pp. 171 - 180. https://doi.org/10.1016/j.jocd.2011.05.007
Development and validation of a disease model for postmenopausal osteoporosis
Gauthier, A., Kanis, John A., Martin, M., Compston, Juliet E., Borgström, F., Cooper, Cyrus and McCloskey, Eugene. (2011) Development and validation of a disease model for postmenopausal osteoporosis. Osteoporosis International. 22(3), pp. 771 - 780. https://doi.org/10.1007/s00198-010-1358-3
Partial adherence: A new perspective on health economic assessment in osteoporosis
Kanis, John A., Cooper, Cyrus, Hiligsmann, Mickaël, Rabenda, V., Reginster, Jean-Yves and Rizzoli, R.. (2011) Partial adherence: A new perspective on health economic assessment in osteoporosis. Osteoporosis International. 22(10), pp. 2565 - 2573. https://doi.org/10.1007/s00198-011-1668-0
Genetic determinants of serum testosterone concentrations in men
Ohlsson, Claes, Wallaschofski, Henri, Lunetta, Kathryn L., Stolk, Lisette, Perry, John R. B., Koster, Annemarie, Petersen, Ann-Kristin, Eriksson, Joel, Lehtima¨ki, Terho, Huhtaniemi, Ilpo T., Hammond, Geoffrey L., Maggio, Marcello, Coviello, Andrea D., Ferrucci, Luigi, Heier, Margit, Hofman, Albert, Holliday, Kate L., Jansson, John-Olov, Kahonen, Mika, ... Melzer, David. (2011) Genetic determinants of serum testosterone concentrations in men. PLoS Genetics. 7(10), pp. 1 - 11. https://doi.org/10.1371/journal.pgen.1002313
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms
Zhai, Guangju, Teumer, Alexander, Stolk, Lisette, Perry, John R. B., Vandenput, Liesbeth, Coviello, Andrea D., Koster, Annemarie, Bell, Jordana T., Bhasin, Shalender, Eriksson, Joel, Ernst, Florian, Ferrucci, Luigi, Frayling, Timothy M., Glass, Daniel, Grundberg, Elin, Haring, Robin, Hedman, Åsa K., Hofman, Albert, Kiel, Douglas P., ... MuTHER Consortium. (2011) Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genetics. 7(4), pp. 1 - 10. https://doi.org/10.1371/journal.pgen.1002025
Osteoporosis: Burden, health care provision and opportunities in the EU
Ström, O., Borgström, F., Kanis, John A., Compston, Juliet E., Cooper, Cyrus, McCloskey, Eugene V. and Jönsson, B.. (2011) Osteoporosis: Burden, health care provision and opportunities in the EU. Archives of Osteoporosis. 6(42767), pp. 59 - 155. https://doi.org/10.1007/s11657-011-0060-1
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis
Rizzoli, Rene, Reginster, Jean-Yves, Boonen, Steven, Bréart, Gérard, Diez-Perez, Adolfo, Felsenberg, Dieter, Kaufman, Jean-Marc, Kanis, John A. and Cooper, Cyrus. (2011) Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcified Tissue International. 89(2), pp. 91 - 104. https://doi.org/10.1007/s00223-011-9499-8
Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden
Johansson, Helena, Oden, Anders, Kanis, John A., McCloskey, Eugene V., Lorentzon, Mattias, Ljunggren, Östen, Karlsson, Magnus K., Orwoll, E., Tivesten, A., Ohlsson, Claes and Mellström, Dan. (2011) Low bone mineral density is associated with increased mortality in elderly men: MrOS Sweden. Osteoporosis International. 22(5), pp. 1411 - 1418. https://doi.org/10.1007/s00198-010-1331-1
Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: A need for international reference standards
Vasikaran, Samuel, Eastell, Richard, Bruyere, O., Foldes, A. J., Garnero, P., Griesmacher, Andrea, McClung, Michael R., Morris, Howard A., Silverman, S., Trenti, Tommaso, Wahl, D. A., Cooper, Cyrus and Kanis, John A.. (2011) Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: A need for international reference standards. Osteoporosis International. 22(2), pp. 391 - 420. https://doi.org/10.1007/s00198-010-1501-1
Secular trends in the incidence of hip and other osteoporotic fractures
Cooper, Cyrus, Cole, Z. A., Holroyd, C. R., Earl, S. C., Harvey, Nicholas C., Dennison, Elaine M., Melton, Lisa, Cummings, Steven R. and Kanis, John A.. (2011) Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporosis International. 22(5), pp. 1277 - 1288. https://doi.org/10.1007/s00198-011-1601-6
International osteoporosis foundation and international federation of clinical chemistry and laboratory medicine position on bone marker standards in osteoporosis
Vasikaran, Samuel, Cooper, Cyrus, Eastell, Richard, Griesmacher, Andrea, Morris, Howard A., Trenti, Tommaso and Kanis, John A.. (2011) International osteoporosis foundation and international federation of clinical chemistry and laboratory medicine position on bone marker standards in osteoporosis. Clinical Chemistry and Laboratory Medicine. 49(8), pp. 1271 - 1274. https://doi.org/10.1515/CCLM.2011.602
Smoking predicts incident fractures in elderly men: Mr OS Sweden
Jutberger, Hans, Lorentzon, Mattias, Barrett-Connor, Elizabeth, Johansson, Helena, Kanis, John, Ljunggren, Östen, Karlsson, Magnus, Rosengren, Björn E., Redlund-Johnell, Inga, Orwoll, E, Ohlsson, Claes and Mellström, Dan. (2010) Smoking predicts incident fractures in elderly men: Mr OS Sweden. Journal of Bone and Mineral Research. 25(5), pp. 1010 - 1016. https://doi.org/10.1359/jbmr.091112
Validation of the IOF quality of life questionnaire for patients with wrist fracture
Lips, P., Jameson, Karen A., Bianchi, Maria L., Goemaere, Stefan, Boonen, Steven, Reeve, Jonathan, Stepan, Jan J., Johnell, O., van Schoor, Natasja M., Dennison, Elaine M., Kanis, John and Cooper, Cyrus. (2010) Validation of the IOF quality of life questionnaire for patients with wrist fracture. Osteoporosis International. 21(1), pp. 61 - 70. https://doi.org/10.1007/s00198-009-0946-6
Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK
Compston, Juliet E., Cooper, Alun, Cooper, Cyrus, Francis, Roger M., Kanis, John, Marsh, D., McCloskey, Eugene, Reid, David M., Selby, P. and Wilkins, M.. (2009) Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. Maturitas. 62(2), pp. 105 - 108. https://doi.org/10.1016/j.maturitas.2008.11.022
Case finding for the management of osteoporosis with FRAX® - Assessment and intervention thresholds for the UK
Kanis, John, McCloskey, Eugene, Johansson, Helena, Ström, O., Borgström, F., Oden, Anders, Compston, Juliet E., Cooper, Alun, Cooper, Cyrus, Francis, Roger M., Marsh, D., Reid, David M., Selby, P. and Wilkins, M.. (2008) Case finding for the management of osteoporosis with FRAX® - Assessment and intervention thresholds for the UK. Osteoporosis International. 19(10), pp. 1395 - 1408. https://doi.org/10.1007/s00198-008-0712-1
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
Kanis, John, Oden, Anders, Johnell, O., Johansson, Helena, Laet, C. De, Brown, Jacques P., Burckhardt, Peter, Cooper, Cyrus, Christiansen, Claus, Cummings, Steven R., Eisman, John A., Fujiwara, S., Glüer, C. C., Goltzman, David, Hans, Didier, Krieg, Marc Antoine, Lacroix, Andrea Z., McCloskey, Eugene, Mellström, Dan, ... Yoshimura, N.. (2007) The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International. 18(8), pp. 1033 - 1046. https://doi.org/10.1007/s00198-007-0343-y
The cost-effectiveness of bisphosphonates in postmenopausal women based on individual long-term fracture risks
van Staa, T. P., Kanis, John, Geusens, P., Boonen, Annelies, Leufkens, H. G. M. and Cooper, Cyrus. (2007) The cost-effectiveness of bisphosphonates in postmenopausal women based on individual long-term fracture risks. Value in Health. 10(5), pp. 348 - 357. https://doi.org/10.1111/j.1524-4733.2007.00188.x
A simple clinical score for estimating the long-term risk of fracture in post-menopausal women
van Staa, T. P., Geusens, P., Kanis, John, Leufkens, H. G. M., Gehlbach, S. and Cooper, Cyrus. (2006) A simple clinical score for estimating the long-term risk of fracture in post-menopausal women. QJM: An International Journal of Medicine. 99(10), pp. 673 - 682. https://doi.org/10.1093/qjmed/hcl094