The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017

Journal article


Tatangelo, Gemma, Watts, Jennifer J., Lim, Karen, Connaughton, Catherine, Abimanyi-Ochom, Julie, Borgström, Fredrik, Nicholson, Geoff C., Shore-Lorenti, Catherine, Stuart, Amanda L., Iuliano-Burns, Sandra, Seeman, Ego, Prince, Richard L., March, Lyn, Cross, Marita, Winzenberg, Tania, Laslett, Laura L., Duque, Gustavo, Ebeling, Peter R. and Sanders, Kerrie M.. (2019). The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017. Journal of Bone and Mineral Research. 34(4), pp. 616 - 625. https://doi.org/10.1002/jbmr.3640
AuthorsTatangelo, Gemma, Watts, Jennifer J., Lim, Karen, Connaughton, Catherine, Abimanyi-Ochom, Julie, Borgström, Fredrik, Nicholson, Geoff C., Shore-Lorenti, Catherine, Stuart, Amanda L., Iuliano-Burns, Sandra, Seeman, Ego, Prince, Richard L., March, Lyn, Cross, Marita, Winzenberg, Tania, Laslett, Laura L., Duque, Gustavo, Ebeling, Peter R. and Sanders, Kerrie M.
Abstract

Osteoporosis and osteopenia are increasingly prevalent conditions among older adults. Not only do the fractures associated with poor bone health have significant health consequences for the individual, but also their economic impact is placing increasing financial burden on governments and society. This study aimed to determine the direct economic cost of osteoporosis, osteopenia, and fractures among Australians aged 50 years and older in 2017. This study uses previous Australian data on the incidence and prevalence of osteoporosis and osteopenia together with recent Australian data on health service utilization after fracture to provide an estimate of the economic burden of osteoporosis. A bottom‐up costing approach was used to determine the average direct health care and non‐health care total costs of a fracture, as well as the average community health service costs of managing individuals with osteoporosis or osteopenia. The total direct cost of osteoporosis in Australia in 2017 was estimated to be $3.44 billion (AUD 2017, USD 2.77 billion). Treatment of fractures accounted for 68% of total direct costs, and non‐fracture management of osteoporosis accounted for 32%. Hip fractures accounted for the highest proportion (43%) of the total direct cost of fractures, although fractures at “other” sites accounted for 38.5%. Fractures among individuals aged 70 years and older accounted for 74% of the direct costs (55% and 19% in women and men, respectively). Fracture costs in those with osteopenia accounted for 50% of direct fracture treatment costs. This up‐to‐date cost analysis estimated that costs in 2017 were three times higher than in 2007. These estimates will aid clinicians, policy makers, researchers, and health care organizations to acknowledge the economic importance of reducing osteoporosis‐related fractures and associated costs. This provides a strong public health case to promote bone health that will assist in reducing future fracture‐related costs. © 2018 American Society for Bone and Mineral Research.

Keywordsosteoporosis; osteopenia; fracture; health economics
Year2019
JournalJournal of Bone and Mineral Research
Journal citation34 (4), pp. 616 - 625
PublisherWiley-Blackwell Publishing, Inc.
ISSN0884-0431
Digital Object Identifier (DOI)https://doi.org/10.1002/jbmr.3640
Scopus EID2-s2.0-85059686298
Page range616 - 625
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Grant IDNHMRC/68251
Place of publicationUnited States of America
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Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide
Zebaze, Roger, Takao-Kawabata, Ryoko, Peng, Yu, Zadeh, Ali Ghasem, Hirano, Kyoko, Yamane, Hiroshi, Takakura, Aya, Isogai, Yukihiro, Ishizuya, Toshinori and Seeman, Ego. (2017). Increased cortical porosity is associated with daily, not weekly, administration of equivalent doses of teriparatide. Bone. 99, pp. 80 - 84. https://doi.org/10.1016/j.bone.2017.03.042
Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults
Shang, Xianwen, Scott, David, Hodge, Allison, English, Dallas, Giles, Graham G., Ebeling, Peter and Sanders, Kerrie. (2017). Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults. Clinical Nutrition. 36(6), pp. 1540 - 1548. https://doi.org/10.1016/j.clnu.2016.09.024
Dairy food supplementation may reduce malnutrition risk in institutionalised elderly
Iuliano, Sandra, Poon, Shirley, Wang, Xiaofang, Bui, Minh and Seeman, Ego. (2017). Dairy food supplementation may reduce malnutrition risk in institutionalised elderly. British Journal of Nutrition. 117(1), pp. 142 - 147. https://doi.org/10.1017/S000711451600461X
Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury
Sanders, Kerrie, Lim, Karen, Stuart, Amanda L., Macleod, Ashley, Scott, David, Nicholson, Geoff and Busija, Lucy. (2017). Diversity in fall characteristics hampers effective prevention: the precipitants, the environment, the fall and the injury. Osteoporosis International. 28(10), pp. 3005 - 3015. https://doi.org/10.1007/s00198-017-4145-6
Osteoporosis costing Victoria: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Victoria: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease
Seeman, Ego. (2017). Overview of bone microstructure, and treatment of bone fragility in chronic kidney disease. Nephrology. 22(Suppl 2), pp. 34 - 35. https://doi.org/10.1111/nep.13024
Sexual dysfunction and relationship stress: how does this association vary for men and women?
McCabe, Marita P. and Connaughton, Catherine. (2017). Sexual dysfunction and relationship stress: how does this association vary for men and women? Current Opinion in Psychology. 13, pp. 81 - 84. https://doi.org/10.1016/j.copsyc.2016.05.007
Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS
Svedbom, A., Borgström, Fredrik, Hernlund, E., Ström, O., Alekna, V., Bianchi, Maria L., Clark, P., Curiel, M. D., Dimai, Hans P., Jürisson, M., Uusküla, A., Lember, M., Kallikorm, R., Lesnyak, Olga, McCloskey, Eugene, Ershova, Olga, Sanders, Kerrie, Silverman, S., Tamulaitiene, M., ... Kanis, John. (2017). Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS. Quality of Life Research. 27(3), pp. 707 - 716. https://doi.org/10.1007/s11136-017-1748-5
Osteoporosis costing NSW and ACT: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing NSW and ACT: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Serum 25-hydroxyvitamin d insufficiency in search of a bone disease
Shah, Sonali, Chiang, Cherie, Sikaris, Ken, Lu, Zhong, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Serum 25-hydroxyvitamin d insufficiency in search of a bone disease. The Journal of Clinical Endocrinology and Metabolism. 102(7), pp. 2321 - 2328. https://doi.org/10.1210/jc.2016-3189
Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding
Bjørnerem, Åshild, Ghasem-Zadeh, Ali, Wang, Xiaofang, Bui, Minh, Walker, Susan P., Zebaze, Roger and Seeman, Ego. (2017). Irreversible deterioration of cortical and trabecular microstructure associated with breastfeeding. Journal of Bone and Mineral Research. 32(4), pp. 681 - 687. https://doi.org/10.1002/jbmr.3018
Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS
Svedbom, A., Borgstöm, F., Hernlund, E., Ström, O., Alekna, V., Bianchi, M. L., Clark, P., Curiel, M. D., Dimai, Hans P., Jürisson, M., Kallikorm, R., Lember, M., Lesnyak, Olga, McCloskey, Eugene, Sanders, Kerrie, Silverman, S., Solodovnikov, A., Tamulaitiene, M., Thomas, T., ... John, Handelshogskolan i Stockholm. (2017). Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS. Osteoporosis International. 29(3), pp. 557 - 566. https://doi.org/10.1007/s00198-017-4317-4
Vitamin D, bones and muscle: myth versus reality
Duque, Gustavo, Daly, Rob, Sanders, Kerrie and Kiel, Douglas P.. (2017). Vitamin D, bones and muscle: myth versus reality. Australasian Journal on Ageing. 36(1), pp. 8 - 13. https://doi.org/10.1111/ajag.12408
Associations between illness duration and health-related quality of life in specified mental and physical chronic health conditions: results from a population-based survey
Busija, Lucy, Tan, Jeretine and Sanders, Kerrie. (2017). Associations between illness duration and health-related quality of life in specified mental and physical chronic health conditions: results from a population-based survey. Quality of Life Research. 26(10), pp. 2671 - 2681. https://doi.org/10.1007/s11136-017-1592-7
The effect of vitamin D status on pain, lower limb strength and knee function during balance recovery in people with knee osteoarthritis: an exploratory study
Levinger, P., Begg, Rezaul, Sanders, Kerrie, Nagano, Hanatsu, Downie, Calum, Petersen, Aaron, Hayes, A. and Cicuttini, Flavia. (2017). The effect of vitamin D status on pain, lower limb strength and knee function during balance recovery in people with knee osteoarthritis: an exploratory study. Archives of Osteoporosis. 12(83), pp. 1 - 6. https://doi.org/10.1007/s11657-017-0378-4
Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure
Ramchand, Sabashini K., Seeman, Ego, Wang, Xiao-Fang, Ghasem-Zadeh, Ali, Francis, Prudence A., Ponnusamy, Evangeline J., Bardin, Michele S., Bui, Minh, Zebaze, Roger, Zajac, Jeffrey D. and Grossmann, Mathis. (2017). Premenopausal women with early breast cancer treated with estradiol suppression have severely deteriorated bone microstructure. Bone. 103, pp. 131 - 135. https://doi.org/10.1016/j.bone.2017.06.024
Osteoporosis costing Tasmania: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Tasmania: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Osteoporosis costing Northern Territory: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Northern Territory: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Dietary quality is associated with abdominal aortic calcification: a mean of 18-year longitudinal study in community-dwelling older adults
Shang, Xianwen, Scott, David, Hodge, Allison, Khan, Belal, Khan, Nayab, English, Dallas, Giles, Graham G., Ebeling, Peter and Sanders, Kerrie. (2017). Dietary quality is associated with abdominal aortic calcification: a mean of 18-year longitudinal study in community-dwelling older adults. Journal of Nutrition, Health and Aging. 21(2), pp. 147 - 151. https://doi.org/10.1007/s12603-016-0738-6
Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions
Ghasem-Zadeh, Ali, Burghardt, Andrew, Wang, Xiao-Fang, Iuliano, Sandra, Bonaretti, Serena, Bui, Minh, Zebaze, Roger and Seeman, Ego. (2017). Quantifying sex, race, and age specific differences in bone microstructure requires measurement of anatomically equivalent regions. Bone. 101, pp. 206 - 213. https://doi.org/10.1016/j.bone.2017.05.010
Osteoporosis costing Western Australia: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Western Australia: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Osteoporosis costing South Australia: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing South Australia: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Osteoporosis costing Queensland: A burden of disease analysis - 2012 to 2022
Sanders, Kerrie, Watts, Jennifer, Abimanyi-Ochom, J. and Murtaza, Ghulam. (2017). Osteoporosis costing Queensland: A burden of disease analysis - 2012 to 2022 Australia: Osteoporosis Australia.
Gender, marital status and longevity
Tatangelo, Gemma, McCabe, Marita, Campbell, Stephen and Szoeke, Cassandra. (2017). Gender, marital status and longevity. Maturitas. 100, pp. 64 - 69. https://doi.org/10.1016/j.maturitas.2017.03.002
Children's body image and social comparisons with peers and the media
Tatangelo, Gemma and Ricciardelli, Lina A.. (2017). Children's body image and social comparisons with peers and the media. Journal of Health Psychology. 22(6), pp. 776 - 787. https://doi.org/10.1177/1359105315615409
Abaloparatide is an anabolic, but does it spare resorption?
Martin, T. John and Seeman, Ego. (2017). Abaloparatide is an anabolic, but does it spare resorption? Journal of Bone and Mineral Research. 32(1), pp. 11 - 16. https://doi.org/10.1001/jama.2016.11136
Healthy me: A gender-specific program to address body image concerns and risk factors among preadolescents
McCabe, Marita P., Connaughton, Catherine, Tatangelo, Gemma, Mellor, David and Busija, Lucy. (2017). Healthy me: A gender-specific program to address body image concerns and risk factors among preadolescents. Body Image. 20, pp. 20 - 30. https://doi.org/10.1016/j.bodyim.2016.10.007
There isn't an easy way of finding the help that's available. Barriers and facilitators of service use among dementia family caregivers: A qualitative study
MacLeod, Ashley, Tatangelo, Gemma, McCabe, Marita and You, Emily. (2017). There isn't an easy way of finding the help that's available. Barriers and facilitators of service use among dementia family caregivers: A qualitative study. International Psychogeriatrics. 29(5), pp. 765 - 776. https://doi.org/10.1017/S1041610216002532
Conceptualization of the sexual response models in men: Are there differences between sexually functional and dysfunctional men?
Connaughton, Catherine, McCabe, Marita Patricia and Karantzas, Gery. (2016). Conceptualization of the sexual response models in men: Are there differences between sexually functional and dysfunctional men? Journal of Sexual Medicine. https://doi.org/10.1016/j.jsxm.2015.12.032
Hepcidin is a better predictor of ron stores in premenopausal women than blood loss or dietary intake
Lim, Karen, Booth, Alison O., Nowson, Carol, Szymlek-Gay, Ewa A., Irving, David O. and Riddell, Lynn J.. (2016). Hepcidin is a better predictor of ron stores in premenopausal women than blood loss or dietary intake. Nutrients. 8(9), pp. 1 - 15. https://doi.org/10.3390/nu8090540
Better with age: A health promotion program for men at midlife
Mellor, David, Connaughton, Catherine, McCabe, Marita Patricia and Tatangelo, Gemma Louise. (2016). Better with age: A health promotion program for men at midlife. Psychology of Men and Masculinity. https://doi.org/10.1037/men0000037
Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age
Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Challenges in the use of cross-sectional data to quantify growth and deterioration of bone structure during advancing age. Journal of Clinical Densitometry. 20(1), pp. 5 - 7. https://doi.org/10.1016/j.jocd.2016.08.006
A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol
Levinger, Itamar, Brennan-Speranza, Tara C., Stepto, Nigel K., Jerums, George, Parker, Lewan, McConell, Glenn K., Anderson, Mitchell, Garnham, Andrew, Hare, David L., Ebeling, Peter R. and Seeman, Ego. (2016). A single dose of prednisolone as a modulator of undercarboxylated osteocalcin and insulin sensitivity post-exercise in healthy young men: A study protocol. JMIR Research Protocols. 5(2), pp. 1 - 7. https://doi.org/10.2196/resprot.5119
A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy
Barker, Anna L., McNeil, John J., Seeman, Ego, Ward, Stephanie A., Sanders, Kerrie M., Khosla, Sundeep, Cumming, Robert G., Pasco, Julie A., Bohensky, Megan A., Ebeling, Peter E., Woods, Robyn L., Lockery, Jessica E., Wolfe, Rory, Talevski, Jason and ASPREE Investigator Group. (2016). A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: Protocol for the ASPREE-Fracture substudy. Injury Prevention. 22(4), pp. 297-301. https://doi.org/10.1136/injuryprev-2015-041655
A systematic review of body dissatisfaction and sociocultural messages related to the body among preschool children
Tatangelo, Gemma Louise, McCabe, Marita Patricia, Mellor, David and Mealey, Alex. (2016). A systematic review of body dissatisfaction and sociocultural messages related to the body among preschool children. Body Image. 18, pp. 86 - 95. https://doi.org/10.1016/j.bodyim.2016.06.003
Glucose-loading reduces bone remodeling in women and osteoblast function in vitro
Levinger, Itamar, Seeman, Ego, Jerums, George, McConell, Glenn K., Rybchyn, Mark S., Cassar, Samantha, Byrnes, Elizabeth, Selig, Steve, Mason, Rebecca S., Ebeling, Peter R. and Brennan-Speranza, Tara C.. (2016). Glucose-loading reduces bone remodeling in women and osteoblast function in vitro. Physiological Reports. 4(3), pp. 1 - 10. https://doi.org/10.14814/phy2.12700
Non-hip and non-vertebral fractures: the neglected fracture sites
Holloway, Kara, Henry, Margaret, Brennan-Olsen, Sharon, Bucki-Smith, Gosia, Nicholson, Geoffrey Charles, Korn, S., Sanders, Kerrie, Pasco, Julie and Kotowicz, Mark. (2016). Non-hip and non-vertebral fractures: the neglected fracture sites. Osteoporosis International. 27(3), pp. 905 - 913. https://doi.org/10.1007/s00198-015-3322-8
Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report
Ramchand, S. K., Chiang, C. Y., Zebaze, R. M. and Seeman, Ego. (2016). Recurrence of bilateral atypical femoral fractures associated with the sequential use of teriparatide and denosumab: A case report. Osteoporosis International. 27(2), pp. 821 - 825. https://doi.org/10.1007/s00198-015-3354-0
The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo
Levinger, Itamar, Lin, X, Zhang, X., Brennan-Speranza, T C., Volpato, B, Hayes, A., Jeru, G, Seeman, Ego and Mcconell, Glenn K.. (2016). The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo. Osteoporosis International. 27(2), pp. 653 - 663. https://doi.org/10.1007/s00198-015-3273-0
The association between anxiety and falls: A meta-analysis
Hallford, David John, Nicholson, Geoffrey Charles, Sanders, Kerrie and McCabe, Marita Patricia. (2016). The association between anxiety and falls: A meta-analysis. Journal of Gerontology: Psychological Sciences. 00(00), pp. 1 - 13. https://doi.org/10.1093/geronb/gbv160
Therapy: New findings on vitamin D3 supplementation and falls-when more is perhaps not better
Sanders, Kerrie and Seibel, Markus J.. (2016). Therapy: New findings on vitamin D3 supplementation and falls-when more is perhaps not better. Nature Reviews Endocrinology. 12(4), pp. 190 - 191. https://doi.org/10.1038/nrendo.2016.29
Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data
Brennan-Olsen, Sharon L., Page, Richard S., Lane, Steven E., Lorimer, Michelle, Buchbinder, Rachelle, Osborne, Richard H., Pasco, Julie A., Wluka, Anita E., Sanders, Kerrie M., Ebeling, Peter R. and Graves, Stephen E.. (2016). Few geographic and socioeconomic variations exist in primary total shoulder arthroplasty: A multi-level study of Australian registry data. BMC Musculoskeletal Disorders. 17(291), pp. 1 - 9. https://doi.org/10.1186/s12891-016-1134-4
Hearing their voice: A systematic review of dementia family caregivers' needs
McCabe, Marita Patricia, You, Emily and Tatangelo, Gemma Louise. (2016). Hearing their voice: A systematic review of dementia family caregivers' needs. The Gerontologist. 56(5), pp. e70 - e88. https://doi.org/10.1093/geront/gnw078
Challenges in the acquisition and analysis of bone microstructure during growth
Seeman, Ego and Ghasem-Zadeh, Ali. (2016). Challenges in the acquisition and analysis of bone microstructure during growth. Journal of Bone and Mineral Research. 31(12), pp. 2239 - 2241. https://doi.org/10.1002/jbmr.3015
Dietary protein intake and risk of type 2 diabetes: Results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies
Shang, Xianwen, Scott, David, Hodge, Allison M., English, Dallas R., Giles, Graham G., Ebeling, Peter R. and Sanders, Kerrie M.. (2016). Dietary protein intake and risk of type 2 diabetes: Results from the Melbourne Collaborative Cohort Study and a meta-analysis of prospective studies. American Journal of Clinical Nutrition. 104(5), pp. 1352 - 1365. https://doi.org/10.3945/ajcn.116.140954
Bone remodeling markers: So easy to measure, so difficult to interpret
Seeman, E. and Nguyen, T. V.. (2016). Bone remodeling markers: So easy to measure, so difficult to interpret. Osteoporosis International. 27, pp. 33 - 35. https://doi.org/10.1007/s00198-015-3374-9
Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis
Zebaze, Roger M., Libanati, Cesar, McClung, Michael R., Zanchetta, Jose Ruben, Kendler, David L., Høiseth, Arne, Wang, Andrea, Ghasem-Zadeh, Ali and Seeman, Ego. (2016). Denosumab reduces cortical porosity of the proximal femoral shaft in postmenopausal women with osteoporosis. Journal of Bone and Mineral Research. 31(10), pp. 1827 - 1834. https://doi.org/10.1002/jbmr.2855
Vitamin D and physical activity status : Associations with five-year changes in body composition and muscle function in community-dwelling older adults
Scott, David, Ebeling, Peter, Sanders, Kerrie, Aitken, Dawn, Winzenberg, Tania and Jones, Graeme. (2015). Vitamin D and physical activity status : Associations with five-year changes in body composition and muscle function in community-dwelling older adults. The Journal of Clinical Endocrinology and Metabolism. 100(2), pp. 670 - 678. https://doi.org/10.1210/jc.2014-3519
Osteoporosis: Treat or let die twice more likely
Nguyen, Tuan V. and Seeman, Ego. (2015). Osteoporosis: Treat or let die twice more likely. Journal of Bone and Mineral Research. 30(9), pp. 1551 - 1552. https://doi.org/10.1002/jbmr.2601/pdf
Associations between dietary iron and zinc intakes, and between biochemical iron and zinc status in women
Lim, Karen, Booth, Alison O., Szymlek-Gay, Ewa A., Gibson, Rosalind S., Bailey, Karl B., Irving, David O., Nowson, Carol and Riddell, Lynn J.. (2015). Associations between dietary iron and zinc intakes, and between biochemical iron and zinc status in women. Nutrients. 7(4), pp. 2983 - 2999. https://doi.org/10.3390/nu7042983
Editorial comment on "Psychology treatment trials for hypoactive sexual desire disorder: A sexual medicine critique and perspective"
McCabe, Marita P. and Connaughton, Catherine. (2015). Editorial comment on "Psychology treatment trials for hypoactive sexual desire disorder: A sexual medicine critique and perspective". Journal of Sexual Medicine. 12(12), pp. 2459 - 2460. https://doi.org/10.1111/jsm.13057
Cortical bone: A challenging geography
Zebaze, Roger and Seeman, Ego. (2015). Cortical bone: A challenging geography. Journal of Bone and Mineral Research. 30(1), pp. 24 - 29. https://doi.org/10.1002/jbmr.2419
Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft
Perilli, Egon, Bala, Yohann, Zebaze, Roger M., Reynolds, Karen J. and Seeman, Ego. (2015). Regional heterogeneity in the configuration of the intracortical canals of the femoral shaft. Calcified Tissue International. 97(4), pp. 327 - 335. https://doi.org/10.1007/s00223-015-0014-5
Validity of 12-month falls recall in community-dwelling older women participating in a clinical trial
Sanders, Kerrie M., Stuart, Amanda L., Scott, David, Kotowicz, Mark A. and Nicholson, Geoff C.. (2015). Validity of 12-month falls recall in community-dwelling older women participating in a clinical trial. International Journal of Endocrinology. https://doi.org/10.1155/2015/210527
Dietary salt intake and discretionary salt use in two general population samples in Australia: 2011 and 2014
Nowson, Carol, Lim, Karen, Grimes, Carley A., O'Halloran, Siobhan, Land, Mary A., Webster, Jacqui, Shaw, J. E., Chalmers, John, Smith, Wayne, Flood, Victoria, Woodward, Mark and Neal, Bruce. (2015). Dietary salt intake and discretionary salt use in two general population samples in Australia: 2011 and 2014. Nutrients. 7(12), pp. 10501 - 10512. https://doi.org/10.3390/nu7125545
Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS)
Abimanyi-Ochom, J., Watts, Jennifer, Borgstrom, F., Nicholson, Geoffrey, Shore-Lorenti, Catherine, Stuart, Amanda, Zhang, Y., Luliano, S., Seeman, Ego, Prince, Richard, March, Lyn, Winzenberg, T., Laslett, Laura, Duque, Gustavo, Ebeling, P. and Sanders, K. M.. (2015). Changes in quality of life associated with fragility fractures : Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS). Osteoporosis International. 26(6), pp. 1781 - 1790. https://doi.org/10.1007/s00198-015-3088-z
Effectiveness of dual-task functional power training for preventing falls in older people : Study protocol for a cluster randomised controlled trial
Daly, Robin, Duckham, Rachel, Tait, Jamie, Rantalainen, Timo, Nowson, Caryl, Taaffe, Dennis, Sanders, Kerrie, Hill, Keith, Kidgell, Dawson and Busija, Ljoudmila. (2015). Effectiveness of dual-task functional power training for preventing falls in older people : Study protocol for a cluster randomised controlled trial. Trials (online). 16(120), pp. 1 - 15. https://doi.org/10.1186/s13063-015-0652-y
Humeral fractures in south-eastern Australia: Epidemiology and risk factors
Holloway, Kara, Bucki-Smith, Gosia, Morse, Amelia, Brennan-Olsen, Sharon, Kotowicz, Mark, Moloney, David, Sanders, Kerrie, Korn, S, Timney, Elizabeth, Dobbins, Amelia and Pasco, Julie. (2015). Humeral fractures in south-eastern Australia: Epidemiology and risk factors. Calcified Tissue International. 97(5), pp. 453 - 465. https://doi.org/10.1007/s00223-015-0039-9
Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study
Bjornerem, Ashild, Bui, Q Minh, Wang, Xiaofang, Ghasem-Zadeh, Ali, Hopper, John L., Zebaze, Roger M. and Seeman, Ego. (2015). Genetic and environmental variances of bone microarchitecture and bone remodeling markers: A twin study. Journal of Bone and Mineral Research. 30(3), pp. 516 - 524. https://doi.org/10.1002/jbmr.2365
Bones material constituents and their contribution to bone strength in health, disease, and treatment
Bala, Y. and Seeman, Ego. (2015). Bones material constituents and their contribution to bone strength in health, disease, and treatment. Calcified Tissue International. 97(3), pp. 308 - 326. https://doi.org/10.1007/s00223-015-9971-y
A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015
Manolagas, Stavros C., Compston, Juliet, Rao, Sudhaker and Seeman, Ego. (2015). A. Michael Parfitt: Enlightened scholar and revered mentor: May 10, 1930-May 18, 2015. Journal of Bone and Mineral Research. 30(8), pp. 1349 - 1355. https://doi.org/10.1002/jbmr.2576
Dietary a-linolenic acid and total omega-3 fatty acids are inversely associated with abdominal aortic calcification in older women, but not in older men
Shang, Xianwen, Sanders, Kerrie, Scott, David, Khan, Belal, Hodge, Allison, Khan, Nayab, English, Dallas, Giles, Graham and Ebeling, Peter. (2015). Dietary a-linolenic acid and total omega-3 fatty acids are inversely associated with abdominal aortic calcification in older women, but not in older men. The Journal of Nutrition. 145(8), pp. 1778 - 1786. https://doi.org/10.3945/jn.115.211789
Co-administration of antiresorptive and anabolic agents: A missed opportunity
Seeman, Ego and Martin, T. John. (2015). Co-administration of antiresorptive and anabolic agents: A missed opportunity. Journal of Bone and Mineral Research. 30(5), pp. 753 - 764. https://doi.org/10.1002/jbmr.2496
Changes in gait performance over several years are associated with recurrent falls status in community-dwelling older women at high risk of fracture
Scott, David, McLaughlin, Patrick, Nicholson, Geoff C., Ebeling, Peter, Stuart, Amanda, Kay, Deborah and Sanders, Kerrie. (2015). Changes in gait performance over several years are associated with recurrent falls status in community-dwelling older women at high risk of fracture. Age and Ageing. 44(2), pp. 287 - 293. https://doi.org/10.1093/ageing/afu169
The ABC of writing a grant proposal
Seeman, Ego. (2015). The ABC of writing a grant proposal. Osteoporosis International. 26(6), pp. 1665 - 1666. https://doi.org/10.1007/s00198-015-3085-2
Growth and age-related abnormalities in cortical structure and fracture risk
Seeman, Ego. (2015). Growth and age-related abnormalities in cortical structure and fracture risk. Endocrinology and Metabolism. 30(4), pp. 419 - 428. https://doi.org/10.3803/EnM.2015.30.4.419
Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: A community-based randomized controlled trial
Gianoudis, Jenny, Bailey, Christine A., Ebeling, Peter R., Nowson, Caryl A., Sanders, Kerrie M., Hill, Keith and Daly, Robin M.. (2014). Effects of a targeted multimodal exercise program incorporating high-speed power training on falls and fracture risk factors in older adults: A community-based randomized controlled trial. Journal of Bone and Mineral Research. 29(1), pp. 182 - 191. https://doi.org/10.1002/jbmr.2014
Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003-10: data from the Australian Orthopaedic Association National Joint Replacement Registry
Brennan, Sharon L., Lane, Stephen E., Lorimer, Michelle, Buchbinder, Rachelle, Wluka, Anita E., Page, Richard S., Osborne, Richard H., Pasco, Julie A., Sanders, Kerrie M., Cashman, Kara, Ebeling, Peter R. and Graves, Stephen E.. (2014). Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003-10: data from the Australian Orthopaedic Association National Joint Replacement Registry. BMC Musculoskeletal Disorders. 15(356), pp. 1 - 9. https://doi.org/10.1186/1471-2474-15-356
Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults
Scott, David, Sanders, Kerrie M., Aitken, Dawn, Hayes, Alan, Ebeling, Peter R. and Jones, Graeme. (2014). Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults. Obesity. 22(6), pp. 1568 - 1574. https://doi.org/10.1002/oby.20734
Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study
Simpson, Richard W., Nicholson, Geoffrey C., Proietto, Joseph, Sarah, Alana, Sanders, Kerrie M., Phillips, Gabrielle, Chambers, Jo, MacGinley, Rob, Orford, Neil, Walder, Ken, Krippner, Guy, Skoff, Kathy and Wacher, Vincent J.. (2014). Efficacy and safety of oral methazolamide in patients with type 2 diabetes: A 24-week, placebo-controlled, double-blind study. Diabetes Care. 37(11), pp. 3121 - 3123. https://doi.org/10.2337/dc14-1038
Shining the Light on Sunshine: A systematic review of the influence of sun exposure on type 2 diabetes mellitus-related outcomes
Shore-Lorenti, Catherine, Brennan, Sharon L., Sanders, Kerrie M., Neale, Rachel E., Lucas, Robyn M. and Ebeling, Peter R.. (2014). Shining the Light on Sunshine: A systematic review of the influence of sun exposure on type 2 diabetes mellitus-related outcomes. Clinical Endocrinology. 81(6), pp. 799 - 811. https://doi.org/10.1111/cen.12567
Iron status and dietary iron intake of female blood donors
Booth, Alison O., Lim, Karen, Capper, Hugh, Irving, David, Fisher, Jenny, McNaughton, Sarah A., Riddell, Lynn, Keller, Anthony and Nowson, Caryl A.. (2014). Iron status and dietary iron intake of female blood donors. Transfusion. 54, pp. 770 - 774. https://doi.org/10.1111/trf.12347
Psychosocial factors associated with male sexual difficulties
McCabe, Marita and Connaughton, Catherine. (2014). Psychosocial factors associated with male sexual difficulties. Journal of Sex Research. 51(1), pp. 31 - 42. https://doi.org/10.1080/00224499.2013.789820
Serum selenium status in Graves' disease with and without orbitopathy: A case-control study
Khong, Jwu Jin, Goldstein, Rebecca F., Sanders, Kerrie M., Schneider, Hans, Pope, Jeffrey, Burdon, Kathryn P., Craigh, Jamie E., Ebeling, Peter R. and Peter, . (2014). Serum selenium status in Graves' disease with and without orbitopathy: A case-control study. Clinical Endocrinology. 80(6), pp. 905 - 910. https://doi.org/10.1111/cen.12392
Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture
Scott, David, Stuart, Amanda, Kay, Deborah, Ebeling, Peter, Nicholson, Geoffrey and Sanders, Kerrie. (2014). Investigating the predictive ability of gait speed and quadriceps strength for incident falls in community-dwelling older women at high risk of fracture. Archives of Gerontology and Geriatrics. 58(3), pp. 308 - 313. https://doi.org/10.1016/j.archger.2013.11.004
The prevalence of vitamin B12 deficiency in a random sample from the Australian population
Moore, Eileen, Pasco, Julie, Mander, Alastair, Sanders, Kerrie, Carne, Ross, Jenkins, Nicole, Black, Marion, Schneider, Hans, Ames, David and Watters, David. (2014). The prevalence of vitamin B12 deficiency in a random sample from the Australian population. Journal of Investigational Biochemistry. 3(3), pp. 95 - 100. https://doi.org/10.5455/jib.20140716041521
Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women
Levinger, Itamar, Scott, David, Nicholson, Geoffrey, Stuart, Amanda, Duque, Gustavo, McCorquodale, Thomas, Herrmann, Markus, Ebeling, Peter and Sanders, Kerrie. (2014). Undercarboxylated osteocalcin, muscle strength and indices of bone health in older women. Bone. 64, pp. 8 - 12. https://doi.org/10.1016/j.bone.2014.03.008
High-resolution in vivo imaging of bone and joints: a window to microarchitecture
Geusens, P., Geusens, P., Chapurlat, Roland D., Chapurlat, Roland D., Schett, G., Ghasem-Zadeh, Ali, Ghasem-Zadeh, Ali, Seeman, Ego, De Jong, J. and Van Den Bergh, J.. (2014). High-resolution in vivo imaging of bone and joints: a window to microarchitecture. Nature Reviews Rheumatology. 10(5), pp. 304 - 313. https://doi.org/10.1038/nrrheum.2014.23
How the Prevalence Rates of Male Sexual Dysfunction Vary Using Different Criteria
McCabe, Marita Patricia and Connaughton, Catherine. (2014). How the Prevalence Rates of Male Sexual Dysfunction Vary Using Different Criteria. International Journal of Sexual Health. 26(3), pp. 229 - 237. https://doi.org/10.1080/19317611.2013.873104
Iron and zinc nutrition in the economically-developed world : A review
Lim, Karen H. C., Riddell, Lynn J., Nowson, Caryl A., Booth, Alison O. and Szymlek-Gay, Ewa A.. (2013). Iron and zinc nutrition in the economically-developed world : A review. Nutrients. 5(8), pp. 3184-3211. https://doi.org/10.3390/nu5083184
A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images
Zebaze, Roger M., Ghasem-Zadeh, Ali, Mbala, A. and Seeman, Ego. (2013). A new method of segmentation of compact-appearing, transitional and trabecular compartments and quantification of cortical porosity from high resolution peripheral quantitative computed tomographic images. Bone. 54(1), pp. 8 - 20. https://doi.org/10.1016/j.bone.2013.01.007
Is high dose Vitamin D harmful?
Sanders, Kerrie, Nicholson, Geoffrey and Ebeling, Peter. (2013). Is high dose Vitamin D harmful? Calcified Tissue International. 92(2), pp. 191 - 206. https://doi.org/10.1007/s00223-012-9679-1
Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy
Chiang, Cherie Ying, Zebaze, Roger M.D., Ghasem-Zadeh, Ali, Iuliano-Burns, Sandra, Hardidge, Andrew and Seeman, Ego. (2013). Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. Bone. 52(1), pp. 360 - 365. https://doi.org/10.1016/j.bone.2012.10.006
A qualitative study of preadolescent boys' and girls' body image: Gendered ideals and sociocultural influences
Tatangelo, Gemma Louise and Ricciardelli, Lina A.. (2013). A qualitative study of preadolescent boys' and girls' body image: Gendered ideals and sociocultural influences. Body Image. 10(4), pp. 591 - 598. https://doi.org/10.1016/j.bodyim.2013.07.006
Vitamin D and health in adults in Australia and New Zealand : A position statement
Nowson, Caryl A., McGrath, John J., Ebeling, Peter R., Haikerwal, Anjali, Daly, Robin M., Sanders, Kerrie M., Seibel, Markus J. and Mason, Rebecca S.. (2012). Vitamin D and health in adults in Australia and New Zealand : A position statement. Medical Journal of Australia. 196(11), pp. 686-687. https://doi.org/10.5694/mja11.10301
Osteo-cise: Strong Bones for Life: Protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fractures
Gianoudis, Jenny, Bailey, Christine A., Sanders, Kerrie M., Nowson, Caryl A., Hill, Keith, Ebeling, Peter R. and Daly, Robin M.. (2012). Osteo-cise: Strong Bones for Life: Protocol for a community-based randomised controlled trial of a multi-modal exercise and osteoporosis education program for older adults at risk of falls and fractures. BMC Musculoskeletal Disorders. 13(78), pp. 1 - 16. https://doi.org/10.1186/1471-2474-13-78
Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial
Wustrack, R., Seeman, Ego, Bucci-Rechtweg, C. and Burch, S.. (2012). Predictors of new and severe vertebral fractures: Results from the HoRIZoN Pivotal Fracture Trial. Osteoporosis International. 23(1), pp. 53 - 58. https://doi.org/10.1007/s00198-011-1664-4
Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials
Rejnmark, Lars, Avenell, Alison, Masud, Tahir, Anderson, Frazer, Meyer, Haakon E., Sanders, Kerrie M., Salovaara, Kari, Cooper, Cyrus, Smith, Helen E., Jacobs, Elizabeth T., Torgerson, David, Jackson, Rebecca D., Manson, JoAnn E., Brixon, Kim, Mosekilde, Leif, Robbins, John A., Francis, Roger M. and Abrahamsen, Bo. (2012). Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials. The Journal of Clinical Endocrinology and Metabolism. 97(8), pp. 2670 - 2681. https://doi.org/10.1210/jc.2011-3328
Fracture risk score and absolute risk of fracture
Henry, Margaret, Pasco, Julie, Merriman, Elizabeth, Zhang, Yu, Sanders, Kerrie, Kotowicz, Mark and Nicholson, Geoffrey. (2011). Fracture risk score and absolute risk of fracture. Radiology. 259(2), pp. 495 - 501. https://doi.org/10.1148/radiol.10101406
Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007
Pasco, Julie, Brennan, Sharon, Henry, Margaret, Nicholson, Geoffrey, Sanders, Kerrie, Zhang, Yu and Kotowicz, Mark. (2011). Changes in hip fracture rates in southeastern Australia spanning the period 1994-2007. Journal of Bone and Mineral Research. 26(7), pp. 1648 - 1654. https://doi.org/10.1002/jbmr.393
The effect of acute exercise on undercarboxylated osteocalcin in obese men
Levinger, Itamar, Zebaze, Roger M., Jeru, G., Hare, David L., Selig, Steve and Seeman, Ego. (2011). The effect of acute exercise on undercarboxylated osteocalcin in obese men. Osteoporosis International. 22(5), pp. 1621 - 1626. https://doi.org/10.1007/s00198-010-1370-7
Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial
Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie, Nicholson, Geoffrey, Seibel, Markus, Salmon, Jo and Daly, Robin. (2011). Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: An 18-month factorial design randomized controlled trial. The Journal of Clinical Endocrinology and Metabolism. 96(4), pp. 955 - 963. https://doi.org/10.1210/jc.2010-2284
Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial
Peake, Jonathan, Kukuljan, Sonja, Nowson, Caryl, Sanders, Kerrie and Daly, Robin. (2011). Inflammatory cytokine responses to progressive resistance training and supplementation with fortified milk in men aged 50+ years: An 18-month randomized controlled trial. European Journal of Applied Physiology. 111(12), pp. 3079 - 3088. https://doi.org/10.1007/s00421-011-1942-z
Paracetamol (acetaminophen) use, fracture and bone mineral density
Williams, Lana, Pasco, Julie, Henry, Margaret, Sanders, Kerrie, Nicholson, Geoffrey, Kotowicz, Mark and Berk, Michael. (2011). Paracetamol (acetaminophen) use, fracture and bone mineral density. Bone. 48(6), pp. 1277 - 1281. https://doi.org/10.1016/j.bone.2011.03.435
Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial
Sanders, Kerrie, Stuart, Amanda, Williamson, Elizabeth, Jacka, Felice, Dodd, Seetal, Nicholson, Geoff and Berk, Michael. (2011). Annual high-dose vitamin D3 and mental well-being: Randomised controlled trial. British Journal of Psychiatry. 198(5), pp. 357 - 364. https://doi.org/10.1192/bjp.bp.110.087544
Teriparatide therapy for osteonecrosis of the jaw REPLY
Cheung, Ada S. and Seeman, Ego. (2011). Teriparatide therapy for osteonecrosis of the jaw REPLY. New England Journal of Medicine. 364, pp. 1081 - 1082. https://doi.org/10.1056/NEJMc1100730
Annual feedback is an effective tool for a sustained increase in calcium intake among older women
Sanders, Kerrie, Stuart, Amanda L., Kotowicz, Mark and Nicholson, Geoff. (2010). Annual feedback is an effective tool for a sustained increase in calcium intake among older women. Nutrients. 2(9), pp. 1018 - 1025. https://doi.org/10.3390/nu2091018
Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial
Sanders, Kerrie, Stuart, Amanda L., Williamson, Elizabeth J., Simpson, Julie A., Kotowicz, Mark, Young, Doris and Nicholson, Geoff. (2010). Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA: Journal of the American Medical Association. 303(18), pp. 1815 - 1822. https://doi.org/10.1001/jama.2010.594
Festschrift to honor Professor Pierre D. Delmas
Seeman, E., Lindsay, R. and Kanis, J. A.. (2009). Festschrift to honor Professor Pierre D. Delmas. Osteoporosis International. 20(Supplement 3), pp. S231 - S233. https://doi.org/10.1007/s00198-008-0811-z
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women
Kanis, John, Oden, Anders, Johnell, O., Johansson, Helena, Laet, C. De, Brown, Jacques P., Burckhardt, Peter, Cooper, Cyrus, Christiansen, Claus, Cummings, Steven R., Eisman, John A., Fujiwara, S., Glüer, C. C., Goltzman, David, Hans, Didier, Krieg, Marc Antoine, Lacroix, Andrea Z., McCloskey, Eugene, Mellström, Dan, ... Yoshimura, N.. (2007). The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporosis International. 18(8), pp. 1033 - 1046. https://doi.org/10.1007/s00198-007-0343-y
Bone fragility in men - Where are we?
Seeman, Ego, Bianchi, Georges, Khosla, Sundeep, Kanis, John and Orwoll, E. (2006). Bone fragility in men - Where are we? Osteoporosis International. 17(11), pp. 1577 - 1583. https://doi.org/10.1007/s00198-006-0160-8