A k-Space Sharing 3D GRASE Pseudocontinuous ASL method for whole-brain resting-state functional connectivity

Journal article


Liang, Xiaoyun, Tournier, Jacques-Donald, Masterton, Richard, Connelly, Alan and Calamante, Fernando. (2012) A k-Space Sharing 3D GRASE Pseudocontinuous ASL method for whole-brain resting-state functional connectivity. International Journal of Imaging Systems and Technology. 22(1), pp. 37-43. https://doi.org/10.1002/ima.22006
AuthorsLiang, Xiaoyun, Tournier, Jacques-Donald, Masterton, Richard, Connelly, Alan and Calamante, Fernando
Abstract

Magnetic resonance imaging (MRI) investigations of resting‐state functional connectivity (RSFC) typically use blood oxygen level‐dependent (BOLD)‐weighted imaging because of its ability to provide whole‐brain coverage and high temporal resolution. Single‐shot 3D gradient‐ and spin‐echo (GRASE) arterial spin labeling (ASL) offers a number of potential advantages for RSFC measurements, such as a more direct quantitative correlate of neural activity and lower variability across subjects; however, current sequences are usually not suitable for whole‐brain acquisitions because of T2 decay during the long echo train. In this study, we proposed a k‐space sharing 3D GRASE ASL sequence to achieve whole‐brain coverage, applied it to measure RSFC on a group of healthy subjects, and compared it with BOLD data. Similar RSFC networks were estimated using both techniques, providing corroboration of the capability of our method for RSFC analysis. Furthermore, ASL data enable calculation of mean cerebral blood flow (CBF) values within the RSFC networks, thus assigning them biologically meaningful values. The inherently quantitative nature of CBF measurements should provide a more stable and interpretable biomarker in comparison to BOLD and may, therefore, be particularly useful for applications such as longitudinal studies of RSFC. © 2012 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 22, 37–43, 2012

Keywordsperfusion functional MRI; arterial spin labeling; 3D gradient- and spin-echo; resting-state functional connectivity
Year2012
JournalInternational Journal of Imaging Systems and Technology
Journal citation22 (1), pp. 37-43
PublisherJohn Wiley & Sons
ISSN0899-9457
Digital Object Identifier (DOI)https://doi.org/10.1002/ima.22006
Scopus EID2-s2.0-84857204645
Open accessOpen access
Research or scholarlyResearch
Page range37-43
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online14 Feb 2012
Publication process dates
Accepted05 Dec 2011
Deposited28 Mar 2021
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