Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure

Journal article


Denfeld, Quin E., Mudd, James O., Hasan, Wohaib, Gelow, Jill M., Hiatt, Shirin O., Winters-Stone, Kerri and Lee, Christopher S.. (2018) Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure. Heart and Lung. 47(4), pp. 281-284. https://doi.org/10.1016/j.hrtlng.2018.05.003
AuthorsDenfeld, Quin E., Mudd, James O., Hasan, Wohaib, Gelow, Jill M., Hiatt, Shirin O., Winters-Stone, Kerri and Lee, Christopher S.
Abstract

Background
The relationship between physical heart failure (HF) symptoms and pathophysiological mechanisms is unclear.

Objective
To quantify the relationship between plasma β-adrenergic receptor kinase-1 (βARK1) and physical symptoms among adults with HF.

Methods
We performed a secondary analysis of data collected from two studies of adults with HF. Plasma βARK1 was quantified using an enzyme-linked immunosorbent assay. Physical symptoms were measured with the HF Somatic Perception Scale (HFSPS). Generalized linear modeling was used to quantify the relationship between βARK1 and HFSPS scores.

Results
The average age (n = 94) was 54.5 ± 13.1 years, 76.6% were male, and a majority (83.0%) had Class III or IV HF. βARK1 was significantly associated with HFSPS scores (β = 0.22 ± 0.10, p = 0.038), adjusting for other predictors of physical symptoms (model R2 = 0.250, F(7, 70) = 3.34, p = 0.004).

Conclusions
Higher βARK1 is associated with worse physical HF symptoms, pinpointing a potential pathophysiologic underpinning.

Keywordsheart failure; symptom; biomarkers; beta-adrenergic receptor kinases; G protein-coupled receptor kinase-2
Year2018
JournalHeart and Lung
Journal citation47 (4), pp. 281-284
PublisherElsevier Inc.
ISSN0147-9563
Digital Object Identifier (DOI)https://doi.org/10.1016/j.hrtlng.2018.05.003
Scopus EID2-s2.0-85047396346
Research or scholarlyResearch
Page range281-284
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online24 May 2018
Publication process dates
Accepted04 May 2018
Deposited15 Apr 2021
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