Impact of b-value on estimates of apparent fibre density
Journal article
Genc, Sila, Tax, Chantal M. W., Raven, Erika P., Chamberland, Maxime, Parker, Greg D. and Jones, Derek K.. (2020). Impact of b-value on estimates of apparent fibre density. Human Brain Mapping. 41(10), pp. 2583-2595. https://doi.org/10.1002/hbm.24964
Authors | Genc, Sila, Tax, Chantal M. W., Raven, Erika P., Chamberland, Maxime, Parker, Greg D. and Jones, Derek K. |
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Abstract | Recent advances in diffusion magnetic resonance imaging (dMRI) analysis techniques have improved our understanding of fibre‐specific variations in white matter microstructure. Increasingly, studies are adopting multi‐shell dMRI acquisitions to improve the robustness of dMRI‐based inferences. However, the impact of b‐value choice on the estimation of dMRI measures such as apparent fibre density (AFD) derived from spherical deconvolution is not known. Here, we investigate the impact of b‐value sampling scheme on estimates of AFD. First, we performed simulations to assess the correspondence between AFD and simulated intra‐axonal signal fraction across multiple b‐value sampling schemes. We then studied the impact of sampling scheme on the relationship between AFD and age in a developmental population (n = 78) aged 8–18 (mean = 12.4, SD = 2.9 years) using hierarchical clustering and whole brain fixel‐based analyses. Multi‐shell dMRI data were collected at 3.0T using ultra‐strong gradients (300 mT/m), using 6 diffusion‐weighted shells ranging from b = 0 to 6,000 s/mm2. Simulations revealed that the correspondence between estimated AFD and simulated intra‐axonal signal fraction was improved with high b‐value shells due to increased suppression of the extra‐axonal signal. These results were supported by in vivo data, as sensitivity to developmental age‐relationships was improved with increasing b‐value (b = 6,000 s/mm2, median R2 = .34; b = 4,000 s/mm2, median R2 = .29; b = 2,400 s/mm2, median R2 = .21; b = 1,200 s/mm2, median R2 = .17) in a tract‐specific fashion. Overall, estimates of AFD and age‐related microstructural development were better characterised at high diffusion‐weightings due to improved correspondence with intra‐axonal properties. |
Keywords | apparent fibre density; constrained spherical deconvolution; development; diffusion MRI; fixel based analysis; white matter |
Year | 2020 |
Journal | Human Brain Mapping |
Journal citation | 41 (10), pp. 2583-2595 |
Publisher | John Wiley & Sons, Inc. |
ISSN | 1065-9471 |
Digital Object Identifier (DOI) | https://doi.org/10.1002/hbm.24964 |
Scopus EID | 2-s2.0-85082314759 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 2583-2595 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 26 Mar 2020 |
Publication process dates | |
Accepted | 13 Feb 2020 |
Deposited | 27 Apr 2021 |
https://acuresearchbank.acu.edu.au/item/8vy5x/impact-of-b-value-on-estimates-of-apparent-fibre-density
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Publisher's version
OA_Genc_2020_Impact_of_b-value_on_estimates.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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